ES2147602T3 - Ensayos de la actividad de la telomerasa. - Google Patents

Ensayos de la actividad de la telomerasa.

Info

Publication number
ES2147602T3
ES2147602T3 ES95903110T ES95903110T ES2147602T3 ES 2147602 T3 ES2147602 T3 ES 2147602T3 ES 95903110 T ES95903110 T ES 95903110T ES 95903110 T ES95903110 T ES 95903110T ES 2147602 T3 ES2147602 T3 ES 2147602T3
Authority
ES
Spain
Prior art keywords
tests
telomerase activity
telomerase
activity
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903110T
Other languages
English (en)
Inventor
Calvin Bruce Harley
Nam Woo Kim
Scott Lawrence Weinrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2147602(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/153,051 external-priority patent/US5645986A/en
Priority claimed from US08/151,477 external-priority patent/US5830644A/en
Priority claimed from US08/255,774 external-priority patent/US5989807A/en
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of ES2147602T3 publication Critical patent/ES2147602T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA ACTIVIDAD DE LA TELOMERASA PRESENTE EN UNA MUESTRA SE PUEDE MEDIR SEGUN DOS PROTOCOLOS DE REACCION EN LOS QUE SE LLEVAN A CABO PASOS DE EXTENSION DE UN IMPRIMADOR Y DE UN SUSTRATO DE TELOMERASA.
ES95903110T 1993-11-12 1994-11-10 Ensayos de la actividad de la telomerasa. Expired - Lifetime ES2147602T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/153,051 US5645986A (en) 1992-05-13 1993-11-12 Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US08/151,477 US5830644A (en) 1992-05-13 1993-11-12 Method for screening for agents which increase telomerase activity in a cell
US08/255,774 US5989807A (en) 1992-05-13 1994-06-07 Detecting cancerous conditions by assaying for telomerase activity
US08/315,214 US5629154A (en) 1993-11-12 1994-09-28 Telomerase activity assays

Publications (1)

Publication Number Publication Date
ES2147602T3 true ES2147602T3 (es) 2000-09-16

Family

ID=27495974

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903110T Expired - Lifetime ES2147602T3 (es) 1993-11-12 1994-11-10 Ensayos de la actividad de la telomerasa.

Country Status (12)

Country Link
US (1) US5629154A (es)
EP (1) EP0728207B1 (es)
JP (2) JP2875394B2 (es)
AT (1) ATE193554T1 (es)
AU (1) AU682082B2 (es)
CA (1) CA2173872C (es)
DE (1) DE69424797T2 (es)
DK (1) DK0728207T3 (es)
ES (1) ES2147602T3 (es)
GR (1) GR3034249T3 (es)
PT (1) PT728207E (es)
WO (1) WO1995013381A1 (es)

Families Citing this family (58)

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US5693474A (en) * 1992-05-13 1997-12-02 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5804380A (en) * 1993-11-12 1998-09-08 Geron Corporation Telomerase activity assays
US5863726A (en) * 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US6013468A (en) * 1994-07-07 2000-01-11 Cold Spring Harbor Laboratory RNA component of telomerase
US5876979A (en) * 1994-07-07 1999-03-02 Cold Spring Harbor Laboratory RNA component of mouse, rat, Chinese hamster and bovine telomerase
US5698686A (en) * 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5741677A (en) * 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5840490A (en) * 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
JPH11507839A (ja) * 1995-06-07 1999-07-13 ジェロン コーポレイション テロメラーゼ活性検定
US6054442A (en) * 1995-07-06 2000-04-25 Board Of Regents, University Of Texas System Methods and compositions for modulation and inhibition of telomerase in vitro
US6004939A (en) * 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
US5856096A (en) * 1995-09-20 1999-01-05 Ctrc Research Foundation Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities
DE19644302A1 (de) * 1995-11-28 1997-06-05 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Telomerase-Aktivität
JPH09262100A (ja) * 1996-03-27 1997-10-07 Mount Sinai School Medicine City Univ New York テロメラーゼ活性の存在を測定することによる尿試料中のヒト膀胱癌細胞の検出方法
JPH1052300A (ja) * 1996-06-03 1998-02-24 Kyowa Hakko Kogyo Co Ltd 細胞内テロメラーゼ活性の測定法
JP3336230B2 (ja) 1996-06-28 2002-10-21 中外製薬株式会社 テロメラーゼ活性の検出方法
WO1998000563A1 (en) * 1996-06-28 1998-01-08 Chugai Seiyaku Kabushiki Kaisha Method for detecting telomerase activity
JPH1028600A (ja) * 1996-07-17 1998-02-03 Kyowa Hakko Kogyo Co Ltd テロメラーゼ活性の測定法
EP0841396B2 (en) 1996-10-01 2012-04-11 Geron Corporation Human telomerase catalytic subunit
CA2270132A1 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
WO1998026095A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
JP2001507229A (ja) 1996-12-20 2001-06-05 ジェロン コーポレイション テロメラーゼのｒｎａ成分を検出および阻害するための方法
DE19705071A1 (de) * 1997-02-11 1998-08-13 Guido Dr Krupp Verfahren zur "Echtzeit-Analyse" von Telomeraseaktivität
WO1999033861A1 (en) 1997-12-31 1999-07-08 University Of Texas Systems Improved telomerase extraction method
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
CA2347067C (en) 1998-03-31 2013-09-17 Geron Corporation Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer
US6017709A (en) * 1998-04-29 2000-01-25 University Of Houston DNA replication templates stabilized by guanine quartets
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US6664046B1 (en) 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
EP1170378A1 (en) * 2000-06-26 2002-01-09 Boehringer Ingelheim International GmbH Method for monitoring the effect of cancer therapies
US20020045219A1 (en) * 2000-08-02 2002-04-18 Whitehead Institute For Biomedical Research Production of human monoclonal antibodies
US6428962B1 (en) 2001-02-12 2002-08-06 Dna Analysis, Inc. Nucleic acid collection barrier method and apparatus
EP1321768A1 (en) * 2001-12-18 2003-06-25 Roche Diagnostics GmbH Diagnosis of endometriosis from menstrual blood
AU2003208580A1 (en) * 2002-02-05 2003-09-02 Technion Research And Development Foundation Ltd Lineage committed stem cells selected for telomerase promoter activity
AU2003220187A1 (en) * 2002-03-11 2003-09-29 Regents Of The University Of Minnesota Immortal porcine cells
US7390621B2 (en) * 2002-11-12 2008-06-24 Allied Biotech, Inc. Methods and compositions for detecting telomerase activity
CA2528483C (en) 2003-06-23 2012-04-10 Geron Corporation Compositions and methods for increasing telomerase activity
US9248088B2 (en) 2003-06-25 2016-02-02 Telomerase Activation Sciences, Inc. Compositions and methods for skin conditioning
US20070122501A1 (en) * 2003-06-27 2007-05-31 Hong Kong University Of Science And Technology Formulations containing astragalus extracts and uses thereof
KR101298493B1 (ko) 2003-09-09 2013-08-21 제론 코포레이션 텔로머라제 억제를 위한 변형 올리고뉴클레오티드
BRPI0608679A2 (pt) * 2005-04-01 2010-12-07 Medvet Science Pty. Ltd. métodos para detectar células neoplásicas não viáveis em um indivìduo, para avaliar e/ou monitorar uma condição neoplásica e a efetividade de um regime de tratamento terapêutico de neoplasma em um indivìduo e para tratar uma condição neoplásica e um cáncer metastásico em um indivìduo, kit diagnóstico para uma amostra biológica, uso de uma molécula interativa, composição farmacêutica, e, agente
US7998938B2 (en) 2005-04-15 2011-08-16 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
EP4474480A2 (en) 2006-10-30 2024-12-11 Geron Corporation Combined telomerase inhibitor and gemcitabine for the treatment of cancer
AU2008259342B2 (en) 2007-06-04 2014-07-10 Ben-Gurion University Of The Negev Research And Development Authority Tri-aryl compounds and compositions comprising the same
JP2011500087A (ja) * 2007-10-22 2011-01-06 ザ ウィスター インスティテュート テロメラーゼ活性を調節する化合物の同定方法
CN102448308B (zh) 2009-05-18 2014-08-06 吉隆公司 用于增加端粒酶活性的组合物和方法
US20120070842A1 (en) * 2009-06-01 2012-03-22 Harley Calvin B Assay for Telomerase Activity Using Microfluidic Device
WO2011106671A1 (en) * 2010-02-26 2011-09-01 Geron Corporation Assay for telomerase activity
CN103328652B (zh) 2010-04-16 2016-12-28 宙斯科学有限公司 测量用于测定未纯化的样品中细胞生活力的酶活性的方法
WO2013095684A1 (en) 2011-12-22 2013-06-27 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
US9708360B2 (en) 2013-09-30 2017-07-18 Geron Corporation Phosphorodiamidate backbone linkage for oligonucleotides
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
AU2018218003B2 (en) 2017-02-12 2024-02-08 Neuromagen Pharma Ltd. Telomerase activating compounds for use in fertility and related applications
IT201800002511A1 (it) 2018-02-08 2019-08-08 Univ Degli Studi Cagliari Metodo per la misurazione dell’attività della telomerasi

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Also Published As

Publication number Publication date
WO1995013381A1 (en) 1995-05-18
EP0728207B1 (en) 2000-05-31
CA2173872C (en) 2001-08-28
HK1011384A1 (en) 1999-07-09
AU682082B2 (en) 1997-09-18
US5629154A (en) 1997-05-13
DE69424797D1 (de) 2000-07-06
EP0728207A1 (en) 1996-08-28
DE69424797T2 (de) 2000-12-28
CA2173872A1 (en) 1995-05-18
DK0728207T3 (da) 2000-10-02
JPH11243998A (ja) 1999-09-14
JP2875394B2 (ja) 1999-03-31
GR3034249T3 (en) 2000-12-29
AU1209095A (en) 1995-05-29
JPH09502102A (ja) 1997-03-04
PT728207E (pt) 2000-11-30
ATE193554T1 (de) 2000-06-15

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