DE69231559D1 - Reagenzien und verfahren zur quantifizierung des totalgehaltes an doxepinen in biologischen flüssigkeiten - Google Patents

Reagenzien und verfahren zur quantifizierung des totalgehaltes an doxepinen in biologischen flüssigkeiten

Info

Publication number
DE69231559D1
DE69231559D1 DE69231559T DE69231559T DE69231559D1 DE 69231559 D1 DE69231559 D1 DE 69231559D1 DE 69231559 T DE69231559 T DE 69231559T DE 69231559 T DE69231559 T DE 69231559T DE 69231559 D1 DE69231559 D1 DE 69231559D1
Authority
DE
Germany
Prior art keywords
doxepin
reagents
formula
prepared
doxepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231559T
Other languages
English (en)
Other versions
DE69231559T2 (de
Inventor
Maciej Adamczyk
R Fishpaugh
E Hruska
Donald Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69231559D1 publication Critical patent/DE69231559D1/de
Application granted granted Critical
Publication of DE69231559T2 publication Critical patent/DE69231559T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9466—Antidepressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69231559T 1991-07-31 1992-07-29 Reagenzien und verfahren zur quantifizierung des totalgehaltes an doxepinen in biologischen flüssigkeiten Expired - Fee Related DE69231559T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73840091A 1991-07-31 1991-07-31
US07/916,066 US5332661A (en) 1991-07-31 1992-07-24 Reagents and methods for the quantification of total doxepins in biological fluids
PCT/US1992/006318 WO1993003372A1 (en) 1991-07-31 1992-07-29 Reagents and methods for the quantification of total doxepins in biological fluids

Publications (2)

Publication Number Publication Date
DE69231559D1 true DE69231559D1 (de) 2000-12-14
DE69231559T2 DE69231559T2 (de) 2001-06-21

Family

ID=27113357

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231559T Expired - Fee Related DE69231559T2 (de) 1991-07-31 1992-07-29 Reagenzien und verfahren zur quantifizierung des totalgehaltes an doxepinen in biologischen flüssigkeiten

Country Status (9)

Country Link
US (2) US5332661A (de)
EP (1) EP0641440B1 (de)
JP (1) JP3071824B2 (de)
AT (1) ATE197508T1 (de)
AU (1) AU2420692A (de)
CA (1) CA2111467C (de)
DE (1) DE69231559T2 (de)
ES (1) ES2153361T3 (de)
WO (1) WO1993003372A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0578292A (ja) * 1991-04-05 1993-03-30 Hokuriku Seiyaku Co Ltd 三環系化合物
US5686237A (en) * 1995-06-05 1997-11-11 Al-Bayati; Mohammed A. S. Use of biomarkers in saliva to evaluate the toxicity of agents and the function of tissues in both biomedical and environmental applications
US5804395A (en) * 1995-12-01 1998-09-08 The United States Of America As Represented By The Secretary Of The Navy Fluorescence polarization assays of enzymes and substrates therefore
WO2007136845A2 (en) 2006-05-19 2007-11-29 Somaxon Pharmaceuticals, Inc. Low-dose doxepin for treatment of sleep disorders in elderly patients
US20100227916A1 (en) * 2006-05-19 2010-09-09 Somaxon Pharmaceuticals, Inc N-desmethyl-doxepin and methods of using the same to treat sleep disorders
US20090042971A1 (en) * 2006-05-19 2009-02-12 Somaxon Pharmaceuticals, Inc. Method of using low-dose doxepin for the improvement of sleep
US20090042972A1 (en) * 2006-05-19 2009-02-12 Somaxon Pharmaceuticals, Inc. Methods of using low-dose doxepin for the improvement of sleep
JP2009537553A (ja) * 2006-05-19 2009-10-29 ソマクソン ファーマシューティカルズ インコーポレイテッド 睡眠改善のための低用量ドキセピンの使用法
US20100179215A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
US20100179214A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
CA2693992C (en) * 2006-07-20 2017-01-31 Somaxon Pharmaceuticals, Inc. Methods of improving the pharmacokinetics of doxepin
US20080182890A1 (en) * 2006-10-04 2008-07-31 Somaxon Pharmaceuticals, Inc. Methods of using low-dose doxepin for the improvement of sleep
US20100105614A1 (en) 2006-10-25 2010-04-29 Somaxon Pharmaceuticals, Inc. Ultra low dose doxepin and methods of using the same to treat sleep disorders
US20110077200A1 (en) * 2006-12-06 2011-03-31 Somaxon Pharmaceuticals, Inc. Combination therapy using low-dose doxepin for the improvement of sleep
EP2148659A2 (de) 2007-04-13 2010-02-03 Somaxon Pharmaceuticals, Inc. Niedrigdosierte doxepin-formulierungen
WO2010080577A2 (en) * 2008-12-18 2010-07-15 Auspex Pharmaceutical, Inc. Oxepine modulators of h1 receptors and/or inhibitors of mast cell degranulation
WO2016070016A1 (en) 2014-10-31 2016-05-06 Massachusetts Institute Of Technology Compositions and methods for forming emulsions
US10060913B2 (en) * 2016-09-19 2018-08-28 Massachusetts Institute Of Technology Systems including janus droplets capable of binding an analyte and changing orientation to provide a detectable change
US11119098B2 (en) 2014-10-31 2021-09-14 Massachusetts Institute Of Technology Systems including Janus droplets
WO2016070027A1 (en) 2014-10-31 2016-05-06 Massachusetts Institute Of Technology Compositions and methods for arranging colloid phases
CN112159385A (zh) * 2020-09-25 2021-01-01 武汉爱民制药股份有限公司 一种去甲基盐酸多塞平的合成方法
CN115326987A (zh) * 2022-08-31 2022-11-11 内蒙古帕默康创医疗仪器有限公司 多塞平血药浓度检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
US4420568A (en) * 1980-07-30 1983-12-13 Abbott Laboratories Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins
US4495281A (en) * 1982-10-21 1985-01-22 Miles Laboratories, Inc. Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
US4629691A (en) * 1983-08-01 1986-12-16 Syntex (U.S.A.) Inc. Tricyclic antidepressant conjugates with antigens and enzymes
DE3689688T2 (de) * 1985-10-15 1994-08-25 Abbott Lab Verbindungen und Immunoassay für tricyclische Antidepressiva.
US4704867A (en) * 1985-12-09 1987-11-10 Allied Corporation Hydraulic brake booster with cam and lever ratio changer
GB9001694D0 (en) * 1990-01-25 1990-03-28 Therapeutic Antibodies Inc Immunogenic compositions
US5413911A (en) * 1990-12-14 1995-05-09 Abbott Laboratories Determination of tricyclic antidepressant drugs in the presence of interfering substances

Also Published As

Publication number Publication date
EP0641440A4 (de) 1996-04-10
EP0641440A1 (de) 1995-03-08
CA2111467C (en) 2002-11-12
US5332661A (en) 1994-07-26
CA2111467A1 (en) 1993-02-18
US5464767A (en) 1995-11-07
JPH06509797A (ja) 1994-11-02
EP0641440B1 (de) 2000-11-08
WO1993003372A1 (en) 1993-02-18
JP3071824B2 (ja) 2000-07-31
ATE197508T1 (de) 2000-11-11
AU2420692A (en) 1993-03-02
ES2153361T3 (es) 2001-03-01
DE69231559T2 (de) 2001-06-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee