ES2162650T3 - Metodo para preparar productos intermedios de inhibidores de proteasas retrovirales. - Google Patents
Metodo para preparar productos intermedios de inhibidores de proteasas retrovirales.Info
- Publication number
- ES2162650T3 ES2162650T3 ES96903641T ES96903641T ES2162650T3 ES 2162650 T3 ES2162650 T3 ES 2162650T3 ES 96903641 T ES96903641 T ES 96903641T ES 96903641 T ES96903641 T ES 96903641T ES 2162650 T3 ES2162650 T3 ES 2162650T3
- Authority
- ES
- Spain
- Prior art keywords
- intermediate products
- preparing intermediate
- retroviral proteases
- proteases inhibitors
- chemical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000001177 retroviral effect Effects 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- -1 HYDROXYETHYLETHYL Chemical class 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000013461 intermediate chemical Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/26—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
LOS ISOSTEROS QUIRALES DE HIDROXIETILAMINA, HIDROXIETILUREA O HIDROXIETILSULFONAMINA QUE CONTIENEN INHIBIDORES DE LA PROTEASA Y LA RENINA RETROVIRALES SE PUEDEN PREPARAR MEDIANTE UNA SINTESIS LLEVADA A CABO EN MULTIPLES PASOS EN DONDE SE UTILIZAN INTERMEDIOS DE AMINA QUIRALES CLAVE. ESTA INVENCION SUPONE UN METODO ECONOMICO PARA LA OBTENCION DE TALES INTERMEDIOS DE AMINA QUIRALES CLAVE ENANTIO, DIASTEREO Y QUIMICAMENTE PUROS. EL METODO ES ADECUADO PARA PRODUCCIONES A GRAN ESCALA (MULTIKILOGRAMOS). ESTA INVENCION TAMBIEN SE REFIERE A SALES DE ACIDOS ORGANICOS Y DE ACIDOS INORGANICOS DE LOS INTERMEDIOS DE AMINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/376,340 US5831117A (en) | 1995-01-20 | 1995-01-20 | Method of preparing retroviral protease inhibitor intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2162650T3 true ES2162650T3 (es) | 2002-01-01 |
Family
ID=23484633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96903641T Expired - Lifetime ES2162650T3 (es) | 1995-01-20 | 1996-01-18 | Metodo para preparar productos intermedios de inhibidores de proteasas retrovirales. |
Country Status (16)
Country | Link |
---|---|
US (7) | US5831117A (es) |
EP (1) | EP0804410B1 (es) |
JP (1) | JP3978229B2 (es) |
KR (1) | KR100385013B1 (es) |
CN (1) | CN1623977A (es) |
AT (1) | ATE204851T1 (es) |
AU (1) | AU692062B2 (es) |
BR (1) | BR9606981A (es) |
CA (1) | CA2210973C (es) |
DE (1) | DE69614824T2 (es) |
DK (1) | DK0804410T3 (es) |
ES (1) | ES2162650T3 (es) |
HU (1) | HUP9702403A3 (es) |
NZ (1) | NZ302072A (es) |
PT (1) | PT804410E (es) |
WO (1) | WO1996022275A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5831117A (en) * | 1995-01-20 | 1998-11-03 | G. D. Searle & Co. | Method of preparing retroviral protease inhibitor intermediates |
US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
CA2401749A1 (en) | 2000-03-23 | 2001-09-27 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
EP1666452A2 (en) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
MXPA02012560A (es) * | 2000-06-30 | 2003-05-14 | Elan Pharm Inc | Compuestos para tratar la enfermedad de alzheimer. |
US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
JP2005500319A (ja) | 2001-06-27 | 2005-01-06 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病の治療に有用なβ−ヒドロキシアミン誘導体 |
US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
US6867302B2 (en) * | 2001-07-13 | 2005-03-15 | Board Of Trustees Of Michigan State University | Process for the catalytic synthesis of biaryls and polymers from aryl compounds |
CA2505098A1 (en) | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
TWI385173B (zh) | 2005-11-28 | 2013-02-11 | Tibotec Pharm Ltd | 作為hiv蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 |
CN103396346A (zh) * | 2008-05-19 | 2013-11-20 | 杏林制药株式会社 | 光学活性氨基醇衍生物的制备方法 |
CN116675613B (zh) * | 2023-08-03 | 2023-10-10 | 北京元延医药科技股份有限公司 | 手性拆分制备重酒石酸去甲肾上腺素的方法 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268688A (en) | 1973-02-16 | 1981-05-19 | Monsanto Company | Asymmetric hydroformylation process |
JPS5825677B2 (ja) | 1977-09-26 | 1983-05-28 | 武田薬品工業株式会社 | 3−テトラゾ−ル−1−アザキサントン誘導体およびその製造法 |
US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US4477414A (en) | 1981-05-20 | 1984-10-16 | Fumakilla Limited | Evaporative container |
EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
DE3377497D1 (en) | 1982-09-15 | 1988-09-01 | Haessle Ab | Enzyme inhibitors |
US4668770A (en) | 1982-12-27 | 1987-05-26 | Merck & Co., Inc. | Renin inhibitory tripeptides |
EP0118223A1 (en) | 1983-02-07 | 1984-09-12 | Aktiebolaget Hässle | Enzyme inhibitors |
JPS59227851A (ja) | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
US4514391A (en) | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
US4477441A (en) | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal disulfide cycle |
US4645759A (en) | 1984-06-22 | 1987-02-24 | Abbott Laboratories | Renin inhibiting compounds |
US4749792A (en) * | 1984-09-26 | 1988-06-07 | E. R. Squibb & Sons, Inc. | Diamino ketones and alcohols as analgesic agents |
US4616088A (en) | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
CN1003504B (zh) | 1984-12-03 | 1989-03-08 | 三井东圧化学有限公司 | 氯气制备方法 |
US4826815A (en) * | 1985-05-17 | 1989-05-02 | Abbott Laboratories | Renin inhibiting compounds |
US4668769A (en) | 1985-08-02 | 1987-05-26 | Hoover Dennis J | Oxa- and azahomocyclostatine polypeptides |
US4599198A (en) | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
CA1282549C (en) | 1985-11-12 | 1991-04-02 | Eric M. Gordon | Aminocarbonyl renin inhibitors |
US4757050A (en) | 1985-12-23 | 1988-07-12 | E. R. Squibb Sons, Inc. | Ureido renin inhibitors |
CA1297631C (en) | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Ureido renin inhibitors |
US4857507A (en) * | 1986-04-11 | 1989-08-15 | Abbott Laboratories | Angiotensinogen analogs |
US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
DE3635907A1 (de) | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
GB2200115B (en) * | 1987-01-21 | 1990-11-14 | Sandoz Ltd | Novel peptide derivatives, their production and use |
DE3800591A1 (de) | 1987-01-21 | 1988-08-04 | Sandoz Ag | Neue peptidderivate, ihre herstellung und verwendung |
USH725H (en) | 1987-02-26 | 1990-01-02 | E. R. Squibb & Sons, Inc. | Ureido amino and imino acids, compositions and methods for use |
GB8707412D0 (en) | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
DE3711911A1 (de) | 1987-04-08 | 1988-10-20 | Bayer Ag | Optisch aktive (alpha)-aminoaldehyde, verfahren zu ihrer herstellung und ihre verwendung zur stereoselektiven herstellung optisch aktiver ss-aminoalkohole |
DE3830825A1 (de) | 1987-09-15 | 1989-03-23 | Sandoz Ag | Hydrophile reninhemmer, ihre herstellung und verwendung |
DE3800059A1 (de) * | 1988-01-04 | 1989-07-13 | Paul Merkle | Modulo-10-zaehler fuer beide zaehl-richtungen |
IL89900A0 (en) | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
US4977277A (en) | 1988-05-09 | 1990-12-11 | Abbott Laboratories | Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof |
IL90218A0 (en) | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
IL91307A0 (en) | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
CA2012306A1 (en) | 1989-03-28 | 1990-09-28 | Werner Neidhart | Amino acid derivatives |
DE3912829A1 (de) | 1989-04-19 | 1990-10-25 | Bayer Ag | Verwendung von renininhibitorischen peptiden als mittel gegen retroviren |
TW225540B (es) | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
AU8233491A (en) | 1990-07-06 | 1992-02-04 | Smithkline Beecham Corporation | Retroviral protease inhibitors |
DE69133464T2 (de) * | 1990-11-19 | 2006-05-18 | Pharmacia Corp.(N.D.Ges.D.Staates Delaware) | Retrovirusprotease Inhibitoren |
ES2091000T3 (es) | 1992-05-20 | 1996-10-16 | Searle & Co | Metodo para elaborar intermedios utiles en la sintesis de inhibidores de proteasas retroviricas. |
DE69321845T2 (de) * | 1992-08-25 | 1999-04-29 | Monsanto Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
ES2061380B1 (es) | 1992-11-23 | 1995-07-01 | Boehringer Ingelheim Espana | Empleo del factor de crecimiento fibroblastico y sus derivados como neuroprotectores y neuromoduladores. |
US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
ATE172970T1 (de) * | 1993-07-15 | 1998-11-15 | Hoffmann La Roche | Verfahren zur herstellung eines n-tert.butylamids |
ES2145252T3 (es) * | 1993-11-23 | 2000-07-01 | Searle & Co | Metodo para elaborar productos intermedios utiles en la sintesis de inhibidores de proteasa retrovirales. |
JP2996459B2 (ja) * | 1994-07-14 | 1999-12-27 | ダイワ精工株式会社 | ゴルフクラブヘッド |
US5831117A (en) * | 1995-01-20 | 1998-11-03 | G. D. Searle & Co. | Method of preparing retroviral protease inhibitor intermediates |
US6849670B2 (en) * | 2000-07-19 | 2005-02-01 | Tokuyama Corporation | Photo-curable reparative material for dental use |
US20040162679A1 (en) | 2002-05-03 | 2004-08-19 | Linheng Li | Method for predicting gene potential and cell commitment |
-
1995
- 1995-01-20 US US08/376,340 patent/US5831117A/en not_active Expired - Fee Related
-
1996
- 1996-01-18 EP EP96903641A patent/EP0804410B1/en not_active Expired - Lifetime
- 1996-01-18 KR KR1019970704936A patent/KR100385013B1/ko not_active IP Right Cessation
- 1996-01-18 AU AU47653/96A patent/AU692062B2/en not_active Ceased
- 1996-01-18 CA CA002210973A patent/CA2210973C/en not_active Expired - Fee Related
- 1996-01-18 ES ES96903641T patent/ES2162650T3/es not_active Expired - Lifetime
- 1996-01-18 HU HU9702403A patent/HUP9702403A3/hu active IP Right Revival
- 1996-01-18 AT AT96903641T patent/ATE204851T1/de not_active IP Right Cessation
- 1996-01-18 CN CNA2004100560283A patent/CN1623977A/zh active Pending
- 1996-01-18 JP JP52244296A patent/JP3978229B2/ja not_active Expired - Lifetime
- 1996-01-18 DK DK96903641T patent/DK0804410T3/da active
- 1996-01-18 WO PCT/US1996/000918 patent/WO1996022275A1/en active IP Right Grant
- 1996-01-18 PT PT96903641T patent/PT804410E/pt unknown
- 1996-01-18 NZ NZ302072A patent/NZ302072A/xx unknown
- 1996-01-18 DE DE69614824T patent/DE69614824T2/de not_active Expired - Fee Related
- 1996-01-18 BR BR9606981A patent/BR9606981A/pt not_active IP Right Cessation
-
1998
- 1998-02-17 US US09/024,662 patent/US6201150B1/en not_active Expired - Fee Related
-
2000
- 2000-12-21 US US09/741,087 patent/US6515162B2/en not_active Expired - Fee Related
-
2002
- 2002-12-23 US US10/325,952 patent/US6849760B2/en not_active Expired - Fee Related
-
2004
- 2004-10-12 US US10/961,405 patent/US7060851B2/en not_active Expired - Fee Related
-
2006
- 2006-05-16 US US11/434,509 patent/US20060270855A1/en not_active Abandoned
- 2006-07-05 US US11/480,586 patent/US20070015818A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK0804410T3 (da) | 2001-11-26 |
DE69614824D1 (de) | 2001-10-04 |
KR100385013B1 (ko) | 2003-08-19 |
US20030171612A1 (en) | 2003-09-11 |
JP3978229B2 (ja) | 2007-09-19 |
CA2210973A1 (en) | 1996-07-25 |
BR9606981A (pt) | 1997-11-04 |
US20010047111A1 (en) | 2001-11-29 |
PT804410E (pt) | 2002-01-30 |
AU4765396A (en) | 1996-08-07 |
KR19980701545A (ko) | 1998-05-15 |
AU692062B2 (en) | 1998-05-28 |
US7060851B2 (en) | 2006-06-13 |
US6849760B2 (en) | 2005-02-01 |
US6515162B2 (en) | 2003-02-04 |
ATE204851T1 (de) | 2001-09-15 |
NZ302072A (en) | 1999-01-28 |
EP0804410B1 (en) | 2001-08-29 |
US5831117A (en) | 1998-11-03 |
CN1623977A (zh) | 2005-06-08 |
HUP9702403A3 (en) | 1999-10-28 |
DE69614824T2 (de) | 2002-04-11 |
US20050131075A1 (en) | 2005-06-16 |
EP0804410A1 (en) | 1997-11-05 |
US6201150B1 (en) | 2001-03-13 |
US20070015818A1 (en) | 2007-01-18 |
WO1996022275A1 (en) | 1996-07-25 |
HUP9702403A2 (hu) | 1999-09-28 |
US20060270855A1 (en) | 2006-11-30 |
JPH10512571A (ja) | 1998-12-02 |
CA2210973C (en) | 2007-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2162650T3 (es) | Metodo para preparar productos intermedios de inhibidores de proteasas retrovirales. | |
ES2145492T3 (es) | Procedimiento para la preparacion de polialcoholes. | |
DK0582790T3 (da) | Ny fremgangsmåde til fremstilling af 7-substituerede-9-[(substitueret glycyl)-amino]-6-demethyl-6-deoxytetracycliner | |
ES2092958B1 (es) | Procedimiento para la sintesis de tensioactivos cationicos derivados de la condensacion de acidos grasos con aminoacidos de caracter basico esterificados y su aplicacion como agentes antimicrobianos. | |
ES2170147T3 (es) | Metodo para mejorar la eficacia de los productos quimicos agricolas. | |
PT849277E (pt) | Processo para a obtencao de insulina atraves de cromatografia liquida de elevada eficiencia | |
ES2184304T3 (es) | Procedimiento de preparacion de un perhidro-isoindol sustituido. | |
ES2147427T3 (es) | Aminas ciclicas n-sustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen. | |
ES2143734T3 (es) | Compuestos bioaromaticos que llevan un grupo adamantilo en para, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones. | |
ES2177965T3 (es) | Derivados de (2-1-piperazinil)etoxi)metilo sustituidos. | |
ES2042965T3 (es) | Agentes blanqueantes y composiciones detergentes que contienen acidos alquil-sulfonilperoxicarboxilicos. | |
ITTO930447A0 (it) | Processo di tagli mediante un fascio laser | |
NO992309D0 (no) | FremgangsmÕte for anvendelse av cyklooksygenase-2 inhibitorer som anti-angiogene midler | |
ES2195364T3 (es) | Procedimiento de eterificacion de un alcohol de tipo bencilico, productos obtenidos y sus aplicaciones. | |
ITRM920405A0 (it) | Perfezionamenti alle macchine portatili per tagli curvi su lastre di marmo, di granito e di altri materiali. | |
ES2130160T3 (es) | Poliesteres insaturados y membranas reticuladas de los mismos para la separacion de compuestos aromaticos/saturados. | |
ES2172130T3 (es) | Procedimiento para la preparacion de acidos trifluoretoxiarenocarboxilicos. | |
ES2151743T3 (es) | Procedimiento para la preparacion de n-((1-n-butil-4-piperidinil)metil)-3,4-dihidro-2h-(1,3)-oxazino(3,2-a)indol-10-carboxamida y las sales y productos intermedios en el procedimiento. | |
GT199900120A (es) | Formulaciones que contienen tensoactivo de acido sulfonico aromatico neutralizado con amina alcoxilada. | |
ES2072126T3 (es) | Procedimiento para la preparacion de acidos difosfonicos y sus sales. | |
HN1999000043A (es) | Procedimiento para alquilar sulfonamidas impedidas estericamente. | |
AU1083395A (en) | Method for making intermediates useful in synthesis of retroviral protease inhibitors | |
ES2063064T3 (es) | Productos de reaccion de acido borico y alcanol-eter-aminas y su utilizacion como agentes protectores frente a la corrosion. | |
ES2173675T3 (es) | Procedimiento de preparacion de carboxamido-4-azaesteroides. | |
HN1998000186A (es) | Forma termodinamicamente estable del acido (r)-3-(((4-fluorofenil) sulfonil amino)-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban). |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 804410 Country of ref document: ES |