ES2161049T3 - Composicion farmaceutica para administracion oral de un derivado de la n-piperidino-3-pirazolcarboxamida, de sus sales y de sus solvatos. - Google Patents

Composicion farmaceutica para administracion oral de un derivado de la n-piperidino-3-pirazolcarboxamida, de sus sales y de sus solvatos.

Info

Publication number
ES2161049T3
ES2161049T3 ES98917259T ES98917259T ES2161049T3 ES 2161049 T3 ES2161049 T3 ES 2161049T3 ES 98917259 T ES98917259 T ES 98917259T ES 98917259 T ES98917259 T ES 98917259T ES 2161049 T3 ES2161049 T3 ES 2161049T3
Authority
ES
Spain
Prior art keywords
piperidino
oral administration
pirazolcarboxamida
solvates
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98917259T
Other languages
English (en)
Inventor
Bernard Abramovici
Christian Condamine
Jean-Claude Gromenil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2161049T3 publication Critical patent/ES2161049T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Abstract

La invención se refiere a composiciones farmacéuticas para administración oral que contienen de 0,5% a 20% de N-piperidino-5-{(}4-clorofenil{-1-{(}2,4-diclorofenil{-4-m etilpirazol-3-carboxamida en forma microcristalina y vehículos farmacéuticos. Las composiciones se formulan mediante granulación por vía húmeda.
ES98917259T 1997-03-28 1998-03-27 Composicion farmaceutica para administracion oral de un derivado de la n-piperidino-3-pirazolcarboxamida, de sus sales y de sus solvatos. Expired - Lifetime ES2161049T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703835A FR2761266B1 (fr) 1997-03-28 1997-03-28 Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates

Publications (1)

Publication Number Publication Date
ES2161049T3 true ES2161049T3 (es) 2001-11-16

Family

ID=9505295

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98917259T Expired - Lifetime ES2161049T3 (es) 1997-03-28 1998-03-27 Composicion farmaceutica para administracion oral de un derivado de la n-piperidino-3-pirazolcarboxamida, de sus sales y de sus solvatos.

Country Status (41)

Country Link
US (1) US6893659B2 (es)
EP (1) EP0969832B1 (es)
JP (1) JP3805797B2 (es)
KR (1) KR100479521B1 (es)
CN (1) CN1126543C (es)
AR (1) AR012160A1 (es)
AT (1) ATE202703T1 (es)
AU (1) AU740486B2 (es)
BR (1) BR9808429A (es)
CA (1) CA2284051C (es)
CO (1) CO4950527A1 (es)
CY (2) CY2275B1 (es)
CZ (1) CZ292129B6 (es)
DE (1) DE69801045T2 (es)
DK (1) DK0969832T3 (es)
DZ (1) DZ2453A1 (es)
EE (1) EE04578B1 (es)
ES (1) ES2161049T3 (es)
FR (1) FR2761266B1 (es)
GR (1) GR3036382T3 (es)
HK (1) HK1022831A1 (es)
HR (1) HRP980163B1 (es)
HU (1) HU224838B1 (es)
ID (1) ID22973A (es)
IL (1) IL131818A (es)
IS (1) IS1960B (es)
MY (1) MY121733A (es)
NO (1) NO321615B1 (es)
NZ (1) NZ337736A (es)
PL (1) PL191107B1 (es)
PT (1) PT969832E (es)
RS (1) RS49606B (es)
RU (1) RU2193886C2 (es)
SA (1) SA98190095B1 (es)
SI (1) SI0969832T1 (es)
SK (1) SK283265B6 (es)
TR (1) TR199902236T2 (es)
TW (1) TW565450B (es)
UA (1) UA49056C2 (es)
WO (1) WO1998043636A1 (es)
ZA (1) ZA982609B (es)

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CN1126543C (zh) 2003-11-05
NZ337736A (en) 2001-02-23
UA49056C2 (uk) 2002-09-16
RS49606B (sr) 2007-06-04
TR199902236T2 (xx) 1999-12-21
DE69801045D1 (de) 2001-08-09
CN1251524A (zh) 2000-04-26
AR012160A1 (es) 2000-09-27
PL335942A1 (en) 2000-05-22
FR2761266B1 (fr) 1999-07-02
CY2006005I1 (el) 2009-11-04
NO321615B1 (no) 2006-06-12
SK283265B6 (sk) 2003-04-01
AU740486B2 (en) 2001-11-08
MY121733A (en) 2006-02-28
HRP980163A2 (en) 1998-12-31
DZ2453A1 (fr) 2004-07-14
JP3805797B2 (ja) 2006-08-09
IS5190A (is) 1999-09-23
ID22973A (id) 1999-12-23
US6893659B2 (en) 2005-05-17
NO994706D0 (no) 1999-09-27
IL131818A0 (en) 2001-03-19
HK1022831A1 (en) 2000-08-25
HUP0001894A3 (en) 2002-01-28
TW565450B (en) 2003-12-11
SI0969832T1 (es) 2001-12-31
BR9808429A (pt) 2000-05-23
HUP0001894A2 (hu) 2001-04-28
DE69801045T2 (de) 2002-03-14
SK130999A3 (en) 2000-03-13
EP0969832A1 (fr) 2000-01-12
IS1960B (is) 2004-11-15
FR2761266A1 (fr) 1998-10-02
US20030003145A1 (en) 2003-01-02
HU224838B1 (en) 2006-03-28
IL131818A (en) 2003-07-31
CZ344199A3 (cs) 2000-01-12
KR100479521B1 (ko) 2005-03-30
EE04578B1 (et) 2006-02-15
CZ292129B6 (cs) 2003-08-13
DK0969832T3 (da) 2001-10-22
JP2001517224A (ja) 2001-10-02
CY2006005I2 (el) 2009-11-04
ZA982609B (en) 1998-09-30
EP0969832B1 (fr) 2001-07-04
CA2284051C (en) 2005-01-11
ATE202703T1 (de) 2001-07-15
EE9900441A (et) 2000-04-17
RU2193886C2 (ru) 2002-12-10
AU7052798A (en) 1998-10-22
YU47099A (sh) 2002-06-19
PT969832E (pt) 2001-11-30
WO1998043636A1 (fr) 1998-10-08
CY2275B1 (en) 2003-07-04
GR3036382T3 (en) 2001-11-30
HRP980163B1 (en) 2002-10-31
NO994706L (no) 1999-11-25
CO4950527A1 (es) 2000-09-01
CA2284051A1 (en) 1998-10-08
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SA98190095B1 (ar) 2006-06-18

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