ES2208911T3 - Electrotransporte perfeccionado de agentes terapeuticos que comprenden contr-iones anionico polibasicos. - Google Patents
Electrotransporte perfeccionado de agentes terapeuticos que comprenden contr-iones anionico polibasicos.Info
- Publication number
- ES2208911T3 ES2208911T3 ES97927937T ES97927937T ES2208911T3 ES 2208911 T3 ES2208911 T3 ES 2208911T3 ES 97927937 T ES97927937 T ES 97927937T ES 97927937 T ES97927937 T ES 97927937T ES 2208911 T3 ES2208911 T3 ES 2208911T3
- Authority
- ES
- Spain
- Prior art keywords
- deposit
- citrate
- donor
- solution
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 125000000129 anionic group Chemical group 0.000 claims abstract description 23
- 150000001768 cations Chemical class 0.000 claims abstract description 18
- 150000001457 metallic cations Chemical class 0.000 claims abstract 3
- 239000000243 solution Substances 0.000 claims description 38
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- 238000000034 method Methods 0.000 claims description 34
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 27
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- 239000011787 zinc oxide Substances 0.000 claims description 18
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical group [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 17
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- 229940001468 citrate Drugs 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims 2
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- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 13
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- 239000011230 binding agent Substances 0.000 description 8
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- 239000004081 narcotic agent Substances 0.000 description 7
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- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
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- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 229940047507 ioxapine Drugs 0.000 description 1
- 239000002648 laminated material Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- CNFIIGJQEIQCSX-UHFFFAOYSA-N n-[1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl]-n-phenylpropanamide;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 CNFIIGJQEIQCSX-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920006112 polar polymer Polymers 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000000000 tetracarboxylic acids Chemical class 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1961896P | 1996-06-12 | 1996-06-12 | |
| US19618P | 1996-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2208911T3 true ES2208911T3 (es) | 2004-06-16 |
Family
ID=21794143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97927937T Expired - Lifetime ES2208911T3 (es) | 1996-06-12 | 1997-06-03 | Electrotransporte perfeccionado de agentes terapeuticos que comprenden contr-iones anionico polibasicos. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0910432B1 (enExample) |
| JP (1) | JP3916669B2 (enExample) |
| CN (1) | CN1108173C (enExample) |
| AT (1) | ATE250957T1 (enExample) |
| AU (1) | AU3227397A (enExample) |
| BR (1) | BR9709780A (enExample) |
| CA (1) | CA2252899A1 (enExample) |
| DE (1) | DE69725312T2 (enExample) |
| DK (1) | DK0910432T3 (enExample) |
| ES (1) | ES2208911T3 (enExample) |
| PT (1) | PT910432E (enExample) |
| WO (1) | WO1997047354A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6719997B2 (en) | 2000-06-30 | 2004-04-13 | Dermatrends, Inc. | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers |
| US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
| WO2007027892A1 (en) * | 2005-08-31 | 2007-03-08 | Alza Corporation | Cathode for electrotransport delivery of anionic drug |
| US20090105632A1 (en) * | 2007-10-18 | 2009-04-23 | Padmanabhan Rama V | Electrotransport Of Lisuride |
| CN101792564B (zh) * | 2010-03-04 | 2012-05-02 | 吉林大学 | 一种抗刮擦涂层及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| US4731049A (en) * | 1987-01-30 | 1988-03-15 | Ionics, Incorporated | Cell for electrically controlled transdermal drug delivery |
| IE64873B1 (en) * | 1990-03-15 | 1995-09-20 | Becton Dickinson Co | Method and composition for iontophoresis |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| JP4090072B2 (ja) * | 1994-07-13 | 2008-05-28 | アルザ・コーポレーション | 経皮電気的移送式作用剤投与を促進するための組成物と方法 |
-
1997
- 1997-06-03 DK DK97927937T patent/DK0910432T3/da active
- 1997-06-03 ES ES97927937T patent/ES2208911T3/es not_active Expired - Lifetime
- 1997-06-03 DE DE69725312T patent/DE69725312T2/de not_active Expired - Fee Related
- 1997-06-03 WO PCT/US1997/009550 patent/WO1997047354A1/en not_active Ceased
- 1997-06-03 CA CA002252899A patent/CA2252899A1/en not_active Abandoned
- 1997-06-03 PT PT97927937T patent/PT910432E/pt unknown
- 1997-06-03 EP EP97927937A patent/EP0910432B1/en not_active Expired - Lifetime
- 1997-06-03 AU AU32273/97A patent/AU3227397A/en not_active Abandoned
- 1997-06-03 AT AT97927937T patent/ATE250957T1/de not_active IP Right Cessation
- 1997-06-03 BR BR9709780A patent/BR9709780A/pt not_active Application Discontinuation
- 1997-06-03 JP JP50166598A patent/JP3916669B2/ja not_active Expired - Fee Related
- 1997-06-03 CN CN97195459.3A patent/CN1108173C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0910432B1 (en) | 2003-10-01 |
| JP2000512181A (ja) | 2000-09-19 |
| JP3916669B2 (ja) | 2007-05-16 |
| EP0910432A1 (en) | 1999-04-28 |
| DK0910432T3 (da) | 2004-02-09 |
| PT910432E (pt) | 2004-01-30 |
| CN1222093A (zh) | 1999-07-07 |
| BR9709780A (pt) | 1999-08-10 |
| DE69725312D1 (de) | 2003-11-06 |
| DE69725312T2 (de) | 2004-07-15 |
| ATE250957T1 (de) | 2003-10-15 |
| AU3227397A (en) | 1998-01-07 |
| WO1997047354A1 (en) | 1997-12-18 |
| CN1108173C (zh) | 2003-05-14 |
| CA2252899A1 (en) | 1997-12-18 |
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