ES2179080T3 - Derivados de poliamida-oligonucleotido, su preparacion y utilizacion. - Google Patents

Derivados de poliamida-oligonucleotido, su preparacion y utilizacion.

Info

Publication number
ES2179080T3
ES2179080T3 ES95103332T ES95103332T ES2179080T3 ES 2179080 T3 ES2179080 T3 ES 2179080T3 ES 95103332 T ES95103332 T ES 95103332T ES 95103332 T ES95103332 T ES 95103332T ES 2179080 T3 ES2179080 T3 ES 2179080T3
Authority
ES
Spain
Prior art keywords
polyamide
dna
covalent
preparation
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95103332T
Other languages
English (en)
Inventor
Eugen Uhlmann
Gerhard Breipohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2179080T3 publication Critical patent/ES2179080T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBE DERIVADO POLIAMIDA - OLIGONUCLEOTIDO DE LA FORMULA DONDE Q, R, S, T DE FORMA INDEPENDIENTE UNO DE OTRO SIGNIFICAN 0 O 1, LA SUMA DE DOS O MAS SIMBOLOS VECINOS Q, R, S Y T SON MAYORES O IGUAL A 2; X ES 1 HASTA 20, DNA ES UN ACIDO NUCLEICO COMO DNA O RNA O UN DERIVADO CONOCIDO DE LOS MISMOS; LI ES UNA LIGADURA COVALENTE ENTRE DNA Y PNA. LA LIGADURA COVALENTE CONTIENE UN ENLACE O UN RESTO ORGANICO CON AL MENOS UN ATOMO DE LA SERIE C, N, O O S; PNA SIGNIFICA UNA ESTRUCTURA POLIAMIDA, QUE CONTIENE AL MENOS UNA NUCLEOBASE, QUE ES DIFERENTE DE IMINA; Y F Y F'' SON GRUPOS TERMINALES Y/O ESTAN UNIDOS UNO CON OTRO A TRAVES DE UN ENLACE COVALENTE, ASI COMO SUS SALES TOLERABLES FISIOLOGICAMENTE, PROCESO PARA SU ELABORACION ASI COMO SU UTILIZACION COMO MEDICAMENTO, COMO SONDA DE GENES Y COMO PRIMER.
ES95103332T 1994-03-14 1995-03-08 Derivados de poliamida-oligonucleotido, su preparacion y utilizacion. Expired - Lifetime ES2179080T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4408528A DE4408528A1 (de) 1994-03-14 1994-03-14 Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
ES2179080T3 true ES2179080T3 (es) 2003-01-16

Family

ID=6512694

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95103332T Expired - Lifetime ES2179080T3 (es) 1994-03-14 1995-03-08 Derivados de poliamida-oligonucleotido, su preparacion y utilizacion.
ES01104012T Expired - Lifetime ES2269239T3 (es) 1994-03-14 1995-03-08 Derivados de poliamida-oligonucleotidos, su preparacion y uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01104012T Expired - Lifetime ES2269239T3 (es) 1994-03-14 1995-03-08 Derivados de poliamida-oligonucleotidos, su preparacion y uso.

Country Status (13)

Country Link
EP (2) EP1113021B1 (es)
JP (1) JP4620810B2 (es)
KR (1) KR100416864B1 (es)
CN (1) CN100379756C (es)
AT (2) ATE220070T1 (es)
AU (1) AU698210B2 (es)
CA (1) CA2144475C (es)
DE (3) DE4408528A1 (es)
DK (2) DK0672677T3 (es)
ES (2) ES2179080T3 (es)
FI (2) FI117135B (es)
NO (1) NO314664B1 (es)
PT (2) PT1113021E (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710164B1 (en) 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
DE4438918A1 (de) 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE19502912A1 (de) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
ATE206131T1 (de) * 1995-03-13 2001-10-15 Aventis Pharma Gmbh Phosphonomonoesternnukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
GB2324534B (en) * 1996-01-06 2000-05-10 Danbiosyst Uk Composition for delivery of nucleic acid to a cell
EP0808898B1 (en) * 1996-05-24 2004-05-19 Aventis Pharma Deutschland GmbH Reagent and method for inhibition of N-ras expression
NZ332780A (en) * 1996-05-31 2000-07-28 Allelix Neuroscience Inc Substituted amines for the treatment of neurological and neuropsychiatric disorders
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
JP3306073B2 (ja) * 1996-07-24 2002-07-24 ブヒャルト，ドルテ 増加した結合親和性、配列特異性および溶解性を有するペプチド核酸
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
WO1999034014A2 (en) * 1997-12-23 1999-07-08 Roche Diagnostics Gmbh A method for the determination of a nucleic acid
US5952202A (en) * 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
US6316230B1 (en) 1999-08-13 2001-11-13 Applera Corporation Polymerase extension at 3′ terminus of PNA-DNA chimera
US7205105B2 (en) 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
DE10019135A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
US7348146B2 (en) 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
JP4942484B2 (ja) 2003-10-28 2012-05-30 エポック・バイオサイエンシーズ・インコーポレイテッド 改良された感度および低バックグラウンドを備えるハイブリダイゼーションによるｄｎａ検出のための蛍光プローブ
DE102006034319A1 (de) * 2006-07-21 2008-01-31 Ugichem Gmbh Chirale mit Phosponsäurester- oder Phosphonsäure- substituierte Verbindungen
EP2781523A1 (en) 2013-03-18 2014-09-24 Miltenyi Biotec GmbH Lipophilic oligonucleotide analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3856406T2 (de) * 1987-10-28 2000-10-19 Howard Florey Institute Of Experimental Physiology And Medicine, Parkville Oligonucleotid-polyamid konjugate
WO1993024511A1 (en) * 1992-05-29 1993-12-09 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
US5138045A (en) * 1990-07-27 1992-08-11 Isis Pharmaceuticals Polyamine conjugated oligonucleotides
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
FI115214B (fi) * 1992-01-22 2005-03-31 Hoechst Ag Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö

Also Published As

Publication number Publication date
AU698210B2 (en) 1998-10-29
EP1113021A3 (de) 2001-07-11
EP1113021A2 (de) 2001-07-04
CN100379756C (zh) 2008-04-09
DE4408528A1 (de) 1995-09-28
CN1112126A (zh) 1995-11-22
NO950955L (no) 1995-09-15
AU1479895A (en) 1995-09-21
FI20051072L (fi) 2005-10-24
FI117135B (fi) 2006-06-30
FI117939B (fi) 2007-04-30
EP1113021B1 (de) 2006-08-09
CA2144475A1 (en) 1995-09-15
EP0672677B1 (de) 2002-07-03
FI951132L (fi) 1995-09-15
EP0672677A2 (de) 1995-09-20
NO950955D0 (no) 1995-03-13
FI951132A0 (fi) 1995-03-10
ATE335760T1 (de) 2006-09-15
PT1113021E (pt) 2006-12-29
DE59511061D1 (de) 2006-09-21
ATE220070T1 (de) 2002-07-15
ES2269239T3 (es) 2007-04-01
DE59510252D1 (de) 2002-08-08
PT672677E (pt) 2002-11-29
DK1113021T3 (da) 2006-12-11
JP4620810B2 (ja) 2011-01-26
JPH07278179A (ja) 1995-10-24
HK1038568A1 (en) 2002-03-22
HK1012003A1 (en) 1999-07-23
KR100416864B1 (ko) 2006-01-27
NO314664B1 (no) 2003-04-28
CA2144475C (en) 2010-06-08
KR950032265A (ko) 1995-12-20
EP0672677A3 (de) 1996-01-17
DK0672677T3 (da) 2002-10-28

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