CO4520229A1 - Derivados de la oxazolidin-2-ona y procedimiento para su obtencion - Google Patents
Derivados de la oxazolidin-2-ona y procedimiento para su obtencionInfo
- Publication number
- CO4520229A1 CO4520229A1 CO95052761A CO95052761A CO4520229A1 CO 4520229 A1 CO4520229 A1 CO 4520229A1 CO 95052761 A CO95052761 A CO 95052761A CO 95052761 A CO95052761 A CO 95052761A CO 4520229 A1 CO4520229 A1 CO 4520229A1
- Authority
- CO
- Colombia
- Prior art keywords
- oxazolidin
- ona
- derivatives
- procedure
- obtaining
- Prior art date
Links
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical class C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 abstract 1
- -1 AMIDINO Chemical class 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1. COMPUESTOS CARACTERIZADOS POR FORMULA I FIGURA 1 EN LA QUE X REPRESENTA O, S, NH, o NA, Y REPRESENTAN UN RESTO DE AZIRIDINO, AZETIDINO, PIRROLIDINO, PIPERIDINO, HEXAHIDROAZEPINO O PIPE- RAZINO SUSTITUIDO CON R2, R1 REPRESENTA R2 ES -CrH2r-COOR3, R3, ES H, A o Ar, A REPRESENTA ALQUILO DE 1 A t ATOMOS DE C, B REPRESENTA H. A, CICLOALQUILO DE 3 A 7 ATOMOS DE C, Ar-CkH2k- o AMIDINO, Ar REPRESENTA FENILO O BENCILO NO SUSTITUIDO, O BIEN MONO O DISUSTITUIDO CON A, Cl, Br, I, NO2, CN, OA, OH, NH2, NHA y/o NA2, k ES 1, 2, 3 o 4, m y r SON INDEPENDIENTEMENTE 0, 1, 2, 3 o 4, y n ES 2, 3 o 4, Y SUS SALES ACEPTABLES DESDE EL PUNTO DE VISTA FISIOLOGICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4439846A DE4439846A1 (de) | 1994-11-08 | 1994-11-08 | Adhäsionsrezeptor-Antagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4520229A1 true CO4520229A1 (es) | 1997-10-15 |
Family
ID=6532768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO95052761A CO4520229A1 (es) | 1994-11-08 | 1995-11-08 | Derivados de la oxazolidin-2-ona y procedimiento para su obtencion |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5776937A (es) |
| EP (1) | EP0711770A1 (es) |
| JP (1) | JPH08208629A (es) |
| KR (1) | KR100384978B1 (es) |
| CN (1) | CN1069640C (es) |
| AR (1) | AR002245A1 (es) |
| AU (1) | AU704184B2 (es) |
| BR (1) | BR9505109A (es) |
| CA (1) | CA2162223A1 (es) |
| CO (1) | CO4520229A1 (es) |
| CZ (1) | CZ291049B6 (es) |
| DE (1) | DE4439846A1 (es) |
| FI (1) | FI955351A (es) |
| HU (1) | HU217085B (es) |
| NO (1) | NO306113B1 (es) |
| PL (1) | PL183595B1 (es) |
| RU (1) | RU2155762C2 (es) |
| SK (1) | SK281815B6 (es) |
| TR (1) | TR199501389A2 (es) |
| TW (1) | TW316903B (es) |
| UA (1) | UA41928C2 (es) |
| ZA (1) | ZA959434B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0710657T3 (da) * | 1994-11-02 | 1999-05-25 | Merck Patent Gmbh | Adhæsionsreceptor-antagonister |
| US6046331A (en) * | 1998-12-17 | 2000-04-04 | Synaptic Pharmaceutical Corporation | Imidazolones and their use in treating benign prostatic hyperplasia and other disorders |
| WO2000038730A2 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia |
| AU4224699A (en) | 1999-01-27 | 2000-08-18 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
| AU2003275480A1 (en) * | 2002-10-07 | 2004-05-04 | Smithkline Beecham Corporation | Compounds |
| CN102796091A (zh) * | 2011-05-24 | 2012-11-28 | 北大方正集团有限公司 | 取代的噁唑烷酮化合物及其制备方法和应用 |
| UA114649C2 (uk) * | 2012-10-29 | 2017-07-10 | Ф. Хоффманн-Ля Рош Аг | Похідні 3,4-дизаміщеного оксазолідинону та їх застосування як інгібіторів кальцій-активованих калієвих каналів |
| CN104230915B (zh) * | 2014-08-29 | 2016-08-17 | 南京大学 | 含噻唑烷二酮的苯基哌嗪衍生物及其制备方法与用途 |
| ES2919779T3 (es) | 2017-06-20 | 2022-07-28 | Imbria Pharmaceuticals Inc | Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3723797A1 (de) * | 1987-07-18 | 1989-01-26 | Merck Patent Gmbh | Oxazolidinone |
| US5053393A (en) * | 1988-07-20 | 1991-10-01 | Monsanto Company | Novel platelet-aggregation inhibitor |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| DE4005371A1 (de) * | 1990-02-21 | 1991-08-22 | Merck Patent Gmbh | Oxazolidinone |
| DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
| DE4405633A1 (de) * | 1993-05-01 | 1994-11-03 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
-
1994
- 1994-11-08 DE DE4439846A patent/DE4439846A1/de not_active Withdrawn
-
1995
- 1995-10-26 EP EP95116889A patent/EP0711770A1/de not_active Withdrawn
- 1995-11-01 UA UA95114761A patent/UA41928C2/uk unknown
- 1995-11-02 AU AU36618/95A patent/AU704184B2/en not_active Ceased
- 1995-11-02 SK SK1368-95A patent/SK281815B6/sk unknown
- 1995-11-06 TW TW084111748A patent/TW316903B/zh active
- 1995-11-06 CZ CZ19952888A patent/CZ291049B6/cs not_active IP Right Cessation
- 1995-11-06 CA CA002162223A patent/CA2162223A1/en not_active Abandoned
- 1995-11-07 KR KR1019950040017A patent/KR100384978B1/ko not_active IP Right Cessation
- 1995-11-07 HU HU9503191A patent/HU217085B/hu not_active IP Right Cessation
- 1995-11-07 PL PL95311257A patent/PL183595B1/pl not_active IP Right Cessation
- 1995-11-07 US US08/551,743 patent/US5776937A/en not_active Expired - Fee Related
- 1995-11-07 CN CN95118753A patent/CN1069640C/zh not_active Expired - Fee Related
- 1995-11-07 BR BR9505109A patent/BR9505109A/pt not_active IP Right Cessation
- 1995-11-07 FI FI955351A patent/FI955351A/fi not_active IP Right Cessation
- 1995-11-07 NO NO954458A patent/NO306113B1/no not_active IP Right Cessation
- 1995-11-07 ZA ZA959434A patent/ZA959434B/xx unknown
- 1995-11-08 JP JP7313684A patent/JPH08208629A/ja active Pending
- 1995-11-08 RU RU95119427/04A patent/RU2155762C2/ru not_active IP Right Cessation
- 1995-11-08 TR TR95/01389A patent/TR199501389A2/xx unknown
- 1995-11-08 AR ARP950100091A patent/AR002245A1/es unknown
- 1995-11-08 CO CO95052761A patent/CO4520229A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE4439846A1 (de) | 1996-05-09 |
| CN1069640C (zh) | 2001-08-15 |
| CA2162223A1 (en) | 1996-05-09 |
| TR199501389A2 (tr) | 1996-07-21 |
| ZA959434B (en) | 1996-05-15 |
| KR960017663A (ko) | 1996-06-17 |
| UA41928C2 (uk) | 2001-10-15 |
| NO954458D0 (no) | 1995-11-07 |
| HU217085B (hu) | 1999-11-29 |
| PL311257A1 (en) | 1996-05-13 |
| TW316903B (es) | 1997-10-01 |
| AR002245A1 (es) | 1998-03-11 |
| AU704184B2 (en) | 1999-04-15 |
| RU2155762C2 (ru) | 2000-09-10 |
| CZ288895A3 (en) | 1996-06-12 |
| CN1132201A (zh) | 1996-10-02 |
| JPH08208629A (ja) | 1996-08-13 |
| FI955351A0 (fi) | 1995-11-07 |
| FI955351A (fi) | 1996-05-09 |
| BR9505109A (pt) | 1997-09-09 |
| NO954458L (no) | 1996-05-09 |
| SK281815B6 (sk) | 2001-08-06 |
| EP0711770A1 (de) | 1996-05-15 |
| HUT76052A (en) | 1997-06-30 |
| NO306113B1 (no) | 1999-09-20 |
| PL183595B1 (pl) | 2002-06-28 |
| CZ291049B6 (cs) | 2002-12-11 |
| US5776937A (en) | 1998-07-07 |
| AU3661895A (en) | 1996-05-23 |
| SK136895A3 (en) | 1996-06-05 |
| HU9503191D0 (en) | 1996-01-29 |
| KR100384978B1 (ko) | 2003-09-02 |
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