DE69231448D1 - Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten - Google Patents
Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeitenInfo
- Publication number
- DE69231448D1 DE69231448D1 DE69231448T DE69231448T DE69231448D1 DE 69231448 D1 DE69231448 D1 DE 69231448D1 DE 69231448 T DE69231448 T DE 69231448T DE 69231448 T DE69231448 T DE 69231448T DE 69231448 D1 DE69231448 D1 DE 69231448D1
- Authority
- DE
- Germany
- Prior art keywords
- imipramine
- desipramine
- reagents
- desimipramine
- quantifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 title abstract 6
- 229960004801 imipramine Drugs 0.000 title abstract 6
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003914 desipramine Drugs 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000012876 carrier material Substances 0.000 abstract 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 238000003018 immunoassay Methods 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 125000005647 linker group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9466—Antidepressants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73901291A | 1991-07-31 | 1991-07-31 | |
| US07/916,161 US5340750A (en) | 1991-07-31 | 1992-07-24 | Reagents and methods for the quantification of imipramine or desipramine in biological fluids |
| PCT/US1992/006303 WO1993003371A1 (en) | 1991-07-31 | 1992-07-29 | Reagents and methods for the quantification of imipramine or desipramine in biological fluids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69231448D1 true DE69231448D1 (de) | 2000-10-19 |
| DE69231448T2 DE69231448T2 (de) | 2001-04-12 |
Family
ID=27113468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69231448T Expired - Fee Related DE69231448T2 (de) | 1991-07-31 | 1992-07-29 | Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5340750A (de) |
| EP (1) | EP0641439B1 (de) |
| JP (1) | JP3285577B2 (de) |
| AT (1) | ATE196364T1 (de) |
| AU (1) | AU2424792A (de) |
| CA (1) | CA2110916C (de) |
| DE (1) | DE69231448T2 (de) |
| ES (1) | ES2151491T3 (de) |
| WO (1) | WO1993003371A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1298693B1 (it) * | 1996-04-24 | 2000-01-12 | Hoffmann La Roche | Derivati della fluoresceina 4'-metil sostituiti |
| US6368814B1 (en) * | 2000-12-22 | 2002-04-09 | Roche Diagnostics Corporation | Tricyclic antidepressant derivatives and immunoassay |
| CN101726530B (zh) * | 2009-12-30 | 2013-01-02 | 中国科学院长春应用化学研究所 | 一种分离检测手性三甲丙咪嗪的方法 |
| CN101799423B (zh) * | 2010-03-15 | 2012-06-27 | 中国科学院长春应用化学研究所 | 一种分离检测丙咪嗪和三甲丙咪嗪的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4223013A (en) * | 1978-12-29 | 1980-09-16 | Syva Company | Amitriptyline conjugates to antigenic proteins and enzymes |
| US4275160A (en) * | 1979-07-06 | 1981-06-23 | Syva Company | Imipramine derivatives and poly(amino acid) conjugates |
| US4420568A (en) * | 1980-07-30 | 1983-12-13 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins |
| US4495281A (en) * | 1982-10-21 | 1985-01-22 | Miles Laboratories, Inc. | Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives |
| US4772697A (en) * | 1983-08-01 | 1988-09-20 | Syntex (U.S.A.) Inc. | Tricylic antidepressant conjugates to antigens and enzymes |
| US4629691A (en) * | 1983-08-01 | 1986-12-16 | Syntex (U.S.A.) Inc. | Tricyclic antidepressant conjugates with antigens and enzymes |
| US4551275A (en) * | 1984-03-23 | 1985-11-05 | Syntex (U.S.A.) Inc. | Desmethylimipramine derivatives and poly(amino acid) conjugates |
| EP0226730B1 (de) * | 1985-10-15 | 1994-03-02 | Abbott Laboratories | Verbindungen und Immunoassay für tricyclische Antidepressiva |
| US5413911A (en) | 1990-12-14 | 1995-05-09 | Abbott Laboratories | Determination of tricyclic antidepressant drugs in the presence of interfering substances |
| US5407835A (en) * | 1991-07-31 | 1995-04-18 | Abbott Laboratories | Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids |
-
1992
- 1992-07-24 US US07/916,161 patent/US5340750A/en not_active Expired - Lifetime
- 1992-07-29 AU AU24247/92A patent/AU2424792A/en not_active Abandoned
- 1992-07-29 CA CA002110916A patent/CA2110916C/en not_active Expired - Fee Related
- 1992-07-29 EP EP92917086A patent/EP0641439B1/de not_active Expired - Lifetime
- 1992-07-29 JP JP50371393A patent/JP3285577B2/ja not_active Expired - Fee Related
- 1992-07-29 DE DE69231448T patent/DE69231448T2/de not_active Expired - Fee Related
- 1992-07-29 ES ES92917086T patent/ES2151491T3/es not_active Expired - Lifetime
- 1992-07-29 AT AT92917086T patent/ATE196364T1/de not_active IP Right Cessation
- 1992-07-29 WO PCT/US1992/006303 patent/WO1993003371A1/en active IP Right Grant
-
1994
- 1994-08-05 US US08/286,731 patent/US5578500A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2110916A1 (en) | 1993-02-18 |
| JPH06509581A (ja) | 1994-10-27 |
| DE69231448T2 (de) | 2001-04-12 |
| US5340750A (en) | 1994-08-23 |
| WO1993003371A1 (en) | 1993-02-18 |
| AU2424792A (en) | 1993-03-02 |
| US5578500A (en) | 1996-11-26 |
| JP3285577B2 (ja) | 2002-05-27 |
| EP0641439A4 (de) | 1996-08-28 |
| ATE196364T1 (de) | 2000-09-15 |
| EP0641439A1 (de) | 1995-03-08 |
| EP0641439B1 (de) | 2000-09-13 |
| ES2151491T3 (es) | 2001-01-01 |
| CA2110916C (en) | 1997-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |