ES2159589T3 - Imidazopiridinas. - Google Patents
Imidazopiridinas.Info
- Publication number
- ES2159589T3 ES2159589T3 ES95113840T ES95113840T ES2159589T3 ES 2159589 T3 ES2159589 T3 ES 2159589T3 ES 95113840 T ES95113840 T ES 95113840T ES 95113840 T ES95113840 T ES 95113840T ES 2159589 T3 ES2159589 T3 ES 2159589T3
- Authority
- ES
- Spain
- Prior art keywords
- opt
- het2
- cooa
- substd
- cyc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
NUEVOS DERIVADOS IMIDAZOPIRIDINAS DE LA FORMULA I DONDE R SIGNIFICA Y R{SUP, 1}, R{SUP, 2}, R{SUP, 3} Y R{SUP, 4} TIENEN LOS SIGNIFICADOS DADOS EN LA REIVINDICACION DE PATENTE 1, ASI COMO SUS SALES QUE MUESTRAN PROPIEDADES ANTAGONISTICAS ANGIOTENSINA II Y PUEDE SER UTILIZADAS PARA TRATAMIENTO DE HIPERTENSION, ALDOSTERONISMO, INSUFICIENCIA CARDIACA Y PRESION INTERNA OCULAR ELEVADA, ASI COMO PERTURBACIONES DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4432860A DE4432860A1 (de) | 1994-09-15 | 1994-09-15 | Imidazopyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2159589T3 true ES2159589T3 (es) | 2001-10-16 |
Family
ID=6528291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95113840T Expired - Lifetime ES2159589T3 (es) | 1994-09-15 | 1995-09-04 | Imidazopiridinas. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5684015A (es) |
EP (1) | EP0702013B1 (es) |
JP (1) | JPH0881466A (es) |
KR (1) | KR100373972B1 (es) |
CN (1) | CN1046942C (es) |
AT (1) | ATE202104T1 (es) |
AU (1) | AU702722B2 (es) |
CA (1) | CA2158225A1 (es) |
CZ (1) | CZ286739B6 (es) |
DE (2) | DE4432860A1 (es) |
DK (1) | DK0702013T3 (es) |
ES (1) | ES2159589T3 (es) |
GR (1) | GR3036339T3 (es) |
HU (1) | HU220042B (es) |
NO (1) | NO305249B1 (es) |
PL (1) | PL310460A1 (es) |
PT (1) | PT702013E (es) |
RU (1) | RU2156251C2 (es) |
SK (1) | SK282116B6 (es) |
TW (1) | TW323280B (es) |
UA (1) | UA41358C2 (es) |
ZA (1) | ZA957754B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19845153A1 (de) | 1998-10-01 | 2000-04-06 | Merck Patent Gmbh | Imidazo[4,5]-pyridin-4-on-derivate |
EP1013273A1 (en) * | 1998-12-23 | 2000-06-28 | Novartis AG | Use of AT-1 receptor antagonist or AT-2 receptor modulator for treating diseases associated with an increase of AT-1 or AT-2 receptors |
KR100646716B1 (ko) * | 1998-12-23 | 2006-11-17 | 노파르티스 아게 | At-1 또는 at-2 수용체의 증가와 관련된 질환의치료에 있어서 at-1 수용체 길항제 또는 at-2 수용체조절제의 용도 |
US6465502B1 (en) | 1998-12-23 | 2002-10-15 | Novartis Ag | Additional therapeutic use |
CZ20012682A3 (cs) * | 1999-01-26 | 2001-10-17 | Novartis Ag | Pouľití antagonistů receptoru angiotensinu II pro léčení akutního infarktu myokardu |
CN101011390A (zh) | 1999-01-26 | 2007-08-08 | 诺瓦提斯公司 | 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用 |
AR037097A1 (es) * | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
AU2003300358A1 (en) * | 2002-12-20 | 2004-07-22 | Migenix Corp. | Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto |
WO2004058683A2 (en) * | 2002-12-20 | 2004-07-15 | Migenix Corp. | Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto |
CN1894234A (zh) | 2003-03-25 | 2007-01-10 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
MXPA06001601A (es) | 2003-08-13 | 2006-08-25 | Takeda Pharmaceutical | Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa. |
WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN102079743B (zh) | 2004-03-15 | 2020-08-25 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
WO2006068978A2 (en) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
WO2007033350A1 (en) | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
CA2727573A1 (en) * | 2008-06-25 | 2009-12-30 | Pfizer Inc. | Diaryl compounds and uses thereof |
GB201321735D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
WO2017184765A1 (en) * | 2016-04-21 | 2017-10-26 | MediSynergics, LLC | Kappa opioid receptor compounds and methods of using same |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5036048A (en) | 1986-03-07 | 1991-07-30 | Schering Corporation | Angiotensin II receptor blockers as antiglaucoma agents |
US4880804A (en) | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
US5332744A (en) * | 1989-05-30 | 1994-07-26 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
EP0430709A3 (en) | 1989-12-01 | 1992-02-12 | Glaxo Group Limited | Benzthiophen derivatives |
US5140037A (en) | 1990-03-20 | 1992-08-18 | E. I. Du Pont De Nemours And Company | Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists |
EP0503838A3 (en) * | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
DE4110019C2 (de) * | 1991-03-27 | 2000-04-13 | Merck Patent Gmbh | Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
CA2109524A1 (en) * | 1991-05-10 | 1992-11-11 | Prasun K. Chakravarty | Acidic aralkyl triazole derivatives active as angiotensin ii antagonists |
US5238942A (en) * | 1991-05-10 | 1993-08-24 | Merck & Co., Inc. | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists |
CZ36394A3 (en) * | 1991-08-19 | 1994-07-13 | Du Pont | Substituted imidazilonone derivatives and pharmaceutical preparations based thereon |
DE4141788A1 (de) * | 1991-12-18 | 1993-06-24 | Merck Patent Gmbh | Imidazopyridine |
DE4305602A1 (de) * | 1992-06-17 | 1993-12-23 | Merck Patent Gmbh | Imidazopyridine |
DE4225835A1 (de) * | 1992-08-05 | 1994-02-10 | Merck Patent Gmbh | Verfahren zur Herstellung von Imidazopyridinen |
DE4236026A1 (de) * | 1992-10-24 | 1994-04-28 | Merck Patent Gmbh | Imidazopyridine |
DE4242459A1 (de) * | 1992-12-16 | 1994-06-23 | Merck Patent Gmbh | Imidazopyridine |
US5262412A (en) * | 1993-03-10 | 1993-11-16 | Merck & Co., Inc. | Substituted pyrazoles, compositions and use |
DE4318813A1 (de) * | 1993-06-07 | 1994-12-08 | Merck Patent Gmbh | Imidazopyridine |
US5395844A (en) * | 1993-06-10 | 1995-03-07 | The Du Pont Merck Pharmaceutical Company | Imidazole 5-position substituted angiotensin II antagonists |
ES2105939B1 (es) * | 1994-08-02 | 1998-07-01 | Uriach & Cia Sa J | Nuevos pirazoles con actividad antagonista de la angiotensina ii. |
-
1994
- 1994-09-15 DE DE4432860A patent/DE4432860A1/de not_active Withdrawn
-
1995
- 1995-08-16 TW TW084108552A patent/TW323280B/zh active
- 1995-09-04 DK DK95113840T patent/DK0702013T3/da active
- 1995-09-04 PT PT95113840T patent/PT702013E/pt unknown
- 1995-09-04 AT AT95113840T patent/ATE202104T1/de not_active IP Right Cessation
- 1995-09-04 ES ES95113840T patent/ES2159589T3/es not_active Expired - Lifetime
- 1995-09-04 DE DE59509331T patent/DE59509331D1/de not_active Expired - Fee Related
- 1995-09-04 EP EP95113840A patent/EP0702013B1/de not_active Expired - Lifetime
- 1995-09-08 AU AU31715/95A patent/AU702722B2/en not_active Ceased
- 1995-09-11 SK SK1123-95A patent/SK282116B6/sk unknown
- 1995-09-13 CN CN95116867A patent/CN1046942C/zh not_active Expired - Fee Related
- 1995-09-13 CA CA002158225A patent/CA2158225A1/en not_active Abandoned
- 1995-09-13 CZ CZ19952362A patent/CZ286739B6/cs not_active IP Right Cessation
- 1995-09-14 ZA ZA957754A patent/ZA957754B/xx unknown
- 1995-09-14 UA UA95094165A patent/UA41358C2/uk unknown
- 1995-09-14 PL PL95310460A patent/PL310460A1/xx unknown
- 1995-09-14 KR KR1019950029948A patent/KR100373972B1/ko not_active IP Right Cessation
- 1995-09-14 US US08/528,305 patent/US5684015A/en not_active Expired - Fee Related
- 1995-09-14 HU HU9502688A patent/HU220042B/hu not_active IP Right Cessation
- 1995-09-14 JP JP7260957A patent/JPH0881466A/ja active Pending
- 1995-09-14 NO NO953624A patent/NO305249B1/no unknown
- 1995-09-14 RU RU95115970/04A patent/RU2156251C2/ru not_active IP Right Cessation
-
2001
- 2001-08-07 GR GR20010401191T patent/GR3036339T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ286739B6 (en) | 2000-06-14 |
ATE202104T1 (de) | 2001-06-15 |
PL310460A1 (en) | 1996-03-18 |
JPH0881466A (ja) | 1996-03-26 |
HU9502688D0 (en) | 1995-11-28 |
SK282116B6 (sk) | 2001-11-06 |
DE4432860A1 (de) | 1996-03-21 |
EP0702013B1 (de) | 2001-06-13 |
UA41358C2 (uk) | 2001-09-17 |
HU220042B (hu) | 2001-10-28 |
NO953624L (no) | 1996-03-18 |
NO953624D0 (no) | 1995-09-14 |
TW323280B (es) | 1997-12-21 |
CA2158225A1 (en) | 1996-03-16 |
SK112395A3 (en) | 1997-06-04 |
AU702722B2 (en) | 1999-03-04 |
CZ236295A3 (en) | 1996-04-17 |
NO305249B1 (no) | 1999-04-26 |
CN1129702A (zh) | 1996-08-28 |
EP0702013A3 (de) | 1996-05-08 |
RU2156251C2 (ru) | 2000-09-20 |
US5684015A (en) | 1997-11-04 |
EP0702013A2 (de) | 1996-03-20 |
PT702013E (pt) | 2001-10-30 |
DE59509331D1 (de) | 2001-07-19 |
AU3171595A (en) | 1996-03-28 |
KR960010639A (ko) | 1996-04-20 |
CN1046942C (zh) | 1999-12-01 |
GR3036339T3 (en) | 2001-11-30 |
DK0702013T3 (da) | 2001-09-03 |
ZA957754B (en) | 1996-04-09 |
HUT74939A (en) | 1997-03-28 |
KR100373972B1 (ko) | 2003-06-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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