ES2144409T3 - Composiciones para el tratamiento de las onicomicosis. - Google Patents
Composiciones para el tratamiento de las onicomicosis.Info
- Publication number
- ES2144409T3 ES2144409T3 ES92400384T ES92400384T ES2144409T3 ES 2144409 T3 ES2144409 T3 ES 2144409T3 ES 92400384 T ES92400384 T ES 92400384T ES 92400384 T ES92400384 T ES 92400384T ES 2144409 T3 ES2144409 T3 ES 2144409T3
- Authority
- ES
- Spain
- Prior art keywords
- hcl
- antifungal
- glycol
- agents
- penetration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
Abstract
LOS AGENTES DE PENETRACION HIDROFILOS HABITUALMENTE UTILIZADOS PARA LA PENETRACION TRANSCUTANEA DE AGENTES ACTIVOS MEJORAN, DE FORMA SORPRENDENTE, LA PENETRACION DE AGENTES ANTIFUNGICOS A TRAVES DE LA UÑA. UNA COMPOSICION DERMATOLOGICA CORRESPONDIENTE COMPRENDE, AL MENOS, UN AGENTE ANTIFUNGICO ELEGIDO, SOBRE TODO, ENTRE LOS DE LA FAMILIA DE LAS ALILAMINAS, COMO LA TERBINAFINA-HCI Y LA NAFTIFINA-HCI; AL MENOS, UN AGENTE DE PENETRACION HIDROFILO ELEGIDO, SOBRE TODO, ENTRE LOS GLICOLES, LOS MONOETERES DE GLICOLES, LOS DIETERES DE GLICOLES, EL DIMETILSULFOXIDO, LA COPRALACTAMA, EL DIMETILISOSORBIDO, EL ISOPROPILIDENO GLICEROL, LA DIMETILIMIDAZOLIDONA, EL LACTATO DE ETILO, LOS GLICERIDOS EN C8-C10 POLIOXIETILENOS, EL POLIETILENO GLICOL 20 GLICERIL LAURATO Y EL DIMETILACETAMIDA; Y UN MEDIO HIDROALCOHOLICO QUE SOLUBILIZA DICHO (O DICHOS) AGENTE(S) ANTIFUNGICO(S) Y CON EL QUE DICHO (O DICHOS) AGENTE(S) ANTIFUNGICO(S) ES (O SON) PARCIALMENTE MEZCLABLE(S).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9102838A FR2673537B1 (fr) | 1991-03-08 | 1991-03-08 | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2144409T3 true ES2144409T3 (es) | 2000-06-16 |
Family
ID=9410536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92400384T Expired - Lifetime ES2144409T3 (es) | 1991-03-08 | 1992-02-13 | Composiciones para el tratamiento de las onicomicosis. |
Country Status (17)
Country | Link |
---|---|
US (3) | US5814305A (es) |
EP (1) | EP0503988B1 (es) |
JP (1) | JP3559973B2 (es) |
AT (1) | ATE190485T1 (es) |
AU (1) | AU1147092A (es) |
BR (1) | BR9200786A (es) |
CA (1) | CA2062341C (es) |
CY (1) | CY2233B1 (es) |
DE (1) | DE69230772T2 (es) |
DK (1) | DK0503988T3 (es) |
ES (1) | ES2144409T3 (es) |
FR (1) | FR2673537B1 (es) |
GR (1) | GR3033297T3 (es) |
MX (1) | MX9200965A (es) |
PT (1) | PT503988E (es) |
SG (1) | SG46660A1 (es) |
ZA (1) | ZA921706B (es) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2673537B1 (fr) | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
HU223343B1 (hu) * | 1991-05-20 | 2004-06-28 | Novartis Ag. | Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására |
US6005001A (en) * | 1991-05-20 | 1999-12-21 | Novartis Ag (Formerly Sandoz Ag) | Pharmaceutical composition |
HU219480B (hu) | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
US5652256A (en) * | 1995-06-06 | 1997-07-29 | Knowles; W. Roy | Topical composition for fungal treatment |
AU4449497A (en) * | 1996-10-16 | 1998-05-11 | Ipr-Institute For Pharmaceutical Research Ag | New carrier systems |
DK0983037T3 (da) * | 1998-02-09 | 2003-09-01 | Macrochem Corp | Fungicid neglelak |
US6740326B1 (en) | 1998-09-10 | 2004-05-25 | Bioequal Ag | Topical nail care compositions |
US6159977A (en) * | 1998-11-16 | 2000-12-12 | Astan, Inc. | Therapeutic anti-fungal nail preparation |
US6517863B1 (en) | 1999-01-20 | 2003-02-11 | Usbiomaterials Corporation | Compositions and methods for treating nails and adjacent tissues |
DE10011081A1 (de) * | 2000-03-09 | 2001-09-13 | Aventis Pharma Gmbh | Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel |
US7074392B1 (en) * | 2000-03-27 | 2006-07-11 | Taro Pharmaceutical Industries Limited | Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections |
US8257688B2 (en) * | 2000-03-27 | 2012-09-04 | Taro Pharmaceuticals Industries | Controlled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues |
GB0014448D0 (en) * | 2000-06-13 | 2000-08-09 | Novartis Ag | Organic compounds |
GB0019283D0 (en) * | 2000-08-04 | 2000-09-27 | Novartis Ag | Organic compounds |
WO2006057616A1 (en) * | 2004-11-29 | 2006-06-01 | Ambria Dermatology Ab | A composition comprising at least 3 different diols |
US6664292B2 (en) | 2001-06-04 | 2003-12-16 | Mark H. Bogart | Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor |
US7244703B2 (en) * | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
US6821508B2 (en) | 2001-06-27 | 2004-11-23 | Rutgers, The State University | Composition and method for topical nail treatment |
US20030049307A1 (en) * | 2002-08-15 | 2003-03-13 | Gyurik Robert J. | Pharmaceutical composition |
AU2003262769A1 (en) * | 2002-08-20 | 2004-03-11 | Pinnell, Doren M | Methods for treating fungal infections |
CA2492976C (en) * | 2002-09-05 | 2011-11-01 | Galderma Research & Development, S.N.C. | Solution for ungual and peri-ungual application |
FR2844197B1 (fr) * | 2002-09-05 | 2006-06-23 | Galderma Res & Dev | Solution pour application ungueale et peri-ungeale |
US20040126343A1 (en) * | 2002-12-26 | 2004-07-01 | Garshowitz Solomon David | Nail drug delivery |
PL2106805T3 (pl) * | 2003-03-21 | 2011-10-31 | Nexmed Holdings Inc | Przeciwgrzybicza powłoka na paznokcie |
WO2004108114A2 (en) * | 2003-03-31 | 2004-12-16 | Dinesh Shantilal Patel | Anti-fungal composition and a process for its manufacture |
JP5435836B2 (ja) * | 2003-07-03 | 2014-03-05 | 大正製薬株式会社 | 外用抗真菌剤組成物 |
JP4784051B2 (ja) * | 2003-07-03 | 2011-09-28 | 大正製薬株式会社 | 容器への吸着を防止した外用抗真菌組成物 |
DE502004007513D1 (de) * | 2003-08-25 | 2008-08-14 | Bioequal Ag | Pharmazeutische und kosmetische formulierungen zur behandlung der nägel |
DE10341944A1 (de) * | 2003-09-11 | 2005-04-28 | York Pharma Plc | Antimykotisch wirksame Nagellackformulierung mit substituierten 2-Aminothiazolen als Wirkstoff |
EP1706128B1 (en) * | 2003-12-08 | 2010-07-21 | CPEX Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for insulin treatment |
US20050238672A1 (en) * | 2004-04-27 | 2005-10-27 | Nimni Marcel E | Antifungal drug delivery |
US20060078580A1 (en) | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
US7740875B2 (en) * | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
US20060078599A1 (en) * | 2004-10-12 | 2006-04-13 | Mathew Ebmeier | Pharmaceutical composition applicable to body tissue |
US20060275230A1 (en) * | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
CN101115475A (zh) * | 2004-12-10 | 2008-01-30 | 塔利马治疗公司 | 用于治疗指甲单位病症的组合物和方法 |
US20060165747A1 (en) * | 2005-01-24 | 2006-07-27 | David Rolf | Antifungal composition, method and kit for topically treating onychomycosis |
WO2006103638A2 (en) * | 2005-03-31 | 2006-10-05 | Ranbaxy Laboratories Limited | Topical pharmaceutical compositions of terbinafine and processes for their preparation |
CN103357015A (zh) * | 2005-09-29 | 2013-10-23 | 瑞士商拜欧伊果公司 | 疣、指甲疾病、及指甲保养用之局部配方 |
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KR20080080355A (ko) * | 2005-12-28 | 2008-09-03 | 데이코쿠 세이야쿠 가부시키가이샤 | 손·발톱용 의약 조성물 |
CA2640889A1 (en) * | 2006-01-02 | 2007-07-12 | Tlt Medical Ltd. | Pharmaceutical composition for the treatment of nail diseases |
WO2007098591A2 (en) * | 2006-03-02 | 2007-09-07 | Nuvo Research Inc. | Topical nail formulation |
ES2421613T3 (es) * | 2006-03-08 | 2013-09-04 | Nihon Nohyaku Co Ltd | Composición farmacéutica externa |
ES2428856T3 (es) | 2006-08-28 | 2013-11-11 | Hisamitsu Pharmaceutical Co., Inc. | Parche para uñas |
US20080135643A1 (en) * | 2006-12-08 | 2008-06-12 | Kimberly-Clark Worldwide, Inc. | Pulsating spray dispensers |
WO2008097530A1 (en) | 2007-02-05 | 2008-08-14 | Biophile Corporation, Ltd | Increased effectiveness of allylamine drug compounds |
US20080261986A1 (en) * | 2007-03-30 | 2008-10-23 | Friden Phillip M | Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug |
MY162090A (en) | 2007-04-20 | 2017-05-31 | Bioequal Ag | Topically applicable fungicide agents for treating nails |
US20080287912A1 (en) * | 2007-05-14 | 2008-11-20 | Horrigan Corporation | Method, Device And Formulation For The Treatment Of Nail Disorders |
CN101808638B (zh) | 2007-09-05 | 2012-07-25 | 宝丽制药股份有限公司 | 抗真菌组合物 |
PL2191828T3 (pl) * | 2007-09-05 | 2017-02-28 | Pola Pharma Inc. | Przeciwgrzybicza kompozycja farmaceutyczna |
US20100204293A1 (en) * | 2007-09-05 | 2010-08-12 | Pola Pharma Inc. | Pharmaceutical composition |
WO2009048841A1 (en) * | 2007-10-09 | 2009-04-16 | Humco Holding Group, Inc. | Antifungal treatment of nails |
US7802314B2 (en) * | 2007-10-31 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Hand-wear article with cutaneous sensory elements |
US8221370B2 (en) * | 2007-10-31 | 2012-07-17 | Kimberly-Clark Worldwide, Inc. | Personal care article with substrate surface topography for evoking a neurosensory skin response |
WO2009071959A2 (en) * | 2007-12-04 | 2009-06-11 | Pannonpharma Gyógyszergyártó Kft. | A composition in the form of a paint tincture or lacquer to treat fungal infections containing itraconazole and a process for the preparation thereof |
US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
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FR2942716B1 (fr) * | 2009-03-06 | 2011-04-15 | Galderma Res & Dev | Methode de solubilisation d'agent antifongique et compositions a haute concentration en agent antifongique applicables sur l'ongle |
US20120309753A1 (en) * | 2009-03-06 | 2012-12-06 | Galderma Research & Development | Method of dissolving antifungal agent, and compositions with a high concentration of antifungal agent, suitable for application to the nail |
US10130610B2 (en) | 2009-04-09 | 2018-11-20 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
KR101409792B1 (ko) | 2009-04-09 | 2014-06-19 | 니혼노야쿠가부시키가이샤 | 항진균성 약제학적 조성물 |
DE102009038512A1 (de) * | 2009-07-30 | 2011-02-10 | Technische Universität Braunschweig | Arzneimittelformulierung zur Behandlung von Nagelerkrankungen |
WO2011014850A2 (en) * | 2009-07-31 | 2011-02-03 | Nuvo Research Inc. | Topical eutectic-based formulations |
JP5635075B2 (ja) | 2009-08-25 | 2014-12-03 | 株式会社ポーラファルマ | 抗真菌医薬組成物 |
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WO2011079234A2 (en) | 2009-12-23 | 2011-06-30 | Nuvo Research Inc. | Highly permeating terbinafine formulation |
US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
US20120061267A1 (en) * | 2010-09-14 | 2012-03-15 | Sally Villalobos | MediTowel Anti-Fungal Wipe |
EP2462991A1 (en) | 2010-12-13 | 2012-06-13 | PQS Group B.V. | Composition and use of a fermented olive leaf product for the treatment of nail infections |
US8697753B1 (en) * | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
RU2015143995A (ru) | 2013-03-14 | 2017-04-20 | Халлюкс, Инк. | Способ лечения инфекций, заболеваний или расстройств ногтевого ложа |
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CN112999223A (zh) | 2013-11-22 | 2021-06-22 | 博世健康爱尔兰有限公司 | 抗感染的方法、组合物和装置 |
WO2016015094A1 (en) * | 2014-07-31 | 2016-02-04 | Acrux Dds Pty Ltd | Topical composition |
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US10993890B2 (en) | 2018-03-15 | 2021-05-04 | Pelli Skin Co., Llc | Antifungal solution and foot wipe |
CN108653195A (zh) * | 2018-08-08 | 2018-10-16 | 江苏知原药业有限公司 | 透皮或透粘膜给药制剂 |
KR20210107043A (ko) * | 2018-12-19 | 2021-08-31 | 말린즈 파마 엘엘씨 | 국소 조성물 |
WO2020231800A1 (en) * | 2019-05-10 | 2020-11-19 | Encube Ethicals Private Limited | Topical antifungal formulation |
EP4129292A1 (en) | 2021-08-04 | 2023-02-08 | OnychoPharm GmbH | Formulation for substituted 2-aminothiazoles in the treatment of fungal and fungal-bacterial infections of the nail |
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US5256647A (en) * | 1986-01-31 | 1993-10-26 | Whitby Research, Inc. | Compositions comprising 1-substituted azacycloalkanes |
DE3783683T2 (de) * | 1986-01-31 | 1993-05-19 | Whitby Research Inc | Hautpenetration verbessernde zusammensetzungen. |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
US4782059A (en) * | 1986-09-29 | 1988-11-01 | Merck & Co., Inc. | Method of controlling mycotic infections and compositions therefor |
FR2613227B1 (fr) * | 1987-04-01 | 1990-12-28 | Oreal | Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles |
DE3720147A1 (de) * | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
US4920112A (en) * | 1988-04-18 | 1990-04-24 | Merck & Co., Inc. | Fungicidal compositions and method |
US5181914A (en) * | 1988-08-22 | 1993-01-26 | Zook Gerald P | Medicating device for nails and adjacent tissue |
US5116603A (en) * | 1989-01-31 | 1992-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Oral antifungal preventative, and method of use |
US5053227A (en) * | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
JP2797401B2 (ja) * | 1989-04-19 | 1998-09-17 | 日産化学工業株式会社 | 爪用抗真菌剤組成物 |
FR2646603B1 (fr) * | 1989-05-03 | 1991-07-12 | Oreal | Composition nettoyante |
JPH0338522A (ja) * | 1989-07-05 | 1991-02-19 | Maruho Kk | 抗真菌性組成物 |
JPH0338521A (ja) * | 1989-07-05 | 1991-02-19 | Maruho Kk | 抗真菌性組成物 |
FR2673537B1 (fr) * | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
US5215520A (en) * | 1991-09-17 | 1993-06-01 | Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) | Method for delivering an active substance topically or percutaneously |
US5661170A (en) * | 1994-03-21 | 1997-08-26 | Woodward Laboratories, Inc. | Antimicrobial compositions and methods for using the same |
-
1991
- 1991-03-08 FR FR9102838A patent/FR2673537B1/fr not_active Expired - Lifetime
-
1992
- 1992-02-13 PT PT92400384T patent/PT503988E/pt unknown
- 1992-02-13 SG SG1996007522A patent/SG46660A1/en unknown
- 1992-02-13 EP EP92400384A patent/EP0503988B1/fr not_active Expired - Lifetime
- 1992-02-13 AT AT92400384T patent/ATE190485T1/de active
- 1992-02-13 DK DK92400384T patent/DK0503988T3/da active
- 1992-02-13 ES ES92400384T patent/ES2144409T3/es not_active Expired - Lifetime
- 1992-02-13 DE DE69230772T patent/DE69230772T2/de not_active Expired - Lifetime
- 1992-03-05 MX MX9200965A patent/MX9200965A/es unknown
- 1992-03-05 CA CA002062341A patent/CA2062341C/fr not_active Expired - Lifetime
- 1992-03-06 JP JP08292492A patent/JP3559973B2/ja not_active Expired - Lifetime
- 1992-03-06 ZA ZA921706A patent/ZA921706B/xx unknown
- 1992-03-06 AU AU11470/92A patent/AU1147092A/en not_active Abandoned
- 1992-03-09 BR BR929200786A patent/BR9200786A/pt not_active Application Discontinuation
-
1995
- 1995-01-30 US US08/381,583 patent/US5814305A/en not_active Expired - Lifetime
-
1998
- 1998-09-28 US US09/162,020 patent/US6143793A/en not_active Expired - Lifetime
-
2000
- 2000-04-21 GR GR20000400979T patent/GR3033297T3/el unknown
- 2000-10-04 US US09/678,772 patent/US6455592B1/en not_active Expired - Lifetime
-
2001
- 2001-09-07 CY CY0100024A patent/CY2233B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2062341C (fr) | 2004-05-11 |
CY2233B1 (en) | 2003-04-18 |
US6143793A (en) | 2000-11-07 |
US5814305A (en) | 1998-09-29 |
BR9200786A (pt) | 1992-11-17 |
FR2673537A1 (fr) | 1992-09-11 |
CA2062341A1 (fr) | 1992-09-09 |
FR2673537B1 (fr) | 1993-06-11 |
US6455592B1 (en) | 2002-09-24 |
DK0503988T3 (da) | 2000-07-24 |
DE69230772D1 (de) | 2000-04-20 |
ZA921706B (en) | 1992-11-25 |
DE69230772T2 (de) | 2000-07-27 |
PT503988E (pt) | 2000-06-30 |
ATE190485T1 (de) | 2000-04-15 |
AU1147092A (en) | 1992-09-10 |
JPH0585929A (ja) | 1993-04-06 |
JP3559973B2 (ja) | 2004-09-02 |
EP0503988B1 (fr) | 2000-03-15 |
MX9200965A (es) | 1992-09-01 |
EP0503988A1 (fr) | 1992-09-16 |
GR3033297T3 (en) | 2000-09-29 |
SG46660A1 (en) | 1998-02-20 |
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