ES2155074T3 - Adenovirus que comprende fibras penton fusionadas a peptidos que alterna la especificidad de union para celulas blanco. - Google Patents

Adenovirus que comprende fibras penton fusionadas a peptidos que alterna la especificidad de union para celulas blanco.

Info

Publication number
ES2155074T3
ES2155074T3 ES93924692T ES93924692T ES2155074T3 ES 2155074 T3 ES2155074 T3 ES 2155074T3 ES 93924692 T ES93924692 T ES 93924692T ES 93924692 T ES93924692 T ES 93924692T ES 2155074 T3 ES2155074 T3 ES 2155074T3
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ES
Spain
Prior art keywords
virus
particle
adenovirus
binding
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93924692T
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English (en)
Inventor
Robert Anthony Spooner
Agamemnon Antoniou Epenetos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
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Transgene SA
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Application filed by Transgene SA filed Critical Transgene SA
Application granted granted Critical
Publication of ES2155074T3 publication Critical patent/ES2155074T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10323—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/854—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from hormones
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN UN VIRUS, O PARTICULA COMO UN VIRUS, DERIVADA DE UN VIRUS O PARTICULA COMO UN VIRUS QUE TIENE UN RECEPTOR PARA UNA CELULA HUESPED QUE COMPRENDE UNA ESPECIFICIDAD DE ENLACE MODIFICADO CONFERIDO POR UNA PARTE DE ENLACE QUE PERMITE AL VIRUS O PARTICULA COMO UN VIRUS ENLAZAR CON UNA CELULA DESTINO CARACTERIZADA EN QUE DICHO RECEPTOR DE CELULA HUESPED ESTA MODIFICADO O AUSENTE POR LO QUE EL VIRUS O PARTICULA COMO UN VIRUS ES SUSTANCIALMENTE INCAPAZ DE ENLAZAR CON LA MENCIONADA CELULA HUESPED. SE DESCRIBE UN ADENOVIRUS O VIRUS DE LA GRIPE O VIRUS DE VACINIA, O UNA DEFECTUOSA REPLICACION DERIVADA DE ALGUNO DE ESTOS, CARACTERIZADA EN QUE EL VIRUS TIENE UNA ESPECIFICIDAD DE ENLACE MODIFICADO CONFERIDO POR UNA PARTE DE ENLACE QUE PERMITE QUE EL VIRUS ENLACE CON UNA CELULA DESTINO. LAS PARTES DE ENLACE APTAS INCLUYEN ANTICUERPOS MONOCLONALES, SCFVS, DABS Y UNIDADES DE RECONOCIMIENTO MINIMAS. SE DESCRIBEN LA UTILIZACION DE AL MENOS ALGUNO DE ESTOS COMO VEHICULOS DE DISTRIBUCION PARA GENESHACIA CELULAS DESTINO EN LOS CAMPOS DE LA TERAPIA GENICA Y TRATAMIENTO DEL CANCER.
ES93924692T 1992-11-04 1993-11-04 Adenovirus que comprende fibras penton fusionadas a peptidos que alterna la especificidad de union para celulas blanco. Expired - Lifetime ES2155074T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929223084A GB9223084D0 (en) 1992-11-04 1992-11-04 Compounds to target cells

Publications (1)

Publication Number Publication Date
ES2155074T3 true ES2155074T3 (es) 2001-05-01

Family

ID=10724509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93924692T Expired - Lifetime ES2155074T3 (es) 1992-11-04 1993-11-04 Adenovirus que comprende fibras penton fusionadas a peptidos que alterna la especificidad de union para celulas blanco.

Country Status (11)

Country Link
US (1) US5885808A (es)
EP (2) EP1038967A3 (es)
JP (1) JPH08506239A (es)
AT (1) ATE198769T1 (es)
DE (1) DE69329879T2 (es)
DK (1) DK0672158T3 (es)
ES (1) ES2155074T3 (es)
GB (2) GB9223084D0 (es)
GR (1) GR3035728T3 (es)
PT (1) PT672158E (es)
WO (1) WO1994010323A1 (es)

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