AR021900A1 - Derivados del cromano, sus sales y enantiomeros, un procedimiento para su preparacion y el empleo de los mismos como productos intermedios para la sintesis de medicamentos. - Google Patents
Derivados del cromano, sus sales y enantiomeros, un procedimiento para su preparacion y el empleo de los mismos como productos intermedios para la sintesis de medicamentos.Info
- Publication number
- AR021900A1 AR021900A1 ARP990106530A ARP990106530A AR021900A1 AR 021900 A1 AR021900 A1 AR 021900A1 AR P990106530 A ARP990106530 A AR P990106530A AR P990106530 A ARP990106530 A AR P990106530A AR 021900 A1 AR021900 A1 AR 021900A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- salts
- chroman
- atoms
- synthesis
- Prior art date
Links
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Derivados del cromano de formula (1) en donde R1 representa acilo de 1 a 6 átomos de C, -CO-R5 o un grupo protector de amino, R2 representa H o alquilo de1 a 6 átomos de C, R3 R4 representan independientemente H, alquilo de 1 a 6 átomos de C, CN,Hal o COOR2, R5 representa fenilo no sustituido o mono odisustituido con alquilo de 1 a 6 átomos de C, OR2, o Hal, X representa H, H u O, Hal representa F, Cl, Br o I, y las sales de estos compuestos. Unprocedimiento para preparar los derivados decroma no de formula (1) y sus sales, en los cuales X representa O, procedimiento en el cual con la ayuda de uncatalizador enriquecido en un enantiomero se hidrogena un compuesto de formula (2) en donde R1, R2 R3 y R4 tienen los significadosindicados en la reivindicacion en (1) y X representa O. Un procedimiento para preparar los derivados del cromano de formula (1) y sus sales, en los cuales X, representa H,Hprocedimiento en el cual con la ayuda de un catalizador enriquecido en unenantiomero se hidro gena un compuesto de formula (2) en donde R1, R2, R3, R4 tienenlos significados indicados en la reivindicacion (1) y X representa O, y luego se reduce de manera usual. El empleo de los compuestos de formula (1) comoproductosintermedios para la sínte sis de medicamentos, en particular, de medicamentos que influyen sobre el sistema nervioso central. El empleo de loscompuestos de formula (1) en la síntesis del (R)-2[5-(4-fluorofenil)-3-piridimetilaminometil]-cromano y sussales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19858341A DE19858341A1 (de) | 1998-12-17 | 1998-12-17 | Chromanderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
AR021900A1 true AR021900A1 (es) | 2002-09-04 |
Family
ID=7891486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990106530A AR021900A1 (es) | 1998-12-17 | 1999-12-17 | Derivados del cromano, sus sales y enantiomeros, un procedimiento para su preparacion y el empleo de los mismos como productos intermedios para la sintesis de medicamentos. |
Country Status (26)
Country | Link |
---|---|
US (1) | US6646136B1 (es) |
EP (1) | EP1140890B1 (es) |
JP (1) | JP4790910B2 (es) |
KR (1) | KR100676017B1 (es) |
CN (1) | CN1140522C (es) |
AR (1) | AR021900A1 (es) |
AT (1) | ATE233253T1 (es) |
AU (1) | AU760501B2 (es) |
BR (1) | BR9916188B1 (es) |
CA (1) | CA2355098C (es) |
CZ (1) | CZ300544B6 (es) |
DE (2) | DE19858341A1 (es) |
DK (1) | DK1140890T3 (es) |
ES (1) | ES2193779T3 (es) |
HK (1) | HK1043119B (es) |
HU (1) | HU229060B1 (es) |
ID (1) | ID29273A (es) |
NO (1) | NO328132B1 (es) |
PL (1) | PL194157B1 (es) |
PT (1) | PT1140890E (es) |
RU (1) | RU2233277C2 (es) |
SK (1) | SK285837B6 (es) |
TW (1) | TWI222866B (es) |
UA (1) | UA72235C2 (es) |
WO (1) | WO2000035901A1 (es) |
ZA (1) | ZA200105840B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6903227B2 (en) | 2000-06-02 | 2005-06-07 | Millennium Pharmaceuticals, Inc. | Synthesis of 2-acyl substituted chromanes and intermediates thereof |
DE10044091A1 (de) | 2000-09-07 | 2002-04-04 | Merck Patent Gmbh | Chromanonderivate |
US6924376B2 (en) | 2002-04-17 | 2005-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
DE60326248D1 (de) * | 2002-07-17 | 2009-04-02 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
AU2003267169A1 (en) * | 2002-09-13 | 2004-04-30 | Cytokinetics, Inc. | Compounds, compositions and methods |
US20050165089A1 (en) * | 2003-10-06 | 2005-07-28 | Gustave Bergnes | Compounds, compositions and methods |
CN100424034C (zh) * | 2006-08-25 | 2008-10-08 | 华中科技大学 | 一种磷石膏复合砖及其生产方法 |
ES2534318B1 (es) * | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck |
ES2534336B1 (es) * | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno como inhibidores de la interacción TCR-Nck |
CN108690017B (zh) * | 2018-05-04 | 2021-06-18 | 新乡学院 | 一种铑催化的莫西沙星侧链中间体的制备方法 |
CN113979983B (zh) * | 2021-11-03 | 2023-10-03 | 中国人民解放军空军军医大学 | 一种非达司他关键中间体的不对称合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2745306A1 (de) * | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide mittel |
DE2745305A1 (de) * | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide und akarizide mittel |
CA2022693A1 (en) * | 1989-08-05 | 1991-02-06 | Rolf Gericke | Chroman derivatives |
DE4102103A1 (de) * | 1991-01-25 | 1992-08-20 | Bayer Ag | Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
EP1123933A1 (en) * | 1994-10-14 | 2001-08-16 | MERCK PATENT GmbH | 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent |
-
1998
- 1998-12-17 DE DE19858341A patent/DE19858341A1/de not_active Withdrawn
-
1999
- 1999-01-12 UA UA2001075094A patent/UA72235C2/uk unknown
- 1999-12-01 PL PL348191A patent/PL194157B1/pl unknown
- 1999-12-01 EP EP99965422A patent/EP1140890B1/de not_active Expired - Lifetime
- 1999-12-01 CA CA002355098A patent/CA2355098C/en not_active Expired - Fee Related
- 1999-12-01 WO PCT/EP1999/009333 patent/WO2000035901A1/de active IP Right Grant
- 1999-12-01 RU RU2001119277/04A patent/RU2233277C2/ru not_active IP Right Cessation
- 1999-12-01 SK SK816-2001A patent/SK285837B6/sk not_active IP Right Cessation
- 1999-12-01 ID IDW00200101558A patent/ID29273A/id unknown
- 1999-12-01 KR KR1020017007512A patent/KR100676017B1/ko not_active IP Right Cessation
- 1999-12-01 PT PT99965422T patent/PT1140890E/pt unknown
- 1999-12-01 JP JP2000588161A patent/JP4790910B2/ja not_active Expired - Lifetime
- 1999-12-01 CN CNB998142247A patent/CN1140522C/zh not_active Expired - Lifetime
- 1999-12-01 DK DK99965422T patent/DK1140890T3/da active
- 1999-12-01 DE DE59904407T patent/DE59904407D1/de not_active Expired - Lifetime
- 1999-12-01 CZ CZ20012145A patent/CZ300544B6/cs not_active IP Right Cessation
- 1999-12-01 AT AT99965422T patent/ATE233253T1/de active
- 1999-12-01 US US09/868,704 patent/US6646136B1/en not_active Expired - Lifetime
- 1999-12-01 AU AU20946/00A patent/AU760501B2/en not_active Expired
- 1999-12-01 ES ES99965422T patent/ES2193779T3/es not_active Expired - Lifetime
- 1999-12-01 HU HU0104819A patent/HU229060B1/hu not_active IP Right Cessation
- 1999-12-01 BR BRPI9916188-5A patent/BR9916188B1/pt not_active IP Right Cessation
- 1999-12-15 TW TW088121987A patent/TWI222866B/zh not_active IP Right Cessation
- 1999-12-17 AR ARP990106530A patent/AR021900A1/es active IP Right Grant
-
2001
- 2001-06-15 NO NO20012964A patent/NO328132B1/no not_active IP Right Cessation
- 2001-07-16 ZA ZA200105840A patent/ZA200105840B/en unknown
-
2002
- 2002-06-18 HK HK02104515.6A patent/HK1043119B/zh not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |