ES2057490T5 - Derivados heterociclicos de acilaminotiazoles, su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados heterociclicos de acilaminotiazoles, su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2057490T5
ES2057490T5 ES90403458T ES90403458T ES2057490T5 ES 2057490 T5 ES2057490 T5 ES 2057490T5 ES 90403458 T ES90403458 T ES 90403458T ES 90403458 T ES90403458 T ES 90403458T ES 2057490 T5 ES2057490 T5 ES 2057490T5
Authority
ES
Spain
Prior art keywords
sub
substituted
group
acilaminotiazoles
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90403458T
Other languages
English (en)
Other versions
ES2057490T3 (es
Inventor
Jean-Pierre Bras
Daniel Frehel
Danielle Gully
Gerard Valette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26227714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2057490(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8916122A external-priority patent/FR2655344B1/fr
Priority claimed from FR9005669A external-priority patent/FR2661677B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2057490T3 publication Critical patent/ES2057490T3/es
Publication of ES2057490T5 publication Critical patent/ES2057490T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

COMPUESTOS DE FORMULA EN LA QUE R SUB 1 REPRESENTA H, UN ALQUILO SUSTITUIDO, R SUB 2 REPRESENTA H , ALQUILO, R SUB 3 REPRESENTA UN CICLOALQUILO EVENTUALMENTE SUSTITUIDO, O UN GRUPO AROMATICO EVENTUALMENTE SUSTITUIDO, QUE PUEDE SER UN FENILO O UN GRUPO HETEROCICLICO QUE COMPRENDE UNO O VARIOS HETEROATOMOS ELEGIDOS ENTRE O, S, N O R SUB 2 Y R SUB 3 CONSIDERADOS JUNTOS REPRESENTAN EL GRUPO EVENTUALMENTE SUSTITUIDO SOBRE EL NUCLEO FENILO, Y Z REPRESENTA UN HETEROCICLO QUE COMPRENDE UNO O VARIOS HETEROATOMOS ELEGIDOS ENTRE O, S, N , CONDENSADO CON UN NUCLEO QUE PUEDE COMPRENDER UN HETEROATOMO Y SER SUSTITUIDO, SIENDO DICHO HETEROCICLO EVENTUALMENTE SUSTITUIDO EN N CUANDO COMPRENDE UNO, POR UN ALQUILO O UN GRUPO ALQUILO SUSTITUIDO Y LAS SALES DE ESTOS COMPUESTOS CON ACIDOS O BASES. UTILIZACION DE ESTOS COMPUESTOS COMO MEDICAMENTOS.
ES90403458T 1989-12-06 1990-12-05 Derivados heterociclicos de acilaminotiazoles, su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2057490T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8916122A FR2655344B1 (fr) 1989-12-06 1989-12-06 Derives heterocycliques d'acylaminothiazoles, leur preparation et compositions pharmaceutiques en contenant.
FR9005669A FR2661677B1 (fr) 1990-05-04 1990-05-04 Derives heterocycliques d'acylaminothiazoles, leur preparation et compositions pharmaceutiques en contenant.

Publications (2)

Publication Number Publication Date
ES2057490T3 ES2057490T3 (es) 1994-10-16
ES2057490T5 true ES2057490T5 (es) 1998-03-16

Family

ID=26227714

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90403458T Expired - Lifetime ES2057490T5 (es) 1989-12-06 1990-12-05 Derivados heterociclicos de acilaminotiazoles, su preparacion y composiciones farmaceuticas que los contienen.

Country Status (20)

Country Link
US (2) US5189049A (es)
EP (1) EP0432040B2 (es)
JP (2) JP2760903B2 (es)
KR (1) KR0147281B1 (es)
AR (1) AR248138A1 (es)
AT (1) ATE109145T1 (es)
AU (1) AU628696B2 (es)
CA (1) CA2031463C (es)
DE (1) DE69011059T3 (es)
DK (1) DK0432040T3 (es)
ES (1) ES2057490T5 (es)
FI (1) FI94249C (es)
GR (1) GR3025940T3 (es)
HK (1) HK1002030A1 (es)
HU (2) HU218276B (es)
IE (1) IE68593B1 (es)
IL (1) IL96577A (es)
LV (1) LV5802B4 (es)
MX (1) MX9203027A (es)
NO (1) NO179584C (es)

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FR2701708B1 (fr) * 1993-02-19 1995-05-19 Sanofi Elf Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
FR2703995B1 (fr) * 1993-04-16 1995-07-21 Sanofi Elf 5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant.
FR2754258B1 (fr) 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
CO4970713A1 (es) * 1997-09-19 2000-11-07 Sanofi Synthelabo Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
FR2768737B1 (fr) * 1997-09-19 2000-05-19 Sanofi Sa Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant
ID24372A (id) 1997-10-27 2000-07-13 Agouron Pharma SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs
FR2781227B1 (fr) * 1998-07-20 2002-02-22 Sanofi Sa Procede pour la preparation du sel potassique du lintitript
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DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
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US6214853B1 (en) 1999-06-30 2001-04-10 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6225330B1 (en) 1999-06-30 2001-05-01 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
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CN105518005B (zh) 2013-07-02 2018-07-20 百时美施贵宝公司 作为rock抑制剂的三环吡啶-甲酰胺衍生物
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Also Published As

Publication number Publication date
GR3025940T3 (en) 1998-04-30
AU6777990A (en) 1991-06-20
DK0432040T3 (da) 1994-10-31
IL96577A0 (en) 1991-09-16
FI94249C (fi) 1995-08-10
DE69011059T2 (de) 1995-03-02
IL96577A (en) 1994-06-24
NO179584B (no) 1996-07-29
NO905255D0 (no) 1990-12-05
CA2031463C (en) 2000-07-25
EP0432040A1 (fr) 1991-06-12
FI94249B (fi) 1995-04-28
HUT59400A (en) 1992-05-28
JP3035253B2 (ja) 2000-04-24
ATE109145T1 (de) 1994-08-15
DE69011059T3 (de) 1998-04-09
NO905255L (no) 1991-06-07
MX9203027A (es) 1992-07-01
JPH10130147A (ja) 1998-05-19
FI905941A (fi) 1991-06-07
USRE37094E1 (en) 2001-03-13
HU908075D0 (en) 1991-06-28
HK1002030A1 (en) 1998-07-24
IE68593B1 (en) 1996-06-26
EP0432040B2 (fr) 1997-12-17
LV5802B4 (lv) 1997-08-20
AR248138A1 (es) 1995-06-30
HU211866A9 (en) 1995-12-28
CA2031463A1 (en) 1991-06-07
HU218276B (en) 2000-07-28
JP2760903B2 (ja) 1998-06-04
FI905941A0 (fi) 1990-12-03
EP0432040B1 (fr) 1994-07-27
ES2057490T3 (es) 1994-10-16
NO179584C (no) 1996-11-06
KR910011814A (ko) 1991-08-07
AU628696B2 (en) 1992-09-17
IE904310A1 (en) 1991-06-19
KR0147281B1 (ko) 1998-08-17
US5189049A (en) 1993-02-23
JPH03279374A (ja) 1991-12-10
LV5802A4 (lv) 1997-02-20
DE69011059D1 (de) 1994-09-01

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