ES2173675T3 - Procedimiento de preparacion de carboxamido-4-azaesteroides. - Google Patents

Procedimiento de preparacion de carboxamido-4-azaesteroides.

Info

Publication number
ES2173675T3
ES2173675T3 ES98966861T ES98966861T ES2173675T3 ES 2173675 T3 ES2173675 T3 ES 2173675T3 ES 98966861 T ES98966861 T ES 98966861T ES 98966861 T ES98966861 T ES 98966861T ES 2173675 T3 ES2173675 T3 ES 2173675T3
Authority
ES
Spain
Prior art keywords
azaesteroid
carboxamido
preparation procedure
sub
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98966861T
Other languages
English (en)
Inventor
Achille Panzeri
Anello Matteo D
Antonio Longo
Marcella Nesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of ES2173675T3 publication Critical patent/ES2173675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la producción de un compuesto de fórmula (I) *fórmula*, en la que la línea de trazos --- representa individualmente un enlace sencillo o un doble enlace, y R, R{sub,1}, R{sub,2} y R{sub,3} son cada uno hidrógeno o un radical orgánico, comprende tratar los correspondientes intermedios de 17{be}-carbonilimidazol con ácidos anhidros en presencia de una amina y, opcionalmente, hidrogenar el compuesto resultante.
ES98966861T 1997-12-31 1998-12-17 Procedimiento de preparacion de carboxamido-4-azaesteroides. Expired - Lifetime ES2173675T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9727522.6A GB9727522D0 (en) 1997-12-31 1997-12-31 Process for preparing carboxamido-4-azasteroids

Publications (1)

Publication Number Publication Date
ES2173675T3 true ES2173675T3 (es) 2002-10-16

Family

ID=10824341

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98966861T Expired - Lifetime ES2173675T3 (es) 1997-12-31 1998-12-17 Procedimiento de preparacion de carboxamido-4-azaesteroides.

Country Status (19)

Country Link
US (2) US6121449A (es)
EP (1) EP0970105B1 (es)
JP (1) JP2001515518A (es)
KR (1) KR20000075845A (es)
CN (1) CN1248263A (es)
AT (1) ATE213741T1 (es)
AU (1) AU753602B2 (es)
CA (1) CA2278487A1 (es)
DE (1) DE69803979T2 (es)
DK (1) DK0970105T3 (es)
ES (1) ES2173675T3 (es)
GB (1) GB9727522D0 (es)
HU (1) HUP0001444A3 (es)
NO (1) NO312195B1 (es)
PT (1) PT970105E (es)
RU (1) RU2198176C2 (es)
TW (1) TW442491B (es)
WO (1) WO1999035161A1 (es)
ZA (1) ZA9811950B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001844A (en) 1995-09-15 1999-12-14 Merck & Co., Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
CA2530182A1 (en) 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
WO2005009949A2 (en) * 2003-06-30 2005-02-03 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
CN1816370A (zh) * 2003-06-30 2006-08-09 麦克公司 用作雄激素受体调节剂的17－乙酰氨基－4－氮杂甾族化合物衍生物
EP1641761A4 (en) * 2003-06-30 2008-05-14 Merck & Co Inc 17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS MODULATORS OF THE ANDROGEN RECEPTOR
CA2537663A1 (en) * 2003-09-10 2005-03-24 Merck & Co., Inc. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
GB9115676D0 (en) * 1991-07-19 1991-09-04 Erba Carlo Spa Process for the preparation of 17 beta substituted-4-aza-5 alpha-androstan-3-one derivatives
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones

Also Published As

Publication number Publication date
AU2514699A (en) 1999-07-26
NO312195B1 (no) 2002-04-08
AU753602B2 (en) 2002-10-24
WO1999035161A1 (en) 1999-07-15
US6121449A (en) 2000-09-19
ZA9811950B (en) 1999-06-30
HUP0001444A3 (en) 2001-03-28
DE69803979T2 (de) 2003-02-06
DE69803979D1 (de) 2002-04-04
NO994199D0 (no) 1999-08-30
HUP0001444A2 (hu) 2000-11-28
DK0970105T3 (da) 2002-05-27
RU2198176C2 (ru) 2003-02-10
ATE213741T1 (de) 2002-03-15
TW442491B (en) 2001-06-23
KR20000075845A (ko) 2000-12-26
NO994199L (no) 1999-10-29
JP2001515518A (ja) 2001-09-18
PT970105E (pt) 2002-07-31
US6284887B1 (en) 2001-09-04
CN1248263A (zh) 2000-03-22
GB9727522D0 (en) 1998-02-25
EP0970105B1 (en) 2002-02-27
CA2278487A1 (en) 1999-07-15
EP0970105A1 (en) 2000-01-12

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