ES2120451T3 - Composicion que contiene un compuesto de la familia del tramadol y del acetaminofeno, y su utilizacion. - Google Patents

Composicion que contiene un compuesto de la familia del tramadol y del acetaminofeno, y su utilizacion.

Info

Publication number
ES2120451T3
ES2120451T3 ES92919762T ES92919762T ES2120451T3 ES 2120451 T3 ES2120451 T3 ES 2120451T3 ES 92919762 T ES92919762 T ES 92919762T ES 92919762 T ES92919762 T ES 92919762T ES 2120451 T3 ES2120451 T3 ES 2120451T3
Authority
ES
Spain
Prior art keywords
tramadol
compositions
acetaminophene
family
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92919762T
Other languages
English (en)
Other versions
ES2120451T7 (es
Inventor
Robert B Raffa
Jeffrey L Vaught
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36791806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2120451(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of ES2120451T3 publication Critical patent/ES2120451T3/es
Application granted granted Critical
Publication of ES2120451T7 publication Critical patent/ES2120451T7/es
Active legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION MUESTRA UNA COMPOSICION QUE CONTIENE UN MATERIAL TRAMADOL Y UN ACETAMINOFENO.LOS USOS DEL TRAMADOL SON LAS DIFERENTES FORMAS DEL MISMO.LAS COMPOSICIONES SON FARMACOLOGICAMENTE UTILES EN EL TRATAMIENTO DE DOLORES Y CONDICIONES TUSIVAS Y ESTAN SUJETAS A MENOS EFECTOS DEL LADO OPOIDE TALES COMO LA DEPRESION RESPIRATORIA,EL CONSTIPADO,TOLERANCIA Y TENDENCIA AL ABUSO.POR ULTIMO LOS COMPONENTES DE LAS MISMAS ESTAN DENTRO DE CIERTOS RADIOS DE EFECTOS FARMACOLOGICOS DONDE LAS COMPOSICIONES SON SUPERADITIVAS.
ES92919762T 1991-09-06 1992-09-03 Composicion que comprende un compuesto de tramadol y acetaminofeno, y su uso. Active ES2120451T7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75592491A 1991-09-06 1991-09-06
US755924 1991-09-06
CN92112594A CN1071571C (zh) 1991-09-06 1992-10-24 含有反胺苯环醇物质和乙酰氨基苯的组合物及其应用

Publications (2)

Publication Number Publication Date
ES2120451T3 true ES2120451T3 (es) 1998-11-01
ES2120451T7 ES2120451T7 (es) 2009-11-05

Family

ID=36791806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92919762T Active ES2120451T7 (es) 1991-09-06 1992-09-03 Composicion que comprende un compuesto de tramadol y acetaminofeno, y su uso.

Country Status (17)

Country Link
US (2) US5336691A (es)
EP (1) EP0566709B3 (es)
JP (1) JP3381190B2 (es)
KR (1) KR100243956B1 (es)
CN (1) CN1071571C (es)
AT (1) ATE169498T1 (es)
AU (1) AU651247B2 (es)
CA (1) CA2095523C (es)
DE (2) DE69226624T3 (es)
DK (1) DK0566709T5 (es)
ES (1) ES2120451T7 (es)
HU (1) HU219332B (es)
LU (1) LU91079I2 (es)
NL (1) NL300152I2 (es)
RU (1) RU2121346C1 (es)
SG (1) SG80535A1 (es)
WO (1) WO1993004675A1 (es)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5840731A (en) * 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
US6017963A (en) 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
WO1998058637A1 (en) * 1996-06-20 1998-12-30 Mcneil-Ppc Acetaminophen and diphenhydramine analgesics
ZA975444B (en) * 1996-06-20 1998-12-21 Mcneil Ppc Inc Acetaminophen and meclizine hydrochloride analgesics
DE19641576C1 (de) * 1996-10-09 1998-05-07 Gruenenthal Gmbh Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten
US5919826A (en) * 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
WO1998046216A1 (fr) * 1997-04-11 1998-10-22 Nippon Shinyaku Co., Ltd. Traitements des mictions frequentes et de l'incontinence urinaire
IE980512A1 (en) 1997-07-15 1999-10-20 Russinsky Ltd A product and process
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
RS50070B (sr) 1997-12-22 2009-01-22 Euro-Celtique S.A., Oralni dozni oblik sa kombinacijom opijatnog agonista i antagonista
US6320214B1 (en) * 1997-12-24 2001-11-20 Matsushita Electric Industrial Co., Ltd. Semiconductor device having a ferroelectric TFT and a dummy element
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
AU782759B2 (en) * 1999-08-20 2005-08-25 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and an anticonvulsant drug
PE20010623A1 (es) 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
ATE526950T1 (de) 1999-10-29 2011-10-15 Euro Celtique Sa Hydrocodon-formulierungen mit gesteuerter freisetzung
AU1164601A (en) * 1999-11-09 2001-06-06 Darwin Discovery Limited Therapeutic use and formulation
EP2517710B1 (en) 2000-02-08 2015-03-25 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
WO2001064202A2 (en) * 2000-03-01 2001-09-07 Euro-Celtique S.A. Tramadol for the treatment of functional gastrointestinal disorders
EP2263658A1 (en) 2000-10-30 2010-12-22 Euro-Celtique S.A. Controlled release hydrocodone formulations
DE10059020A1 (de) * 2000-11-28 2002-05-29 Gruenenthal Gmbh Parenteral applizierbare Darreichungsformen
EP1397126B9 (en) 2001-03-16 2007-02-21 DMI Biosciences, Inc. Use of tramadol for delaying ejaculation
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
CN1525851A (zh) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ 抗滥用阿片样物质控释剂型
ATE419039T1 (de) 2001-07-18 2009-01-15 Euro Celtique Sa Pharmazeutische kombinationen von oxycodon und naloxon
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
DE60232417D1 (de) 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
DK2425824T5 (en) 2002-04-05 2018-02-12 Mundipharma As Pharmaceutical preparation containing oxycodone and naloxone
EP1364649A1 (en) * 2002-05-23 2003-11-26 Cilag AG Adduct of topiramate and tramadol hydrochioride and uses thereof
EP2422772A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
US20090162431A1 (en) * 2002-09-21 2009-06-25 Shuyi Zhang Sustained release formulations containing acetaminophen and tramadol
AU2003271024A1 (en) * 2002-09-21 2004-04-08 Jin Wang Sustained release compound of acetamidophenol and tramadol
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US6864271B2 (en) * 2002-11-12 2005-03-08 The Foundation For The Lsu Health Sciences Center Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
BR0317177A (pt) * 2002-12-13 2005-10-25 Cilag Ag Preparações de liberação controlada compreendendo tramadol e topiramato
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
US20050065172A1 (en) * 2003-09-23 2005-03-24 Shah Indukumar G. Solid dosage form comprising caffeine
US20050067163A1 (en) * 2003-09-25 2005-03-31 George Flint R. Monobore release for tubing conveyed perforating
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
RU2389480C2 (ru) * 2004-08-12 2010-05-20 РЕКИТТ БЕНКАЙЗЕР ХЕЛТКЭА (Ю Кей) ЛИМИТЕД Гранулы, содержащие нпвлс и сахарный спирт, изготовленные экструзией из расплава
CN100348180C (zh) * 2004-12-24 2007-11-14 河南大学 盐酸曲马多口腔崩解片剂及其制备方法
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US8221792B2 (en) 2005-07-07 2012-07-17 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs
JP5269595B2 (ja) 2005-09-09 2013-08-21 アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー 1日1回投与用トラゾドン組成物
KR101486228B1 (ko) 2006-06-19 2015-01-26 알파마 파머슈티컬스 엘엘씨 약제학적 조성물
US7645767B2 (en) * 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
SI2124556T1 (sl) * 2006-10-09 2015-01-30 Charleston Laboratories, Inc. Farmacevtske sestave
DE102006056458A1 (de) * 2006-11-28 2008-05-29 Grünenthal GmbH Arzneimittelzubereitung von Tramadol und Acetaminophen
AU2008216356C1 (en) * 2007-02-12 2014-07-24 Aytu Bioscience, Inc. Treatment of comorbid premature ejaculation and erectile dysfunction
PL2114147T3 (pl) * 2007-02-12 2012-10-31 Vyrix Pharmaceuticals Inc Zmniejszanie skutków ubocznych tramadolu
US20080031950A1 (en) * 2007-04-27 2008-02-07 Nectid Inc. Novel anelgesic combination
US20080026054A1 (en) * 2007-04-27 2008-01-31 Nectid Inc. Novel anelgesic combination
US20090028873A1 (en) * 2007-07-27 2009-01-29 Auspex Pharmaceuticals, Inc. Substituted cyclohexanols
ES2541809T3 (es) * 2007-10-16 2015-07-24 Paladin Labs Inc. Composición bicapa para la liberación sostenida de acetaminofeno y tramadol
CA2705733C (en) 2007-11-13 2015-02-03 Cadence Pharmaceuticals Reduced dose intravenous acetaminophen
EP2219612A4 (en) 2007-12-17 2013-10-30 Paladin Labs Inc CONTROLLED RELEASE FORMULATION AVOIDING IMPROPER USES
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
EP3090743A1 (en) 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
EP2262484B1 (en) 2008-03-11 2013-01-23 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
US20100069501A1 (en) * 2008-09-05 2010-03-18 Gruenenthal Gmbh Pharmaceutical Composition Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and Paracetamol
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
JP5713911B2 (ja) 2008-10-27 2015-05-07 アルザ・コーポレーシヨン 長期放出型経口アセトアミノフェン/トラマドール投与形態
EP2367541B1 (en) 2008-12-16 2014-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
WO2010103039A1 (en) 2009-03-10 2010-09-16 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
ES2353541B1 (es) 2009-07-30 2011-09-20 Farmalider, S.A. Combinacion de ingredientes activos cosmeticos y composicion cosmetica obtenida a partir de la misma, y su utilizacion.
EP2281558A1 (en) * 2009-08-06 2011-02-09 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compounds of O-Desmethyl-Tramadol and COX-inhibitors
US20110104272A1 (en) * 2009-11-05 2011-05-05 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of acetaminophen and phenylephrine
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
DE202010001237U1 (de) 2010-01-21 2010-04-01 Grünenthal GmbH Kombination aus Tramadol und Acetaminophen als Brausetablette
GR1007315B (el) * 2010-04-19 2011-06-14 Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, Υγρομορφη παρεντερικης χορηγησης συνθεση που περιλαμβανει τραμαδολη hci και παρακεταμολη
EP2377514A3 (en) * 2010-04-19 2012-04-11 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Liquid parenteral formulation comprising a tramadol material and paracetamol
US9532959B2 (en) 2010-07-08 2017-01-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US20180264013A1 (en) * 2010-07-08 2018-09-20 Wellesley Pharmaceuticals, Llc Composition and methods for treating sleep disorders
US10010514B2 (en) 2010-07-08 2018-07-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US8658631B1 (en) 2011-05-17 2014-02-25 Mallinckrodt Llc Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
JP2015503583A (ja) * 2012-01-04 2015-02-02 ウェルズリー ファーマスーティカルズ、エルエルシー 排尿頻度を減少させるための延長放出製剤およびその使用の方法
KR20180023057A (ko) * 2012-01-04 2018-03-06 웰즐리 파마슈티컬스 엘엘씨 배뇨 빈도를 감소시키기 위한 서방형 제제 및 이의 사용 방법
US10278925B2 (en) 2012-01-04 2019-05-07 Wellesley Pharmaceuticals, Llc Delayed-release formulations, methods of making and use thereof
US10105330B2 (en) 2012-01-04 2018-10-23 Wellesley Pharmaceuticals, Llc Extended, delayed and immediate release formulation method of manufacturing and use thereof
ZA201300398B (en) 2012-11-27 2013-09-25 Genfarma Laboratories S L Injectable liquid formulation of the combination of tramadol and paracetamol
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
TW202348234A (zh) 2013-12-24 2023-12-16 維吉尼亞聯邦大學 氧化膽固醇硫酸鹽(ocs)之用途
US10105328B2 (en) 2014-06-06 2018-10-23 Wellesley Pharmaceuticals, Llc Composition for reducing frequency of urination, method of making and use thereof
US9693949B1 (en) * 2015-12-22 2017-07-04 Revogenex Ireland Ltd Intravenous administration of tramadol
WO2017152130A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
TWI620577B (zh) * 2016-11-23 2018-04-11 乙醯胺酚及曲馬多共溶複方止痛口服液
EP3684753A1 (en) 2017-09-18 2020-07-29 R L Fine Chem Private Limited A process for preparation of o-desmethyltramadol and salts thereof
KR20190038027A (ko) 2017-09-29 2019-04-08 한미약품 주식회사 아세트아미노펜, 및 트라마돌 또는 이의 약학적 허용 가능한 염을 포함하는 연질캡슐 조성물
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2770569A (en) 1952-08-01 1956-11-13 Hoffmann La Roche Analgesic compositions
US3830934A (en) 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3773955A (en) 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
CA1083044A (en) 1976-05-04 1980-08-05 Stewart Wong Antiarthritic potentiation
JPS5492631A (en) * 1977-12-27 1979-07-23 Kowa Co Analgestic
EP0017102A1 (en) 1979-03-22 1980-10-15 Merck & Co. Inc. Composition containing a phenyl benzoic acid compound and acetaminophen combination for the treatment of pain and inflammation and process for preparing the same
US4237140A (en) 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4260629A (en) 1979-10-25 1981-04-07 E. I. Du Pont De Nemours And Company Treating pain with acetaminophen and 1,4-dimethyl-5-p-chlorobenzoyl-pyrrole-2-acetic acid
JPS57128626A (en) 1981-01-30 1982-08-10 Morishita Seiyaku Kk Analgesic composition
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
AU570937B2 (en) * 1982-12-09 1988-03-31 Stephen A. Cooper Synergistic composition of hydroxyzine and salts thereof with nsaids
US4631284A (en) 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US4571400A (en) 1984-12-18 1986-02-18 Belleview Pharmaceutical, Inc. Dihydrocodeine/ibuprofen pharmaceutical compositions and method
US4601894A (en) 1985-03-29 1986-07-22 Schering Corporation Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate
JPS61293911A (ja) 1985-06-24 1986-12-24 Teisan Seiyaku Kk 徐放化製剤
US4730007A (en) 1985-09-04 1988-03-08 Seymour Ehrenpreis Novel analgesic compositions
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
US4769372A (en) 1986-06-18 1988-09-06 The Rockefeller University Method of treating patients suffering from chronic pain or chronic cough
US4943565A (en) 1986-09-15 1990-07-24 Bristol-Myers Squibb Company Analgesic tablet of aspirin and caffeine containing low-substituted hydroxypropyl cellulose
US4806543A (en) 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury
US4829064A (en) 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
DE3830353A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
DE3830355A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur herstellung von pharmazeutischen tabletten
HU208633B (en) 1991-02-04 1993-12-28 Alkaloida Vegyeszeti Gyar Process for production of analgetic compositions as applicable for blocking of opioid-binding spaces /2-receptors/ causing respiration depression
MX9205106A (es) 1991-09-06 1993-05-01 Johnson & Johnson Composiciones que comprenden un material de tramadol y cualquiera de codeina, oxicodona o hidrocodona y su uso
US5223541A (en) 1991-09-13 1993-06-29 Mcneilab, Inc. Tramadol n-oxide material, enantiomers and compositions thereof, and their use
US5516803A (en) 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5352680A (en) 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
AU782759B2 (en) 1999-08-20 2005-08-25 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and an anticonvulsant drug

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CA2095523C (en) 2004-06-22
CA2095523A1 (en) 1993-03-07
DE122004000032I1 (de) 2005-11-24
KR100243956B1 (ko) 2000-03-02
EP0566709A1 (en) 1993-10-27
HUT64838A (en) 1994-03-28
DE122004000032I2 (de) 2006-02-09
US5336691A (en) 1994-08-09
EP0566709B3 (en) 2009-04-08
WO1993004675A1 (en) 1993-03-18
DK0566709T3 (da) 1999-05-10
DE69226624T3 (de) 2009-11-05
EP0566709B1 (en) 1998-08-12
ES2120451T7 (es) 2009-11-05
NL300152I2 (nl) 2006-05-01
JPH06502869A (ja) 1994-03-31
EP0566709A4 (es) 1994-04-06
DK0566709T5 (da) 2009-05-18
HU219332B (hu) 2001-03-28
LU91079I2 (fr) 2004-07-26
CN1086133A (zh) 1994-05-04
DE69226624T2 (de) 1999-03-04
CN1071571C (zh) 2001-09-26
SG80535A1 (en) 2001-05-22
ATE169498T1 (de) 1998-08-15
HU9301313D0 (en) 1993-09-28
RU2121346C1 (ru) 1998-11-10
NL300152I1 (nl) 2004-08-02
USRE39221E1 (en) 2006-08-01
AU651247B2 (en) 1994-07-14
JP3381190B2 (ja) 2003-02-24
DE69226624D1 (de) 1998-09-17
AU2579992A (en) 1993-04-05

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