ES2164892T3 - Polimorfos del profarmaco 6-n-(l-ala-l-ala)-trovafloxacino. - Google Patents

Polimorfos del profarmaco 6-n-(l-ala-l-ala)-trovafloxacino.

Info

Publication number
ES2164892T3
ES2164892T3 ES96918806T ES96918806T ES2164892T3 ES 2164892 T3 ES2164892 T3 ES 2164892T3 ES 96918806 T ES96918806 T ES 96918806T ES 96918806 T ES96918806 T ES 96918806T ES 2164892 T3 ES2164892 T3 ES 2164892T3
Authority
ES
Spain
Prior art keywords
ala
trovafloxacino
profarmaco
polymorphes
pilps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96918806T
Other languages
English (en)
Inventor
Timothy Norris
James J Mcgarry
Douglas J M Allen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2164892T3 publication Critical patent/ES2164892T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

SE DESCRIBE UN PROFARMACO DE TROVAFLOXACINA QUE PRESENTA LA FORMULA (I), QUE SE SELECCIONA ENTRE SU POLIMORFO PII Y EL PILM MONOHIDRATADO Y LOS PSEUDOMORFOS PILPS DE LOS MISMOS, Y PROCEDIMIENTOS PARA SU PREPARACION. EN DICHA FORMULA SE DESCRIBEN EL POLIMORFO PII Y Y EL PILM MONOHIDRATADO Y EL PSEUDOMORFO PILPS DE LOS MISMOS. LA INVENCION TAMBIEN TRATA DE PROCEDIMIENTOS DE UTILIZACION, Y DE COMPOSICIONES FARMACEUTICAS QUE INCLUYEN LOS COMPUESTOS DE LA INVENCION PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS EN MAMIFEROS.
ES96918806T 1995-08-29 1996-07-05 Polimorfos del profarmaco 6-n-(l-ala-l-ala)-trovafloxacino. Expired - Lifetime ES2164892T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US510995P 1995-08-29 1995-08-29

Publications (1)

Publication Number Publication Date
ES2164892T3 true ES2164892T3 (es) 2002-03-01

Family

ID=21714229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96918806T Expired - Lifetime ES2164892T3 (es) 1995-08-29 1996-07-05 Polimorfos del profarmaco 6-n-(l-ala-l-ala)-trovafloxacino.

Country Status (35)

Country Link
US (1) US6080756A (es)
EP (1) EP0847400B1 (es)
JP (1) JPH11509188A (es)
KR (1) KR100274736B1 (es)
CN (1) CN1193977A (es)
AP (1) AP639A (es)
AR (1) AR004507A1 (es)
AT (1) ATE208790T1 (es)
AU (1) AU696414B2 (es)
BR (1) BR9610283A (es)
CA (1) CA2230303C (es)
CO (1) CO4480740A1 (es)
CZ (1) CZ291524B6 (es)
DE (1) DE69617027T2 (es)
DK (1) DK0847400T3 (es)
DZ (1) DZ2088A1 (es)
ES (1) ES2164892T3 (es)
GT (1) GT199600061A (es)
HR (1) HRP960396A2 (es)
HU (1) HUP9900226A3 (es)
IL (1) IL122652A (es)
MA (1) MA23965A1 (es)
NO (1) NO309039B1 (es)
NZ (1) NZ310542A (es)
OA (1) OA10670A (es)
PL (1) PL185709B1 (es)
PT (1) PT847400E (es)
RU (1) RU2151152C1 (es)
SK (1) SK283354B6 (es)
TN (1) TNSN96110A1 (es)
TR (1) TR199800340T1 (es)
UA (1) UA48982C2 (es)
WO (1) WO1997008191A1 (es)
YU (1) YU48296A (es)
ZA (1) ZA967281B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000106A (es) * 1997-08-01 1999-01-08 Pfizer Prod Inc Composiciones parenterales de alatroflaxacino
US6239141B1 (en) * 1999-06-04 2001-05-29 Pfizer Inc. Trovafloxacin oral suspensions
CN105510497A (zh) * 2015-11-30 2016-04-20 精晶药业股份有限公司 L-丙氨酰-l-丙氨酸的定量检测方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids

Also Published As

Publication number Publication date
GT199600061A (es) 1998-01-31
PL325203A1 (en) 1998-07-06
IL122652A (en) 2000-01-31
TNSN96110A1 (fr) 2005-03-15
HUP9900226A3 (en) 1999-11-29
SK283354B6 (sk) 2003-06-03
DZ2088A1 (fr) 2002-07-22
OA10670A (en) 2000-11-06
BR9610283A (pt) 1999-03-16
DK0847400T3 (da) 2002-03-25
CZ55298A3 (cs) 1999-02-17
HRP960396A2 (en) 1998-04-30
RU2151152C1 (ru) 2000-06-20
DE69617027D1 (de) 2001-12-20
IL122652A0 (en) 1996-08-16
CA2230303A1 (en) 1997-03-06
EP0847400A1 (en) 1998-06-17
JPH11509188A (ja) 1999-08-17
DE69617027T2 (de) 2002-03-21
YU48296A (sh) 1998-12-23
NZ310542A (en) 1999-09-29
PL185709B1 (pl) 2003-07-31
SK23798A3 (en) 1999-05-07
WO1997008191A1 (en) 1997-03-06
MA23965A1 (fr) 1997-04-01
ZA967281B (en) 1998-03-02
KR19990044231A (ko) 1999-06-25
PT847400E (pt) 2002-03-28
AU696414B2 (en) 1998-09-10
CO4480740A1 (es) 1997-07-09
AU6135196A (en) 1997-03-19
HUP9900226A2 (hu) 1999-05-28
CA2230303C (en) 2001-07-24
CZ291524B6 (cs) 2003-03-12
NO980863D0 (no) 1998-02-27
TR199800340T1 (xx) 1998-06-22
NO980863L (no) 1998-02-27
AP9600854A0 (en) 1996-10-31
AP639A (en) 1998-04-14
UA48982C2 (uk) 2002-09-16
US6080756A (en) 2000-06-27
NO309039B1 (no) 2000-12-04
MX9801665A (es) 1998-08-30
KR100274736B1 (ko) 2000-12-15
AR004507A1 (es) 1998-12-16
EP0847400B1 (en) 2001-11-14
CN1193977A (zh) 1998-09-23
ATE208790T1 (de) 2001-11-15

Similar Documents

Publication Publication Date Title
PA8452001A1 (es) Derivados de macrolidos c-4" sustituidos
ES2095432T3 (es) Derivados de 2,4-tiazolidin-diona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
PA8451801A1 (es) Derivados de la 9-oxima eritromicina
AR023423A1 (es) Derivados de adamantano, procedimientos para su preparacion, composicion farmaceutica, procedimiento para la preparacion de la composicion farmaceutica, yuso de dichos derivados para la manufactura de medicamentos
PA8486001A1 (es) Composiciones de celecoxib
UY28510A1 (es) Compuestos quimicos
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
BR9714082A (pt) Composto, uso do mesmo, composição farmacêutica, e, processos para tratamento ou profilaxia de doenças inflamatórias, e para a preparação de um composto.
SE8300736D0 (sv) Novel pharmacologically active compounds
PA8465901A1 (es) Nuevos derivados de la eritromicina
PA8452201A1 (es) Derivados de 9-desoxo-9a-aza-9a -homoeritromicina a c-4"sustituidos.
PA8465301A1 (es) Nuevos macrolidos
PA8485601A1 (es) Azalidas de 13 miembros y su uso como agentes antibioticos.
ECSP003682A (es) Compuestos para el tratamiento de la isquemia
ES2178037T3 (es) Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.
BR0010938A (pt) Derivados da 13-metil eritromicina
ES2169147T3 (es) Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento.
BR9610527A (pt) Novos derivados de substâncias de ciclodepsipeptìdeo pf1022
BR9712141A (pt) Aplicação de 1-hifróxi-2-piridonas para tratamento de infecções cutâneas.
ES2176321T3 (es) Derivados tetrasustituidos del imidazol, su procedimiento de preparacion, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
DE69613975D1 (de) Dialkyltiacumicine
DE69819539D1 (de) Antithrombotische mittel
ES2148458T3 (es) Derivados de fenil-4-tiazoles sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2164892T3 (es) Polimorfos del profarmaco 6-n-(l-ala-l-ala)-trovafloxacino.
PA8471801A1 (es) Derivados de higromicina a

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 847400

Country of ref document: ES