ES2173500T3 - Procedimiento de obtencion de d,1-alfa-tocoferol. - Google Patents
Procedimiento de obtencion de d,1-alfa-tocoferol.Info
- Publication number
- ES2173500T3 ES2173500T3 ES97950150T ES97950150T ES2173500T3 ES 2173500 T3 ES2173500 T3 ES 2173500T3 ES 97950150 T ES97950150 T ES 97950150T ES 97950150 T ES97950150 T ES 97950150T ES 2173500 T3 ES2173500 T3 ES 2173500T3
- Authority
- ES
- Spain
- Prior art keywords
- met
- procedure
- alfa
- condensation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
UN PROCEDIMIENTO DE FABRICACION DE D, 1 - ALFA - TOCOFEROL, POR CONDENSACION CATALIZADA DE TRIMETIL - HIDROQUINONA Y DE ISOFITOL, CONSISTE EN REALIZAR DICHA CONDENSACION EN PRESENCIA DE UN BIS-(TRIFLUOROMETILSULFONILO)AMINA [HN(SO 2 CF SUB, 3) 2] O DE UNA SAL METALICA DE DICHA COMPOSICION, DE LA FORMULA MET [N(SO 2 CF 3 ) 2] N (I), EN LA CUAL MET ES UN ATOMO METALICO SELECCIONADO EN EL GRUPO CONSTITUIDO POR LITIO, BORO, MAGNESIO, ALUMINIO, SILICIO, ESCANDIO, TITANIO, VANADIO, MANGANESO, HIERRO, COBALTO, NIQUEL, COBRE, CINC, ITRIO, CIRCONIO, RODIO, PALADIO, PLATA, ESTAÑO, LANTANO, CERIO, NEODIMIO, PRASEODIMIO, EUROPIO, DISPROSIO, ITERBIO, HAFNIO, PLATINO Y ORO Y N ES LA VALENCIA CORRESPONDIENTE (1, 2, 3 O 4) DEL ATOMO METALICO MET, COMO CATALIZADOR, O DE UNA SAL METALICA DE LA FORMULA (I) COMBINADO CON UN ACIDO FUERTE DE BRONSTED, COMO SISTEMA CATALIZADOR, EN UN DISOLVENTE ORGANICO. EL PRODUCTO OBTENIDO MEDIANTE ESTE PROCEDIMIENTO ES EL ELEMENTO MAS ACTIVO DEL GRUPO DE LA VITAMINA E.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96118037 | 1996-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173500T3 true ES2173500T3 (es) | 2002-10-16 |
Family
ID=8223387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97950150T Expired - Lifetime ES2173500T3 (es) | 1996-11-11 | 1997-11-10 | Procedimiento de obtencion de d,1-alfa-tocoferol. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5908939A (es) |
EP (1) | EP0937055B1 (es) |
JP (1) | JP2001504111A (es) |
CN (1) | CN1105714C (es) |
DE (1) | DE69711669T2 (es) |
DK (1) | DK0937055T3 (es) |
ES (1) | ES2173500T3 (es) |
WO (1) | WO1998021197A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
FR2784104B1 (fr) * | 1998-09-18 | 2002-12-27 | Rhone Poulenc Nutrition Animal | Procede de preparation de la vitamine e |
EP1000940A1 (en) * | 1998-11-11 | 2000-05-17 | F. Hoffmann-La Roche Ag | Process for manufacturing d,l-alpha-tocopherol |
CA2288851A1 (en) * | 1998-11-11 | 2000-05-11 | F. Hoffmann-La Roche Ag | Process for manufacturing d,i-alpha-tocopherol |
KR100452291B1 (ko) * | 1999-12-14 | 2004-10-08 | 에스케이 주식회사 | 고수율 및 고순도로 DL-α-토코페롤를 제조하는 방법 |
US6369242B2 (en) | 2000-03-17 | 2002-04-09 | Roche Vitamins Inc. | Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof |
ATE246181T1 (de) | 2000-08-18 | 2003-08-15 | Roche Vitamins Ag | Verfahren zur herstellung von (alle-rac)-alfa- tocopherol |
EP1857432A3 (en) * | 2001-03-12 | 2008-05-14 | The Queen's University of Belfast | Synthesis of metal bis-triflimide compounds and methods for purification thereof |
DK1390340T3 (en) * | 2001-04-24 | 2017-05-15 | Massachusetts Inst Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
JP4508642B2 (ja) * | 2001-12-14 | 2010-07-21 | ディーエスエム アイピー アセッツ ビー.ブイ. | トリメチルヒドロキノンジアシレートの製造 |
AU2003257062A1 (en) * | 2002-08-02 | 2004-02-23 | Massachusetts Institute Of Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
DE60333493D1 (de) * | 2003-01-13 | 2010-09-02 | Dsm Ip Assets Bv | Verfahren zur herstellung von alpha-tocopherol-acetat |
CN100355745C (zh) * | 2005-03-18 | 2007-12-19 | 清华大学 | 离子液体催化合成D,L-α-生育酚的方法 |
FR2889519B1 (fr) * | 2005-08-04 | 2008-07-11 | Rhodia Chimie Sa | Procede de c-alkylation de composes aromatiques hydroxyles avec un catalyseur de type tfsih |
EP2050743A1 (en) * | 2007-10-19 | 2009-04-22 | Humboldt-Universität zu Berlin | Method for the synthesis of dl.(alpha)-tocopherol and means therefore |
US8226850B1 (en) * | 2009-09-22 | 2012-07-24 | Clemson University Research Foundation | Thermally enhanced oxygen scavengers including a transition metal and a free radical scavenger |
CN102285955B (zh) * | 2011-09-14 | 2012-12-05 | 重庆大学 | 一种α-生育酚乙酸酯的制备方法 |
CN102276572B (zh) * | 2011-09-14 | 2013-03-27 | 重庆大学 | 一种制备维生素e乙酸酯的方法 |
US9469620B2 (en) | 2012-12-21 | 2016-10-18 | Rhodia Operations | Process for forming a primary, a secondary or a tertiary amine via a direct amination reaction |
CN104936941A (zh) * | 2012-12-21 | 2015-09-23 | 罗地亚经营管理公司 | 用于经由直接胺化反应形成伯胺、仲胺或叔胺的方法 |
CN108017610B (zh) * | 2017-12-22 | 2020-11-06 | 浙江新和成药业有限公司 | 一种维生素e的制备方法 |
CN108409704A (zh) * | 2018-01-24 | 2018-08-17 | 上海优合生物科技有限公司 | 一种高纯度生育酚琥珀酸酯盐的制备方法 |
CN109705082B (zh) * | 2018-12-19 | 2021-04-20 | 万华化学集团股份有限公司 | 一种制备维生素e乙酸酯的方法 |
CN113321669B (zh) * | 2020-02-28 | 2023-03-24 | 中国科学院上海有机化学研究所 | 一种磺酰亚胺类金属盐、其制备方法及应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2723278A (en) * | 1954-01-25 | 1955-11-08 | Hoffmann La Roche | Preparation of alpha-tocopherol |
GB1148652A (en) * | 1965-07-20 | 1969-04-16 | Dunlop Co Ltd | Polymer compositions comprising polymerized episulphides and a process for the preparation of reaction products of polymerized episulphides |
US3459773A (en) * | 1966-12-27 | 1969-08-05 | Takasago Perfumery Co Ltd | Process for producing alpha-tocopherol and its esters |
CH547278A (de) * | 1971-01-11 | 1974-03-29 | Hoffmann La Roche | Verfahren zur herstellung von chromanderivaten. |
US4208334A (en) * | 1978-12-22 | 1980-06-17 | Hoffmann-La Roches Inc. | Process for preparation of α-tocopherol |
US4634781A (en) * | 1982-09-30 | 1987-01-06 | Basf Corporation | Alpha tocopherol process |
FR2637284B1 (fr) * | 1988-10-05 | 1991-07-05 | Elf Aquitaine | Methode de synthese de sulfonylimidures |
DE4243464A1 (de) * | 1992-12-22 | 1994-06-23 | Basf Ag | Verfahren zur Herstellung von alpha-Tocopherol und alpha-Tocopherylacetat in flüssigem oder überkritischem Kohlendioxid |
EP0677522A4 (en) * | 1992-12-28 | 1995-12-27 | Yoshitomi Pharmaceutical | 8-METHOXYQUINOLONECARBOXYLIC ACID DERIVATIVE. |
US5526821A (en) * | 1993-06-03 | 1996-06-18 | Medical Biopsy, Inc. | Biopsy needle with sample retaining means |
JP3848380B2 (ja) * | 1993-12-14 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | α−トコフェロール誘導体の製造法 |
JP3166959B2 (ja) * | 1994-03-11 | 2001-05-14 | セントラル硝子株式会社 | ルイス酸触媒 |
DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
JP3117369B2 (ja) * | 1994-09-12 | 2000-12-11 | セントラル硝子株式会社 | スルホンイミドの製造方法 |
EP0782993B1 (de) * | 1996-01-05 | 2003-02-26 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von d,l-alpha-Tocopherol in Gegenwart einer Perfluoralkylensulfonsäure als Katalysator |
-
1997
- 1997-10-16 US US08/951,273 patent/US5908939A/en not_active Expired - Lifetime
- 1997-11-10 DK DK97950150T patent/DK0937055T3/da active
- 1997-11-10 EP EP97950150A patent/EP0937055B1/en not_active Expired - Lifetime
- 1997-11-10 CN CN97199633A patent/CN1105714C/zh not_active Expired - Lifetime
- 1997-11-10 ES ES97950150T patent/ES2173500T3/es not_active Expired - Lifetime
- 1997-11-10 DE DE69711669T patent/DE69711669T2/de not_active Expired - Lifetime
- 1997-11-10 WO PCT/EP1997/006227 patent/WO1998021197A2/en not_active Application Discontinuation
- 1997-11-10 JP JP52215398A patent/JP2001504111A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO1998021197A3 (en) | 1998-07-23 |
JP2001504111A (ja) | 2001-03-27 |
CN1237163A (zh) | 1999-12-01 |
US5908939A (en) | 1999-06-01 |
CN1105714C (zh) | 2003-04-16 |
DE69711669T2 (de) | 2002-10-02 |
EP0937055A2 (en) | 1999-08-25 |
EP0937055B1 (en) | 2002-04-03 |
DE69711669D1 (de) | 2002-05-08 |
WO1998021197A2 (en) | 1998-05-22 |
DK0937055T3 (da) | 2002-07-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2173500T3 (es) | Procedimiento de obtencion de d,1-alfa-tocoferol. | |
ID27584A (id) | Katalis kompleks sianida logam ganda yang diperlakukan dengan asam | |
ATE420215T1 (de) | Verfahren zur auflösung von kupfermetall | |
WO2004010952A3 (en) | Methods and compositions for treatment of dermal conditions | |
MX9605134A (es) | Medio para la eliminacion de vapor para la electroextraccion de metales con extraccion del solvente. | |
BRPI0403520A (pt) | Catalisadores de cianeto de metal duplo (dmc) contendo hidróxido | |
MX9301556A (es) | Proceso de oximacion | |
PL1466599T3 (pl) | Stężone roztwory oksaliplatyny | |
PE20030888A1 (es) | Metodo y composicion de silicato de cobre y silicato cinc para controlar microbios | |
WO2003008489A3 (en) | Composition and process for inhibiting corrosion of metallic substrates | |
Barley et al. | Iron porphyrin-based electrocatalytic reduction of nitrite to ammonia | |
DE50202024D1 (de) | Verfahren zur herstellung von dunklen schutzschichten auf flacherzeugnissen aus titanzink | |
WO2005016503A3 (en) | Catalytic reduction and oxidation processes | |
EP0381130A3 (en) | Production of alpha-unsaturated amines | |
DE60010254D1 (de) | Gepresste produkte aus nichtklumpendem salz | |
EP2848608B1 (en) | Silver complex compounds, method for their production and their use | |
JP3229625B2 (ja) | ベンチュリア防除方法 | |
FR2438425A2 (fr) | Composition a base de a1+++ en vue de la lutte contre des maladies des plantes, en particulier cryptogamiques et bacteriennes | |
PE20040017A1 (es) | Metodo para la purificacion de una solucion de cloruro de cobre | |
MY137974A (en) | Chromium-free catalysts of metallic cu and at least one second metal | |
Wellise | Effect of carbamate pesticides on cadmium and zinc bioaccumulation in a bivalve (Potamocorbula amurensis) | |
Mikhailova et al. | Simultaneous determination of carbonates and borates by a kinetic method | |
Đilović | The story of a flexible receptor: from self-assembly strategies to succesful separation of isomeric dicarboxylic acids | |
Gehmecker et al. | Process of Forming Phosphate Coatings on Metals | |
DE20100131U1 (de) | Haarfärbemittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 937055 Country of ref document: ES |