DE69427723D1 - Verfahren zur Bestimmung der Wirksamkeit einer Testsubstanz - Google Patents

Verfahren zur Bestimmung der Wirksamkeit einer Testsubstanz

Info

Publication number
DE69427723D1
DE69427723D1 DE69427723T DE69427723T DE69427723D1 DE 69427723 D1 DE69427723 D1 DE 69427723D1 DE 69427723 T DE69427723 T DE 69427723T DE 69427723 T DE69427723 T DE 69427723T DE 69427723 D1 DE69427723 D1 DE 69427723D1
Authority
DE
Germany
Prior art keywords
coagulation factor
factor xii
blood coagulation
blood
tested substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69427723T
Other languages
English (en)
Other versions
DE69427723T2 (de
Inventor
Katsumi Nishikawa
Nobuyuki Ishibashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zoki Pharmaceutical Co Ltd filed Critical Nippon Zoki Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69427723D1 publication Critical patent/DE69427723D1/de
Publication of DE69427723T2 publication Critical patent/DE69427723T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96458—Factor XII (3.4.21.38)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69427723T 1993-08-06 1994-08-05 Verfahren zur Bestimmung der Wirksamkeit einer Testsubstanz Expired - Fee Related DE69427723T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21517793A JP3213831B2 (ja) 1993-08-06 1993-08-06 被検物質の活性測定方法

Publications (2)

Publication Number Publication Date
DE69427723D1 true DE69427723D1 (de) 2001-08-23
DE69427723T2 DE69427723T2 (de) 2002-05-08

Family

ID=16667948

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427723T Expired - Fee Related DE69427723T2 (de) 1993-08-06 1994-08-05 Verfahren zur Bestimmung der Wirksamkeit einer Testsubstanz

Country Status (8)

Country Link
US (1) US5599683A (de)
EP (1) EP0637633B1 (de)
JP (1) JP3213831B2 (de)
KR (1) KR100270161B1 (de)
CN (1) CN1080763C (de)
AT (1) ATE203277T1 (de)
DE (1) DE69427723T2 (de)
ES (1) ES2159535T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1084995A (ja) * 1996-09-12 1998-04-07 Nippon Zoki Pharmaceut Co Ltd 血液凝固第ｘｉｉ因子活性化法
US6632678B2 (en) 2001-01-03 2003-10-14 Sienco, Inc. Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
US6913900B2 (en) 2001-08-29 2005-07-05 Nippon Zoki Pharmaceutical Co., Ltd. Plasma prekallikrein activation and kallikrein production assay
US20030143444A1 (en) * 2002-01-31 2003-07-31 Qin Liu Fuel cell with fuel droplet fuel supply
US20060024745A1 (en) * 2002-12-20 2006-02-02 Pritchard David J Variants of factor XllA
RU2504771C2 (ru) * 2011-06-29 2014-01-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) Способ отбора анальгетических средств

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB697351A (en) * 1951-01-16 1953-09-23 Masuichi Takino Improved process for the manufacture of nerve sedatives
JPS53101515A (en) * 1977-02-17 1978-09-05 Nippon Zoki Pharmaceutical Co Medicine having anodyne * sedative and antiallergic activity and production thereof
JPS5777697A (en) * 1980-11-04 1982-05-15 Nippon Zoki Pharmaceut Co Ltd Physiologically active substance nsq
JPS5835117A (ja) * 1981-08-25 1983-03-01 Nippon Zoki Pharmaceut Co Ltd 新規生理活性物質ｎｓｈ
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
DE3504405A1 (de) * 1985-02-08 1986-08-14 Boehringer Mannheim Gmbh, 6800 Mannheim Bestimmung von prokallikrein
JPS63185398A (ja) * 1986-09-10 1988-07-30 Nippon Zoki Pharmaceut Co Ltd 生理活性物質測定法
US4882272A (en) * 1986-10-01 1989-11-21 Temple University - Of The Commonwealth System Of Higher Education High molecular weight kininogen assay
JP2651674B2 (ja) * 1987-07-23 1997-09-10 日本臓器製薬 株式会社 新規生理活性物質及びその製造方法
US4985254A (en) * 1987-11-06 1991-01-15 Nippon Zoki Pharmaceutical Co., Ltd. Method of treating ischemic diseases
EP0341209B1 (de) * 1988-04-30 1993-09-15 Nippon Zoki Pharmaceutical Co. Ltd. Physiologisch wirkende Substanzen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen davon
JP2539665B2 (ja) * 1988-06-20 1996-10-02 日本臓器製薬株式会社 神経疾患治療剤
AU7793291A (en) * 1990-05-10 1991-11-27 Cetus Corporation Inhibitors of factor xii activation and applications thereof

Also Published As

Publication number Publication date
CN1110409A (zh) 1995-10-18
JPH0751097A (ja) 1995-02-28
DE69427723T2 (de) 2002-05-08
KR950006461A (ko) 1995-03-21
US5599683A (en) 1997-02-04
ES2159535T3 (es) 2001-10-16
CN1080763C (zh) 2002-03-13
ATE203277T1 (de) 2001-08-15
KR100270161B1 (ko) 2000-10-16
EP0637633B1 (de) 2001-07-18
EP0637633A3 (de) 1998-01-07
JP3213831B2 (ja) 2001-10-02
EP0637633A2 (de) 1995-02-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee