ES2129482T3 - Anticuerpos monoclonales que aglutinan los basofilos, procedimiento de separacion de basofilos, procedimiento para liberar mediadores quimicos de basofilos y procedimiento para comprobar la liberacion de mediadores quimicos derivados de basofilos. - Google Patents
Anticuerpos monoclonales que aglutinan los basofilos, procedimiento de separacion de basofilos, procedimiento para liberar mediadores quimicos de basofilos y procedimiento para comprobar la liberacion de mediadores quimicos derivados de basofilos.Info
- Publication number
- ES2129482T3 ES2129482T3 ES93117830T ES93117830T ES2129482T3 ES 2129482 T3 ES2129482 T3 ES 2129482T3 ES 93117830 T ES93117830 T ES 93117830T ES 93117830 T ES93117830 T ES 93117830T ES 2129482 T3 ES2129482 T3 ES 2129482T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- basophils
- chemical
- release
- monoclonal antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LOS ANTICUERPOS MONOCLONALES DE LA INVENCION HACEN POSIBLE SEPARAR BASOFILOS ADECUADOS PARA LA PRUEBA DE LIBERACION DE MEDIADORES QUIMICOS ESPECIFICOS INTERMEDIADOS POR IGE, A CAUSA DE QUE RETIENE SU REACTIVIDAD CON LOS BASOFILOS INCLUSO DESPUES DE SER INMOVILIZADO SOBRE UN PORTADOR SOLIDO, Y ACUSA DE QUE NO INHIBEN LA LIBERACION DE LOS MEDIADORES QUIMICOS INDUCIDOS POR ALERGENOS O ANTICUERPOS ANTIIGE, Y NO INDUCEN LA LIBERACION NO ESPECIFICA DE MEDIADORES QUIMICOS. TAMBIEN, EL METODO PARA SEPARAR LOS BASOFILOS DE LA INVENCION SIMPLIFICA LA SEPARACION DE LOS BASOFILOS DE LA SANGRE, Y MEDIANTE EL USO DE ESTE METODO, LA PRUEBA DE LIBERACION DE ISTAMINA QUE DE OTRA FORMA REQUIERE LOS PROCEDIMIENTOS COMPLEJOS PUEDE SIMPLIFICARSE. ADEMAS, EL GRUPO DE CELULAS OBTENIDAS POR EL METODO PARA SEPARAR BASOFILOS DE LA INVENCION, PUEDE UTILIZARSE FACILMENTE EN LAS PRUEBAS DE LIBERACION PARA MEDIADORES QUIMICOS LIBERADOS A PARTIR DE LOS BASOFILOS TALES COMO EL LEUCOTRIENO Y EL PAF, QUE DE OTRA FORMA REQUIEREN UN MANEJO EXPERTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32116492 | 1992-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2129482T3 true ES2129482T3 (es) | 1999-06-16 |
Family
ID=18129523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93117830T Expired - Lifetime ES2129482T3 (es) | 1992-11-04 | 1993-11-03 | Anticuerpos monoclonales que aglutinan los basofilos, procedimiento de separacion de basofilos, procedimiento para liberar mediadores quimicos de basofilos y procedimiento para comprobar la liberacion de mediadores quimicos derivados de basofilos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5500348A (es) |
EP (1) | EP0596479B1 (es) |
JP (1) | JP3550410B2 (es) |
KR (1) | KR100280239B1 (es) |
AT (1) | ATE176930T1 (es) |
DE (1) | DE69323589T2 (es) |
DK (1) | DK0596479T3 (es) |
ES (1) | ES2129482T3 (es) |
TW (1) | TW378213B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6905680B2 (en) * | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
US6352694B1 (en) * | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
US7479269B2 (en) * | 1988-11-23 | 2009-01-20 | Genetics Institute, Llc | Methods for selectively enriching TH1 and TH2 cells |
US6534055B1 (en) * | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US7175843B2 (en) * | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
US5722470A (en) * | 1995-11-09 | 1998-03-03 | Glaxo Group Limited | Bead dispensing device and methods |
DE19643427C1 (de) * | 1996-10-22 | 1998-02-12 | Bundesrep Deutschland | Verfahren zur Bestimmung von Allergenen in der Luft |
FR2765341A1 (fr) * | 1997-06-25 | 1998-12-31 | Alain Funes | Methode pour l'analyse de l'activation des basophiles humains par mesure de l'expression membranaire du marqueur cd63 |
US6151973A (en) * | 1999-01-29 | 2000-11-28 | Glaxo Wellcome Inc. | Bead picking apparatus and method |
ES2230108T3 (es) * | 1999-05-19 | 2005-05-01 | Eberhard-Karls-Universitat Tubingen Universitatsklinikum | Utilizacion de un anticuerpo para detectar basofilos y/o mastocitos. |
WO2002003068A1 (fr) * | 2000-06-30 | 2002-01-10 | Kyowa Medex Co.,Ltd. | Reactif de dosage immunologique nephelometrique a particules-supports insolubles |
CN1215332C (zh) * | 2000-07-27 | 2005-08-17 | 协和梅迪克斯株式会社 | 采用不溶性载体粒子的免疫测定方法、免疫测定试剂及其稳定化方法 |
US20030022250A1 (en) * | 2001-05-29 | 2003-01-30 | Dreskin Stephen C. | Functional IgE test methods and compositions |
US8242874B2 (en) * | 2005-08-23 | 2012-08-14 | Lear Corporation | Electrical connector housing |
CN112415191A (zh) * | 2020-11-06 | 2021-02-26 | 郑州人福博赛生物技术有限责任公司 | 一种白细胞三烯检测试剂盒 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4559310A (en) * | 1983-05-20 | 1985-12-17 | Dana Farber Cancer Institute | Assay methods and systems utilizing mast cell clones |
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
FR2621128B1 (fr) * | 1987-09-30 | 1994-05-06 | Sanofi | Trousse et methode de dosage immunometrique applicables a des cellules entieres |
GB8916859D0 (en) * | 1989-07-24 | 1989-09-06 | Dynal As | Hapten linking |
-
1993
- 1993-10-06 TW TW082108242A patent/TW378213B/zh not_active IP Right Cessation
- 1993-11-02 US US08/144,447 patent/US5500348A/en not_active Expired - Lifetime
- 1993-11-02 JP JP29737993A patent/JP3550410B2/ja not_active Expired - Lifetime
- 1993-11-03 AT AT93117830T patent/ATE176930T1/de not_active IP Right Cessation
- 1993-11-03 KR KR1019930023230A patent/KR100280239B1/ko not_active IP Right Cessation
- 1993-11-03 EP EP93117830A patent/EP0596479B1/en not_active Expired - Lifetime
- 1993-11-03 DE DE69323589T patent/DE69323589T2/de not_active Expired - Lifetime
- 1993-11-03 ES ES93117830T patent/ES2129482T3/es not_active Expired - Lifetime
- 1993-11-03 DK DK93117830T patent/DK0596479T3/da active
Also Published As
Publication number | Publication date |
---|---|
TW378213B (en) | 2000-01-01 |
US5500348A (en) | 1996-03-19 |
EP0596479A3 (en) | 1995-04-19 |
JPH06205695A (ja) | 1994-07-26 |
KR100280239B1 (ko) | 2001-02-01 |
DK0596479T3 (da) | 1999-09-27 |
DE69323589T2 (de) | 1999-10-14 |
EP0596479B1 (en) | 1999-02-24 |
KR940011480A (ko) | 1994-06-21 |
JP3550410B2 (ja) | 2004-08-04 |
DE69323589D1 (de) | 1999-04-01 |
ATE176930T1 (de) | 1999-03-15 |
EP0596479A2 (en) | 1994-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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