ES2223110T3 - Derivados de n-arilpiperidina y su empleo como ligandos del receptor 5-ht1b. - Google Patents
Derivados de n-arilpiperidina y su empleo como ligandos del receptor 5-ht1b.Info
- Publication number
- ES2223110T3 ES2223110T3 ES98400711T ES98400711T ES2223110T3 ES 2223110 T3 ES2223110 T3 ES 2223110T3 ES 98400711 T ES98400711 T ES 98400711T ES 98400711 T ES98400711 T ES 98400711T ES 2223110 T3 ES2223110 T3 ES 2223110T3
- Authority
- ES
- Spain
- Prior art keywords
- dihydro
- piperidin
- benzodioxin
- fumarate
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical compound NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 description 1
- 150000003053 piperidines Chemical group 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9703760A FR2761358B1 (fr) | 1997-03-27 | 1997-03-27 | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR9703760 | 1997-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2223110T3 true ES2223110T3 (es) | 2005-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98400711T Expired - Lifetime ES2223110T3 (es) | 1997-03-27 | 1998-03-26 | Derivados de n-arilpiperidina y su empleo como ligandos del receptor 5-ht1b. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5965575A (enExample) |
| EP (1) | EP0867436B1 (enExample) |
| JP (1) | JPH10279578A (enExample) |
| CN (1) | CN1090628C (enExample) |
| AT (1) | ATE268767T1 (enExample) |
| AU (1) | AU731018B2 (enExample) |
| BR (1) | BR9803295A (enExample) |
| CA (1) | CA2232116C (enExample) |
| DE (1) | DE69824332T2 (enExample) |
| DK (1) | DK0867436T3 (enExample) |
| ES (1) | ES2223110T3 (enExample) |
| FR (1) | FR2761358B1 (enExample) |
| NO (1) | NO314628B1 (enExample) |
| NZ (1) | NZ330041A (enExample) |
| PL (1) | PL194118B1 (enExample) |
| PT (1) | PT867436E (enExample) |
| ZA (1) | ZA982607B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2782515B1 (fr) * | 1998-08-21 | 2000-09-22 | Adir | NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
| US6225324B1 (en) * | 1999-01-28 | 2001-05-01 | Bristol-Myers Squibb Company | Antidepressant heterocyclic compounds |
| PT1189900E (pt) * | 1999-06-30 | 2004-05-31 | Bristol Myers Squibb Co | Derivados de aminopirrolidina heterociclicos utilizados como agentes melatonergicos |
| GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
| SE0103650D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
| SE0103646D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic chroman compounds |
| KR100864356B1 (ko) * | 2001-01-16 | 2008-10-17 | 아스트라제네카 아베 | 치료용 헤테로시클릭 화합물 |
| NZ526699A (en) * | 2001-01-16 | 2005-03-24 | Astrazeneca Ab | 8-amino derivatives and their use in treating migraine |
| US6713479B2 (en) * | 2001-03-02 | 2004-03-30 | Sepracor Inc. | Piperidine-piperazine ligands for neurotransmitter receptors |
| SE0103836D0 (sv) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
| JP2005343790A (ja) * | 2002-05-31 | 2005-12-15 | Ajinomoto Co Inc | カルシウムチャネル拮抗薬を含有する医薬組成物 |
| SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| TW200510407A (en) * | 2003-06-30 | 2005-03-16 | Altana Pharma Ag | Novel pyrrolodihydroisoquinolines as PDE 10 inhibitors |
| US20070105840A1 (en) * | 2003-06-30 | 2007-05-10 | Altana Pharma Ag | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
| JP4591349B2 (ja) * | 2003-07-14 | 2010-12-01 | 宇部興産株式会社 | ４−アミノテトラヒドロピラン化合物及びその酸塩の製法、その合成中間体およびその製法 |
| AR045258A1 (es) * | 2003-08-21 | 2005-10-19 | Altana Pharma Ag | Un producto farmaceutico para inyeccion |
| US20060085924A1 (en) * | 2004-10-13 | 2006-04-27 | Gaelle Brun | Coloring composition comprising at least one pigment and at least one electrophilic cyanoacrylate monomer |
| EP1838708A2 (en) * | 2005-01-12 | 2007-10-03 | Nycomed GmbH | Pyrrolodihydroisoquinolines as antiproliferative agents |
| EP1838707B1 (en) * | 2005-01-12 | 2009-04-29 | Nycomed GmbH | Novel pyrrolodihydroisoquinolines as pde10 inhibitors |
| US8599822B2 (en) * | 2005-03-23 | 2013-12-03 | Cisco Technology, Inc. | Slot-based transmission synchronization mechanism in wireless mesh networks |
| FR2884251B1 (fr) * | 2005-04-08 | 2007-07-13 | Servier Lab | Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UY29892A1 (es) * | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones |
| JP5682051B2 (ja) | 2006-05-18 | 2015-03-11 | ファーマサイクリックス，インク． | 細胞内キナーゼ阻害剤 |
| ES2388454T3 (es) | 2007-03-22 | 2012-10-15 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias |
| PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
| TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| FR2734819B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
-
1997
- 1997-03-27 FR FR9703760A patent/FR2761358B1/fr not_active Expired - Fee Related
-
1998
- 1998-03-12 CA CA002232116A patent/CA2232116C/fr not_active Expired - Fee Related
- 1998-03-26 DE DE69824332T patent/DE69824332T2/de not_active Expired - Fee Related
- 1998-03-26 AT AT98400711T patent/ATE268767T1/de not_active IP Right Cessation
- 1998-03-26 CN CN98109437A patent/CN1090628C/zh not_active Expired - Fee Related
- 1998-03-26 PT PT98400711T patent/PT867436E/pt unknown
- 1998-03-26 PL PL325575A patent/PL194118B1/pl not_active IP Right Cessation
- 1998-03-26 NZ NZ330041A patent/NZ330041A/xx unknown
- 1998-03-26 DK DK98400711T patent/DK0867436T3/da active
- 1998-03-26 EP EP98400711A patent/EP0867436B1/fr not_active Expired - Lifetime
- 1998-03-26 ES ES98400711T patent/ES2223110T3/es not_active Expired - Lifetime
- 1998-03-27 AU AU59677/98A patent/AU731018B2/en not_active Ceased
- 1998-03-27 NO NO19981415A patent/NO314628B1/no unknown
- 1998-03-27 US US09/049,233 patent/US5965575A/en not_active Expired - Fee Related
- 1998-03-27 JP JP10081710A patent/JPH10279578A/ja active Pending
- 1998-03-27 BR BR9803295A patent/BR9803295A/pt not_active Application Discontinuation
- 1998-03-27 ZA ZA982607A patent/ZA982607B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10279578A (ja) | 1998-10-20 |
| PT867436E (pt) | 2004-09-30 |
| NZ330041A (en) | 1999-01-28 |
| PL194118B1 (pl) | 2007-04-30 |
| CA2232116C (fr) | 2003-09-16 |
| DE69824332D1 (de) | 2004-07-15 |
| US5965575A (en) | 1999-10-12 |
| FR2761358A1 (fr) | 1998-10-02 |
| NO314628B1 (no) | 2003-04-22 |
| DE69824332T2 (de) | 2005-06-16 |
| DK0867436T3 (da) | 2004-10-04 |
| ZA982607B (en) | 1998-09-30 |
| AU5967798A (en) | 1998-10-01 |
| AU731018B2 (en) | 2001-03-22 |
| ATE268767T1 (de) | 2004-06-15 |
| NO981415L (no) | 1998-09-28 |
| NO981415D0 (no) | 1998-03-27 |
| FR2761358B1 (fr) | 1999-05-07 |
| PL325575A1 (en) | 1998-09-28 |
| BR9803295A (pt) | 2000-03-21 |
| CN1090628C (zh) | 2002-09-11 |
| EP0867436A1 (fr) | 1998-09-30 |
| EP0867436B1 (fr) | 2004-06-09 |
| CN1197072A (zh) | 1998-10-28 |
| CA2232116A1 (fr) | 1998-09-27 |
| HK1014954A1 (en) | 1999-10-08 |
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