ES2182211T3 - Proceso para la fabricacion de compuestos de bis(oxido de fosfina) y bis(fosfonato). - Google Patents
Proceso para la fabricacion de compuestos de bis(oxido de fosfina) y bis(fosfonato).Info
- Publication number
- ES2182211T3 ES2182211T3 ES98123996T ES98123996T ES2182211T3 ES 2182211 T3 ES2182211 T3 ES 2182211T3 ES 98123996 T ES98123996 T ES 98123996T ES 98123996 T ES98123996 T ES 98123996T ES 2182211 T3 ES2182211 T3 ES 2182211T3
- Authority
- ES
- Spain
- Prior art keywords
- bis
- bisphosphine
- manufacture
- compounds
- phosphine oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 title 1
- 229940122361 Bisphosphonate Drugs 0.000 abstract 2
- 150000004663 bisphosphonates Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- -1 phosphine oxide compound Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
- C07B37/04—Substitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5329—Polyphosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
- C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE OXIDO DE BISFOSFINA Y DE BISFOSFONATOS COMO INTERMEDIOS PARA LA PRODUCCION DE LIGANDOS DE BISFOSFINA SEGUN EL CUAL, EN UN PROCEDIMIENTO DE UN SOLO PASO A) SE HACE REACCIONAR UN COMPUESTO DE OXIDO DE FOSFINA EN UN SOLVENTE ORGANICO A UNA TEMPERATURA DE -70°C A 20°C CON UN EQ. DE 0,5 A 3 DE UN COMPUESTO DE AMIDURO DE LITIO O DE MAGNESIO, B) UN EQ. DE 0,5 A 3 DE UNA SAL METALICA QUE ACTUA DE FORMA OXIDATIVA O UN COMPLEJO DE SALES METALICAS AÑADIDAS A LA MEZCLA OBTENIDA EN EL PASO A) A UNA TEMPERATURA DE -70°C A 20°C, OBTENIENDOSE UN RACEMATO DE UN COMPUESTO DE OXIDO DE BISFOSFINA; C) SE LLEVA A CABO, SI SE DESEA UNA EXFOLIACION DEL RACEMATO; Y D) SE CONVIERTEN LOS BISFOSFONATOS OBTENIDOS EN EL PASO B) O C) EN OXIDOS DE BISFOSFINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97122720 | 1997-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182211T3 true ES2182211T3 (es) | 2003-03-01 |
Family
ID=8227865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98123996T Expired - Lifetime ES2182211T3 (es) | 1997-12-23 | 1998-12-17 | Proceso para la fabricacion de compuestos de bis(oxido de fosfina) y bis(fosfonato). |
Country Status (10)
Country | Link |
---|---|
US (1) | US6162929A (es) |
EP (1) | EP0926152B1 (es) |
JP (1) | JP4326614B2 (es) |
KR (1) | KR100657060B1 (es) |
CN (1) | CN1132839C (es) |
AT (1) | ATE223923T1 (es) |
CA (1) | CA2256828C (es) |
DE (1) | DE69807832T2 (es) |
DK (1) | DK0926152T3 (es) |
ES (1) | ES2182211T3 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19918420A1 (de) * | 1999-04-23 | 2000-10-26 | Aventis Res & Tech Gmbh & Co | Bidentate Organophosphorliganden und ihre Verwendung |
US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
JP3844927B2 (ja) | 2000-01-07 | 2006-11-15 | 高砂香料工業株式会社 | ジホスフィンオキシドおよびジホスホナートの製造方法 |
DE10056310A1 (de) * | 2000-11-14 | 2002-05-16 | Bayer Ag | Verbessertes Verfahren zur Herstellung von enantiomerenreinen(5,5`-Dichlor-6,6`-dimethoxybiphenyl-2,2`-diyl)-bis-(diphenylphosphinoxiden) |
US20060269602A1 (en) * | 2001-04-13 | 2006-11-30 | Dasch James R | Method of modifying the release profile of sustained release compositions |
US6558702B2 (en) * | 2001-04-13 | 2003-05-06 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
GB0129112D0 (en) * | 2001-12-05 | 2002-01-23 | Chirotech Technology Ltd | Chiral ligands for asymmetric catalysis |
EP1636243B1 (de) * | 2003-06-13 | 2013-11-06 | Boehringer Ingelheim International GmbH | Chirale liganden zur anwendung in asymmetrischen synthesen |
EA200601513A1 (ru) | 2004-02-19 | 2007-02-27 | Лонца Аг | Способ получения энантиомерно чистых 1-замещённых 3-аминоспиртов |
DE102004022397A1 (de) * | 2004-05-06 | 2005-12-01 | Consortium für elektrochemische Industrie GmbH | Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen |
US20110065838A1 (en) * | 2009-09-11 | 2011-03-17 | Chemtura Corporation | Hydroxyphenyl Phosphine Oxide Mixtures and their use as Flame Retardants for Epoxy Resins |
FR2952638A1 (fr) | 2009-11-17 | 2011-05-20 | Univ Strasbourg | Procede de phosphination catalytique double ou triple de composes di, tri ou tetrahalobiaryles, intermediaires employes, composes obtenus et leurs utilisations |
US9062085B2 (en) | 2010-09-10 | 2015-06-23 | Kanata Chemical Technologies Inc. | Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis |
CN103204877A (zh) * | 2012-01-11 | 2013-07-17 | 中国科学院大连化学物理研究所 | 一类具有轴手性的缺电子双膦配体及其制备方法 |
ITMI20121489A1 (it) * | 2012-09-06 | 2014-03-07 | Univ Degli Studi Milano | Metodo per la riduzione di nitro derivati ad ammine |
CN114805436B (zh) * | 2022-05-27 | 2023-09-05 | 海南大学 | 一种有机膦氧类化合物及其合成方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3032589A (en) * | 1959-08-04 | 1962-05-01 | American Cyanamid Co | Method of preparing organophosphorus oxides |
GB8429537D0 (en) * | 1984-11-22 | 1985-01-03 | Shell Int Research | Bis-phosphineoxide compounds |
US4879008A (en) * | 1987-11-09 | 1989-11-07 | Eastman Kodak Company | Preparation of bidentate ligands |
DE59009670D1 (de) * | 1989-05-18 | 1995-10-26 | Hoffmann La Roche | Phosphorverbindungen. |
ATE135008T1 (de) * | 1991-03-15 | 1996-03-15 | Hoffmann La Roche | Chirale phosphine |
ATE141278T1 (de) * | 1991-03-15 | 1996-08-15 | Hoffmann La Roche | Diphosphonsaurederivate als zwischenprodukte zur herstellung von diphosphinliganden |
JP3369561B2 (ja) * | 1992-01-31 | 2003-01-20 | エフ・ホフマン−ラ ロシユ アーゲー | 燐化合物 |
DE4330730A1 (de) * | 1993-09-10 | 1995-03-16 | Bayer Ag | Neue Bisphosphine für asymmetrische Hydrierkatalysatoren |
IT1270082B (it) * | 1994-07-12 | 1997-04-28 | Univ Degli Studi Milano | Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali |
JP3148136B2 (ja) * | 1996-12-26 | 2001-03-19 | 高砂香料工業株式会社 | 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒 |
-
1998
- 1998-12-15 US US09/212,646 patent/US6162929A/en not_active Expired - Lifetime
- 1998-12-17 EP EP98123996A patent/EP0926152B1/en not_active Expired - Lifetime
- 1998-12-17 DK DK98123996T patent/DK0926152T3/da active
- 1998-12-17 DE DE69807832T patent/DE69807832T2/de not_active Expired - Lifetime
- 1998-12-17 AT AT98123996T patent/ATE223923T1/de active
- 1998-12-17 ES ES98123996T patent/ES2182211T3/es not_active Expired - Lifetime
- 1998-12-18 CA CA002256828A patent/CA2256828C/en not_active Expired - Lifetime
- 1998-12-22 JP JP36404498A patent/JP4326614B2/ja not_active Expired - Lifetime
- 1998-12-23 CN CN98125786A patent/CN1132839C/zh not_active Expired - Lifetime
- 1998-12-23 KR KR1019980057844A patent/KR100657060B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH11246576A (ja) | 1999-09-14 |
DE69807832D1 (de) | 2002-10-17 |
ATE223923T1 (de) | 2002-09-15 |
KR100657060B1 (ko) | 2007-04-25 |
JP4326614B2 (ja) | 2009-09-09 |
EP0926152A1 (en) | 1999-06-30 |
CA2256828C (en) | 2009-04-07 |
US6162929A (en) | 2000-12-19 |
CA2256828A1 (en) | 1999-06-23 |
CN1132839C (zh) | 2003-12-31 |
DE69807832T2 (de) | 2003-07-31 |
KR19990063389A (ko) | 1999-07-26 |
CN1224019A (zh) | 1999-07-28 |
DK0926152T3 (da) | 2003-01-20 |
EP0926152B1 (en) | 2002-09-11 |
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