ES2167346T3 - Derivados de 2,3-dihidro-1,4-benzodioxano-5-il-piperazina que tienen actividad antagonista de 5-ht1a. - Google Patents

Derivados de 2,3-dihidro-1,4-benzodioxano-5-il-piperazina que tienen actividad antagonista de 5-ht1a.

Info

Publication number
ES2167346T3
ES2167346T3 ES94201900T ES94201900T ES2167346T3 ES 2167346 T3 ES2167346 T3 ES 2167346T3 ES 94201900 T ES94201900 T ES 94201900T ES 94201900 T ES94201900 T ES 94201900T ES 2167346 T3 ES2167346 T3 ES 2167346T3
Authority
ES
Spain
Prior art keywords
hydroxide
ht1a
dihidro
benzodioxan
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94201900T
Other languages
English (en)
Inventor
Jan Hartog
Steen B J Van
Johannes Mos
Jacques Schipper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of ES2167346T3 publication Critical patent/ES2167346T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS QUE TIENEN ACTIVAD ANTAGONICA DEL 5-HT1A UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL Y QUE TIENEN LA FORMULA (2) EN LA CUAL R1 ES HALOGENO, ALQUILO INFERIOR O ALCOXIDO, HIDROXIDO, TRIFLUOROMETIL O CIANO, M TIENE UN VALOR ENTRE 1 Y 2 Y N TIENE UN VALOR DE 0 O 1, A REPRESENTA UNA CADENA DE ALQUILENO QUE CONTIENE ENTRE 2 Y 6 ATOMOS DE CARBONO QUE PUEDE ESTAR SUSTITUIDA CON UNO O MAS GRUPOS DE ALQUILO INFERIOR O CON UN GRUPO DE (HETERO)ARILO MONOCICLICO, Y B ES METILENO, ETILENO, CARBONILO, SULFINILO, SULFONILO O AZUFRE, ASIMISMO SE PRESENTAN LAS SALES DE ESTOS COMPUESTOS.
ES94201900T 1993-07-05 1994-07-01 Derivados de 2,3-dihidro-1,4-benzodioxano-5-il-piperazina que tienen actividad antagonista de 5-ht1a. Expired - Lifetime ES2167346T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93201950 1993-07-05

Publications (1)

Publication Number Publication Date
ES2167346T3 true ES2167346T3 (es) 2002-05-16

Family

ID=8213949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94201900T Expired - Lifetime ES2167346T3 (es) 1993-07-05 1994-07-01 Derivados de 2,3-dihidro-1,4-benzodioxano-5-il-piperazina que tienen actividad antagonista de 5-ht1a.

Country Status (21)

Country Link
US (1) US5462942A (es)
EP (1) EP0633260B1 (es)
JP (1) JP3572102B2 (es)
KR (1) KR100363988B1 (es)
CN (1) CN1044244C (es)
AT (1) ATE208385T1 (es)
AU (1) AU680900B2 (es)
CA (1) CA2127084C (es)
CZ (1) CZ286503B6 (es)
DE (1) DE69428943T2 (es)
DK (1) DK0633260T3 (es)
ES (1) ES2167346T3 (es)
FI (1) FI120306B (es)
HU (1) HU218215B (es)
IL (1) IL110209A (es)
NO (1) NO301980B1 (es)
NZ (1) NZ260891A (es)
PT (1) PT633260E (es)
RU (1) RU2118322C1 (es)
SK (1) SK281681B6 (es)
ZA (1) ZA944787B (es)

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US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
CA2213192A1 (en) * 1995-02-23 1996-08-29 Merck & Co., Inc. Alpha.1a. adrenergic receptor antagonists
US5620997A (en) * 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
AU7734496A (en) * 1995-11-15 1997-06-05 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
US6001863A (en) * 1996-11-26 1999-12-14 Warner-Lambert Company Isothiazolones
TW530054B (en) * 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
US6177566B1 (en) 1998-06-30 2001-01-23 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
CN1081128C (zh) * 1999-08-18 2002-03-20 湖北省化学研究所 软性印刷电路板专用的高分子塑料薄膜双面复合金属板的制造方法
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
AU2001278609B2 (en) * 2000-08-21 2005-04-14 Astrazeneca Ab Quinazoline derivatives
DK1408976T5 (da) * 2001-07-20 2011-01-10 Psychogenics Inc Behandling af ADHD (Attention deficit hyperactivity disorder)
TWI288642B (en) * 2002-03-12 2007-10-21 Wyeth Corp Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
PL375441A1 (en) * 2002-07-29 2005-11-28 F.Hoffmann-La Roche Ag Novel benzodioxoles
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US20040215284A1 (en) * 2003-01-30 2004-10-28 Recordati S.A. Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
RU2281085C2 (ru) * 2004-05-25 2006-08-10 Закрытое акционерное общество "Мастерлек" Антидепрессивные лекарственные средства для парентерального применения на основе сульфонатных солей пирлиндола
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
NL2023581B1 (en) * 2019-07-29 2021-02-22 Atlas Pharmaceuticals Bv Serotonergic agent and 5-HT1A-receptor antagonist
CN111253335B (zh) * 2020-03-12 2023-06-06 浙江扬帆新材料股份有限公司 一种n-取代苯并异噻唑啉-3-酮衍生物的新合成方法
CN116621792B (zh) * 2023-05-16 2025-02-25 常州大学 一种制备n-正丁基-1,2-苯并异噻唑啉-3-酮-1-氧化物的方法
CN118063403A (zh) * 2024-03-29 2024-05-24 大连百傲化学股份有限公司 一种1,2-苯并异噻唑啉-3-酮-1-氧化物的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519986A1 (fr) * 1982-01-21 1983-07-22 Adir Nouveaux derives de benzodioxine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
NZ209876A (en) * 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
EP0185429A1 (en) * 1984-12-21 1986-06-25 Duphar International Research B.V New bicyclic heteroaryl piperazines
US4748182A (en) * 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
DE3726425A1 (de) * 1987-03-18 1988-09-29 Bayer Ag Basisch substituierte saccharine
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
IL92544A0 (en) * 1988-12-08 1990-08-31 Duphar Int Res Piperazine derivatives,their preparation and pharmaceutical compositions containing them
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
JPH02184667A (ja) * 1989-01-11 1990-07-19 Meiji Seika Kaisha Ltd Ｎ，ｎ’―ジ置換ピペラジル誘導体及びそれを有効成分とする排尿障害改善剤
DE4127849A1 (de) * 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds

Also Published As

Publication number Publication date
DE69428943D1 (de) 2001-12-13
KR100363988B1 (ko) 2003-02-05
RU2118322C1 (ru) 1998-08-27
JP3572102B2 (ja) 2004-09-29
KR950003289A (ko) 1995-02-16
ZA944787B (en) 1995-02-20
IL110209A0 (en) 1994-10-21
NZ260891A (en) 1995-04-27
EP0633260B1 (en) 2001-11-07
RU94023250A (ru) 1996-08-10
DK0633260T3 (da) 2002-02-25
AU6613994A (en) 1995-01-12
ATE208385T1 (de) 2001-11-15
IL110209A (en) 2000-02-29
CZ159794A3 (en) 1995-05-17
AU680900B2 (en) 1997-08-14
NO942471D0 (no) 1994-06-30
HUT75155A (en) 1997-04-28
FI120306B (fi) 2009-09-15
SK78894A3 (en) 1995-03-08
HU218215B (hu) 2000-06-28
PT633260E (pt) 2002-04-29
JPH07215972A (ja) 1995-08-15
US5462942A (en) 1995-10-31
NO301980B1 (no) 1998-01-05
FI943149A0 (fi) 1994-06-30
DE69428943T2 (de) 2002-08-01
CA2127084C (en) 2007-04-10
NO942471L (no) 1995-01-06
FI943149L (fi) 1995-01-06
HU9401965D0 (en) 1994-09-28
CZ286503B6 (en) 2000-04-12
EP0633260A1 (en) 1995-01-11
CN1106813A (zh) 1995-08-16
CA2127084A1 (en) 1995-01-06
SK281681B6 (sk) 2001-06-11
CN1044244C (zh) 1999-07-21

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