NO321615B1 - Farmasoytisk preparat for oral administrering av et N-piperidino-3-pyrazolkarboksyamidderivat, samt salter og solvater derav og fremgangsmate for fremstilling derav - Google Patents
Farmasoytisk preparat for oral administrering av et N-piperidino-3-pyrazolkarboksyamidderivat, samt salter og solvater derav og fremgangsmate for fremstilling derav Download PDFInfo
- Publication number
- NO321615B1 NO321615B1 NO19994706A NO994706A NO321615B1 NO 321615 B1 NO321615 B1 NO 321615B1 NO 19994706 A NO19994706 A NO 19994706A NO 994706 A NO994706 A NO 994706A NO 321615 B1 NO321615 B1 NO 321615B1
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- Norway
- Prior art keywords
- weight
- pharmaceutical preparation
- preparation according
- sodium
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 48
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 8
- 150000003839 salts Chemical class 0.000 title claims description 5
- 239000012453 solvate Substances 0.000 title claims description 4
- 230000008569 process Effects 0.000 title description 2
- 238000005550 wet granulation Methods 0.000 claims description 16
- 239000007903 gelatin capsule Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 239000011734 sodium Substances 0.000 claims description 14
- 229910052708 sodium Inorganic materials 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 12
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 11
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 11
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 8
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- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
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- 229940126062 Compound A Drugs 0.000 description 19
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 19
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
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- 229920000881 Modified starch Polymers 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical class CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
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- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
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- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
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- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- LRNUFCLZJXZYLW-UHFFFAOYSA-N n-piperidin-1-yl-1h-pyrazole-5-carboxamide Chemical class C1=CNN=C1C(=O)NN1CCCCC1 LRNUFCLZJXZYLW-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- Bioinformatics & Cheminformatics (AREA)
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- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9703835A FR2761266B1 (fr) | 1997-03-28 | 1997-03-28 | Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates |
| PCT/FR1998/000631 WO1998043636A1 (fr) | 1997-03-28 | 1998-03-27 | Composition pharmaceutique pour administration orale d'un derive du n-piperidino-3-pyrazolecarboxamide, de ses sels et de leurs s olvates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994706D0 NO994706D0 (no) | 1999-09-27 |
| NO994706L NO994706L (no) | 1999-11-25 |
| NO321615B1 true NO321615B1 (no) | 2006-06-12 |
Family
ID=9505295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994706A NO321615B1 (no) | 1997-03-28 | 1999-09-27 | Farmasoytisk preparat for oral administrering av et N-piperidino-3-pyrazolkarboksyamidderivat, samt salter og solvater derav og fremgangsmate for fremstilling derav |
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| EP (1) | EP0969832B1 (es) |
| JP (1) | JP3805797B2 (es) |
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| CN (1) | CN1126543C (es) |
| AR (1) | AR012160A1 (es) |
| AT (1) | ATE202703T1 (es) |
| AU (1) | AU740486B2 (es) |
| BR (1) | BR9808429A (es) |
| CA (1) | CA2284051C (es) |
| CO (1) | CO4950527A1 (es) |
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| CZ (1) | CZ292129B6 (es) |
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| HK (1) | HK1022831A1 (es) |
| HR (1) | HRP980163B1 (es) |
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| ID (1) | ID22973A (es) |
| IL (1) | IL131818A (es) |
| IS (1) | IS1960B (es) |
| MY (1) | MY121733A (es) |
| NO (1) | NO321615B1 (es) |
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| PT (1) | PT969832E (es) |
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| SA (1) | SA98190095B1 (es) |
| SI (1) | SI0969832T1 (es) |
| SK (1) | SK283265B6 (es) |
| TR (1) | TR199902236T2 (es) |
| TW (1) | TW565450B (es) |
| UA (1) | UA49056C2 (es) |
| WO (1) | WO1998043636A1 (es) |
| ZA (1) | ZA982609B (es) |
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1998
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- 1998-03-27 UA UA99095239A patent/UA49056C2/uk unknown
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- 1998-03-27 EP EP98917259A patent/EP0969832B1/fr not_active Expired - Lifetime
- 1998-03-27 DK DK98917259T patent/DK0969832T3/da active
- 1998-03-27 SK SK1309-99A patent/SK283265B6/sk not_active IP Right Cessation
- 1998-03-27 SI SI9830054T patent/SI0969832T1/xx unknown
- 1998-03-27 KR KR10-1999-7008823A patent/KR100479521B1/ko not_active IP Right Cessation
- 1998-03-27 PT PT98917259T patent/PT969832E/pt unknown
- 1998-03-27 NZ NZ337736A patent/NZ337736A/en not_active IP Right Cessation
- 1998-03-27 WO PCT/FR1998/000631 patent/WO1998043636A1/fr active IP Right Grant
- 1998-03-27 CZ CZ19993441A patent/CZ292129B6/cs not_active IP Right Cessation
- 1998-03-27 IL IL13181898A patent/IL131818A/xx not_active IP Right Cessation
- 1998-03-27 ZA ZA982609A patent/ZA982609B/xx unknown
- 1998-05-26 SA SA98190095A patent/SA98190095B1/ar unknown
-
1999
- 1999-09-23 IS IS5190A patent/IS1960B/is unknown
- 1999-09-27 NO NO19994706A patent/NO321615B1/no not_active IP Right Cessation
-
2000
- 2000-03-22 HK HK00101773A patent/HK1022831A1/xx not_active IP Right Cessation
-
2001
- 2001-08-10 GR GR20010401238T patent/GR3036382T3/el unknown
-
2002
- 2002-05-01 US US10/136,148 patent/US6893659B2/en not_active Expired - Lifetime
- 2002-05-15 CY CY0200028A patent/CY2275B1/xx unknown
-
2006
- 2006-08-07 CY CY200600005C patent/CY2006005I2/el unknown
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| MM1K | Lapsed by not paying the annual fees |