ES2159535T3 - Metodo para la determinacion de la actividad de una substancia de ensayo. - Google Patents

Metodo para la determinacion de la actividad de una substancia de ensayo.

Info

Publication number
ES2159535T3
ES2159535T3 ES94112272T ES94112272T ES2159535T3 ES 2159535 T3 ES2159535 T3 ES 2159535T3 ES 94112272 T ES94112272 T ES 94112272T ES 94112272 T ES94112272 T ES 94112272T ES 2159535 T3 ES2159535 T3 ES 2159535T3
Authority
ES
Spain
Prior art keywords
coagulation factor
factor xii
blood coagulation
activity
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94112272T
Other languages
English (en)
Inventor
Katsumi Nishikawa
Nobuyuki Ishibashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zoki Pharmaceutical Co Ltd filed Critical Nippon Zoki Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2159535T3 publication Critical patent/ES2159535T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96458—Factor XII (3.4.21.38)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION OFRECE UN METODO PARA MEDIR LA ACTIVIDAD DE UNA SUSTANCIA TESTADA QUE INHIBE O PROMUEVE LA PRODUCCION DEL FACTOR XII DE COAGULACION DE LA SANGRE DE UNA FORMA ACTIVA. UNA REACCION DE ACTIVACION DE UN FACTOR XII DE COAGULACION DE SANGRE SE INICIALIZA MEDIANTE LA INICIACION DE UNA ACTIVADOR DE FACTOR XII DE COAGULACION DE SANGRE AL PLASMA ANIMAL EN PRESENCIA DE LA SUSTANCIA TESTADA, LUEGO LA REACCION SE PARA Y EL FACTOR XII DE COAGULACION DE SANGRE EN FORMA ACTIVA PRODUCIDO EN LA REACCION ANTES DESCRITA SE DETERMINA CUANTITATIVAMENTE. FXIIA DESEMPEÑA UN PAPEL MUY IMPORTANTE EN LA ETAPA DE INICIACION EN EL SISTEMA INTRINSECO COAGULANTE DE LA SANGRE , SISTEMA DE FIBRINOLISIS Y SISTEMA CALICREINA-QUININA Y, CONSECUENTEMENTE, TAMBIEN EN EL METODO DE MEDIDA DE LA PRESENTE INVENCION, EN LA QUE LA ACTIVIDAD DE LA SUSTANCIA TESTADA QUE TIENE LA ACCION INHIBIDORA O PROMOTORA DE LA PRODUCCION DE FXIIA ES MUY UTIL EN LA SELECCION DE DROGAS RELATIVA A SISTEMAS DE COAGULACION DE SANGRE Y FIBRINOLISIS Y AQUELLOS RELATIVOS AL SISTEMA CALICREINAQUININA TAL COMO, POR EJEMPLO, AGENTE DE CONTROL DE PRESION DE LA SANGRE, AGENTES ANTIINFLAMATORIOS, ANALGESICOS, AGENTES ANTIALERGICOS, ETC.
ES94112272T 1993-08-06 1994-08-05 Metodo para la determinacion de la actividad de una substancia de ensayo. Expired - Lifetime ES2159535T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21517793A JP3213831B2 (ja) 1993-08-06 1993-08-06 被検物質の活性測定方法

Publications (1)

Publication Number Publication Date
ES2159535T3 true ES2159535T3 (es) 2001-10-16

Family

ID=16667948

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94112272T Expired - Lifetime ES2159535T3 (es) 1993-08-06 1994-08-05 Metodo para la determinacion de la actividad de una substancia de ensayo.

Country Status (8)

Country Link
US (1) US5599683A (es)
EP (1) EP0637633B1 (es)
JP (1) JP3213831B2 (es)
KR (1) KR100270161B1 (es)
CN (1) CN1080763C (es)
AT (1) ATE203277T1 (es)
DE (1) DE69427723T2 (es)
ES (1) ES2159535T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1084995A (ja) * 1996-09-12 1998-04-07 Nippon Zoki Pharmaceut Co Ltd 血液凝固第ｘｉｉ因子活性化法
US6632678B2 (en) 2001-01-03 2003-10-14 Sienco, Inc. Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
US6913900B2 (en) 2001-08-29 2005-07-05 Nippon Zoki Pharmaceutical Co., Ltd. Plasma prekallikrein activation and kallikrein production assay
US20030143444A1 (en) * 2002-01-31 2003-07-31 Qin Liu Fuel cell with fuel droplet fuel supply
CA2511125A1 (en) * 2002-12-20 2004-07-08 Axis-Shield Diagnostics Limited Detection or determination of variants of factor xiia
RU2504771C2 (ru) * 2011-06-29 2014-01-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) Способ отбора анальгетических средств

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB697351A (en) * 1951-01-16 1953-09-23 Masuichi Takino Improved process for the manufacture of nerve sedatives
JPS53101515A (en) * 1977-02-17 1978-09-05 Nippon Zoki Pharmaceutical Co Medicine having anodyne * sedative and antiallergic activity and production thereof
JPS5777697A (en) * 1980-11-04 1982-05-15 Nippon Zoki Pharmaceut Co Ltd Physiologically active substance nsq
JPS5835117A (ja) * 1981-08-25 1983-03-01 Nippon Zoki Pharmaceut Co Ltd 新規生理活性物質ｎｓｈ
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
DE3504405A1 (de) * 1985-02-08 1986-08-14 Boehringer Mannheim Gmbh, 6800 Mannheim Bestimmung von prokallikrein
KR960009766B1 (ko) * 1986-09-10 1996-07-24 니혼 소오끼 세이야꾸 가부시기가이샤 생리 활성물질 측정법
US4882272A (en) * 1986-10-01 1989-11-21 Temple University - Of The Commonwealth System Of Higher Education High molecular weight kininogen assay
JP2651674B2 (ja) * 1987-07-23 1997-09-10 日本臓器製薬 株式会社 新規生理活性物質及びその製造方法
US4985254A (en) * 1987-11-06 1991-01-15 Nippon Zoki Pharmaceutical Co., Ltd. Method of treating ischemic diseases
EP0341209B1 (en) * 1988-04-30 1993-09-15 Nippon Zoki Pharmaceutical Co. Ltd. Physiologically active substances, a process for preparation and pharmaceutical compositions thereof
JP2539665B2 (ja) * 1988-06-20 1996-10-02 日本臓器製薬株式会社 神経疾患治療剤
EP0534988A1 (en) * 1990-05-10 1993-04-07 Cetus Corporation Inhibitors of factor xii activation and applications thereof

Also Published As

Publication number Publication date
KR950006461A (ko) 1995-03-21
ATE203277T1 (de) 2001-08-15
EP0637633A2 (en) 1995-02-08
JPH0751097A (ja) 1995-02-28
US5599683A (en) 1997-02-04
KR100270161B1 (ko) 2000-10-16
JP3213831B2 (ja) 2001-10-02
CN1110409A (zh) 1995-10-18
DE69427723D1 (de) 2001-08-23
DE69427723T2 (de) 2002-05-08
CN1080763C (zh) 2002-03-13
EP0637633A3 (en) 1998-01-07
EP0637633B1 (en) 2001-07-18

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