ES2189142T3 - Arilsulfonamidas y sus analogos y su uso en el tratamiento de enfermedades neurodegenerativas. - Google Patents

Arilsulfonamidas y sus analogos y su uso en el tratamiento de enfermedades neurodegenerativas.

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Publication number
ES2189142T3
ES2189142T3 ES98909427T ES98909427T ES2189142T3 ES 2189142 T3 ES2189142 T3 ES 2189142T3 ES 98909427 T ES98909427 T ES 98909427T ES 98909427 T ES98909427 T ES 98909427T ES 2189142 T3 ES2189142 T3 ES 2189142T3
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Spain
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formula
groups
reacting
reaction
product
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ES98909427T
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Inventor
Joachim Mittendorf
Jurgen Dressel
Michael Matzke
Jorg Keldenich
Klaus-Helmut Mohrs
Siegfried Raddatz
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Bayer AG
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Bayer AG
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Priority claimed from DE19740785A external-priority patent/DE19740785A1/de
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    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

Oligómeros de bloque conteniendo grupos 1 - hidro-carbiloxi - 2,2,6,6 - tetrametil - 4 - piperidilo como estabilizadores para materiales orgánicos. Estos productos se pueden obtener 1) haciendo reaccionar un compuesto de fórmula (alfa) con un compuesto de fórmula (beta); 2) haciendo reaccionar los grupos extremos de la fórmula (gamma) presente en el producto de la reacción 1) con, por ejemplo, dibutilamina, y 3) transfiriendo los grupos de la fórmula (G-I) presentes en el producto de la reacción 2) a grupos de la fórmula (G-II), realizando dicha transferencia por reacción del producto de la reacción 2) con un hidroperóxido, en un disolvente hidrocarbúrico, y en presencia de un catalizador de descomposición de peróxido. Los productos obtenidos son útiles como estabilizadores de la luz, del calor y de la oxidación para materiales orgánicos, en particular polímeros sintéticos, como las poliolefinas.
ES98909427T 1997-02-21 1998-02-10 Arilsulfonamidas y sus analogos y su uso en el tratamiento de enfermedades neurodegenerativas. Expired - Lifetime ES2189142T3 (es)

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