ATE274521T1 - Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion - Google Patents

Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion

Info

Publication number
ATE274521T1
ATE274521T1 AT00917075T AT00917075T ATE274521T1 AT E274521 T1 ATE274521 T1 AT E274521T1 AT 00917075 T AT00917075 T AT 00917075T AT 00917075 T AT00917075 T AT 00917075T AT E274521 T1 ATE274521 T1 AT E274521T1
Authority
AT
Austria
Prior art keywords
treatment
nitrates
steroid
oxidative damage
endothelial dysfunction
Prior art date
Application number
AT00917075T
Other languages
English (en)
Inventor
Piero Del Soldato
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of ATE274521T1 publication Critical patent/ATE274521T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
AT00917075T 1999-04-13 2000-04-11 Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion ATE274521T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
PCT/EP2000/003238 WO2000061604A2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ATE274521T1 true ATE274521T1 (de) 2004-09-15

Family

ID=11382683

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00917075T ATE274521T1 (de) 1999-04-13 2000-04-11 Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion

Country Status (25)

Country Link
US (3) US6909007B1 (de)
EP (2) EP1169337B1 (de)
JP (1) JP2002542162A (de)
KR (2) KR100687821B1 (de)
CN (2) CN1296380C (de)
AT (1) ATE274521T1 (de)
AU (2) AU766798B2 (de)
BR (1) BR0009696A (de)
CA (2) CA2370446C (de)
DE (1) DE60013266T2 (de)
DK (1) DK1169337T3 (de)
ES (1) ES2226805T3 (de)
HU (1) HUP0201872A3 (de)
IL (2) IL145633A0 (de)
IT (1) IT1311922B1 (de)
MX (1) MXPA01010212A (de)
NO (2) NO323374B1 (de)
NZ (1) NZ514572A (de)
PL (1) PL199579B1 (de)
PT (1) PT1169337E (de)
RU (1) RU2240325C2 (de)
SI (1) SI1169337T1 (de)
TR (2) TR200201899T2 (de)
WO (1) WO2000061604A2 (de)
ZA (1) ZA200108124B (de)

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IL150368A0 (en) 1999-12-23 2002-12-01 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (de) 2000-12-29 2002-07-03 Nicox S.A. Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004002420A2 (en) 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2005538110A (ja) 2002-07-29 2005-12-15 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
CA2621117A1 (en) 2005-09-02 2007-03-08 Nicox S.A. Steroids nitrooxyderivatives
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
ES2601102T3 (es) * 2007-02-05 2017-02-14 Nicox S.A. Esteroides que liberan óxido nítrico
US20090087425A1 (en) * 2007-08-10 2009-04-02 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
CN101896184A (zh) * 2007-10-19 2010-11-24 伯恩哈姆医学研究协会 抗凋亡蛋白抑制剂
EP2321333A1 (de) 2008-08-05 2011-05-18 Nicox S.A. Neue no-freisetzende steroide zur behandlung von netzhaut- und makula-lutea-krankheiten
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CU20110244A7 (es) 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
KR101711513B1 (ko) * 2015-06-26 2017-03-02 주식회사 엘지생활건강 피부 개선용 조성물

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GB1458372A (en) 1973-03-05 1976-12-15 Leo Ab Steroid carbamates and allophanates
JPS5845724A (ja) * 1981-09-11 1983-03-17 Oriza Yuka Kk オリザノ−ル乳化液の製造法
FR2600653B1 (fr) * 1986-06-24 1988-12-16 Pasteur Strasbourg Universite Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications
IT1204571B (it) 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
EP0688865B1 (de) * 1987-06-29 2002-01-16 Massachusetts Institute Of Technology Nucleotidsequenz für Acetoacetyl-CoA Reduktase kodierend und Verfahren zur Herstellung von Polyester-Biopolymeren
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
JPH04273892A (ja) 1991-02-27 1992-09-30 Kao Corp 新規な２１−置換ステロイド化合物
JP3108474B2 (ja) 1991-08-07 2000-11-13 日清製粉株式会社 活性型ビタミンｄ誘導体
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DE19634793A1 (de) * 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
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Also Published As

Publication number Publication date
US7524836B2 (en) 2009-04-28
KR20010108489A (ko) 2001-12-07
NO20014925L (no) 2001-12-13
US20070142342A1 (en) 2007-06-21
CA2370446A1 (en) 2000-10-19
TR200102929T2 (tr) 2002-04-22
IT1311922B1 (it) 2002-03-20
EP1169337A2 (de) 2002-01-09
NZ514572A (en) 2004-03-26
NO20065784L (no) 2001-12-13
NO323374B1 (no) 2007-04-16
ES2226805T3 (es) 2005-04-01
JP2002542162A (ja) 2002-12-10
AU2004200263B2 (en) 2006-05-04
TR200201899T2 (tr) 2002-11-21
CA2586538C (en) 2010-06-22
CN1420891A (zh) 2003-05-28
EP1475386A2 (de) 2004-11-10
CN1916013A (zh) 2007-02-21
AU2004200263A1 (en) 2004-02-19
CA2586538A1 (en) 2000-10-19
KR20060123788A (ko) 2006-12-04
HUP0201872A2 (en) 2002-10-28
DE60013266D1 (de) 2004-09-30
IL175398A0 (en) 2006-09-05
CN1296380C (zh) 2007-01-24
BR0009696A (pt) 2002-01-08
AU3820100A (en) 2000-11-14
US6909007B1 (en) 2005-06-21
DE60013266T2 (de) 2005-01-20
US20050176694A1 (en) 2005-08-11
WO2000061604A3 (en) 2001-03-15
AU766798B2 (en) 2003-10-23
PT1169337E (pt) 2004-11-30
RU2240325C2 (ru) 2004-11-20
HUP0201872A3 (en) 2004-04-28
NO20014925D0 (no) 2001-10-10
ZA200108124B (en) 2003-03-26
PL350775A1 (en) 2003-02-10
ITMI990751A1 (it) 2000-10-13
KR100744701B1 (ko) 2007-08-02
EP1169337B1 (de) 2004-08-25
WO2000061604A2 (en) 2000-10-19
EP1475386A3 (de) 2011-12-28
DK1169337T3 (da) 2004-12-06
IL145633A0 (en) 2002-06-30
PL199579B1 (pl) 2008-10-31
CA2370446C (en) 2008-03-25
KR100687821B1 (ko) 2007-02-28
US7186708B2 (en) 2007-03-06
MXPA01010212A (es) 2002-09-18
SI1169337T1 (en) 2005-04-30

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