ATE193554T1 - Telomerase-aktivitätsversuche - Google Patents
Telomerase-aktivitätsversucheInfo
- Publication number
- ATE193554T1 ATE193554T1 AT95903110T AT95903110T ATE193554T1 AT E193554 T1 ATE193554 T1 AT E193554T1 AT 95903110 T AT95903110 T AT 95903110T AT 95903110 T AT95903110 T AT 95903110T AT E193554 T1 ATE193554 T1 AT E193554T1
- Authority
- AT
- Austria
- Prior art keywords
- telomerase activity
- activity experiments
- telomerase
- experiments
- sample
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/151,477 US5830644A (en) | 1992-05-13 | 1993-11-12 | Method for screening for agents which increase telomerase activity in a cell |
US08/153,051 US5645986A (en) | 1992-05-13 | 1993-11-12 | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US08/255,774 US5989807A (en) | 1992-05-13 | 1994-06-07 | Detecting cancerous conditions by assaying for telomerase activity |
US08/315,214 US5629154A (en) | 1993-11-12 | 1994-09-28 | Telomerase activity assays |
PCT/US1994/012951 WO1995013381A1 (en) | 1993-11-12 | 1994-11-10 | Telomerase activity assays |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE193554T1 true ATE193554T1 (de) | 2000-06-15 |
Family
ID=27495974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95903110T ATE193554T1 (de) | 1993-11-12 | 1994-11-10 | Telomerase-aktivitätsversuche |
Country Status (13)
Country | Link |
---|---|
US (1) | US5629154A (de) |
EP (1) | EP0728207B1 (de) |
JP (2) | JP2875394B2 (de) |
AT (1) | ATE193554T1 (de) |
AU (1) | AU682082B2 (de) |
CA (1) | CA2173872C (de) |
DE (1) | DE69424797T2 (de) |
DK (1) | DK0728207T3 (de) |
ES (1) | ES2147602T3 (de) |
GR (1) | GR3034249T3 (de) |
HK (1) | HK1011384A1 (de) |
PT (1) | PT728207E (de) |
WO (1) | WO1995013381A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5693474A (en) * | 1992-05-13 | 1997-12-02 | Board Of Regents, University Of Texas System | Methods for cancer diagnosis and prognosis |
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
US5804380A (en) * | 1993-11-12 | 1998-09-08 | Geron Corporation | Telomerase activity assays |
US5863726A (en) * | 1993-11-12 | 1999-01-26 | Geron Corporation | Telomerase activity assays |
US6013468A (en) * | 1994-07-07 | 2000-01-11 | Cold Spring Harbor Laboratory | RNA component of telomerase |
US5876979A (en) * | 1994-07-07 | 1999-03-02 | Cold Spring Harbor Laboratory | RNA component of mouse, rat, Chinese hamster and bovine telomerase |
US5698686A (en) * | 1994-10-20 | 1997-12-16 | Arch Development Corporation | Yeast telomerase compositions |
US5840490A (en) * | 1995-06-07 | 1998-11-24 | Mcmaster University | Telomerase activity associated with hematological and colorectal malignancies |
WO1997015687A1 (en) * | 1995-06-07 | 1997-05-01 | Geron Corporation | Telomerase activity assays |
US5741677A (en) * | 1995-06-07 | 1998-04-21 | Geron Corporation | Methods for measuring telomere length |
US6004939A (en) | 1995-07-06 | 1999-12-21 | Ctrc Research Foundation Board Of Regents | Methods for modulation and inhibition of telomerase |
US6054442A (en) * | 1995-07-06 | 2000-04-25 | Board Of Regents, University Of Texas System | Methods and compositions for modulation and inhibition of telomerase in vitro |
US5856096A (en) * | 1995-09-20 | 1999-01-05 | Ctrc Research Foundation | Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities |
DE19644302A1 (de) * | 1995-11-28 | 1997-06-05 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Telomerase-Aktivität |
JPH09262100A (ja) * | 1996-03-27 | 1997-10-07 | Mount Sinai School Medicine City Univ New York | テロメラーゼ活性の存在を測定することによる尿試料中のヒト膀胱癌細胞の検出方法 |
JPH1052300A (ja) * | 1996-06-03 | 1998-02-24 | Kyowa Hakko Kogyo Co Ltd | 細胞内テロメラーゼ活性の測定法 |
AU3276497A (en) * | 1996-06-28 | 1998-01-21 | Chugai Seiyaku Kabushiki Kaisha | Method for detecting telomerase activity |
JPH1028600A (ja) * | 1996-07-17 | 1998-02-03 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ活性の測定法 |
JP2001523947A (ja) | 1996-10-01 | 2001-11-27 | ジェロン コーポレイション | テロメラーゼ逆転写酵素 |
WO1998020166A2 (en) * | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
US7390891B1 (en) | 1996-11-15 | 2008-06-24 | Amgen Inc. | Polynucleotides encoding a telomerase component TP2 |
AU733610B2 (en) | 1996-12-20 | 2001-05-17 | Geron Corporation | Methods for detecting and inhibiting the RNA component of telomerase |
US5846723A (en) * | 1996-12-20 | 1998-12-08 | Geron Corporation | Methods for detecting the RNA component of telomerase |
DE19705071A1 (de) * | 1997-02-11 | 1998-08-13 | Guido Dr Krupp | Verfahren zur "Echtzeit-Analyse" von Telomeraseaktivität |
WO1999033861A1 (en) | 1997-12-31 | 1999-07-08 | University Of Texas Systems | Improved telomerase extraction method |
DE19804372A1 (de) * | 1998-02-04 | 1999-08-05 | Michael W Dr Dr Dahm | Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits |
JP2002509716A (ja) | 1998-03-31 | 2002-04-02 | ユニバーシティ テクノロジー コーポレイション | テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物 |
US6017709A (en) * | 1998-04-29 | 2000-01-25 | University Of Houston | DNA replication templates stabilized by guanine quartets |
JP4013333B2 (ja) * | 1998-06-05 | 2007-11-28 | 株式会社B&Cラボラトリーズ | 皮膚の老化度の測定方法および測定用キット |
US6664046B1 (en) | 1999-12-16 | 2003-12-16 | Roche Molecular Systems, Inc. | Quantitation of hTERT mRNA expression |
EP1170378A1 (de) * | 2000-06-26 | 2002-01-09 | Boehringer Ingelheim International GmbH | Verfahren zur Abschätzung des Effektes von Krebstherapien |
US20020045219A1 (en) * | 2000-08-02 | 2002-04-18 | Whitehead Institute For Biomedical Research | Production of human monoclonal antibodies |
US6428962B1 (en) | 2001-02-12 | 2002-08-06 | Dna Analysis, Inc. | Nucleic acid collection barrier method and apparatus |
EP1321768A1 (de) * | 2001-12-18 | 2003-06-25 | Roche Diagnostics GmbH | Diagnose von Endometriose aus Menstruationsblut |
AU2003208580A1 (en) * | 2002-02-05 | 2003-09-02 | Technion Research And Development Foundation Ltd | Lineage committed stem cells selected for telomerase promoter activity |
US20030232409A1 (en) * | 2002-03-11 | 2003-12-18 | Regents Of The University Of Minnesota | Immortal porcine cells |
MXPA05005039A (es) * | 2002-11-12 | 2005-11-17 | Allied Biotech Inc | Metodos y composiciones para detectar actividad telomerasa. |
CN1809364B (zh) | 2003-06-23 | 2010-06-16 | 杰龙公司 | 增加端粒酶活性的组合物和方法 |
US9248088B2 (en) | 2003-06-25 | 2016-02-02 | Telomerase Activation Sciences, Inc. | Compositions and methods for skin conditioning |
US20070122501A1 (en) * | 2003-06-27 | 2007-05-31 | Hong Kong University Of Science And Technology | Formulations containing astragalus extracts and uses thereof |
KR20060132802A (ko) | 2003-09-09 | 2006-12-22 | 제론 코포레이션 | 텔로머라제 억제를 위한 변형 올리고뉴클레오티드 |
US20090214420A1 (en) * | 2005-04-01 | 2009-08-27 | Medvet Science Pty. Ltd. | Method of Diagnosis and Treatment and Agents Useful for Same |
WO2006113470A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
LT2898887T (lt) | 2006-10-30 | 2018-11-12 | Geron Corporation | Telomerazės inhibitoriaus ir gemcitabino derinys vėžio gydymui |
AU2008259342B2 (en) | 2007-06-04 | 2014-07-10 | Ben-Gurion University Of The Negev Research And Development Authority | Tri-aryl compounds and compositions comprising the same |
AU2008317002A1 (en) * | 2007-10-22 | 2009-04-30 | The Wistar Institute | Method for identifying a compound that modulates telomerase activity |
DK2437606T3 (en) * | 2009-05-18 | 2016-09-12 | Telomerase Activation Sciences Inc | Compositions and methods for increasing the telomerase activity |
US20120070842A1 (en) * | 2009-06-01 | 2012-03-22 | Harley Calvin B | Assay for Telomerase Activity Using Microfluidic Device |
WO2011106671A1 (en) * | 2010-02-26 | 2011-09-01 | Geron Corporation | Assay for telomerase activity |
MY161567A (en) | 2010-04-16 | 2017-04-28 | Zeus Scientific Inc | Methods for measuring enzyme activity useful in determining cell viability in non-purified samples |
EP3578563B1 (de) | 2011-12-22 | 2021-04-14 | Geron Corporation | Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren |
EP3868772A1 (de) | 2013-09-30 | 2021-08-25 | Geron Corporation | Phosphorodiamidat-rückgratverbindung für oligonukleotide |
JOP20200257A1 (ar) | 2014-05-01 | 2017-06-16 | Geron Corp | تركيبات أوليجو نوكليوتيد وطرق لتحضيرها |
WO2018146689A1 (en) | 2017-02-12 | 2018-08-16 | Ben-Gurion University Of The Negev Research And Development Authority | Telomerase activating compounds for use in fertility and related applications |
IT201800002511A1 (it) | 2018-02-08 | 2019-08-08 | Univ Degli Studi Cagliari | Metodo per la misurazione dell’attività della telomerasi |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3942482A (en) * | 1974-10-09 | 1976-03-09 | Foster Wheeler Energy Corporation | Bayonet tube steam generator |
US4424279A (en) * | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
CH663475A5 (de) * | 1983-09-02 | 1987-12-15 | Zellweger Uster Ag | Verfahren und vorrichtung zum programmieren von messgeraeten und reglern. |
JPS60135753A (ja) * | 1983-12-23 | 1985-07-19 | Koa Sangyo Kk | 非接触水分検知装置 |
JPS60161554A (ja) * | 1984-02-01 | 1985-08-23 | Furuno Electric Co Ltd | 塩分濃度計 |
US5310652A (en) * | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
US5334499A (en) * | 1989-04-17 | 1994-08-02 | Eastman Kodak Company | Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction |
US5231015A (en) * | 1989-10-18 | 1993-07-27 | Eastman Kodak Company | Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme |
US5413924A (en) * | 1992-02-13 | 1995-05-09 | Kosak; Kenneth M. | Preparation of wax beads containing a reagent for release by heating |
US5489508A (en) * | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
IL107150A0 (en) * | 1992-09-29 | 1993-12-28 | Isis Pharmaceuticals Inc | Oligonucleotides having a conserved g4 core sequence |
-
1994
- 1994-09-28 US US08/315,214 patent/US5629154A/en not_active Expired - Lifetime
- 1994-11-10 AU AU12090/95A patent/AU682082B2/en not_active Expired
- 1994-11-10 WO PCT/US1994/012951 patent/WO1995013381A1/en active IP Right Grant
- 1994-11-10 PT PT95903110T patent/PT728207E/pt unknown
- 1994-11-10 DE DE1994624797 patent/DE69424797T2/de not_active Expired - Lifetime
- 1994-11-10 EP EP19950903110 patent/EP0728207B1/de not_active Expired - Lifetime
- 1994-11-10 CA CA 2173872 patent/CA2173872C/en not_active Expired - Lifetime
- 1994-11-10 ES ES95903110T patent/ES2147602T3/es not_active Expired - Lifetime
- 1994-11-10 AT AT95903110T patent/ATE193554T1/de active
- 1994-11-10 DK DK95903110T patent/DK0728207T3/da active
- 1994-11-10 JP JP51399795A patent/JP2875394B2/ja not_active Expired - Lifetime
-
1998
- 1998-09-28 JP JP10273689A patent/JPH11243998A/ja active Pending
- 1998-11-30 HK HK98112561A patent/HK1011384A1/xx unknown
-
2000
- 2000-08-23 GR GR20000401936T patent/GR3034249T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT728207E (pt) | 2000-11-30 |
EP0728207B1 (de) | 2000-05-31 |
CA2173872C (en) | 2001-08-28 |
EP0728207A1 (de) | 1996-08-28 |
DE69424797T2 (de) | 2000-12-28 |
US5629154A (en) | 1997-05-13 |
AU682082B2 (en) | 1997-09-18 |
AU1209095A (en) | 1995-05-29 |
HK1011384A1 (en) | 1999-07-09 |
WO1995013381A1 (en) | 1995-05-18 |
DK0728207T3 (da) | 2000-10-02 |
JPH11243998A (ja) | 1999-09-14 |
JP2875394B2 (ja) | 1999-03-31 |
DE69424797D1 (de) | 2000-07-06 |
GR3034249T3 (en) | 2000-12-29 |
CA2173872A1 (en) | 1995-05-18 |
ES2147602T3 (es) | 2000-09-16 |
JPH09502102A (ja) | 1997-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |