ES2163806T3 - Proceso para la preparacion de antagonistas de nmda. - Google Patents

Proceso para la preparacion de antagonistas de nmda.

Info

Publication number
ES2163806T3
ES2163806T3 ES97950551T ES97950551T ES2163806T3 ES 2163806 T3 ES2163806 T3 ES 2163806T3 ES 97950551 T ES97950551 T ES 97950551T ES 97950551 T ES97950551 T ES 97950551T ES 2163806 T3 ES2163806 T3 ES 2163806T3
Authority
ES
Spain
Prior art keywords
formula
corresponds
represent independently
nmda
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97950551T
Other languages
English (en)
Inventor
Alan Richard Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2163806T3 publication Critical patent/ES2163806T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCEDIMIENTO MEJORADO PARA LA PRODUCCION COMPUESTOS AMINOS CONOCIDOS QUE SE UTILIZAN COMO MEDICAMENTOS Y QUE CORRESPONDEN A LA FORMULA (I) DONDE R 1 Y R 2 REPRESENTAN INDEPENDIENTEMENTE FENILO O 4 - FLUOROCENILO, MIENTRAS QUE R 3 REPRESENTA HIDROGENO, ALQ UILO C 1 - 4 O METOXICARBONILO, Y QUE R 4 REPRESENTA HIDROGENO METILO. ESTE PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UN COMPUESTO QUE CORRESPONDE A LA FORMULA (II) CON UN COMPUESTO QUE CORRESPONDE A LA FORMULA (III) DONDE R 5 , R 6 , R 7 , R 8 , R 9 Y R 10 REPRESENTAN INDEPENDIENTEMENTE ALQUILO C 1 - 6 . ESTE PRO CEDIMIENTO CONSISTE LUEGO EN LLEVAR A CABO UNA DESPROTECCION, Y LUEGO EN PREPARAR OCASIONALMENTE UNA SAL FARMACEUTICAMENTE ACEPTABLE.
ES97950551T 1996-12-19 1997-12-12 Proceso para la preparacion de antagonistas de nmda. Expired - Lifetime ES2163806T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9626319.9A GB9626319D0 (en) 1996-12-19 1996-12-19 Synthetic method

Publications (1)

Publication Number Publication Date
ES2163806T3 true ES2163806T3 (es) 2002-02-01

Family

ID=10804657

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97950551T Expired - Lifetime ES2163806T3 (es) 1996-12-19 1997-12-12 Proceso para la preparacion de antagonistas de nmda.

Country Status (33)

Country Link
US (1) US6063962A (es)
EP (1) EP0946497B1 (es)
JP (1) JP2002512595A (es)
KR (1) KR100522337B1 (es)
CN (1) CN1105098C (es)
AR (1) AR010366A1 (es)
AT (1) ATE207053T1 (es)
AU (1) AU725683B2 (es)
BR (1) BR9713950A (es)
CA (1) CA2273286A1 (es)
CZ (1) CZ296780B6 (es)
DE (1) DE69707503T2 (es)
DK (1) DK0946497T3 (es)
EE (1) EE03762B1 (es)
EG (1) EG21486A (es)
ES (1) ES2163806T3 (es)
GB (1) GB9626319D0 (es)
HU (1) HUP0000420A3 (es)
ID (1) ID23994A (es)
IL (1) IL130425A (es)
IS (1) IS5059A (es)
MY (1) MY115259A (es)
NO (1) NO993065D0 (es)
NZ (1) NZ335870A (es)
PL (1) PL191196B1 (es)
PT (1) PT946497E (es)
RU (1) RU2190597C2 (es)
SI (1) SI0946497T1 (es)
SK (1) SK283033B6 (es)
TR (1) TR199901394T2 (es)
TW (1) TW415931B (es)
WO (1) WO1998027052A1 (es)
ZA (1) ZA9711057B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100826497B1 (ko) 2007-01-22 2008-05-02 삼성전자주식회사 전력 소모를 줄이기 위한 반도체 메모리 장치의 입출력센스 앰프 회로

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE955508C (de) * 1954-07-28 1957-01-03 Cilag Ag Verfahren zur Herstellung von antikonvulsivisch wirkenden Carbonsaeureamiden
IL84305A (en) * 1987-02-06 1992-01-15 Fisons Corp 2-aminoacetamide derivatives

Also Published As

Publication number Publication date
JP2002512595A (ja) 2002-04-23
DK0946497T3 (da) 2001-12-17
ID23994A (id) 2000-06-14
PT946497E (pt) 2002-03-28
EG21486A (en) 2001-11-28
CZ219899A3 (cs) 1999-11-17
SK283033B6 (sk) 2003-02-04
RU2190597C2 (ru) 2002-10-10
CN1105098C (zh) 2003-04-09
GB9626319D0 (en) 1997-02-05
KR20000069552A (ko) 2000-11-25
NO993065L (no) 1999-06-21
EE03762B1 (et) 2002-06-17
DE69707503D1 (de) 2001-11-22
IS5059A (is) 1999-05-28
PL333919A1 (en) 2000-01-31
BR9713950A (pt) 2000-03-21
IL130425A (en) 2003-02-12
PL191196B1 (pl) 2006-03-31
KR100522337B1 (ko) 2005-10-19
EP0946497A1 (en) 1999-10-06
HUP0000420A2 (hu) 2000-08-28
IL130425A0 (en) 2000-06-01
CN1240420A (zh) 2000-01-05
US6063962A (en) 2000-05-16
AU5352498A (en) 1998-07-15
TR199901394T2 (xx) 1999-08-23
ATE207053T1 (de) 2001-11-15
EE9900257A (et) 1999-12-15
CZ296780B6 (cs) 2006-06-14
MY115259A (en) 2003-04-30
NZ335870A (en) 2001-05-25
EP0946497B1 (en) 2001-10-17
AR010366A1 (es) 2000-06-07
CA2273286A1 (en) 1998-06-25
SI0946497T1 (en) 2002-06-30
DE69707503T2 (de) 2002-05-16
HUP0000420A3 (en) 2000-09-28
NO993065D0 (no) 1999-06-21
SK65699A3 (en) 1999-11-08
TW415931B (en) 2000-12-21
WO1998027052A1 (en) 1998-06-25
ZA9711057B (en) 1998-06-19
AU725683B2 (en) 2000-10-19

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