ES2209242T3 - Metodo analitico que usa particulas y kit de ensayo para realizar el metodo. - Google Patents
Metodo analitico que usa particulas y kit de ensayo para realizar el metodo.Info
- Publication number
- ES2209242T3 ES2209242T3 ES98965942T ES98965942T ES2209242T3 ES 2209242 T3 ES2209242 T3 ES 2209242T3 ES 98965942 T ES98965942 T ES 98965942T ES 98965942 T ES98965942 T ES 98965942T ES 2209242 T3 ES2209242 T3 ES 2209242T3
- Authority
- ES
- Spain
- Prior art keywords
- reagent
- particles
- analyte
- matrix
- hydrophilic groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title claims abstract description 142
- 238000000034 method Methods 0.000 title claims abstract description 46
- 238000012360 testing method Methods 0.000 title claims description 24
- 238000004458 analytical method Methods 0.000 title claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 157
- 239000011159 matrix material Substances 0.000 claims abstract description 74
- 239000012491 analyte Substances 0.000 claims abstract description 63
- 238000001514 detection method Methods 0.000 claims abstract description 49
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 239000003550 marker Substances 0.000 claims abstract description 10
- 239000013566 allergen Substances 0.000 claims description 26
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 230000027455 binding Effects 0.000 claims description 12
- 238000004873 anchoring Methods 0.000 claims description 10
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 206010020751 Hypersensitivity Diseases 0.000 claims description 7
- 230000007815 allergy Effects 0.000 claims description 7
- 238000003745 diagnosis Methods 0.000 claims description 4
- 208000023275 Autoimmune disease Diseases 0.000 claims description 3
- 229920001222 biopolymer Polymers 0.000 claims description 3
- 229920001059 synthetic polymer Polymers 0.000 claims 4
- 238000002372 labelling Methods 0.000 claims 3
- 239000012620 biological material Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 description 26
- 230000032258 transport Effects 0.000 description 18
- 239000004793 Polystyrene Substances 0.000 description 16
- 229920002223 polystyrene Polymers 0.000 description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
- 239000012528 membrane Substances 0.000 description 15
- 239000000872 buffer Substances 0.000 description 14
- 239000007788 liquid Substances 0.000 description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- 238000005859 coupling reaction Methods 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- 235000018185 Betula X alpestris Nutrition 0.000 description 8
- 235000018212 Betula X uliginosa Nutrition 0.000 description 8
- 241001460678 Napo <wasp> Species 0.000 description 8
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 230000002209 hydrophobic effect Effects 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 8
- WBOURNUBSRYUJE-UHFFFAOYSA-M 4-(dimethylamino)pyridin-1-ium-1-carbonitrile;bromide Chemical compound [Br-].CN(C)C1=CC=[N+](C#N)C=C1 WBOURNUBSRYUJE-UHFFFAOYSA-M 0.000 description 7
- 108010090804 Streptavidin Proteins 0.000 description 7
- 239000012131 assay buffer Substances 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 238000001179 sorption measurement Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000000020 Nitrocellulose Substances 0.000 description 6
- 230000008021 deposition Effects 0.000 description 6
- 229920001220 nitrocellulos Polymers 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- -1 arylvinyl ether Chemical compound 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229920001477 hydrophilic polymer Polymers 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 235000013922 glutamic acid Nutrition 0.000 description 3
- 239000004220 glutamic acid Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- 235000009109 Betula pendula Nutrition 0.000 description 2
- 241000219430 Betula pendula Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229960004784 allergens Drugs 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000006287 biotinylation Effects 0.000 description 2
- 238000007413 biotinylation Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000007767 bonding agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229910052681 coesite Inorganic materials 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229910052906 cristobalite Inorganic materials 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 108010074605 gamma-Globulins Proteins 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 125000001165 hydrophobic group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000003068 molecular probe Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229910052682 stishovite Inorganic materials 0.000 description 2
- 229910052905 tridymite Inorganic materials 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010053317 Hydrophobia Diseases 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 229940074608 allergen extract Drugs 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 239000013575 birch pollen allergen Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 150000001720 carbohydrates Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000003891 environmental analysis Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- REKHIPAOQFESGJ-UHFFFAOYSA-N hydroxy(sulfo)carbamic acid Chemical compound C(=O)(O)N(S(O)(=O)=O)O REKHIPAOQFESGJ-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 238000003317 immunochromatography Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 239000013528 metallic particle Substances 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704935 | 1997-12-30 | ||
| SE9704935A SE9704935D0 (sv) | 1997-12-30 | 1997-12-30 | Analysmetod med partiklar |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2209242T3 true ES2209242T3 (es) | 2004-06-16 |
Family
ID=20409629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98965942T Expired - Lifetime ES2209242T3 (es) | 1997-12-30 | 1998-12-30 | Metodo analitico que usa particulas y kit de ensayo para realizar el metodo. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7405084B1 (https=) |
| EP (1) | EP1044376B1 (https=) |
| JP (1) | JP4531252B2 (https=) |
| AT (1) | ATE251307T1 (https=) |
| AU (1) | AU750153B2 (https=) |
| CA (1) | CA2314870C (https=) |
| DE (1) | DE69818706T2 (https=) |
| DK (1) | DK1044376T3 (https=) |
| ES (1) | ES2209242T3 (https=) |
| PT (1) | PT1044376E (https=) |
| SE (1) | SE9704935D0 (https=) |
| WO (1) | WO1999036780A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1493029B1 (en) * | 2002-04-10 | 2010-03-31 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| US7175992B2 (en) | 2002-04-10 | 2007-02-13 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| FR2853077B1 (fr) * | 2003-03-28 | 2005-12-30 | Vedalab | Procedes immunochromatographiques en phase solide |
| CN101184999B (zh) | 2005-05-23 | 2013-03-27 | 法迪亚股份有限公司 | 两步侧向流测定方法和设备 |
| WO2008106021A1 (en) | 2007-02-26 | 2008-09-04 | Response Biomedical Corporation | Comparative multiple analyte assay |
| DE102009037791A1 (de) * | 2009-08-17 | 2011-02-24 | Dst Diagnostische Systeme & Technologien Gmbh | Testsystem zur visuellen Auswertung |
| US20120214230A1 (en) * | 2009-10-22 | 2012-08-23 | Ge Healthcare Bio-Sciences Ab | Cell culture/handling product and method for production and use thereof |
| BR102013001324A2 (pt) * | 2012-01-20 | 2015-07-28 | Ortho Clinical Diagnostics Inc | Dispositivo de ensaio tendo tamanho de amostra controlável e método para controlar o tamanho da amostra em um dispositivo de ensaio |
| KR101403028B1 (ko) | 2013-01-09 | 2014-06-05 | 배진현 | 증폭된 신호가 발생되는 전기장을 이용한 면역 크로마토그래피 분석 방법 |
| HK1220759A1 (zh) | 2013-03-15 | 2017-05-12 | Hycor Biomedical Llc | 用於进行过敏症和自身免疫性疾病的诊断测定的自动化免疫分析系统 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) * | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US4446231A (en) * | 1979-10-03 | 1984-05-01 | Self Colin H | Immunoassay using an amplified cyclic detection system |
| DE3174918D1 (en) * | 1980-12-23 | 1986-08-14 | Boehringer Mannheim Gmbh | Hydrophilic latex particles, process for their preparation and their use |
| JPS57200862A (en) * | 1981-06-05 | 1982-12-09 | Fuji Photo Film Co Ltd | Mutilayer analysis element utilizing unique binding reaction |
| JPS59170768A (ja) | 1983-03-17 | 1984-09-27 | Fuji Photo Film Co Ltd | 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法 |
| US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| CA1272127A (en) | 1985-04-04 | 1990-07-31 | Hybritech Incorporated | Solid phase system for use in ligand-receptor assays |
| TW203120B (https=) | 1985-10-04 | 1993-04-01 | Abbott Lab | |
| US5160701A (en) | 1986-02-18 | 1992-11-03 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| US4916056A (en) | 1986-02-18 | 1990-04-10 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| DE3856421T2 (de) | 1987-04-27 | 2000-12-14 | Unilever Nv | Spezifische Bindungstestverfahren |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US4981786A (en) * | 1987-09-04 | 1991-01-01 | Syntex (U.S.A.) Inc. | Multiple port assay device |
| CA1312544C (en) * | 1987-12-21 | 1993-01-12 | James L. Wilcox | Chromatographic binding assay devices and methods |
| AU2684488A (en) * | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| CA2003942A1 (en) | 1989-09-26 | 1991-03-26 | Julie Lia Rudolph | Solid assay support systems |
| ES2092523T3 (es) | 1990-05-09 | 1996-12-01 | Abbott Lab | Ensayos que utilizan enlaces con recuperacion de conjugado. |
| US5846703A (en) * | 1990-05-15 | 1998-12-08 | Diatron Corporation | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding |
| FR2665087B1 (fr) | 1990-07-24 | 1992-10-09 | Lorraine Carbone | Procede de fabrication d'une membrane minerale ultra-mince et asymetrique. |
| JP2955405B2 (ja) * | 1990-08-31 | 1999-10-04 | ジェイエスアール株式会社 | イムノクロマトグラフ法 |
| US5356782A (en) | 1992-09-03 | 1994-10-18 | Boehringer Mannheim Corporation | Analytical test apparatus with on board negative and positive control |
| WO1994029696A1 (en) * | 1993-06-09 | 1994-12-22 | Quidel Corporation | Antigen-specific one-step assays |
| WO1995031485A1 (en) * | 1994-05-15 | 1995-11-23 | Pharmacia Biotech Ab | A method of manufacturing particles, and particles that can be produced in accordance with the method |
| SE9500184D0 (sv) | 1995-01-20 | 1995-01-20 | Pharmacia Ab | Analysmetod som utnyttjar biospecifika affinitetsreaktioner och märkt reaktant samt reagens att användas i föredragen utförandeform |
-
1997
- 1997-12-30 SE SE9704935A patent/SE9704935D0/xx unknown
-
1998
- 1998-12-30 DE DE69818706T patent/DE69818706T2/de not_active Expired - Lifetime
- 1998-12-30 WO PCT/SE1998/002462 patent/WO1999036780A1/en not_active Ceased
- 1998-12-30 AT AT98965942T patent/ATE251307T1/de active
- 1998-12-30 ES ES98965942T patent/ES2209242T3/es not_active Expired - Lifetime
- 1998-12-30 EP EP98965942A patent/EP1044376B1/en not_active Expired - Lifetime
- 1998-12-30 CA CA002314870A patent/CA2314870C/en not_active Expired - Lifetime
- 1998-12-30 PT PT98965942T patent/PT1044376E/pt unknown
- 1998-12-30 DK DK98965942T patent/DK1044376T3/da active
- 1998-12-30 US US09/582,808 patent/US7405084B1/en not_active Expired - Fee Related
- 1998-12-30 JP JP2000540441A patent/JP4531252B2/ja not_active Expired - Lifetime
- 1998-12-30 AU AU21949/99A patent/AU750153B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818706T2 (de) | 2004-09-23 |
| US7405084B1 (en) | 2008-07-29 |
| PT1044376E (pt) | 2004-02-27 |
| CA2314870C (en) | 2009-11-24 |
| JP4531252B2 (ja) | 2010-08-25 |
| ATE251307T1 (de) | 2003-10-15 |
| AU2194999A (en) | 1999-08-02 |
| SE9704935D0 (sv) | 1997-12-30 |
| AU750153B2 (en) | 2002-07-11 |
| EP1044376B1 (en) | 2003-10-01 |
| CA2314870A1 (en) | 1999-07-22 |
| JP2002509253A (ja) | 2002-03-26 |
| EP1044376A1 (en) | 2000-10-18 |
| WO1999036780A1 (en) | 1999-07-22 |
| DE69818706D1 (de) | 2003-11-06 |
| DK1044376T3 (da) | 2004-02-09 |
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