BR0009696A - Compostos esteróides ou seus sais, uso dos mesmos, e, formulações farmacêuticas - Google Patents

Compostos esteróides ou seus sais, uso dos mesmos, e, formulações farmacêuticas

Info

Publication number
BR0009696A
BR0009696A BR0009696-2A BR0009696A BR0009696A BR 0009696 A BR0009696 A BR 0009696A BR 0009696 A BR0009696 A BR 0009696A BR 0009696 A BR0009696 A BR 0009696A
Authority
BR
Brazil
Prior art keywords
salts
pharmaceutical formulations
steroid compounds
steroid
compounds
Prior art date
Application number
BR0009696-2A
Other languages
English (en)
Inventor
Piero Del Soldato
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of BR0009696A publication Critical patent/BR0009696A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)

Abstract

"COMPOSTOS ESTERóIDES OU SEUS SAIS, USO DOS MESMOS, E, FORMULAçõES FARMACêUTICAS". Compostos esteróides ou seus sais tendo as fórmulas gerais (I) e (II) em que: s é um número inteiro igual a 1 ou 2, preferivelmente s = 2; b0 = 0 ou 1; A = R-, em que R é o radical de medicamento esteróide, C e C~ 1~ são dois radicais bivalentes. Os precursores dos radicais B e B~ 1~, são tais como encontrados nos testes farmacológicos apresentados no relatório descritivo.
BR0009696-2A 1999-04-13 2000-04-11 Compostos esteróides ou seus sais, uso dos mesmos, e, formulações farmacêuticas BR0009696A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
PCT/EP2000/003238 WO2000061604A2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
BR0009696A true BR0009696A (pt) 2002-01-08

Family

ID=11382683

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009696-2A BR0009696A (pt) 1999-04-13 2000-04-11 Compostos esteróides ou seus sais, uso dos mesmos, e, formulações farmacêuticas

Country Status (25)

Country Link
US (3) US6909007B1 (pt)
EP (2) EP1475386A3 (pt)
JP (1) JP2002542162A (pt)
KR (2) KR100744701B1 (pt)
CN (2) CN1916013A (pt)
AT (1) ATE274521T1 (pt)
AU (2) AU766798B2 (pt)
BR (1) BR0009696A (pt)
CA (2) CA2586538C (pt)
DE (1) DE60013266T2 (pt)
DK (1) DK1169337T3 (pt)
ES (1) ES2226805T3 (pt)
HU (1) HUP0201872A3 (pt)
IL (2) IL145633A0 (pt)
IT (1) IT1311922B1 (pt)
MX (1) MXPA01010212A (pt)
NO (2) NO323374B1 (pt)
NZ (1) NZ514572A (pt)
PL (1) PL199579B1 (pt)
PT (1) PT1169337E (pt)
RU (1) RU2240325C2 (pt)
SI (1) SI1169337T1 (pt)
TR (2) TR200102929T2 (pt)
WO (1) WO2000061604A2 (pt)
ZA (1) ZA200108124B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045703A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
AU2006286838C1 (en) 2005-09-02 2013-05-02 Ferrer Internacional S.A. Nitrooxy derivatives of glucocorticoids
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7645749B2 (en) * 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
US7645748B2 (en) * 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
EP2109617A1 (en) 2007-02-05 2009-10-21 Nicox S.A. Nitric oxide releasing steroids
WO2009037584A2 (en) * 2007-08-10 2009-03-26 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
WO2009071990A2 (en) * 2007-08-31 2009-06-11 Topigen Pharmaceuticals Inc. No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
AU2008311824A1 (en) * 2007-10-19 2009-04-23 Burnham Institute For Medical Research Inhibitors of anti-apoptotic proteins
CA2731520A1 (en) 2008-08-05 2010-02-11 Nicox S.A. New no-releasing steroids for the treatment of retina and macula lutea diseases
MX2012012225A (es) 2010-04-23 2013-08-27 Piramal Entpr Ltd Profármacos de agentes tearapéuticos de liberación de óxido nítrico.
CU20110244A7 (es) 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
KR101711513B1 (ko) * 2015-06-26 2017-03-02 주식회사 엘지생활건강 피부 개선용 조성물

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Also Published As

Publication number Publication date
KR100687821B1 (ko) 2007-02-28
KR20060123788A (ko) 2006-12-04
CA2586538C (en) 2010-06-22
AU2004200263A1 (en) 2004-02-19
HUP0201872A3 (en) 2004-04-28
AU3820100A (en) 2000-11-14
ATE274521T1 (de) 2004-09-15
CN1916013A (zh) 2007-02-21
EP1169337A2 (en) 2002-01-09
IL145633A0 (en) 2002-06-30
MXPA01010212A (es) 2002-09-18
SI1169337T1 (en) 2005-04-30
EP1475386A3 (en) 2011-12-28
DE60013266D1 (de) 2004-09-30
DK1169337T3 (da) 2004-12-06
PL199579B1 (pl) 2008-10-31
JP2002542162A (ja) 2002-12-10
IT1311922B1 (it) 2002-03-20
HUP0201872A2 (en) 2002-10-28
US7524836B2 (en) 2009-04-28
AU766798B2 (en) 2003-10-23
NO20014925L (no) 2001-12-13
CA2370446A1 (en) 2000-10-19
RU2240325C2 (ru) 2004-11-20
IL175398A0 (en) 2006-09-05
NZ514572A (en) 2004-03-26
KR20010108489A (ko) 2001-12-07
NO20065784L (no) 2001-12-13
CA2370446C (en) 2008-03-25
ITMI990751A1 (it) 2000-10-13
EP1475386A2 (en) 2004-11-10
KR100744701B1 (ko) 2007-08-02
PT1169337E (pt) 2004-11-30
WO2000061604A2 (en) 2000-10-19
PL350775A1 (en) 2003-02-10
AU2004200263B2 (en) 2006-05-04
NO323374B1 (no) 2007-04-16
TR200201899T2 (tr) 2002-11-21
ZA200108124B (en) 2003-03-26
US20070142342A1 (en) 2007-06-21
NO20014925D0 (no) 2001-10-10
US7186708B2 (en) 2007-03-06
CN1296380C (zh) 2007-01-24
CN1420891A (zh) 2003-05-28
DE60013266T2 (de) 2005-01-20
TR200102929T2 (tr) 2002-04-22
ES2226805T3 (es) 2005-04-01
WO2000061604A3 (en) 2001-03-15
EP1169337B1 (en) 2004-08-25
US6909007B1 (en) 2005-06-21
US20050176694A1 (en) 2005-08-11
CA2586538A1 (en) 2000-10-19

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: NICOX S.A. (FR)

Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS NA PETICAO NO 020050046572/RJ DE 06/06/2005.

B25G Requested change of headquarter approved

Owner name: NICOX S.A. (FR)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070016104/RJ DE 07/02/2007.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A E 11A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.