JP4531252B2 - 粒子を使用した分析法および本方法を行うための試験キット - Google Patents
粒子を使用した分析法および本方法を行うための試験キット Download PDFInfo
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- JP4531252B2 JP4531252B2 JP2000540441A JP2000540441A JP4531252B2 JP 4531252 B2 JP4531252 B2 JP 4531252B2 JP 2000540441 A JP2000540441 A JP 2000540441A JP 2000540441 A JP2000540441 A JP 2000540441A JP 4531252 B2 JP4531252 B2 JP 4531252B2
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704935-7 | 1997-12-30 | ||
| SE9704935A SE9704935D0 (sv) | 1997-12-30 | 1997-12-30 | Analysmetod med partiklar |
| PCT/SE1998/002462 WO1999036780A1 (en) | 1997-12-30 | 1998-12-30 | Analytical method using particles and test kit for performing the method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002509253A JP2002509253A (ja) | 2002-03-26 |
| JP2002509253A5 JP2002509253A5 (https=) | 2006-02-23 |
| JP4531252B2 true JP4531252B2 (ja) | 2010-08-25 |
Family
ID=20409629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000540441A Expired - Lifetime JP4531252B2 (ja) | 1997-12-30 | 1998-12-30 | 粒子を使用した分析法および本方法を行うための試験キット |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7405084B1 (https=) |
| EP (1) | EP1044376B1 (https=) |
| JP (1) | JP4531252B2 (https=) |
| AT (1) | ATE251307T1 (https=) |
| AU (1) | AU750153B2 (https=) |
| CA (1) | CA2314870C (https=) |
| DE (1) | DE69818706T2 (https=) |
| DK (1) | DK1044376T3 (https=) |
| ES (1) | ES2209242T3 (https=) |
| PT (1) | PT1044376E (https=) |
| SE (1) | SE9704935D0 (https=) |
| WO (1) | WO1999036780A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1493029B1 (en) * | 2002-04-10 | 2010-03-31 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| US7175992B2 (en) | 2002-04-10 | 2007-02-13 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| FR2853077B1 (fr) * | 2003-03-28 | 2005-12-30 | Vedalab | Procedes immunochromatographiques en phase solide |
| CN101184999B (zh) | 2005-05-23 | 2013-03-27 | 法迪亚股份有限公司 | 两步侧向流测定方法和设备 |
| WO2008106021A1 (en) | 2007-02-26 | 2008-09-04 | Response Biomedical Corporation | Comparative multiple analyte assay |
| DE102009037791A1 (de) * | 2009-08-17 | 2011-02-24 | Dst Diagnostische Systeme & Technologien Gmbh | Testsystem zur visuellen Auswertung |
| US20120214230A1 (en) * | 2009-10-22 | 2012-08-23 | Ge Healthcare Bio-Sciences Ab | Cell culture/handling product and method for production and use thereof |
| BR102013001324A2 (pt) * | 2012-01-20 | 2015-07-28 | Ortho Clinical Diagnostics Inc | Dispositivo de ensaio tendo tamanho de amostra controlável e método para controlar o tamanho da amostra em um dispositivo de ensaio |
| KR101403028B1 (ko) | 2013-01-09 | 2014-06-05 | 배진현 | 증폭된 신호가 발생되는 전기장을 이용한 면역 크로마토그래피 분석 방법 |
| HK1220759A1 (zh) | 2013-03-15 | 2017-05-12 | Hycor Biomedical Llc | 用於进行过敏症和自身免疫性疾病的诊断测定的自动化免疫分析系统 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) * | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US4446231A (en) * | 1979-10-03 | 1984-05-01 | Self Colin H | Immunoassay using an amplified cyclic detection system |
| DE3174918D1 (en) * | 1980-12-23 | 1986-08-14 | Boehringer Mannheim Gmbh | Hydrophilic latex particles, process for their preparation and their use |
| JPS57200862A (en) * | 1981-06-05 | 1982-12-09 | Fuji Photo Film Co Ltd | Mutilayer analysis element utilizing unique binding reaction |
| JPS59170768A (ja) | 1983-03-17 | 1984-09-27 | Fuji Photo Film Co Ltd | 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法 |
| US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| CA1272127A (en) | 1985-04-04 | 1990-07-31 | Hybritech Incorporated | Solid phase system for use in ligand-receptor assays |
| TW203120B (https=) | 1985-10-04 | 1993-04-01 | Abbott Lab | |
| US5160701A (en) | 1986-02-18 | 1992-11-03 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| US4916056A (en) | 1986-02-18 | 1990-04-10 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| DE3856421T2 (de) | 1987-04-27 | 2000-12-14 | Unilever Nv | Spezifische Bindungstestverfahren |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US4981786A (en) * | 1987-09-04 | 1991-01-01 | Syntex (U.S.A.) Inc. | Multiple port assay device |
| CA1312544C (en) * | 1987-12-21 | 1993-01-12 | James L. Wilcox | Chromatographic binding assay devices and methods |
| AU2684488A (en) * | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| CA2003942A1 (en) | 1989-09-26 | 1991-03-26 | Julie Lia Rudolph | Solid assay support systems |
| ES2092523T3 (es) | 1990-05-09 | 1996-12-01 | Abbott Lab | Ensayos que utilizan enlaces con recuperacion de conjugado. |
| US5846703A (en) * | 1990-05-15 | 1998-12-08 | Diatron Corporation | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding |
| FR2665087B1 (fr) | 1990-07-24 | 1992-10-09 | Lorraine Carbone | Procede de fabrication d'une membrane minerale ultra-mince et asymetrique. |
| JP2955405B2 (ja) * | 1990-08-31 | 1999-10-04 | ジェイエスアール株式会社 | イムノクロマトグラフ法 |
| US5356782A (en) | 1992-09-03 | 1994-10-18 | Boehringer Mannheim Corporation | Analytical test apparatus with on board negative and positive control |
| WO1994029696A1 (en) * | 1993-06-09 | 1994-12-22 | Quidel Corporation | Antigen-specific one-step assays |
| WO1995031485A1 (en) * | 1994-05-15 | 1995-11-23 | Pharmacia Biotech Ab | A method of manufacturing particles, and particles that can be produced in accordance with the method |
| SE9500184D0 (sv) | 1995-01-20 | 1995-01-20 | Pharmacia Ab | Analysmetod som utnyttjar biospecifika affinitetsreaktioner och märkt reaktant samt reagens att användas i föredragen utförandeform |
-
1997
- 1997-12-30 SE SE9704935A patent/SE9704935D0/xx unknown
-
1998
- 1998-12-30 DE DE69818706T patent/DE69818706T2/de not_active Expired - Lifetime
- 1998-12-30 WO PCT/SE1998/002462 patent/WO1999036780A1/en not_active Ceased
- 1998-12-30 AT AT98965942T patent/ATE251307T1/de active
- 1998-12-30 ES ES98965942T patent/ES2209242T3/es not_active Expired - Lifetime
- 1998-12-30 EP EP98965942A patent/EP1044376B1/en not_active Expired - Lifetime
- 1998-12-30 CA CA002314870A patent/CA2314870C/en not_active Expired - Lifetime
- 1998-12-30 PT PT98965942T patent/PT1044376E/pt unknown
- 1998-12-30 DK DK98965942T patent/DK1044376T3/da active
- 1998-12-30 US US09/582,808 patent/US7405084B1/en not_active Expired - Fee Related
- 1998-12-30 JP JP2000540441A patent/JP4531252B2/ja not_active Expired - Lifetime
- 1998-12-30 AU AU21949/99A patent/AU750153B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818706T2 (de) | 2004-09-23 |
| US7405084B1 (en) | 2008-07-29 |
| PT1044376E (pt) | 2004-02-27 |
| CA2314870C (en) | 2009-11-24 |
| ES2209242T3 (es) | 2004-06-16 |
| ATE251307T1 (de) | 2003-10-15 |
| AU2194999A (en) | 1999-08-02 |
| SE9704935D0 (sv) | 1997-12-30 |
| AU750153B2 (en) | 2002-07-11 |
| EP1044376B1 (en) | 2003-10-01 |
| CA2314870A1 (en) | 1999-07-22 |
| JP2002509253A (ja) | 2002-03-26 |
| EP1044376A1 (en) | 2000-10-18 |
| WO1999036780A1 (en) | 1999-07-22 |
| DE69818706D1 (de) | 2003-11-06 |
| DK1044376T3 (da) | 2004-02-09 |
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