ATE274521T1 - Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion - Google Patents
Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktionInfo
- Publication number
- ATE274521T1 ATE274521T1 AT00917075T AT00917075T ATE274521T1 AT E274521 T1 ATE274521 T1 AT E274521T1 AT 00917075 T AT00917075 T AT 00917075T AT 00917075 T AT00917075 T AT 00917075T AT E274521 T1 ATE274521 T1 AT E274521T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- nitrates
- steroid
- oxidative damage
- endothelial dysfunction
- Prior art date
Links
- 206010048554 Endothelial dysfunction Diseases 0.000 title 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title 1
- 230000008694 endothelial dysfunction Effects 0.000 title 1
- 230000004792 oxidative damage Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000751A IT1311922B1 (it) | 1999-04-13 | 1999-04-13 | Composti farmaceutici. |
| PCT/EP2000/003238 WO2000061604A2 (en) | 1999-04-13 | 2000-04-11 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE274521T1 true ATE274521T1 (de) | 2004-09-15 |
Family
ID=11382683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00917075T ATE274521T1 (de) | 1999-04-13 | 2000-04-11 | Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6909007B1 (enExample) |
| EP (2) | EP1169337B1 (enExample) |
| JP (1) | JP2002542162A (enExample) |
| KR (2) | KR100687821B1 (enExample) |
| CN (2) | CN1916013A (enExample) |
| AT (1) | ATE274521T1 (enExample) |
| AU (2) | AU766798B2 (enExample) |
| BR (1) | BR0009696A (enExample) |
| CA (2) | CA2370446C (enExample) |
| DE (1) | DE60013266T2 (enExample) |
| DK (1) | DK1169337T3 (enExample) |
| ES (1) | ES2226805T3 (enExample) |
| HU (1) | HUP0201872A3 (enExample) |
| IL (2) | IL145633A0 (enExample) |
| IT (1) | IT1311922B1 (enExample) |
| MX (1) | MXPA01010212A (enExample) |
| NO (2) | NO323374B1 (enExample) |
| NZ (1) | NZ514572A (enExample) |
| PL (1) | PL199579B1 (enExample) |
| PT (1) | PT1169337E (enExample) |
| RU (1) | RU2240325C2 (enExample) |
| SI (1) | SI1169337T1 (enExample) |
| TR (2) | TR200201899T2 (enExample) |
| WO (1) | WO2000061604A2 (enExample) |
| ZA (1) | ZA200108124B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20020148A1 (it) | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| ITMI20021025A1 (it) * | 2002-05-14 | 2003-11-14 | Nicox Sa | Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale |
| EP1539134A4 (en) | 2002-06-11 | 2007-04-11 | Nitromed Inc | SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE |
| US7211598B2 (en) | 2002-06-28 | 2007-05-01 | Nitromed, Inc. | Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| US7163958B2 (en) | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
| CN100513415C (zh) * | 2005-08-03 | 2009-07-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
| AU2006286838C1 (en) | 2005-09-02 | 2013-05-02 | Ferrer Internacional S.A. | Nitrooxy derivatives of glucocorticoids |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US7645748B2 (en) * | 2006-04-03 | 2010-01-12 | Forbes Medi-Tech Inc. | Sterol/stanol phosphorylnitroderivatives and use thereof |
| US7645749B2 (en) * | 2006-04-03 | 2010-01-12 | Forbes Medi-Tech Inc. | Sterol/stanol nitroderivatives and use thereof |
| CN101652380A (zh) * | 2007-02-05 | 2010-02-17 | 尼科克斯公司 | 释放一氧化氮的类固醇 |
| CA2695435A1 (en) * | 2007-08-10 | 2009-03-26 | Nicox S.A. | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease |
| WO2009071990A2 (en) * | 2007-08-31 | 2009-06-11 | Topigen Pharmaceuticals Inc. | No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| CA2703723A1 (en) * | 2007-10-19 | 2009-04-23 | Burnham Institute Of Medical Research | Inhibitors of anti-apoptotic proteins |
| US20110130375A1 (en) | 2008-08-05 | 2011-06-02 | Nicox S.A. | New no-releasing steroids for the treatment of retina and macula lutea diseases |
| AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
| CU20110244A7 (es) | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| KR101711513B1 (ko) * | 2015-06-26 | 2017-03-02 | 주식회사 엘지생활건강 | 피부 개선용 조성물 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2077750B1 (enExample) | 1970-02-11 | 1973-03-16 | Clin Byla Ets | |
| GB1458372A (en) | 1973-03-05 | 1976-12-15 | Leo Ab | Steroid carbamates and allophanates |
| JPS5845724A (ja) | 1981-09-11 | 1983-03-17 | Oriza Yuka Kk | オリザノ−ル乳化液の製造法 |
| FR2600653B1 (fr) | 1986-06-24 | 1988-12-16 | Pasteur Strasbourg Universite | Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications |
| IT1204571B (it) | 1987-05-08 | 1989-03-10 | Chiesi Farma Spa | Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche |
| EP0688865B1 (en) * | 1987-06-29 | 2002-01-16 | Massachusetts Institute Of Technology | Nucleotide sequence encoding acetoacetyl-CoA reductase and a method for producing polyester biopolymers |
| DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| JPH04273892A (ja) | 1991-02-27 | 1992-09-30 | Kao Corp | 新規な２１−置換ステロイド化合物 |
| JP3108474B2 (ja) | 1991-08-07 | 2000-11-13 | 日清製粉株式会社 | 活性型ビタミンｄ誘導体 |
| AU656829B2 (en) | 1991-12-26 | 1995-02-16 | Wisconsin Alumni Research Foundation | 26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same |
| EP0562497A1 (en) | 1992-03-27 | 1993-09-29 | Nisshin Flour Milling Co., Ltd. | 1 alpha-hydroxy vitamins D7 and D4' processes for the preparation thereof and pharmaceutical compositions |
| US5194431A (en) | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
| US5707984A (en) | 1995-12-08 | 1998-01-13 | G. D. Searle & Co. | Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs |
| US5837698A (en) | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| DE19634793A1 (de) | 1996-08-29 | 1998-03-05 | Sanol Arznei Schwarz Gmbh | S- und O-Nitratoacylverbindungen |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
-
1999
- 1999-04-13 IT IT1999MI000751A patent/IT1311922B1/it active
-
2000
- 2000-04-11 BR BR0009696-2A patent/BR0009696A/pt not_active IP Right Cessation
- 2000-04-11 JP JP2000611546A patent/JP2002542162A/ja active Pending
- 2000-04-11 CA CA002370446A patent/CA2370446C/en not_active Expired - Fee Related
- 2000-04-11 AT AT00917075T patent/ATE274521T1/de not_active IP Right Cessation
- 2000-04-11 DK DK00917075T patent/DK1169337T3/da active
- 2000-04-11 MX MXPA01010212A patent/MXPA01010212A/es active IP Right Grant
- 2000-04-11 PL PL350775A patent/PL199579B1/pl unknown
- 2000-04-11 AU AU38201/00A patent/AU766798B2/en not_active Ceased
- 2000-04-11 US US09/926,327 patent/US6909007B1/en not_active Expired - Fee Related
- 2000-04-11 CN CNA2006101516855A patent/CN1916013A/zh active Pending
- 2000-04-11 HU HU0201872A patent/HUP0201872A3/hu unknown
- 2000-04-11 RU RU2001127575/04A patent/RU2240325C2/ru not_active IP Right Cessation
- 2000-04-11 IL IL14563300A patent/IL145633A0/xx active IP Right Grant
- 2000-04-11 EP EP00917075A patent/EP1169337B1/en not_active Expired - Lifetime
- 2000-04-11 DE DE60013266T patent/DE60013266T2/de not_active Expired - Lifetime
- 2000-04-11 KR KR1020017012940A patent/KR100687821B1/ko not_active Expired - Fee Related
- 2000-04-11 EP EP04102751A patent/EP1475386A3/en not_active Withdrawn
- 2000-04-11 SI SI200030523T patent/SI1169337T1/xx unknown
- 2000-04-11 WO PCT/EP2000/003238 patent/WO2000061604A2/en not_active Ceased
- 2000-04-11 KR KR1020067024049A patent/KR100744701B1/ko not_active Expired - Fee Related
- 2000-04-11 ES ES00917075T patent/ES2226805T3/es not_active Expired - Lifetime
- 2000-04-11 CA CA2586538A patent/CA2586538C/en not_active Expired - Fee Related
- 2000-04-11 TR TR2002/01899T patent/TR200201899T2/xx unknown
- 2000-04-11 CN CNB008087741A patent/CN1296380C/zh not_active Expired - Fee Related
- 2000-04-11 PT PT00917075T patent/PT1169337E/pt unknown
- 2000-04-11 NZ NZ514572A patent/NZ514572A/xx unknown
- 2000-04-11 TR TR2001/02929T patent/TR200102929T2/xx unknown
-
2001
- 2001-10-03 ZA ZA200108124A patent/ZA200108124B/xx unknown
- 2001-10-10 NO NO20014925A patent/NO323374B1/no unknown
-
2004
- 2004-01-22 AU AU2004200263A patent/AU2004200263B2/en not_active Ceased
-
2005
- 2005-01-04 US US11/028,198 patent/US7186708B2/en not_active Expired - Fee Related
-
2006
- 2006-05-02 IL IL175398A patent/IL175398A0/en unknown
- 2006-12-13 NO NO20065784A patent/NO20065784L/no not_active Application Discontinuation
- 2006-12-22 US US11/643,887 patent/US7524836B2/en not_active Expired - Fee Related
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