DE69418689D1 - Nitrone verwendbar zum abfangen von freien radikalen - Google Patents
Nitrone verwendbar zum abfangen von freien radikalenInfo
- Publication number
- DE69418689D1 DE69418689D1 DE69418689T DE69418689T DE69418689D1 DE 69418689 D1 DE69418689 D1 DE 69418689D1 DE 69418689 T DE69418689 T DE 69418689T DE 69418689 T DE69418689 T DE 69418689T DE 69418689 D1 DE69418689 D1 DE 69418689D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- free radicals
- pyrroline
- methyl
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 title 1
- BOFVQDDXYSLVJX-UHFFFAOYSA-N (2-methyl-1-oxido-3,4-dihydropyrrol-1-ium-2-yl)phosphonic acid Chemical compound OP(=O)(O)C1(C)CCC=[N+]1[O-] BOFVQDDXYSLVJX-UHFFFAOYSA-N 0.000 abstract 1
- OKCDBZSDRSXFIB-UHFFFAOYSA-N 2-diethoxyphosphoryl-2-methyl-1-oxido-3,4-dihydropyrrol-1-ium Chemical compound CCOP(=O)(OCC)C1(C)CCC=[N+]1[O-] OKCDBZSDRSXFIB-UHFFFAOYSA-N 0.000 abstract 1
- OKCDBZSDRSXFIB-OJYSAGIRSA-N 4,4,5-trideuterio-2-diethoxyphosphoryl-2-methyl-1-oxido-3h-pyrrol-1-ium Chemical compound [2H]C1=[N+]([O-])C(C)(P(=O)(OCC)OCC)CC1([2H])[2H] OKCDBZSDRSXFIB-OJYSAGIRSA-N 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9308906A FR2707990B1 (fr) | 1993-07-20 | 1993-07-20 | Nouvelles nitrones utilisables pour le piégeage des radicaux libres. |
| PCT/FR1994/000909 WO1995003314A1 (fr) | 1993-07-20 | 1994-07-20 | Nouvelles nitrones utilisables pour le piegeage des radicaux libres |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69418689D1 true DE69418689D1 (de) | 1999-07-01 |
| DE69418689T2 DE69418689T2 (de) | 1999-09-30 |
Family
ID=9449421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69418689T Expired - Lifetime DE69418689T2 (de) | 1993-07-20 | 1994-07-20 | Nitrone verwendbar zum abfangen von freien radikalen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5750710A (de) |
| EP (1) | EP0660841B1 (de) |
| JP (1) | JP3768524B2 (de) |
| AT (1) | ATE180485T1 (de) |
| DE (1) | DE69418689T2 (de) |
| FR (1) | FR2707990B1 (de) |
| WO (1) | WO1995003314A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0675892A1 (de) * | 1993-10-25 | 1995-10-11 | Oklahoma Medical Research Foundation | Neue phosphor-enthaltende radikalfänger-zusammensetzungen |
| FR2731428B1 (fr) * | 1995-03-06 | 1997-06-06 | Centre Nat Rech Scient | Derives phosphoryles de nitrones, leur procede de preparation et compositions les contenant |
| FR2776293B1 (fr) | 1998-03-18 | 2002-10-04 | Centre Nat Rech Scient | Nouveaux aminophosphonates et utilisation d'aminophosphonates comme marqueurs de ph et rmn du 31p |
| US20060235370A1 (en) * | 2005-04-04 | 2006-10-19 | Oblong John E | Method of regulating mammalian keratinous tissue |
| JPWO2007043202A1 (ja) * | 2005-10-06 | 2009-04-16 | 三國製薬工業株式会社 | 安定な新規ニトロン化合物とその用途 |
| FR2903407B1 (fr) * | 2006-07-07 | 2008-10-03 | Univ Provence | Nouvelles nitrones portant une charge positive utilisables pour le piegeage de radicaux libres et notamment le radical superoxyde |
| MX2011005910A (es) | 2008-12-04 | 2011-06-17 | Opko Curna Llc | Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina. |
| CN117222684B (zh) * | 2021-05-11 | 2024-06-14 | 科莱恩国际有限公司 | 包含阻燃聚氨酯的软质泡沫、其生产方法及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4920974B1 (de) * | 1970-06-01 | 1974-05-29 | ||
| US4099918A (en) * | 1977-04-18 | 1978-07-11 | State Board Of Higher Education For And On Behalf Of The University Of Oregon | Proxyl nitroxides as spin labels |
| FR2639350B1 (fr) * | 1988-11-21 | 1990-12-21 | Commissariat Energie Atomique | Radical nitroxyde, son procede de fabrication et son application en magnetometrie |
-
1993
- 1993-07-20 FR FR9308906A patent/FR2707990B1/fr not_active Expired - Fee Related
-
1994
- 1994-07-20 US US08/403,783 patent/US5750710A/en not_active Expired - Lifetime
- 1994-07-20 WO PCT/FR1994/000909 patent/WO1995003314A1/fr active IP Right Grant
- 1994-07-20 DE DE69418689T patent/DE69418689T2/de not_active Expired - Lifetime
- 1994-07-20 EP EP94922283A patent/EP0660841B1/de not_active Expired - Lifetime
- 1994-07-20 JP JP50497895A patent/JP3768524B2/ja not_active Expired - Lifetime
- 1994-07-20 AT AT94922283T patent/ATE180485T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69418689T2 (de) | 1999-09-30 |
| ATE180485T1 (de) | 1999-06-15 |
| US5750710A (en) | 1998-05-12 |
| WO1995003314A1 (fr) | 1995-02-02 |
| EP0660841A1 (de) | 1995-07-05 |
| JP3768524B2 (ja) | 2006-04-19 |
| FR2707990A1 (fr) | 1995-01-27 |
| JPH08501808A (ja) | 1996-02-27 |
| EP0660841B1 (de) | 1999-05-26 |
| FR2707990B1 (fr) | 1995-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |