ES2151491T3 - Reactivos y procedimientos de cuantificacion de la imipramina o de la desipramina en fluidos biologicos. - Google Patents

Reactivos y procedimientos de cuantificacion de la imipramina o de la desipramina en fluidos biologicos.

Info

Publication number
ES2151491T3
ES2151491T3 ES92917086T ES92917086T ES2151491T3 ES 2151491 T3 ES2151491 T3 ES 2151491T3 ES 92917086 T ES92917086 T ES 92917086T ES 92917086 T ES92917086 T ES 92917086T ES 2151491 T3 ES2151491 T3 ES 2151491T3
Authority
ES
Spain
Prior art keywords
imipramine
deipramine
reagents
biological fluids
immunogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92917086T
Other languages
English (en)
Inventor
Maciej Adamczyk
Donald Johnson
Charles A Harrington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2151491T3 publication Critical patent/ES2151491T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9466—Antidepressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Luminescent Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

SE PRESENTAN METODOS DE INMUNOENSAYOS Y REACTIVOS PARA LA CUANTIFICACION ESPECIFICA DE IMIPRAMINA O DESIPRAMINA EN UNA MUESTRA DE PRUEBA. LAS MEDICIONES DE IMIPRAMINA O DESIPRAMINA SE REALIZAN EN UN INMUNOENSAYO ESPECIFICO QUE EMPLEA ANTICUERPOS PREPARADOS CON DERIVADOS DE IMIPRAMINA O DESIPRAMINA DE FORMULA (III), DONDE P ES UN MATERIAL PORTADOR INMUNOGENICO, X ES DOS HETEROATOMOS, Y ES UN GRUPO DE ENLACE QUE COMPRENDE DE 1 A 6 ATOMOS DE CARBONO, Y P ES UN MATERIAL PORTADOR INMUNOGENICO, Y DONDE PARA LA IMIPRAMINA, R ES CH3, Y PARA LA DESIPRAMINA, R ES H. LA PRESENTE INVENCION DESCRIBE TAMBIEN LA SINTESIS DE REACTIVOS UNICOS ETIQUETADOS DE LA ESTRUCTURA DE FORMULA (IV), DONDE Z ES UN GRUPO DE ENLACE QUE COMPRENDE 1 A 4 ATOMOS DE CARBONO Y 0 A 2 HETEROATOMOS Y Q ES UNA UNIDAD DETECTABLE, PREFERENTEMENTE FLUORESCENTE UN DERIVADO DE FLUORESCENCIA, Y DONDE PARA LA IMIPRAMINA R1 ES CH3 Y PARA LA DESIPRAMINA, R1 ES H.
ES92917086T 1991-07-31 1992-07-29 Reactivos y procedimientos de cuantificacion de la imipramina o de la desipramina en fluidos biologicos. Expired - Lifetime ES2151491T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73901291A 1991-07-31 1991-07-31
US07/916,161 US5340750A (en) 1991-07-31 1992-07-24 Reagents and methods for the quantification of imipramine or desipramine in biological fluids

Publications (1)

Publication Number Publication Date
ES2151491T3 true ES2151491T3 (es) 2001-01-01

Family

ID=27113468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92917086T Expired - Lifetime ES2151491T3 (es) 1991-07-31 1992-07-29 Reactivos y procedimientos de cuantificacion de la imipramina o de la desipramina en fluidos biologicos.

Country Status (9)

Country Link
US (2) US5340750A (es)
EP (1) EP0641439B1 (es)
JP (1) JP3285577B2 (es)
AT (1) ATE196364T1 (es)
AU (1) AU2424792A (es)
CA (1) CA2110916C (es)
DE (1) DE69231448T2 (es)
ES (1) ES2151491T3 (es)
WO (1) WO1993003371A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1298693B1 (it) * 1996-04-24 2000-01-12 Hoffmann La Roche Derivati della fluoresceina 4'-metil sostituiti
US6368814B1 (en) * 2000-12-22 2002-04-09 Roche Diagnostics Corporation Tricyclic antidepressant derivatives and immunoassay
CN101726530B (zh) * 2009-12-30 2013-01-02 中国科学院长春应用化学研究所 一种分离检测手性三甲丙咪嗪的方法
CN101799423B (zh) * 2010-03-15 2012-06-27 中国科学院长春应用化学研究所 一种分离检测丙咪嗪和三甲丙咪嗪的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
US4275160A (en) * 1979-07-06 1981-06-23 Syva Company Imipramine derivatives and poly(amino acid) conjugates
US4420568A (en) * 1980-07-30 1983-12-13 Abbott Laboratories Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins
US4495281A (en) * 1982-10-21 1985-01-22 Miles Laboratories, Inc. Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
US4772697A (en) * 1983-08-01 1988-09-20 Syntex (U.S.A.) Inc. Tricylic antidepressant conjugates to antigens and enzymes
US4629691A (en) * 1983-08-01 1986-12-16 Syntex (U.S.A.) Inc. Tricyclic antidepressant conjugates with antigens and enzymes
US4551275A (en) * 1984-03-23 1985-11-05 Syntex (U.S.A.) Inc. Desmethylimipramine derivatives and poly(amino acid) conjugates
EP0226730B1 (en) * 1985-10-15 1994-03-02 Abbott Laboratories Compounds and assay for tricyclic antidepressants
US5413911A (en) 1990-12-14 1995-05-09 Abbott Laboratories Determination of tricyclic antidepressant drugs in the presence of interfering substances
US5407835A (en) * 1991-07-31 1995-04-18 Abbott Laboratories Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids

Also Published As

Publication number Publication date
US5578500A (en) 1996-11-26
WO1993003371A1 (en) 1993-02-18
CA2110916C (en) 1997-02-25
DE69231448D1 (de) 2000-10-19
EP0641439A1 (en) 1995-03-08
CA2110916A1 (en) 1993-02-18
AU2424792A (en) 1993-03-02
EP0641439B1 (en) 2000-09-13
EP0641439A4 (en) 1996-08-28
JPH06509581A (ja) 1994-10-27
JP3285577B2 (ja) 2002-05-27
ATE196364T1 (de) 2000-09-15
DE69231448T2 (de) 2001-04-12
US5340750A (en) 1994-08-23

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