ES2184452T3 - Preparacion farmaceutica que contiene levotiroxina de sodio. - Google Patents

Preparacion farmaceutica que contiene levotiroxina de sodio.

Info

Publication number
ES2184452T3
ES2184452T3 ES99922182T ES99922182T ES2184452T3 ES 2184452 T3 ES2184452 T3 ES 2184452T3 ES 99922182 T ES99922182 T ES 99922182T ES 99922182 T ES99922182 T ES 99922182T ES 2184452 T3 ES2184452 T3 ES 2184452T3
Authority
ES
Spain
Prior art keywords
containing sodium
levotiroxin
pharmaceutical preparation
preparation containing
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99922182T
Other languages
English (en)
Inventor
Sven Schreder
Marion Nischwitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2184452T3 publication Critical patent/ES2184452T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Abstract

Tabletas que contienen levotiroxina de sodio, gelatina y cargas y que están exentas de residuos de disolventes orgánicos.
ES99922182T 1998-05-15 1999-05-05 Preparacion farmaceutica que contiene levotiroxina de sodio. Expired - Lifetime ES2184452T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19821625A DE19821625C1 (de) 1998-05-15 1998-05-15 Pharmazeutische Zubereitung

Publications (1)

Publication Number Publication Date
ES2184452T3 true ES2184452T3 (es) 2003-04-01

Family

ID=7867752

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99922182T Expired - Lifetime ES2184452T3 (es) 1998-05-15 1999-05-05 Preparacion farmaceutica que contiene levotiroxina de sodio.

Country Status (25)

Country Link
US (2) US6646007B1 (es)
EP (1) EP1077681B1 (es)
JP (1) JP4709379B2 (es)
CN (1) CN1145479C (es)
AR (1) AR018607A1 (es)
AT (1) ATE225651T1 (es)
AU (1) AU742382B2 (es)
BR (1) BRPI9910445B8 (es)
CA (1) CA2333193A1 (es)
CZ (1) CZ300908B6 (es)
DE (2) DE19821625C1 (es)
DK (1) DK1077681T3 (es)
ES (1) ES2184452T3 (es)
HU (1) HU228958B1 (es)
ID (1) ID27281A (es)
MY (1) MY120570A (es)
NO (1) NO331655B1 (es)
PL (1) PL194088B1 (es)
PT (1) PT1077681E (es)
RU (1) RU2225711C2 (es)
SK (1) SK284155B6 (es)
TW (1) TW561058B (es)
UA (1) UA73474C2 (es)
WO (1) WO1999059551A1 (es)
ZA (1) ZA200007509B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
ITMI20011401A1 (it) * 2001-07-02 2003-01-02 Altergon Sa Formulazioni farmaceutiche per ormoni tiroidei
US20030099699A1 (en) * 2001-11-13 2003-05-29 Hanshew Dwight D. Storage stable thyroxine active drug formulations and methods for their production
WO2004041208A2 (en) * 2002-11-05 2004-05-21 New River Pharmaceuticals Inc. Controlled absorption of mixed thyroyd hormone formulations
ITMI20110713A1 (it) 2011-04-29 2012-10-30 Bracco Imaging Spa Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina
ITMI20022394A1 (it) 2002-11-13 2004-05-14 Bracco Spa Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche.
GB0316206D0 (en) * 2003-07-10 2003-08-13 Glaxo Group Ltd Pharmaceutical formulation
DK1811987T3 (da) 2004-11-18 2008-07-14 Uni Pharma Kleon Tsetis Pharmaceutical Lab Sa Törpulver omfattende levothyroxinnatrium indgivet via inhalator
GB0525461D0 (en) * 2005-12-15 2006-01-25 Archimedes Dev Ltd Pharmaceutical compositions
ITMI20062254A1 (it) * 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
NO2885005T3 (es) * 2012-08-20 2018-02-24
EP2932963A1 (en) 2014-04-16 2015-10-21 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Stable pharmaceutical dosage forms comprising Levothyroxine sodium
US9682045B2 (en) 2014-11-21 2017-06-20 Cadila Healthcare Limited Stable pharmaceutical compositions of thyroid hormone drug
US20200046664A1 (en) 2016-10-10 2020-02-13 Ftf Pharma Private Limited Method for preparation of liquid oral composition of l-thyroxin
CN109010295A (zh) * 2018-08-29 2018-12-18 北京兴源联合医药科技有限公司 一种左甲状腺素钠冻干口腔崩解片
CN115737576B (zh) * 2022-11-14 2024-05-07 山东创新药物研发有限公司 一种左甲状腺素钠片剂及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6191M (es) * 1966-02-18 1968-07-22
US3808332A (en) * 1969-01-27 1974-04-30 Armour Pharma Pharmaceutical compositions containing the reaction product of a tertiary phosphine with thyroxine
US3621098A (en) 1969-03-17 1971-11-16 Geigy Chem Corp HYPOTENSIVE METHODS AND COMPOSITIONS UTILIZING HEXAHYDROBENZO{8 b{9 {0 QUINOLIZINES
US3621096A (en) * 1969-04-03 1971-11-16 Univ North Carolina Antidepressant method and composition for same comprising a tricyclic antidepressant and a thyroid hormone
DE2126533A1 (de) * 1971-05-28 1972-12-14 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur Herstellung pharma zeutischer Zubereitungen
HUT67319A (en) * 1991-08-30 1995-03-28 Life Medical Sciences Inc Compositions for treating wounds
US5225204A (en) 1991-11-05 1993-07-06 Chen Jivn Ren Stable dosage of levothyroxine sodium and process of production
DE69405752T2 (de) * 1993-06-14 1998-02-05 Janssen Pharmaceutica Nv Filmbeschichtete tablette von astemizol und pseudoephedrin mit verlängerter freigabe
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US5738875A (en) * 1994-10-28 1998-04-14 R.P. Scherer Corporation Process for preparing solid pharmaceutical dosage forms
SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
CN1126589A (zh) * 1995-06-09 1996-07-17 中国科学院成都有机化学研究所 一种激素缓释微囊注射剂及其制备方法
DE19541128C2 (de) * 1995-10-27 1997-11-27 Henning Berlin Gmbh & Co Stabilisierte schilddrüsenhormonhaltige Arzneimittel
WO1997017951A1 (en) * 1995-11-14 1997-05-22 Knoll Pharmaceutical Company Stabilized thyroid hormone preparations and methods of making same
HUT75956A (en) * 1995-11-29 1997-05-28 Cyclolab Pharmaceutical composition containing thyroxine
US20010039335A1 (en) * 1997-04-10 2001-11-08 Kenneth Jacobs Secreted proteins and polynucleotides encoding them
FR2772615B1 (fr) * 1997-12-23 2002-06-14 Lipha Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
DE19830246A1 (de) * 1998-07-07 2000-01-13 Merck Patent Gmbh Pharmazeutische Zubereitung

Also Published As

Publication number Publication date
CA2333193A1 (en) 1999-11-25
EP1077681B1 (de) 2002-10-09
SK284155B6 (sk) 2004-10-05
CZ300908B6 (cs) 2009-09-09
SK16892000A3 (sk) 2001-04-09
DK1077681T3 (da) 2002-12-30
UA73474C2 (uk) 2005-08-15
NO331655B1 (no) 2012-02-13
US8008349B2 (en) 2011-08-30
NO20005758D0 (no) 2000-11-14
BRPI9910445B1 (pt) 2017-05-09
ID27281A (id) 2001-03-22
PL194088B1 (pl) 2007-04-30
DE59903028D1 (de) 2002-11-14
WO1999059551A1 (de) 1999-11-25
CZ20004201A3 (cs) 2001-03-14
ATE225651T1 (de) 2002-10-15
CN1301148A (zh) 2001-06-27
HUP0102125A3 (en) 2001-12-28
BRPI9910445B8 (pt) 2021-05-25
DE19821625C1 (de) 2000-01-05
RU2225711C2 (ru) 2004-03-20
AU742382B2 (en) 2002-01-03
US20040063611A1 (en) 2004-04-01
EP1077681A1 (de) 2001-02-28
PL346395A1 (en) 2002-02-11
ZA200007509B (en) 2002-06-14
CN1145479C (zh) 2004-04-14
NO20005758L (no) 2000-11-14
MY120570A (en) 2005-11-30
AR018607A1 (es) 2001-11-28
PT1077681E (pt) 2003-02-28
BR9910445A (pt) 2001-01-02
TW561058B (en) 2003-11-11
US6646007B1 (en) 2003-11-11
HU228958B1 (en) 2013-07-29
AU3932199A (en) 1999-12-06
JP4709379B2 (ja) 2011-06-22
HUP0102125A2 (hu) 2001-11-28
JP2002515421A (ja) 2002-05-28

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