ES2155091T3 - Procedimiento para la produccion de inhibidores de la proteasa del vih. - Google Patents

Procedimiento para la produccion de inhibidores de la proteasa del vih.

Info

Publication number
ES2155091T3
ES2155091T3 ES94922511T ES94922511T ES2155091T3 ES 2155091 T3 ES2155091 T3 ES 2155091T3 ES 94922511 T ES94922511 T ES 94922511T ES 94922511 T ES94922511 T ES 94922511T ES 2155091 T3 ES2155091 T3 ES 2155091T3
Authority
ES
Spain
Prior art keywords
hiv protease
procedure
production
protease inhibitors
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94922511T
Other languages
English (en)
Inventor
David Askin
Ralph P Volante
Kan K Eng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,664 external-priority patent/US5463067A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2155091T3 publication Critical patent/ES2155091T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS INTERMEDIOS DE LA FORMULA ESTRUCTURA (IV) SE PUEDEN PRODUCIR HACIENDO REACCIIBAR GLICIDOL O UN DERIVADO ACTIVADO DEL MISMO CON UNA AMIDA. EL PROCESO Y LOS INTERMEDIOS SON UTILES PARA LA SINTETIZACION DE COMPUESTOS INHIBIDORES DE LA PROTEASA DEL VIH.
ES94922511T 1993-07-16 1994-07-11 Procedimiento para la produccion de inhibidores de la proteasa del vih. Expired - Lifetime ES2155091T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9322593A 1993-07-16 1993-07-16
US08/187,664 US5463067A (en) 1993-07-16 1994-01-26 Process for making HIV protease inhibitors

Publications (1)

Publication Number Publication Date
ES2155091T3 true ES2155091T3 (es) 2001-05-01

Family

ID=26787287

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94922511T Expired - Lifetime ES2155091T3 (es) 1993-07-16 1994-07-11 Procedimiento para la produccion de inhibidores de la proteasa del vih.

Country Status (22)

Country Link
US (2) US5491238A (es)
EP (1) EP0708762B1 (es)
JP (1) JP3547136B2 (es)
CN (2) CN1066723C (es)
AT (1) ATE200079T1 (es)
AU (1) AU676079B2 (es)
CZ (1) CZ293953B6 (es)
DE (1) DE69426979T2 (es)
DK (1) DK0708762T3 (es)
ES (1) ES2155091T3 (es)
FI (1) FI119473B (es)
GR (1) GR3035645T3 (es)
HU (1) HUT74583A (es)
IL (1) IL110342A (es)
LV (1) LV12825B (es)
NO (1) NO306297B1 (es)
NZ (1) NZ269904A (es)
PL (1) PL179039B1 (es)
PT (1) PT708762E (es)
RU (1) RU2125561C1 (es)
SK (1) SK282616B6 (es)
WO (1) WO1995002584A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
IL111584A0 (en) * 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
ES2116029T3 (es) * 1994-11-04 1998-07-01 Yamakawa Chemical Ind Procedimiento para preparar derivados de piperazina opticamente activos e intermedios para prepararlos.
DE4446025A1 (de) * 1994-12-22 1996-06-27 Basf Ag 2-Caroxamido-1,4,5,6-tetrahydropyrazine
ATE209190T1 (de) * 1995-05-23 2001-12-15 Lonza Ag Verfahren zur herstellung von optisch aktiven 2- piperazincarbonsäurederivaten
EP1125930A1 (de) * 1995-05-23 2001-08-22 Lonza Ag Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
CA2201218C (en) * 1996-04-23 2004-09-28 Rudolf Fuchs Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en) 1997-03-07 2003-11-11 Merck & Co., Inc. Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en) 2000-06-20 2002-11-19 Merck & Co., Inc. Process for preparing acetonides
US7218837B2 (en) 2000-09-25 2007-05-15 Victor Company Of Japan, Ltd. Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2052907A1 (en) * 1990-10-11 1992-04-12 Joseph P. Vacca Hiv protease inhibitors having symmetrical structure
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
US5169952A (en) * 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides

Also Published As

Publication number Publication date
FI119473B (fi) 2008-11-28
US5496948A (en) 1996-03-05
CN1192014C (zh) 2005-03-09
ATE200079T1 (de) 2001-04-15
EP0708762A1 (en) 1996-05-01
IL110342A (en) 1998-12-27
AU7358894A (en) 1995-02-13
CN1130380A (zh) 1996-09-04
US5491238A (en) 1996-02-13
DE69426979D1 (de) 2001-05-03
CN1066723C (zh) 2001-06-06
CZ293953B6 (cs) 2004-08-18
RU2125561C1 (ru) 1999-01-27
PL179039B1 (pl) 2000-07-31
NO960168L (no) 1996-03-15
WO1995002584A3 (en) 1995-03-09
HUT74583A (en) 1997-01-28
DE69426979T2 (de) 2001-09-20
GR3035645T3 (en) 2001-06-29
CN1252402A (zh) 2000-05-10
AU676079B2 (en) 1997-02-27
JP3547136B2 (ja) 2004-07-28
NZ269904A (en) 1997-11-24
PT708762E (pt) 2001-07-31
HU9600077D0 (en) 1996-03-28
NO306297B1 (no) 1999-10-18
PL312613A1 (en) 1996-04-29
SK5596A3 (en) 1997-01-08
EP0708762B1 (en) 2001-03-28
SK282616B6 (sk) 2002-10-08
IL110342A0 (en) 1994-10-21
NO960168D0 (no) 1996-01-15
FI960184A (fi) 1996-03-14
LV12825A (en) 2002-05-20
WO1995002584A2 (en) 1995-01-26
CZ13196A3 (en) 1996-04-17
FI960184A0 (fi) 1996-01-15
LV12825B (en) 2002-09-20
DK0708762T3 (da) 2001-04-30
JPH08509985A (ja) 1996-10-22

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