IT1311922B1 - Composti farmaceutici. - Google Patents

Composti farmaceutici.

Info

Publication number
IT1311922B1
IT1311922B1 IT1999MI000751A ITMI990751A IT1311922B1 IT 1311922 B1 IT1311922 B1 IT 1311922B1 IT 1999MI000751 A IT1999MI000751 A IT 1999MI000751A IT MI990751 A ITMI990751 A IT MI990751A IT 1311922 B1 IT1311922 B1 IT 1311922B1
Authority
IT
Italy
Prior art keywords
pharmaceutical compounds
salt
treatment
general formula
following general
Prior art date
Application number
IT1999MI000751A
Other languages
English (en)
Italian (it)
Inventor
Piero Del Soldato
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999MI000751A priority Critical patent/IT1311922B1/it
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to DK00917075T priority patent/DK1169337T3/da
Priority to EP04102751A priority patent/EP1475386A3/en
Priority to MXPA01010212A priority patent/MXPA01010212A/es
Priority to AT00917075T priority patent/ATE274521T1/de
Priority to DE60013266T priority patent/DE60013266T2/de
Priority to RU2001127575/04A priority patent/RU2240325C2/ru
Priority to ES00917075T priority patent/ES2226805T3/es
Priority to NZ514572A priority patent/NZ514572A/xx
Priority to KR1020017012940A priority patent/KR100687821B1/ko
Priority to CA002370446A priority patent/CA2370446C/en
Priority to IL14563300A priority patent/IL145633A0/xx
Priority to PCT/EP2000/003238 priority patent/WO2000061604A2/en
Priority to SI200030523T priority patent/SI1169337T1/xx
Priority to PL350775A priority patent/PL199579B1/pl
Priority to PT00917075T priority patent/PT1169337E/pt
Priority to KR1020067024049A priority patent/KR100744701B1/ko
Priority to US09/926,327 priority patent/US6909007B1/en
Priority to CA2586538A priority patent/CA2586538C/en
Priority to CNA2006101516855A priority patent/CN1916013A/zh
Priority to TR2001/02929T priority patent/TR200102929T2/xx
Priority to CNB008087741A priority patent/CN1296380C/zh
Priority to HU0201872A priority patent/HUP0201872A3/hu
Priority to EP00917075A priority patent/EP1169337B1/en
Priority to JP2000611546A priority patent/JP2002542162A/ja
Priority to BR0009696-2A priority patent/BR0009696A/pt
Priority to TR2002/01899T priority patent/TR200201899T2/xx
Priority to AU38201/00A priority patent/AU766798B2/en
Publication of ITMI990751A1 publication Critical patent/ITMI990751A1/it
Priority to ZA200108124A priority patent/ZA200108124B/xx
Priority to NO20014925A priority patent/NO323374B1/no
Application granted granted Critical
Publication of IT1311922B1 publication Critical patent/IT1311922B1/it
Priority to AU2004200263A priority patent/AU2004200263B2/en
Priority to US11/028,198 priority patent/US7186708B2/en
Priority to IL175398A priority patent/IL175398A0/en
Priority to NO20065784A priority patent/NO20065784L/no
Priority to US11/643,887 priority patent/US7524836B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
IT1999MI000751A 1999-04-13 1999-04-13 Composti farmaceutici. IT1311922B1 (it)

Priority Applications (35)

Application Number Priority Date Filing Date Title
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
CNA2006101516855A CN1916013A (zh) 1999-04-13 2000-04-11 药用化合物
MXPA01010212A MXPA01010212A (es) 1999-04-13 2000-04-11 Compuestos farmaceuticos.
AT00917075T ATE274521T1 (de) 1999-04-13 2000-04-11 Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion
DE60013266T DE60013266T2 (de) 1999-04-13 2000-04-11 Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion
CNB008087741A CN1296380C (zh) 1999-04-13 2000-04-11 药用化合物
ES00917075T ES2226805T3 (es) 1999-04-13 2000-04-11 Esterpodes nitrados para el tratamiento de las alteraciones causadas por oxidantes y el disfuncionamiento endotelial.
NZ514572A NZ514572A (en) 1999-04-13 2000-04-11 Steroidal compounds
KR1020017012940A KR100687821B1 (ko) 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한 스테로이드 질산염
CA002370446A CA2370446C (en) 1999-04-13 2000-04-11 Pharmaceutical compounds
IL14563300A IL145633A0 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds
PCT/EP2000/003238 WO2000061604A2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds
SI200030523T SI1169337T1 (en) 1999-04-13 2000-04-11 Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction
PL350775A PL199579B1 (pl) 1999-04-13 2000-04-11 Związki steroidowe, ich zastosowanie i zawierające je preparaty farmaceutyczne
PT00917075T PT1169337E (pt) 1999-04-13 2000-04-11 Nitratos esteroides para o tratamento de lesoes oxidativas e disfuncoes endoteliais
KR1020067024049A KR100744701B1 (ko) 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한스테로이드 질산염
DK00917075T DK1169337T3 (da) 1999-04-13 2000-04-11 Steroidnitrater til behandlingen af oxidativ beskadigelse og endothel dysfunktion
CA2586538A CA2586538C (en) 1999-04-13 2000-04-11 Nitroxy steroids
TR2001/02929T TR200102929T2 (tr) 1999-04-13 2000-04-11 Farmasötik bileşikler.
EP04102751A EP1475386A3 (en) 1999-04-13 2000-04-11 Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction
RU2001127575/04A RU2240325C2 (ru) 1999-04-13 2000-04-11 Стероидное соединение, фармацевтические композиции
HU0201872A HUP0201872A3 (en) 1999-04-13 2000-04-11 Steroid compounds and pharmaceutical compositions of the same
EP00917075A EP1169337B1 (en) 1999-04-13 2000-04-11 Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction
JP2000611546A JP2002542162A (ja) 1999-04-13 2000-04-11 医薬化合物
BR0009696-2A BR0009696A (pt) 1999-04-13 2000-04-11 Compostos esteróides ou seus sais, uso dos mesmos, e, formulações farmacêuticas
TR2002/01899T TR200201899T2 (tr) 1999-04-13 2000-04-11 Farmasötik bileşikler
AU38201/00A AU766798B2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds
US09/926,327 US6909007B1 (en) 1999-04-13 2000-04-11 Steroidal pharmaceutical compounds
ZA200108124A ZA200108124B (en) 1999-04-13 2001-10-03 Pharmaceutical compounds.
NO20014925A NO323374B1 (no) 1999-04-13 2001-10-10 Steroidforbindelser, anvendelse og farmasoytisk formulering omfattende slike.
AU2004200263A AU2004200263B2 (en) 1999-04-13 2004-01-22 Pharmaceutical compounds
US11/028,198 US7186708B2 (en) 1999-04-13 2005-01-04 Steroidal compounds
IL175398A IL175398A0 (en) 1999-04-13 2006-05-02 Steroidal compounds and pharmaceutical compositions containing them for treating oxidative stress and inflammation
NO20065784A NO20065784L (no) 1999-04-13 2006-12-13 Steroidforbindelser og anvendelse av slike
US11/643,887 US7524836B2 (en) 1999-04-13 2006-12-22 Nitrooxyderivative steroidal compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.

Publications (2)

Publication Number Publication Date
ITMI990751A1 ITMI990751A1 (it) 2000-10-13
IT1311922B1 true IT1311922B1 (it) 2002-03-20

Family

ID=11382683

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.

Country Status (25)

Country Link
US (3) US6909007B1 (enExample)
EP (2) EP1169337B1 (enExample)
JP (1) JP2002542162A (enExample)
KR (2) KR100687821B1 (enExample)
CN (2) CN1916013A (enExample)
AT (1) ATE274521T1 (enExample)
AU (2) AU766798B2 (enExample)
BR (1) BR0009696A (enExample)
CA (2) CA2370446C (enExample)
DE (1) DE60013266T2 (enExample)
DK (1) DK1169337T3 (enExample)
ES (1) ES2226805T3 (enExample)
HU (1) HUP0201872A3 (enExample)
IL (2) IL145633A0 (enExample)
IT (1) IT1311922B1 (enExample)
MX (1) MXPA01010212A (enExample)
NO (2) NO323374B1 (enExample)
NZ (1) NZ514572A (enExample)
PL (1) PL199579B1 (enExample)
PT (1) PT1169337E (enExample)
RU (1) RU2240325C2 (enExample)
SI (1) SI1169337T1 (enExample)
TR (2) TR200201899T2 (enExample)
WO (1) WO2000061604A2 (enExample)
ZA (1) ZA200108124B (enExample)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法
EP1406609B1 (en) 2000-12-21 2006-09-06 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
EP1539134A4 (en) 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
US7211598B2 (en) 2002-06-28 2007-05-01 Nitromed, Inc. Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
AU2006286838C1 (en) 2005-09-02 2013-05-02 Ferrer Internacional S.A. Nitrooxy derivatives of glucocorticoids
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7645748B2 (en) * 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
US7645749B2 (en) * 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
CN101652380A (zh) * 2007-02-05 2010-02-17 尼科克斯公司 释放一氧化氮的类固醇
CA2695435A1 (en) * 2007-08-10 2009-03-26 Nicox S.A. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
WO2009071990A2 (en) * 2007-08-31 2009-06-11 Topigen Pharmaceuticals Inc. No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
CA2703723A1 (en) * 2007-10-19 2009-04-23 Burnham Institute Of Medical Research Inhibitors of anti-apoptotic proteins
US20110130375A1 (en) 2008-08-05 2011-06-02 Nicox S.A. New no-releasing steroids for the treatment of retina and macula lutea diseases
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CU20110244A7 (es) 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
KR101711513B1 (ko) * 2015-06-26 2017-03-02 주식회사 엘지생활건강 피부 개선용 조성물

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US20050176694A1 (en) 2005-08-11
US20070142342A1 (en) 2007-06-21
PL350775A1 (en) 2003-02-10
DK1169337T3 (da) 2004-12-06
CA2370446C (en) 2008-03-25
EP1169337A2 (en) 2002-01-09
KR100687821B1 (ko) 2007-02-28
CN1420891A (zh) 2003-05-28
CA2586538C (en) 2010-06-22
AU2004200263B2 (en) 2006-05-04
ITMI990751A1 (it) 2000-10-13
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NO20014925D0 (no) 2001-10-10
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