WO2003047634A3 - Nucleic acids and methods for treating ebv-positive cancers - Google Patents

Nucleic acids and methods for treating ebv-positive cancers Download PDF

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Publication number
WO2003047634A3
WO2003047634A3 PCT/CA2002/001870 CA0201870W WO03047634A3 WO 2003047634 A3 WO2003047634 A3 WO 2003047634A3 CA 0201870 W CA0201870 W CA 0201870W WO 03047634 A3 WO03047634 A3 WO 03047634A3
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WO
WIPO (PCT)
Prior art keywords
positive cancers
methods
nucleic acids
ebv
gene
Prior art date
Application number
PCT/CA2002/001870
Other languages
French (fr)
Other versions
WO2003047634A2 (en
Inventor
Fei-Fei Liu
Henry Joseph Klamut
Marie Chia
Jian-Hua Li
Original Assignee
Univ Health Network
Fei-Fei Liu
Henry Joseph Klamut
Marie Chia
Jian-Hua Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network, Fei-Fei Liu, Henry Joseph Klamut, Marie Chia, Jian-Hua Li filed Critical Univ Health Network
Priority to AU2002351568A priority Critical patent/AU2002351568A1/en
Publication of WO2003047634A2 publication Critical patent/WO2003047634A2/en
Publication of WO2003047634A3 publication Critical patent/WO2003047634A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is in the area of gene therapy, in particular in the treatment and prevention of EBV-positive cancers by administering a nucleic acid molecule comprising an EBNA1-responsive promoter region operatively linked to a gene necessary for viral replication, preferably in adenovirus replication, and optionally one or more heterologous genes. In embodiments, the one or more heterologous genes comprise a therapeutic gene that can limit tumour cell growth and/or cause the tumour cell to die.
PCT/CA2002/001870 2001-12-06 2002-12-06 Nucleic acids and methods for treating ebv-positive cancers WO2003047634A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002351568A AU2002351568A1 (en) 2001-12-06 2002-12-06 Nucleic acids and methods for treating ebv-positive cancers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33618001P 2001-12-06 2001-12-06
US60/336,180 2001-12-06

Publications (2)

Publication Number Publication Date
WO2003047634A2 WO2003047634A2 (en) 2003-06-12
WO2003047634A3 true WO2003047634A3 (en) 2004-01-29

Family

ID=23314915

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001870 WO2003047634A2 (en) 2001-12-06 2002-12-06 Nucleic acids and methods for treating ebv-positive cancers

Country Status (2)

Country Link
AU (1) AU2002351568A1 (en)
WO (1) WO2003047634A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014101A1 (en) * 1993-11-18 1995-05-26 Rhone-Poulenc Rorer S.A. Recombinant adenoviruses for gene therapy in cancers
WO2002056917A1 (en) * 2001-01-18 2002-07-25 Virgene Biotechnology Limited A recombination virus able to specifically kill tumor associated with eb virus and the constructing method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014101A1 (en) * 1993-11-18 1995-05-26 Rhone-Poulenc Rorer S.A. Recombinant adenoviruses for gene therapy in cancers
WO2002056917A1 (en) * 2001-01-18 2002-07-25 Virgene Biotechnology Limited A recombination virus able to specifically kill tumor associated with eb virus and the constructing method thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"EFFICACY OF IONIZING RADIATION COMBINED WITH ADENOVIRAL P53 THERAPY IN EBV-POSITIVE NASOPHARYNGEAL CARCINOMA", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 87, no. 4, 15 August 2000 (2000-08-15), pages 606 - 610, XP001145455, ISSN: 0020-7136 *
CHIA, M.C. ET AL.: "A novel conditionally oncolytic adenovirus for the treatment of nasopharyngeal carcinoma (NPC)", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), pages 1098 - 1099, XP001147482 *
DATABASE WPI Derwent World Patents Index; AN 2002-566772, XP002242870, CHE, X. ET AL.: "Construction of reproductive recombination virus able to specifically kill Epstein-Barr associated tumor cells, useful in drugs for treating e.g. nasopharyngeal cancer, Hodgkin's lymphoma and gastric cancer" *
HALLENBECK, P.L. ET AL.: "A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma", HUMAN GENE THERAPY, vol. 10, 1 July 1999 (1999-07-01), pages 1721 - 1733, XP002242915 *
HERNANDEZ-ALCOCEBA, R. ET AL.: "A novel, conditionally replicative adenovirus for th4 treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors", HUMAN GENE THERAPY, vol. 11, 20 September 2000 (2000-09-20), pages 2009 - 2024, XP001152711 *
JUDDE, J.-G. ET AL.: "Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia", HUMAN GENE THERAPY, vol. 7, 20 March 1996 (1996-03-20), pages 647 - 653, XP009010762 *
KURIHARA, T. ET AL.: "Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressiong the MUC1 antigen", JOURNAL OF CLINICAL INVESTIGATION, vol. 106, no. 6, September 2000 (2000-09-01), pages 763 - 771, XP002242916 *

Also Published As

Publication number Publication date
AU2002351568A8 (en) 2003-06-17
AU2002351568A1 (en) 2003-06-17
WO2003047634A2 (en) 2003-06-12

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