CA2252899A1 - Enhanced electrotransport of therapeutic agents having polybasic anionic counter-ions - Google Patents
Enhanced electrotransport of therapeutic agents having polybasic anionic counter-ions Download PDFInfo
- Publication number
- CA2252899A1 CA2252899A1 CA002252899A CA2252899A CA2252899A1 CA 2252899 A1 CA2252899 A1 CA 2252899A1 CA 002252899 A CA002252899 A CA 002252899A CA 2252899 A CA2252899 A CA 2252899A CA 2252899 A1 CA2252899 A1 CA 2252899A1
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- Canada
- Prior art keywords
- reservoir
- solution
- therapeutic agent
- citrate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- SMNRFWMNPDABKZ-WVALLCKVSA-N [[(2R,3S,4R,5S)-5-(2,6-dioxo-3H-pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4S,5R,6R)-4-fluoro-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)C2C=CC(=O)NC2=O)[C@H](O)[C@@H](F)[C@@H]1O SMNRFWMNPDABKZ-WVALLCKVSA-N 0.000 description 1
- NOSIYYJFMPDDSA-UHFFFAOYSA-N acepromazine Chemical compound C1=C(C(C)=O)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 NOSIYYJFMPDDSA-UHFFFAOYSA-N 0.000 description 1
- 229960005054 acepromazine Drugs 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 229960000847 dextromoramide tartrate Drugs 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960000418 lisuride maleate Drugs 0.000 description 1
- YQZBAXDVDZTKEQ-UHFFFAOYSA-N loxapine succinate Chemical compound [H+].[H+].[O-]C(=O)CCC([O-])=O.C1CN(C)CCN1C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C12 YQZBAXDVDZTKEQ-UHFFFAOYSA-N 0.000 description 1
- 229960000589 loxapine succinate Drugs 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229960002984 metaraminol bitartrate Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000000000 tetracarboxylic acids Chemical class 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1961896P | 1996-06-12 | 1996-06-12 | |
| US60/019,618 | 1996-06-12 | ||
| PCT/US1997/009550 WO1997047354A1 (en) | 1996-06-12 | 1997-06-03 | Enhanced electrotransport of therapeutic agents having polybasic anionic counter-ions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2252899A1 true CA2252899A1 (en) | 1997-12-18 |
Family
ID=21794143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002252899A Abandoned CA2252899A1 (en) | 1996-06-12 | 1997-06-03 | Enhanced electrotransport of therapeutic agents having polybasic anionic counter-ions |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0910432B1 (enExample) |
| JP (1) | JP3916669B2 (enExample) |
| CN (1) | CN1108173C (enExample) |
| AT (1) | ATE250957T1 (enExample) |
| AU (1) | AU3227397A (enExample) |
| BR (1) | BR9709780A (enExample) |
| CA (1) | CA2252899A1 (enExample) |
| DE (1) | DE69725312T2 (enExample) |
| DK (1) | DK0910432T3 (enExample) |
| ES (1) | ES2208911T3 (enExample) |
| PT (1) | PT910432E (enExample) |
| WO (1) | WO1997047354A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6719997B2 (en) | 2000-06-30 | 2004-04-13 | Dermatrends, Inc. | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers |
| US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
| WO2007027892A1 (en) * | 2005-08-31 | 2007-03-08 | Alza Corporation | Cathode for electrotransport delivery of anionic drug |
| US20090105632A1 (en) * | 2007-10-18 | 2009-04-23 | Padmanabhan Rama V | Electrotransport Of Lisuride |
| CN101792564B (zh) * | 2010-03-04 | 2012-05-02 | 吉林大学 | 一种抗刮擦涂层及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| US4731049A (en) * | 1987-01-30 | 1988-03-15 | Ionics, Incorporated | Cell for electrically controlled transdermal drug delivery |
| IE64873B1 (en) * | 1990-03-15 | 1995-09-20 | Becton Dickinson Co | Method and composition for iontophoresis |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| JP4090072B2 (ja) * | 1994-07-13 | 2008-05-28 | アルザ・コーポレーション | 経皮電気的移送式作用剤投与を促進するための組成物と方法 |
-
1997
- 1997-06-03 DK DK97927937T patent/DK0910432T3/da active
- 1997-06-03 ES ES97927937T patent/ES2208911T3/es not_active Expired - Lifetime
- 1997-06-03 DE DE69725312T patent/DE69725312T2/de not_active Expired - Fee Related
- 1997-06-03 WO PCT/US1997/009550 patent/WO1997047354A1/en not_active Ceased
- 1997-06-03 CA CA002252899A patent/CA2252899A1/en not_active Abandoned
- 1997-06-03 PT PT97927937T patent/PT910432E/pt unknown
- 1997-06-03 EP EP97927937A patent/EP0910432B1/en not_active Expired - Lifetime
- 1997-06-03 AU AU32273/97A patent/AU3227397A/en not_active Abandoned
- 1997-06-03 AT AT97927937T patent/ATE250957T1/de not_active IP Right Cessation
- 1997-06-03 BR BR9709780A patent/BR9709780A/pt not_active Application Discontinuation
- 1997-06-03 JP JP50166598A patent/JP3916669B2/ja not_active Expired - Fee Related
- 1997-06-03 CN CN97195459.3A patent/CN1108173C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0910432B1 (en) | 2003-10-01 |
| JP2000512181A (ja) | 2000-09-19 |
| ES2208911T3 (es) | 2004-06-16 |
| JP3916669B2 (ja) | 2007-05-16 |
| EP0910432A1 (en) | 1999-04-28 |
| DK0910432T3 (da) | 2004-02-09 |
| PT910432E (pt) | 2004-01-30 |
| CN1222093A (zh) | 1999-07-07 |
| BR9709780A (pt) | 1999-08-10 |
| DE69725312D1 (de) | 2003-11-06 |
| DE69725312T2 (de) | 2004-07-15 |
| ATE250957T1 (de) | 2003-10-15 |
| AU3227397A (en) | 1998-01-07 |
| WO1997047354A1 (en) | 1997-12-18 |
| CN1108173C (zh) | 2003-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |