DK0728207T3 - Telomeraseaktivitetsassays - Google Patents

Telomeraseaktivitetsassays

Info

Publication number
DK0728207T3
DK0728207T3 DK95903110T DK95903110T DK0728207T3 DK 0728207 T3 DK0728207 T3 DK 0728207T3 DK 95903110 T DK95903110 T DK 95903110T DK 95903110 T DK95903110 T DK 95903110T DK 0728207 T3 DK0728207 T3 DK 0728207T3
Authority
DK
Denmark
Prior art keywords
telomerase activity
activity assays
telomerase
sample
measured
Prior art date
Application number
DK95903110T
Other languages
English (en)
Inventor
Calvin Bruce Harley
Nam Woo Kim
Scott Lawrence Weinrich
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0728207(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/153,051 external-priority patent/US5645986A/en
Priority claimed from US08/151,477 external-priority patent/US5830644A/en
Priority claimed from US08/255,774 external-priority patent/US5989807A/en
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of DK0728207T3 publication Critical patent/DK0728207T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
DK95903110T 1993-11-12 1994-11-10 Telomeraseaktivitetsassays DK0728207T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/153,051 US5645986A (en) 1992-05-13 1993-11-12 Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US08/151,477 US5830644A (en) 1992-05-13 1993-11-12 Method for screening for agents which increase telomerase activity in a cell
US08/255,774 US5989807A (en) 1992-05-13 1994-06-07 Detecting cancerous conditions by assaying for telomerase activity
US08/315,214 US5629154A (en) 1993-11-12 1994-09-28 Telomerase activity assays
PCT/US1994/012951 WO1995013381A1 (en) 1993-11-12 1994-11-10 Telomerase activity assays

Publications (1)

Publication Number Publication Date
DK0728207T3 true DK0728207T3 (da) 2000-10-02

Family

ID=27495974

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903110T DK0728207T3 (da) 1993-11-12 1994-11-10 Telomeraseaktivitetsassays

Country Status (13)

Country Link
US (1) US5629154A (da)
EP (1) EP0728207B1 (da)
JP (2) JP2875394B2 (da)
AT (1) ATE193554T1 (da)
AU (1) AU682082B2 (da)
CA (1) CA2173872C (da)
DE (1) DE69424797T2 (da)
DK (1) DK0728207T3 (da)
ES (1) ES2147602T3 (da)
GR (1) GR3034249T3 (da)
HK (1) HK1011384A1 (da)
PT (1) PT728207E (da)
WO (1) WO1995013381A1 (da)

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US5804380A (en) * 1993-11-12 1998-09-08 Geron Corporation Telomerase activity assays
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US5876979A (en) * 1994-07-07 1999-03-02 Cold Spring Harbor Laboratory RNA component of mouse, rat, Chinese hamster and bovine telomerase
US6013468A (en) * 1994-07-07 2000-01-11 Cold Spring Harbor Laboratory RNA component of telomerase
US5698686A (en) * 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
US5741677A (en) * 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5840490A (en) * 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
WO1997015687A1 (en) * 1995-06-07 1997-05-01 Geron Corporation Telomerase activity assays
US6054442A (en) * 1995-07-06 2000-04-25 Board Of Regents, University Of Texas System Methods and compositions for modulation and inhibition of telomerase in vitro
US6004939A (en) 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
US5856096A (en) * 1995-09-20 1999-01-05 Ctrc Research Foundation Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities
DE19644302A1 (de) * 1995-11-28 1997-06-05 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Telomerase-Aktivität
JPH09262100A (ja) * 1996-03-27 1997-10-07 Mount Sinai School Medicine City Univ New York テロメラーゼ活性の存在を測定することによる尿試料中のヒト膀胱癌細胞の検出方法
JPH1052300A (ja) * 1996-06-03 1998-02-24 Kyowa Hakko Kogyo Co Ltd 細胞内テロメラーゼ活性の測定法
DE69734595T2 (de) * 1996-06-28 2006-08-10 Rebio Gen, Inc., Hachioji Verfahren zum entdecken von telomerase-aktivität
JPH1028600A (ja) * 1996-07-17 1998-02-03 Kyowa Hakko Kogyo Co Ltd テロメラーゼ活性の測定法
DE69723531T3 (de) 1996-10-01 2012-09-06 Geron Corp. Katalytische Untereinheit der menschlichen Telomerase
EP0954612A2 (en) * 1996-11-06 1999-11-10 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
CA2274586A1 (en) 1996-12-20 1998-07-02 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
DE19705071A1 (de) * 1997-02-11 1998-08-13 Guido Dr Krupp Verfahren zur "Echtzeit-Analyse" von Telomeraseaktivität
US6210915B1 (en) 1997-12-31 2001-04-03 University Of Texas Systems Telomerase extraction method
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
JP2002509716A (ja) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物
US6017709A (en) * 1998-04-29 2000-01-25 University Of Houston DNA replication templates stabilized by guanine quartets
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US6664046B1 (en) 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
EP1170378A1 (en) * 2000-06-26 2002-01-09 Boehringer Ingelheim International GmbH Method for monitoring the effect of cancer therapies
US20020045219A1 (en) * 2000-08-02 2002-04-18 Whitehead Institute For Biomedical Research Production of human monoclonal antibodies
US6428962B1 (en) 2001-02-12 2002-08-06 Dna Analysis, Inc. Nucleic acid collection barrier method and apparatus
EP1321768A1 (en) * 2001-12-18 2003-06-25 Roche Diagnostics GmbH Diagnosis of endometriosis from menstrual blood
WO2003066839A1 (en) * 2002-02-05 2003-08-14 Rappaport Family Institute For Research In The Medical Sciences Lineage committed stem cells selected for telomerase promoter activity
AU2003220187A1 (en) * 2002-03-11 2003-09-29 Regents Of The University Of Minnesota Immortal porcine cells
CA2505871A1 (en) * 2002-11-12 2004-05-27 Allied Biotech, Inc. Methods and compositions for detecting telomerase activity
DK1644009T3 (da) * 2003-06-23 2018-03-05 Telomerase Activation Sciences Inc Sammensætninger til forøgelse af telomeraseaktivitet og behandling af HIV-infektion
WO2005000248A2 (en) 2003-06-25 2005-01-06 Geron Corporation Compositions and methods for skin conditioning
US20070122501A1 (en) * 2003-06-27 2007-05-31 Hong Kong University Of Science And Technology Formulations containing astragalus extracts and uses thereof
PL1667522T3 (pl) 2003-09-09 2018-06-29 Geron Corporation Zmodyfikowane oligonukleotydy do hamowania telomerazy
RU2007140371A (ru) * 2005-04-01 2009-06-10 Медвет Сайенс Пти. Лтд. (Au) Способ диагностики и лечения рака и пригодные для этого вещества
WO2006113470A2 (en) 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
TR201819789T4 (tr) * 2006-10-30 2019-01-21 Geron Corp Kanser tedavisine yönelik gemsitabin ve kombine telomeraz inhibitörü.
EA021544B1 (ru) 2007-06-04 2015-07-30 Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити Триарильные соединения и фармацевтические композиции, их содержащие
US8374838B2 (en) * 2007-10-22 2013-02-12 The Wistar Institute Method for identifying a compound that modulates telomerase activity
ES2596631T3 (es) * 2009-05-18 2017-01-11 Telomerase Activation Sciences, Inc. Composiciones y métodos para aumentar la actividad telomerasa
WO2010141385A1 (en) * 2009-06-01 2010-12-09 Geron Corporation Assay for telomerase activity using microfluidic device
WO2011106671A1 (en) * 2010-02-26 2011-09-01 Geron Corporation Assay for telomerase activity
CA2796676C (en) † 2010-04-16 2020-07-14 Zeus Scientific, Inc. Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
US9593137B2 (en) 2011-12-22 2017-03-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
JP6794258B2 (ja) 2013-09-30 2020-12-02 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ オリゴヌクレオチドについてのホスホロジアミデート骨格結合
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
WO2018146689A1 (en) 2017-02-12 2018-08-16 Ben-Gurion University Of The Negev Research And Development Authority Telomerase activating compounds for use in fertility and related applications
IT201800002511A1 (it) 2018-02-08 2019-08-08 Univ Degli Studi Cagliari Metodo per la misurazione dell’attività della telomerasi

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Also Published As

Publication number Publication date
EP0728207A1 (en) 1996-08-28
JP2875394B2 (ja) 1999-03-31
PT728207E (pt) 2000-11-30
JPH11243998A (ja) 1999-09-14
JPH09502102A (ja) 1997-03-04
ES2147602T3 (es) 2000-09-16
DE69424797T2 (de) 2000-12-28
CA2173872A1 (en) 1995-05-18
US5629154A (en) 1997-05-13
ATE193554T1 (de) 2000-06-15
GR3034249T3 (en) 2000-12-29
DE69424797D1 (de) 2000-07-06
WO1995013381A1 (en) 1995-05-18
AU682082B2 (en) 1997-09-18
CA2173872C (en) 2001-08-28
EP0728207B1 (en) 2000-05-31
HK1011384A1 (en) 1999-07-09
AU1209095A (en) 1995-05-29

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