ES2216079T3 - Procedimiento para la elaboracion de composiciones de carotenoides. - Google Patents

Procedimiento para la elaboracion de composiciones de carotenoides.

Info

Publication number
ES2216079T3
ES2216079T3 ES97106957T ES97106957T ES2216079T3 ES 2216079 T3 ES2216079 T3 ES 2216079T3 ES 97106957 T ES97106957 T ES 97106957T ES 97106957 T ES97106957 T ES 97106957T ES 2216079 T3 ES2216079 T3 ES 2216079T3
Authority
ES
Spain
Prior art keywords
carotenoid
suspension
powder
procedure
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97106957T
Other languages
English (en)
Spanish (es)
Inventor
Ray Edward Kowalski
William Joseph Mergens
Leonard Joseph Scialpi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of ES2216079T3 publication Critical patent/ES2216079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
ES97106957T 1996-05-14 1997-04-26 Procedimiento para la elaboracion de composiciones de carotenoides. Expired - Lifetime ES2216079T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1756896P 1996-05-14 1996-05-14
US17568 1996-05-14

Publications (1)

Publication Number Publication Date
ES2216079T3 true ES2216079T3 (es) 2004-10-16

Family

ID=21783319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97106957T Expired - Lifetime ES2216079T3 (es) 1996-05-14 1997-04-26 Procedimiento para la elaboracion de composiciones de carotenoides.

Country Status (10)

Country Link
US (1) US6093348A (en, 2012)
EP (1) EP0807431B1 (en, 2012)
JP (1) JP3961070B2 (en, 2012)
CN (1) CN1079212C (en, 2012)
AT (1) ATE262316T1 (en, 2012)
BR (1) BR9703134A (en, 2012)
DE (1) DE69728206T2 (en, 2012)
DK (1) DK0807431T3 (en, 2012)
ES (1) ES2216079T3 (en, 2012)
IN (1) IN183685B (en, 2012)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT876109E (pt) * 1996-01-22 2003-12-31 Chr Hansen As Composicoes dispersaveis em agua com um pigmento natural hidrofobico as suas tecnicas de preparacao e de utilizacao
CA2349203C (en) 1998-11-20 2013-05-21 Rtp Pharma Inc. Dispersible phospholipid stabilized microparticles
US6682761B2 (en) * 2000-04-20 2004-01-27 Rtp Pharma, Inc. Water-insoluble drug particle process
US20030104090A1 (en) * 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
AU2001262945B2 (en) 2000-09-20 2006-02-02 Skyepharma Canada Inc. Spray drying process and compositions of fenofibrate
DE10064387A1 (de) 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
WO2002077105A1 (fr) * 2001-03-22 2002-10-03 Fuji Chemical Industry Co., Ltd. Compositions pulverulentes a base d'astaxanthine et procede de production associe
US6811801B2 (en) * 2001-12-12 2004-11-02 Abbott Laboratories Methods and compositions for brightening the color of thermally processed nutritionals
US7901708B2 (en) * 2002-06-28 2011-03-08 Protiva Biotherapeutics, Inc. Liposomal apparatus and manufacturing methods
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US20050148517A1 (en) * 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US7320997B2 (en) * 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US7723327B2 (en) 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050143475A1 (en) * 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US7375133B2 (en) * 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US7345091B2 (en) * 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US7763649B2 (en) 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US7521584B2 (en) * 2002-07-29 2009-04-21 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
EP1532108B1 (en) * 2002-07-29 2016-06-29 Cardax Pharma, Inc. Astaxanthin esters for the inhibition and amelioration of disease
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
EP1605917B1 (en) 2003-03-27 2015-04-22 DSM IP Assets B.V. Process for the production of cross-linked gelatin microbeadlets
US7332178B2 (en) 2003-04-25 2008-02-19 Abbott Laboratories Stable nutritional powder containing ascorbyl palmitate
US7110827B2 (en) * 2003-04-25 2006-09-19 Medtronic, Inc. Electrical connectors for medical lead having weld-less wiring connection
US9247765B2 (en) 2004-01-14 2016-02-02 Omniactive Health Technologies Limited Stable beadlets of lipophilic nutrients
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
EP1750723A1 (en) * 2004-04-14 2007-02-14 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
JP4562174B2 (ja) * 2004-08-23 2010-10-13 カゴメ株式会社 カロテノイド含有物の製造方法
CA2578903A1 (en) * 2004-08-31 2006-03-09 Akzo Nobel N.V. Method for pigment solubilisation, a pigment composition and its use
US10463061B2 (en) * 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
US8755258B2 (en) 2005-02-16 2014-06-17 Mitsubishi Electric Corporation Optical disc and optical disc device
CN100421650C (zh) * 2005-03-23 2008-10-01 浙江新和成股份有限公司 水分散性类胡萝卜素粉的制备方法
EP1937213B1 (en) * 2005-07-27 2017-10-25 Protiva Biotherapeutics Inc. Systems and methods for manufacturing liposomes
CA2618447C (en) * 2005-08-15 2015-06-02 Phares Pharmaceutical Research N.V. Crystal forms of astaxanthin
US7435846B2 (en) 2006-08-18 2008-10-14 Industrial Organica, S.A. De C.V. Absorption and bioavailability of carotenoids, formulations and applications
WO2008110626A1 (en) * 2007-03-15 2008-09-18 Dsm Ip Assets B.V. Stabilized micronised particles
WO2009093595A1 (ja) * 2008-01-25 2009-07-30 Fujifilm Corporation カロテノイド含有エマルション組成物の製造方法、それにより得られるカロテノイド含有エマルション組成物並びにカロテノイド含有粉末組成物、該組成物を含む機能性食品及び化粧品
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
PT3130396T (pt) 2009-03-27 2021-05-12 Bend Res Inc Processo de secagem por pulverização
AU2010293447B2 (en) 2009-09-14 2013-07-04 National University Corporation Hokkaido University Anti-plant-virus agent
CN102933098B (zh) * 2010-06-08 2017-03-29 三荣源有限公司 防止类胡萝卜色素附着于容器的方法
JP5600513B2 (ja) * 2010-07-29 2014-10-01 理研ビタミン株式会社 クロセチン製剤の製造方法
EP2611530B1 (en) 2010-09-03 2019-01-16 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2611529B1 (en) 2010-09-03 2019-01-23 Bend Research, Inc. Spray-drying method
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
WO2012069322A1 (en) 2010-11-26 2012-05-31 Dsm Ip Assets B.V. Protective hydrocolloid for active ingredients
US20120157547A1 (en) 2010-12-21 2012-06-21 Ricardo Montoya-Olvera Compositions and applications of carotenoids of improved absorption and bioavailability
US20150272188A1 (en) * 2012-10-18 2015-10-01 Dsm Ip Assets B.V. Beadlets comprising carotenoids
WO2015044222A1 (en) * 2013-09-24 2015-04-02 Dsm Ip Assets B.V. Stable formulations for coloring beverages and food products
JP6650933B2 (ja) 2014-10-31 2020-02-19 ベンド リサーチ， インコーポレイテッド マトリックス中に分散された活性薬剤ドメインを形成するためのプロセス
US11744266B2 (en) 2016-03-15 2023-09-05 Dsm Ip Assets B.V. Coated particles
JP6954917B2 (ja) * 2016-03-24 2021-10-27 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ 多相活性物質調製物
EP3487319A1 (de) * 2016-07-19 2019-05-29 Basf Se Propylgallathaltige vitaminzubereitungen
US11197493B2 (en) * 2017-09-12 2021-12-14 Omniactive Health Technologies Limited Stabilized fat soluble nutrient compositions and process for the preparation thereof
JP7225820B2 (ja) 2019-01-21 2023-02-21 株式会社アイシン 車両用開閉体制御装置
KR20220024543A (ko) * 2019-06-17 2022-03-03 디에스엠 아이피 어셋츠 비.브이. 메트포르민 HCl, 비타민 B12 및 하나 이상의 유동 첨가제를 포함하는 조성물
CN114007591A (zh) * 2019-06-17 2022-02-01 帝斯曼知识产权资产管理有限公司 包含经喷雾干燥的维生素b12的固体药物剂型
KR20220024544A (ko) * 2019-06-17 2022-03-03 디에스엠 아이피 어셋츠 비.브이. 메트포르민 및 칼슘 시트레이트를 포함하는 약학적 투여 형태
CN112438950A (zh) * 2019-08-16 2021-03-05 北京化工大学 一种β-胡萝卜素透明水分散液及其制备方法
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
CN111838648B (zh) * 2020-06-16 2023-04-25 嘉必优生物技术（武汉）股份有限公司 一种生产纳米级类胡萝卜素乳液的装置及方法
CN112841645A (zh) * 2021-01-14 2021-05-28 江南大学 一种β-胡萝卜素微胶囊的制备方法
CN113426355A (zh) * 2021-06-25 2021-09-24 骏马化纤股份有限公司 一种化纤生产用油剂乳液自动化控制系统及制备方法
US12129223B2 (en) 2021-12-16 2024-10-29 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN118525919A (zh) * 2023-02-22 2024-08-23 浙江可明生物医药有限公司 类胡萝卜素制剂的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2756177A (en) * 1953-03-09 1956-07-24 Hoffmann La Roche Process for making fat-soluble vitamin active powder
US2861891A (en) * 1956-12-13 1958-11-25 Hoffmann La Roche Water dispersible carotenoid compositions and process of making the same
DE1211911B (de) * 1959-09-08 1966-03-03 Hoffmann La Roche Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
DE3048000A1 (de) * 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4908154A (en) * 1981-04-17 1990-03-13 Biotechnology Development Corporation Method of forming a microemulsion
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
SE8604117D0 (sv) * 1986-09-29 1986-09-29 Kabivitrum Ab Composition
DE3702031A1 (de) * 1987-01-24 1988-08-04 Basf Ag Verfahren zur herstellung von mikrodispersen fischoelpraeparaten
DK0410236T3 (da) * 1989-07-25 1993-12-13 Hoffmann La Roche Fremgangsmåde til fremstilling af caratenoidpræparater
DK546289D0 (da) * 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere
DK19393D0 (da) * 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
DE4329446A1 (de) * 1993-09-01 1995-03-02 Basf Ag Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen

Also Published As

Publication number Publication date
US6093348A (en) 2000-07-25
EP0807431A3 (en) 1998-08-12
ATE262316T1 (de) 2004-04-15
DE69728206D1 (de) 2004-04-29
DE69728206T2 (de) 2005-03-10
JPH1046041A (ja) 1998-02-17
CN1176760A (zh) 1998-03-25
EP0807431A2 (en) 1997-11-19
BR9703134A (pt) 1998-08-18
EP0807431B1 (en) 2004-03-24
DK0807431T3 (da) 2004-07-26
JP3961070B2 (ja) 2007-08-15
CN1079212C (zh) 2002-02-20
IN183685B (en, 2012) 2000-03-18

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