ES2193779T3 - Derivados de cromano. - Google Patents

Derivados de cromano.

Info

Publication number
ES2193779T3
ES2193779T3 ES99965422T ES99965422T ES2193779T3 ES 2193779 T3 ES2193779 T3 ES 2193779T3 ES 99965422 T ES99965422 T ES 99965422T ES 99965422 T ES99965422 T ES 99965422T ES 2193779 T3 ES2193779 T3 ES 2193779T3
Authority
ES
Spain
Prior art keywords
carbon atoms
hal
alkyl
chroman
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99965422T
Other languages
English (en)
Inventor
Heinz-Hermann Bokel
Peter Mackert
Christoph Murmann
Norbert Schweickert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2193779T3 publication Critical patent/ES2193779T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Derivados de cromano de la fórmula I **(Fórmula)** donde Rl significa acilo con 1 a 6 átomos de carbono, -CO-R5, fenilacetilo, fenoxiacetilo, metoxicarbonilo, etoxicarbonilo, 2, 2, 2-tricloroetoxicarbonilo, terc-butoxicarbonilo, 2-yodoetoxicarbonilo, carbobenzoxicarbonilo, 4-metoxibenciloxicarbonilo, 9-fluorenilmetoxicarbonilo o 4-metoxi-2, 3, 6-trimetilfenilsulfonilo, R2 significa H o alquilo con 1 a 6 átomos de carbono, R3, R4 significan, independientemente entre sí, H, alquilo con 1 a 6 átomos de carbono, CN, Hal o COOR2, R5 significa fenilo no substituido o mono- o disubstituido por alquilo con 1 a 6 átomos de carbono, OR2 o Hal, X significa H, H u O, Hal significa F, Cl, Br o I, así como sus sales, estando excluida la amida de ácido N-(croman-2-ilmetil)-ciclopropanocarboxílico.
ES99965422T 1998-12-17 1999-12-01 Derivados de cromano. Expired - Lifetime ES2193779T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19858341A DE19858341A1 (de) 1998-12-17 1998-12-17 Chromanderivate

Publications (1)

Publication Number Publication Date
ES2193779T3 true ES2193779T3 (es) 2003-11-01

Family

ID=7891486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99965422T Expired - Lifetime ES2193779T3 (es) 1998-12-17 1999-12-01 Derivados de cromano.

Country Status (26)

Country Link
US (1) US6646136B1 (es)
EP (1) EP1140890B1 (es)
JP (1) JP4790910B2 (es)
KR (1) KR100676017B1 (es)
CN (1) CN1140522C (es)
AR (1) AR021900A1 (es)
AT (1) ATE233253T1 (es)
AU (1) AU760501B2 (es)
BR (1) BR9916188B1 (es)
CA (1) CA2355098C (es)
CZ (1) CZ300544B6 (es)
DE (2) DE19858341A1 (es)
DK (1) DK1140890T3 (es)
ES (1) ES2193779T3 (es)
HK (1) HK1043119B (es)
HU (1) HU229060B1 (es)
ID (1) ID29273A (es)
NO (1) NO328132B1 (es)
PL (1) PL194157B1 (es)
PT (1) PT1140890E (es)
RU (1) RU2233277C2 (es)
SK (1) SK285837B6 (es)
TW (1) TWI222866B (es)
UA (1) UA72235C2 (es)
WO (1) WO2000035901A1 (es)
ZA (1) ZA200105840B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092250A2 (en) * 2000-06-02 2001-12-06 Cor Therapeutics, Inc. Synthesis of 2-acyl substituted chromanes and intermediates thereof
DE10044091A1 (de) 2000-09-07 2002-04-04 Merck Patent Gmbh Chromanonderivate
RU2308454C9 (ru) 2002-04-17 2008-05-10 Цитокинетикс, Инк. Соединения, композиции на их основе и способы их использования
DE60326248D1 (de) * 2002-07-17 2009-04-02 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
EP1554265A4 (en) * 2002-09-13 2008-05-07 Cytokinetics Inc COMPOSITIONS, COMPOSITIONS AND M THODES
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods
CN100424034C (zh) * 2006-08-25 2008-10-08 华中科技大学 一种磷石膏复合砖及其生产方法
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck
CN108690017B (zh) * 2018-05-04 2021-06-18 新乡学院 一种铑催化的莫西沙星侧链中间体的制备方法
CN113979983B (zh) * 2021-11-03 2023-10-03 中国人民解放军空军军医大学 一种非达司他关键中间体的不对称合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2745306A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide mittel
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
CA2022693A1 (en) * 1989-08-05 1991-02-06 Rolf Gericke Chroman derivatives
DE4102103A1 (de) * 1991-01-25 1992-08-20 Bayer Ag Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
EP0707007B1 (en) * 1994-10-14 2001-12-12 MERCK PATENT GmbH (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent

Also Published As

Publication number Publication date
CN1140522C (zh) 2004-03-03
CA2355098A1 (en) 2000-06-22
HUP0104819A3 (en) 2003-01-28
ZA200105840B (en) 2002-10-16
CN1329606A (zh) 2002-01-02
AU760501B2 (en) 2003-05-15
EP1140890A1 (de) 2001-10-10
NO20012964D0 (no) 2001-06-15
US6646136B1 (en) 2003-11-11
DE59904407D1 (en) 2003-04-03
SK8162001A3 (en) 2001-11-06
ATE233253T1 (de) 2003-03-15
UA72235C2 (uk) 2005-02-15
NO328132B1 (no) 2009-12-14
PT1140890E (pt) 2003-07-31
EP1140890B1 (de) 2003-02-26
WO2000035901A1 (de) 2000-06-22
HU229060B1 (hu) 2013-07-29
JP2002532488A (ja) 2002-10-02
SK285837B6 (sk) 2007-09-06
NO20012964L (no) 2001-06-15
HK1043119B (zh) 2004-12-24
CZ20012145A3 (cs) 2001-09-12
DE19858341A1 (de) 2000-06-21
HK1043119A1 (en) 2002-09-06
ID29273A (id) 2001-08-16
HUP0104819A2 (en) 2002-06-29
AU2094600A (en) 2000-07-03
BR9916188B1 (pt) 2011-10-18
BR9916188A (pt) 2001-09-04
PL194157B1 (pl) 2007-05-31
CA2355098C (en) 2009-10-13
KR100676017B1 (ko) 2007-01-29
AR021900A1 (es) 2002-09-04
DK1140890T3 (da) 2003-06-02
PL348191A1 (en) 2002-05-06
KR20010086111A (ko) 2001-09-07
TWI222866B (en) 2004-11-01
JP4790910B2 (ja) 2011-10-12
RU2233277C2 (ru) 2004-07-27
CZ300544B6 (cs) 2009-06-10

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