ES2147602T3 - Ensayos de la actividad de la telomerasa. - Google Patents

Ensayos de la actividad de la telomerasa.

Info

Publication number
ES2147602T3
ES2147602T3 ES95903110T ES95903110T ES2147602T3 ES 2147602 T3 ES2147602 T3 ES 2147602T3 ES 95903110 T ES95903110 T ES 95903110T ES 95903110 T ES95903110 T ES 95903110T ES 2147602 T3 ES2147602 T3 ES 2147602T3
Authority
ES
Spain
Prior art keywords
tests
telomerase activity
telomerase
activity
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903110T
Other languages
English (en)
Inventor
Calvin Bruce Harley
Nam Woo Kim
Scott Lawrence Weinrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2147602(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/151,477 external-priority patent/US5830644A/en
Priority claimed from US08/153,051 external-priority patent/US5645986A/en
Priority claimed from US08/255,774 external-priority patent/US5989807A/en
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of ES2147602T3 publication Critical patent/ES2147602T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA ACTIVIDAD DE LA TELOMERASA PRESENTE EN UNA MUESTRA SE PUEDE MEDIR SEGUN DOS PROTOCOLOS DE REACCION EN LOS QUE SE LLEVAN A CABO PASOS DE EXTENSION DE UN IMPRIMADOR Y DE UN SUSTRATO DE TELOMERASA.
ES95903110T 1993-11-12 1994-11-10 Ensayos de la actividad de la telomerasa. Expired - Lifetime ES2147602T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/151,477 US5830644A (en) 1992-05-13 1993-11-12 Method for screening for agents which increase telomerase activity in a cell
US08/153,051 US5645986A (en) 1992-05-13 1993-11-12 Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US08/255,774 US5989807A (en) 1992-05-13 1994-06-07 Detecting cancerous conditions by assaying for telomerase activity
US08/315,214 US5629154A (en) 1993-11-12 1994-09-28 Telomerase activity assays

Publications (1)

Publication Number Publication Date
ES2147602T3 true ES2147602T3 (es) 2000-09-16

Family

ID=27495974

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903110T Expired - Lifetime ES2147602T3 (es) 1993-11-12 1994-11-10 Ensayos de la actividad de la telomerasa.

Country Status (13)

Country Link
US (1) US5629154A (es)
EP (1) EP0728207B1 (es)
JP (2) JP2875394B2 (es)
AT (1) ATE193554T1 (es)
AU (1) AU682082B2 (es)
CA (1) CA2173872C (es)
DE (1) DE69424797T2 (es)
DK (1) DK0728207T3 (es)
ES (1) ES2147602T3 (es)
GR (1) GR3034249T3 (es)
HK (1) HK1011384A1 (es)
PT (1) PT728207E (es)
WO (1) WO1995013381A1 (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693474A (en) * 1992-05-13 1997-12-02 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5863726A (en) * 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US5804380A (en) * 1993-11-12 1998-09-08 Geron Corporation Telomerase activity assays
US5876979A (en) * 1994-07-07 1999-03-02 Cold Spring Harbor Laboratory RNA component of mouse, rat, Chinese hamster and bovine telomerase
US6013468A (en) * 1994-07-07 2000-01-11 Cold Spring Harbor Laboratory RNA component of telomerase
US5698686A (en) * 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
WO1997015687A1 (en) * 1995-06-07 1997-05-01 Geron Corporation Telomerase activity assays
US5741677A (en) * 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5840490A (en) * 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
US6004939A (en) 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
US6054442A (en) * 1995-07-06 2000-04-25 Board Of Regents, University Of Texas System Methods and compositions for modulation and inhibition of telomerase in vitro
US5856096A (en) * 1995-09-20 1999-01-05 Ctrc Research Foundation Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities
DE19644302A1 (de) * 1995-11-28 1997-06-05 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Telomerase-Aktivität
JPH09262100A (ja) * 1996-03-27 1997-10-07 Mount Sinai School Medicine City Univ New York テロメラーゼ活性の存在を測定することによる尿試料中のヒト膀胱癌細胞の検出方法
JPH1052300A (ja) * 1996-06-03 1998-02-24 Kyowa Hakko Kogyo Co Ltd 細胞内テロメラーゼ活性の測定法
EP0930369B1 (en) * 1996-06-28 2005-11-09 Rebio Gen, Inc. Method for detecting telomerase activity
JPH1028600A (ja) * 1996-07-17 1998-02-03 Kyowa Hakko Kogyo Co Ltd テロメラーゼ活性の測定法
EP1783139B8 (en) 1996-10-01 2009-09-23 Geron Corporation Human telomerase catalytic subunit
US20030129589A1 (en) * 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
WO1998028442A1 (en) 1996-12-20 1998-07-02 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
DE19705071A1 (de) * 1997-02-11 1998-08-13 Guido Dr Krupp Verfahren zur "Echtzeit-Analyse" von Telomeraseaktivität
US6210915B1 (en) 1997-12-31 2001-04-03 University Of Texas Systems Telomerase extraction method
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
JP2002509716A (ja) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物
US6017709A (en) * 1998-04-29 2000-01-25 University Of Houston DNA replication templates stabilized by guanine quartets
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US6664046B1 (en) 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
EP1170378A1 (en) * 2000-06-26 2002-01-09 Boehringer Ingelheim International GmbH Method for monitoring the effect of cancer therapies
US20020045219A1 (en) * 2000-08-02 2002-04-18 Whitehead Institute For Biomedical Research Production of human monoclonal antibodies
US6428962B1 (en) 2001-02-12 2002-08-06 Dna Analysis, Inc. Nucleic acid collection barrier method and apparatus
EP1321768A1 (en) * 2001-12-18 2003-06-25 Roche Diagnostics GmbH Diagnosis of endometriosis from menstrual blood
EP1472340A4 (en) * 2002-02-05 2006-11-08 Rappaport Family Inst For Res STRAIN CELLS SELECTED FOR TELOMERASEPROMOTORACTIVITY, CELL-LINKED
US20030232409A1 (en) * 2002-03-11 2003-12-18 Regents Of The University Of Minnesota Immortal porcine cells
RU2005118073A (ru) * 2002-11-12 2006-06-10 Эллайд Байотек, Инк. (Us) Способы и композиции для детекции теломеразной активности
BRPI0411856A (pt) * 2003-06-23 2006-08-29 Geron Corp composições e métodos para o aumento da atividade de telomerase
WO2005000248A2 (en) 2003-06-25 2005-01-06 Geron Corporation Compositions and methods for skin conditioning
US20070122501A1 (en) * 2003-06-27 2007-05-31 Hong Kong University Of Science And Technology Formulations containing astragalus extracts and uses thereof
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
KR20080003388A (ko) * 2005-04-01 2008-01-07 메드벳 싸이언스 피티와이. 리미티드 진단 및 치료 방법, 및 이에 유용한 제제
EP1876893B1 (en) 2005-04-15 2012-04-11 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
PL2101789T3 (pl) 2006-10-30 2015-05-29 Geron Corp Inhibitor telomerazy skojarzony z gemcytabiną do leczenia nowotworu
CA2690004C (en) 2007-06-04 2018-01-23 Ben-Gurion University Of The Negev Research And Development Authority Tri-aryl compounds and compositions comprising the same
CN101835899A (zh) * 2007-10-22 2010-09-15 威斯特研究所 调节端粒酶活性的化合物的鉴定方法
WO2010135247A1 (en) 2009-05-18 2010-11-25 TA Therapeutics, Ltd. Compositions and methods for increasing telomerase activity
WO2010141385A1 (en) * 2009-06-01 2010-12-09 Geron Corporation Assay for telomerase activity using microfluidic device
US9249452B2 (en) * 2010-02-26 2016-02-02 Zhu Zhen Pirot Method of detecting and assaying telomerase activity of telomerase bound by anti-telomerase antibodies
SG10201502900PA (en) 2010-04-16 2015-06-29 Zeus Scientific Inc Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
EP3868772A1 (en) 2013-09-30 2021-08-25 Geron Corporation Phosphorodiamidate backbone linkage for oligonucleotides
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
AU2018218003B2 (en) 2017-02-12 2024-02-08 Neuromagen Pharma Ltd. Telomerase activating compounds for use in fertility and related applications
IT201800002511A1 (it) 2018-02-08 2019-08-08 Univ Degli Studi Cagliari Metodo per la misurazione dell’attività della telomerasi

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3942482A (en) * 1974-10-09 1976-03-09 Foster Wheeler Energy Corporation Bayonet tube steam generator
US4424279A (en) * 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
CH663475A5 (de) * 1983-09-02 1987-12-15 Zellweger Uster Ag Verfahren und vorrichtung zum programmieren von messgeraeten und reglern.
JPS60135753A (ja) * 1983-12-23 1985-07-19 Koa Sangyo Kk 非接触水分検知装置
JPS60161554A (ja) * 1984-02-01 1985-08-23 Furuno Electric Co Ltd 塩分濃度計
US5310652A (en) * 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5334499A (en) * 1989-04-17 1994-08-02 Eastman Kodak Company Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction
US5231015A (en) * 1989-10-18 1993-07-27 Eastman Kodak Company Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme
US5413924A (en) * 1992-02-13 1995-05-09 Kosak; Kenneth M. Preparation of wax beads containing a reagent for release by heating
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5523389A (en) * 1992-09-29 1996-06-04 Isis Pharmaceuticals, Inc. Inhibitors of human immunodeficiency virus

Also Published As

Publication number Publication date
DK0728207T3 (da) 2000-10-02
EP0728207A1 (en) 1996-08-28
PT728207E (pt) 2000-11-30
GR3034249T3 (en) 2000-12-29
EP0728207B1 (en) 2000-05-31
ATE193554T1 (de) 2000-06-15
HK1011384A1 (en) 1999-07-09
DE69424797D1 (de) 2000-07-06
CA2173872A1 (en) 1995-05-18
DE69424797T2 (de) 2000-12-28
JPH11243998A (ja) 1999-09-14
AU682082B2 (en) 1997-09-18
CA2173872C (en) 2001-08-28
US5629154A (en) 1997-05-13
JPH09502102A (ja) 1997-03-04
JP2875394B2 (ja) 1999-03-31
AU1209095A (en) 1995-05-29
WO1995013381A1 (en) 1995-05-18

Similar Documents

Publication Publication Date Title
ES2147602T3 (es) Ensayos de la actividad de la telomerasa.
BRPI9816332B8 (pt) tira de teste de biossensor eletroquímico aperfeiçoada
NL191956C (nl) Elektrochemische meetcel voor amperometrische bepaling van ammoniak en zijn derivaten.
CA2142868A1 (en) Chemical and microbiological test kit
MY115627A (en) Visual blood glucose test strip
DE69836126D1 (de) Verfahren zur einbringung einer funktionalität
DE3686349D1 (de) Einzelschritt-heterogene probe und satz.
NO873479D0 (no) Podede kopolymerer fremstilt ved opploesningsmiddelfrie reaksjoner og dispersjonsmiddelderivater derav.
EP0653637A3 (en) Dry elements, test devices and kits and methods for chemiluminescent detection of analytes using reagents marked with peroxidase.
DE69616689D1 (de) Stanzbearbeitungsverfahren und mit diesem Bearbeitungsverfahren benutztes rollenförmiges Werkzeug
DK0513078T3 (da) Kolorimetrisk, enzymatisk analyse
DK0645007T3 (da) Sensor til optisk analyse
AU6927587A (en) Quantitative determination of nucleic acid molecules and the reagent kit used
AU6617294A (en) Use of electrode system, comprising measurement electrode, reference electrode and counterelectrode, in measuring hydrogen peroxide concentration
BR8701763A (pt) Composicao de revestimento;e substrato
AU2666997A (en) In vitro prognostic test for progressors and non-progressors after hiv infection
AU5297390A (en) Method of immunologically assaying human thrombin- antithrombin iii complex, assay reagent and kit therefor
BR9003462A (pt) Dispersao tixotropica,composicao de revestimento e substrato revestido
BR9407433A (pt) Reagente e teste de célula
DE69709485D1 (de) Reagenszusammensetzung, Teststück und Testkit
EP0811693A3 (en) A method of determining intracellular telomerase activity
DE68920659D1 (de) Nukleosidoxidase und analytisches verfahren.
AU635355B2 (en) Immunoassay of human thrombomodulin, and reagent and kit therefor
BR9605715A (pt) Conjunto de porta-recipeinte e conjunto de retentor
DE69017090D1 (de) Chromogene Dibenzoxazepinon- und Dibenzothiazepinon-Enzymsubstrate.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 728207

Country of ref document: ES