ES2193949T3 - Nuevos derivados del acido lipoico, su preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados del acido lipoico, su preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2193949T3 ES2193949T3 ES00918930T ES00918930T ES2193949T3 ES 2193949 T3 ES2193949 T3 ES 2193949T3 ES 00918930 T ES00918930 T ES 00918930T ES 00918930 T ES00918930 T ES 00918930T ES 2193949 T3 ES2193949 T3 ES 2193949T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- lipoic acid
- pharmaceutical compositions
- derivatives
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- AGBQKNBQESQNJD-ZETCQYMHSA-N (S)-lipoic acid Chemical class OC(=O)CCCC[C@H]1CCSS1 AGBQKNBQESQNJD-ZETCQYMHSA-N 0.000 title 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 235000006708 antioxidants Nutrition 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical class [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 abstract 2
- 230000008929 regeneration Effects 0.000 abstract 2
- 238000011069 regeneration method Methods 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000003642 reactive oxygen metabolite Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
Abstract
Nuevos derivados del ácido lipoico, su preparación y composiciones farmacéuticas que los contienen. La presente invención tiene como objetivo nuevos derivados del ácido lipoico que presentan una actividad inhibidora de las enzimas NO-sintasas que producen monóxido de nitrógeno NO y son agentes que permiten la regeneraci on de antioxidantes o de entidades trampa de las formas reactivas del oxígeno (generalmente conocidas como ROS por sus iniciales en inglés: reactive oxygen species) e intervienen de una forma más general en el estado redox de los grupos tiol. La invención se refiere particularmente a los derivados que corresponden a la fórmula general (I), sus métodos de preparación, las preparaciones farmacéuticas que los contienen y su utilización con fines terapéuticos, en particular, su utilización como inhibidores de las NO-sintasas y agentes que permiten la regeneración de antioxidantes o de entidades trampa de las ROS e intervienen de una forma más general en el estado redox de los grupos tiol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9904132A FR2791677B1 (fr) | 1999-04-02 | 1999-04-02 | Nouveaux derives de l'acide lipoique, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
FR0002315A FR2805537A1 (fr) | 2000-02-24 | 2000-02-24 | Nouveaux derives de l'acide lipoique, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2193949T3 true ES2193949T3 (es) | 2003-11-16 |
Family
ID=26212205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00918930T Expired - Lifetime ES2193949T3 (es) | 1999-04-02 | 2000-03-31 | Nuevos derivados del acido lipoico, su preparacion y composiciones farmaceuticas que los contienen. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6605637B1 (es) |
EP (1) | EP1169316B9 (es) |
JP (1) | JP2003505341A (es) |
KR (1) | KR100758763B1 (es) |
CN (1) | CN1173969C (es) |
AR (1) | AR042572A1 (es) |
AT (1) | ATE233752T1 (es) |
AU (1) | AU763572B2 (es) |
CA (1) | CA2369071A1 (es) |
DE (1) | DE60001546T9 (es) |
DK (1) | DK1169316T3 (es) |
ES (1) | ES2193949T3 (es) |
HK (1) | HK1046134B (es) |
HU (1) | HUP0200863A3 (es) |
MY (1) | MY119231A (es) |
NZ (1) | NZ514888A (es) |
PL (1) | PL350994A1 (es) |
PT (1) | PT1169316E (es) |
TW (1) | TWI269794B (es) |
WO (1) | WO2000059899A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19941217A1 (de) * | 1999-08-30 | 2001-03-15 | Asta Medica Ag | Behandlung der Migräne durch Verabreichung von alpha-Liponsäure oder Derivaten derselben |
WO2001068643A2 (fr) * | 2000-03-16 | 2001-09-20 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Nouveaux derives heterocycliques ou benzeniques de l'acide lipoique, leur preparation et leur application a titre de medicaments |
IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
ES2266299T3 (es) | 2000-11-30 | 2007-03-01 | Basf Aktiengesellschaft | Procedimiento para la obtencion acido lipoico y de acido dihidrolipoico. |
DE10137381A1 (de) * | 2001-07-31 | 2003-02-13 | Viatris Gmbh | Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung |
EP1432473A2 (en) * | 2001-09-28 | 2004-06-30 | Meagan Medical, Inc. | Method and apparatus for controlling percutaneous electrical signals |
EP1566182A4 (en) * | 2002-11-10 | 2009-08-19 | Inst Of Cell Biophysics Russia | ANTIOXIDATIVE PHARMACEUTICAL COMPOUND, METHOD OF PREPARING POLYPEPTIDE AND HEALING PROCESSES |
US7202270B2 (en) * | 2003-06-20 | 2007-04-10 | Sami Labs Limited | Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses |
US8916546B2 (en) | 2003-08-29 | 2014-12-23 | Therapeutic Research Llc | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress |
CN101146800A (zh) * | 2005-01-27 | 2008-03-19 | 生物工程大学精神物质实验室 | 用于治疗阿尔茨海默病的有机化合物,它们的用途和制备方法 |
US20070299093A1 (en) * | 2005-01-27 | 2007-12-27 | Alma Mater Studiorum-Universitá Di Bologna | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation |
PT1754478E (pt) | 2005-08-04 | 2009-03-31 | Encrypta Gmbh | Composição líquida compreendendo arginina e ácido alfalipóico e sua utilização para melhorar a função sexual |
FR2908769B1 (fr) * | 2006-11-17 | 2008-12-26 | Oreal | Nouveaux composes derives dithiolanes silicies et leur utilisation |
JP2010520333A (ja) * | 2007-03-01 | 2010-06-10 | セダーズ−シナイ メディカル センター | 〔1,2〕−ジチオラン部分を含有する抗酸化剤重合体およびその使用 |
BRPI0810660A2 (pt) * | 2007-04-18 | 2014-10-07 | Cornerstone Pharmaceuticals Inc | Derivados do ácido lipóico |
CN101707877B (zh) | 2007-06-13 | 2013-01-09 | 杰伊·普拉夫达 | 诊断与治疗氧化过激类病症的材料和方法 |
DE102007038849A1 (de) | 2007-08-16 | 2009-02-19 | Adscil Gmbh | Verwendung von R(+)-alpha-Liponsäure zur Behandlung der kryptogenen Neuropathie |
US9028874B2 (en) * | 2008-01-03 | 2015-05-12 | Cedars-Sinai Medical Center | Antioxidant nanosphere comprising [1,2]-dithiolane moieties |
MX2010010867A (es) * | 2008-04-04 | 2011-05-25 | Robert Shorr | Composicion farmaceutica. |
WO2009148698A1 (en) | 2008-06-02 | 2009-12-10 | Cedars-Sinai Medical Center | Nanometer-sized prodrugs of nsaids |
FR2937035B1 (fr) * | 2008-10-10 | 2010-12-31 | Oreal | Composes dithiolanes ; compositions les contenant ; utilisations pour la photoprotection de la peau |
EP2350274B1 (en) * | 2008-10-21 | 2019-01-23 | The General Hospital Corporation | Cell transplantation |
ES2529060T3 (es) | 2008-11-24 | 2015-02-16 | Cedars-Sinai Medical Center | Derivados antioxidantes de la camptotecina y nanoesferas antineoplásicas antioxidantes de los mismos |
CN102395560A (zh) * | 2009-02-17 | 2012-03-28 | 因瓦斯科医疗有限公司 | 包括一氧化氮的二氢硫辛酸衍生物及其治疗应用 |
US8632512B2 (en) | 2010-04-09 | 2014-01-21 | Kci Licensing, Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
WO2012019103A2 (en) | 2010-08-06 | 2012-02-09 | The General Hospital Corporation D/B/A | System and apparatus for cell treatment |
US8529873B2 (en) | 2011-08-24 | 2013-09-10 | Los Alamos National Security, Llc | SE-72/AS-72 generator system based on Se extraction/ As reextraction |
EP3181120A1 (en) | 2012-11-09 | 2017-06-21 | Scidose LLC | Enema composition for treatment of ulcerative colitis having long term stability |
WO2015195070A1 (en) | 2014-06-19 | 2015-12-23 | Robert Shorr | Pharmaceutical compounds |
ES2747702T3 (es) | 2014-06-19 | 2020-03-11 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
CN105949180B (zh) * | 2016-05-10 | 2018-07-10 | 中山大学 | 治疗中枢神经系统退行性疾病的化合物及其应用 |
CN106279136B (zh) * | 2016-08-15 | 2019-06-21 | 中山大学 | 治疗中枢神经系统退行性疾病或脑肿瘤的化合物及其应用 |
CN106957298B (zh) * | 2017-04-18 | 2019-07-16 | 湖南中医药大学 | 一种硫辛酸苯酚酯衍生物及其制备方法和应用 |
CN107382987A (zh) * | 2017-07-19 | 2017-11-24 | 佛山市第五人民医院 | 一种具有预防和治疗创伤性脑损伤活性的化合物及其制备方法和用途 |
EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE |
CN112999220B (zh) * | 2021-04-07 | 2022-12-13 | 中国人民解放军南部战区总医院 | α-硫辛酸在作为和/或制备金属β-内酰胺酶抑制剂中的应用 |
CN115778930B (zh) * | 2022-12-08 | 2024-02-27 | 陕西中医药大学 | 一种具有血管舒张活性的二硫缩醛类化合物在制备具有血管舒张活性药物方面的应用 |
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DE1205972B (de) | 1963-08-20 | 1965-12-02 | Merck Ag E | Verfahren zur Herstellung eines Liponsaeure-derivates |
US4938636A (en) | 1988-11-14 | 1990-07-03 | Aidlin Automation Corp. | Method and apparatus for feeding container bodies |
JPH06250330A (ja) * | 1993-03-01 | 1994-09-09 | Konica Corp | 写真フィルムの加工方法 |
IL123887A0 (en) * | 1997-04-02 | 1998-10-30 | Sankyo Co | Dithiolan derivatives their use and pharmaceutical compositions containing the same |
CA2339123A1 (en) * | 1998-07-31 | 2000-02-10 | Nippon Soda Co., Ltd. | Phenylazole compounds, process for producing the same and drugs for hyperlipemia |
WO2000024734A1 (en) * | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
US6369098B1 (en) * | 1999-10-05 | 2002-04-09 | Bethesda Pharmaceuticals, Inc. | Dithiolane derivatives |
US6492405B2 (en) * | 1999-12-30 | 2002-12-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nitric oxide donors and pharmaceutical compositions containing them |
US6387945B2 (en) * | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
-
2000
- 2000-03-30 AR ARP000101441A patent/AR042572A1/es active IP Right Grant
- 2000-03-31 DK DK00918930T patent/DK1169316T3/da active
- 2000-03-31 AU AU39709/00A patent/AU763572B2/en not_active Ceased
- 2000-03-31 US US09/937,823 patent/US6605637B1/en not_active Expired - Fee Related
- 2000-03-31 PL PL00350994A patent/PL350994A1/xx unknown
- 2000-03-31 DE DE60001546T patent/DE60001546T9/de not_active Expired - Fee Related
- 2000-03-31 WO PCT/FR2000/000814 patent/WO2000059899A1/fr active IP Right Grant
- 2000-03-31 AT AT00918930T patent/ATE233752T1/de not_active IP Right Cessation
- 2000-03-31 ES ES00918930T patent/ES2193949T3/es not_active Expired - Lifetime
- 2000-03-31 CA CA002369071A patent/CA2369071A1/fr not_active Abandoned
- 2000-03-31 HU HU0200863A patent/HUP0200863A3/hu unknown
- 2000-03-31 KR KR1020017012615A patent/KR100758763B1/ko not_active IP Right Cessation
- 2000-03-31 EP EP00918930A patent/EP1169316B9/fr not_active Expired - Lifetime
- 2000-03-31 NZ NZ514888A patent/NZ514888A/xx not_active IP Right Cessation
- 2000-03-31 PT PT00918930T patent/PT1169316E/pt unknown
- 2000-03-31 JP JP2000609410A patent/JP2003505341A/ja active Pending
- 2000-03-31 MY MYPI20001317A patent/MY119231A/en unknown
- 2000-03-31 CN CNB008069778A patent/CN1173969C/zh not_active Expired - Fee Related
- 2000-04-01 TW TW089106172A patent/TWI269794B/zh active
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2002
- 2002-10-10 HK HK02107396.3A patent/HK1046134B/zh not_active IP Right Cessation
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2003
- 2003-04-21 US US10/419,671 patent/US6887891B2/en not_active Expired - Fee Related
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Publication number | Publication date |
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HUP0200863A2 (en) | 2002-08-28 |
MY119231A (en) | 2005-04-30 |
AU3970900A (en) | 2000-10-23 |
US20040019084A1 (en) | 2004-01-29 |
TWI269794B (en) | 2007-01-01 |
EP1169316A1 (fr) | 2002-01-09 |
ATE233752T1 (de) | 2003-03-15 |
HK1046134B (zh) | 2005-04-22 |
DE60001546T9 (de) | 2004-11-04 |
PL350994A1 (en) | 2003-02-24 |
HUP0200863A3 (en) | 2005-02-28 |
AU763572B2 (en) | 2003-07-24 |
DE60001546T2 (de) | 2004-02-19 |
KR20010108444A (ko) | 2001-12-07 |
CA2369071A1 (fr) | 2000-10-12 |
PT1169316E (pt) | 2003-07-31 |
EP1169316B9 (fr) | 2003-10-29 |
WO2000059899A1 (fr) | 2000-10-12 |
DE60001546D1 (de) | 2003-04-10 |
US6887891B2 (en) | 2005-05-03 |
CN1349523A (zh) | 2002-05-15 |
DK1169316T3 (da) | 2003-06-30 |
JP2003505341A (ja) | 2003-02-12 |
AR042572A1 (es) | 2005-06-29 |
KR100758763B1 (ko) | 2007-09-14 |
WO2000059899A8 (fr) | 2001-03-22 |
CN1173969C (zh) | 2004-11-03 |
EP1169316B1 (fr) | 2003-03-05 |
NZ514888A (en) | 2002-12-20 |
US6605637B1 (en) | 2003-08-12 |
HK1046134A1 (en) | 2002-12-27 |
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