US5478577A
(en)
*
|
1993-11-23 |
1995-12-26 |
Euroceltique, S.A. |
Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
|
US5968551A
(en)
|
1991-12-24 |
1999-10-19 |
Purdue Pharma L.P. |
Orally administrable opioid formulations having extended duration of effect
|
US5958459A
(en)
*
|
1991-12-24 |
1999-09-28 |
Purdue Pharma L.P. |
Opioid formulations having extended controlled released
|
US5965161A
(en)
*
|
1994-11-04 |
1999-10-12 |
Euro-Celtique, S.A. |
Extruded multi-particulates
|
US5840731A
(en)
*
|
1995-08-02 |
1998-11-24 |
Virginia Commonwealth University |
Pain-alleviating drug composition and method for alleviating pain
|
US6017963A
(en)
*
|
1995-11-14 |
2000-01-25 |
Euro-Celtique, S.A. |
Formulation for intranasal administration
|
DE19601744C2
(de)
|
1996-01-19 |
1998-04-16 |
Gruenenthal Gmbh |
Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
|
WO1998058637A1
(en)
*
|
1996-06-20 |
1998-12-30 |
Mcneil-Ppc |
Acetaminophen and diphenhydramine analgesics
|
ZA975444B
(en)
*
|
1996-06-20 |
1998-12-21 |
Mcneil Ppc Inc |
Acetaminophen and meclizine hydrochloride analgesics
|
DE19641576C1
(de)
*
|
1996-10-09 |
1998-05-07 |
Gruenenthal Gmbh |
Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten
|
US5919826A
(en)
*
|
1996-10-24 |
1999-07-06 |
Algos Pharmaceutical Corporation |
Method of alleviating pain
|
EP1005861B1
(de)
*
|
1997-04-11 |
2005-06-29 |
Nippon Shinyaku Co., Ltd. |
Arzneimittel zur behandlung von häufigem wasserlassen und harninkontinenz
|
GB2342352B
(en)
|
1997-07-15 |
2002-03-27 |
Russinsky Ltd |
Pure cis-tramadol hydrochloride production
|
US6375957B1
(en)
|
1997-12-22 |
2002-04-23 |
Euro-Celtique, S.A. |
Opioid agonist/opioid antagonist/acetaminophen combinations
|
WO1999032119A1
(en)
|
1997-12-22 |
1999-07-01 |
Euro-Celtique, S.A. |
Opioid agonist/antagonist combinations
|
US6320214B1
(en)
*
|
1997-12-24 |
2001-11-20 |
Matsushita Electric Industrial Co., Ltd. |
Semiconductor device having a ferroelectric TFT and a dummy element
|
US6156342A
(en)
*
|
1998-05-26 |
2000-12-05 |
Andex Pharmaceuticals, Inc. |
Controlled release oral dosage form
|
TR200201067T2
(tr)
*
|
1999-08-20 |
2002-09-23 |
Ortho-Mcneil Pharmaceutical, Inc. |
Bir tramadol maddesi ve bir antikonvülsan ilaç içeren bileşimler
|
PE20010623A1
(es)
|
1999-10-05 |
2001-07-07 |
Gruenenthal Chemie |
Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
|
NZ529928A
(en)
|
1999-10-29 |
2005-10-28 |
Euro Celtique Sa |
Controlled release hydrocodone formulations
|
US10179130B2
(en)
|
1999-10-29 |
2019-01-15 |
Purdue Pharma L.P. |
Controlled release hydrocodone formulations
|
AU1164601A
(en)
*
|
1999-11-09 |
2001-06-06 |
Darwin Discovery Limited |
Therapeutic use and formulation
|
HU229705B1
(en)
|
2000-02-08 |
2014-05-28 |
Euro Celtique Sa |
Tamper-resistant oral opioid agonist formulations
|
DE60107393T2
(de)
*
|
2000-03-01 |
2005-12-01 |
Euro-Celtique S.A. |
Verwendung von tramadol zur herstellung eines arzneimittels zur behandlung von funktionelle gastrointestinale krankenheiten
|
KR101045144B1
(ko)
|
2000-10-30 |
2011-06-30 |
유로-셀티크 소시에떼 아노뉨 |
서방성 하이드로코돈 제형
|
DE10059020A1
(de)
*
|
2000-11-28 |
2002-05-29 |
Gruenenthal Gmbh |
Parenteral applizierbare Darreichungsformen
|
DE60211689T2
(de)
|
2001-03-16 |
2007-01-11 |
DMI Biosciences, Inc., Englewood |
Verwendung von Tramadol zur Verzögerung der Ejakulation
|
US20110104214A1
(en)
|
2004-04-15 |
2011-05-05 |
Purdue Pharma L.P. |
Once-a-day oxycodone formulations
|
ATE493130T1
(de)
|
2001-05-11 |
2011-01-15 |
Endo Pharmaceuticals Inc |
Opioid enthaltende arzneiform gegen missbrauch
|
DE60230632D1
(de)
|
2001-07-18 |
2009-02-12 |
Euro Celtique Sa |
Pharmazeutische kombinationen von oxycodon und naloxon
|
US20030044458A1
(en)
|
2001-08-06 |
2003-03-06 |
Curtis Wright |
Oral dosage form comprising a therapeutic agent and an adverse-effect agent
|
ATE431738T1
(de)
|
2001-08-06 |
2009-06-15 |
Euro Celtique Sa |
Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
|
WO2003013433A2
(en)
|
2001-08-06 |
2003-02-20 |
Euro-Celtique S.A. |
Sequestered antagonist formulations
|
EP2243471A1
(de)
|
2002-04-05 |
2010-10-27 |
Euro-Celtique S.A. |
Matrix für die modifizierte Freigabe von aktiven Substanzen
|
EP1364649A1
(de)
*
|
2002-05-23 |
2003-11-26 |
Cilag AG |
Topirimat-Tramadol Addukt und seine Verwendung
|
DK1551372T3
(en)
|
2002-09-20 |
2018-07-23 |
Alpharma Pharmaceuticals Llc |
SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
|
ATE386509T1
(de)
*
|
2002-09-21 |
2008-03-15 |
Shuyi Zhang |
Formulierung von acetaminophen und tramadol mit verzögerter freisetzung
|
US20090162431A1
(en)
*
|
2002-09-21 |
2009-06-25 |
Shuyi Zhang |
Sustained release formulations containing acetaminophen and tramadol
|
TWI319713B
(en)
|
2002-10-25 |
2010-01-21 |
|
Sustained-release tramadol formulations with 24-hour efficacy
|
US8487002B2
(en)
|
2002-10-25 |
2013-07-16 |
Paladin Labs Inc. |
Controlled-release compositions
|
US6864271B2
(en)
*
|
2002-11-12 |
2005-03-08 |
The Foundation For The Lsu Health Sciences Center |
Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
|
JP2006514986A
(ja)
*
|
2002-12-13 |
2006-05-18 |
シラグ・アクチエンゲゼルシヤフト |
トラマドールおよびトピラメートを含んでなる制御放出調製物
|
US20040202717A1
(en)
|
2003-04-08 |
2004-10-14 |
Mehta Atul M. |
Abuse-resistant oral dosage forms and method of use thereof
|
TWI347201B
(en)
|
2003-04-21 |
2011-08-21 |
Euro Celtique Sa |
Pharmaceutical products,uses thereof and methods for preparing the same
|
US20050065172A1
(en)
*
|
2003-09-23 |
2005-03-24 |
Shah Indukumar G. |
Solid dosage form comprising caffeine
|
US20050067163A1
(en)
*
|
2003-09-25 |
2005-03-31 |
George Flint R. |
Monobore release for tubing conveyed perforating
|
US20060172006A1
(en)
*
|
2003-10-10 |
2006-08-03 |
Vincent Lenaerts |
Sustained-release tramadol formulations with 24-hour clinical efficacy
|
EP1604666A1
(de)
|
2004-06-08 |
2005-12-14 |
Euro-Celtique S.A. |
Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit
|
PL1799195T3
(pl)
*
|
2004-08-12 |
2016-09-30 |
|
Granulki zawierające paracetamol, nlpz i alkohol cukrowy wytwarzane przez wytłaczanie ze stopionego materiału
|
CN100348180C
(zh)
*
|
2004-12-24 |
2007-11-14 |
河南大学 |
盐酸曲马多口腔崩解片剂及其制备方法
|
EP1702558A1
(de)
|
2005-02-28 |
2006-09-20 |
Euro-Celtique S.A. |
Verfahren und Vorrichtung zur Darmtätigkeitserfassung
|
EP1917000A2
(de)
|
2005-07-07 |
2008-05-07 |
Farnam Companies, Inc. |
Pharmazeutische zusammensetzungen mit verzögerter freisetzung für hoch wasserlösliche arzneimittel
|
KR101655455B1
(ko)
|
2005-09-09 |
2016-09-07 |
안젤리니 라보팜 엘엘씨 |
일일 1회 투여를 위한 트라조돈 조성물
|
CN101677963B
(zh)
|
2006-06-19 |
2012-05-30 |
奥尔制药公司 |
药物组合物
|
US7645767B2
(en)
*
|
2006-08-31 |
2010-01-12 |
Trinity Laboratories, Inc. |
Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
|
PL2124556T3
(pl)
|
2006-10-09 |
2015-02-27 |
Charleston Laboratories Inc |
Kompozycje farmaceutyczne
|
DE102006056458A1
(de)
*
|
2006-11-28 |
2008-05-29 |
Grünenthal GmbH |
Arzneimittelzubereitung von Tramadol und Acetaminophen
|
BRPI0807281A2
(pt)
*
|
2007-02-12 |
2014-04-29 |
Dmi Biosciences Inc |
Reduzindo os efeitos colaterais de tramadol
|
BRPI0807282A2
(pt)
*
|
2007-02-12 |
2014-04-29 |
Dmi Biosciences Inc |
Tratamento de ejaculação precoce e disfunção erétil co-mórbidas
|
US20080031950A1
(en)
*
|
2007-04-27 |
2008-02-07 |
Nectid Inc. |
Novel anelgesic combination
|
US20080026054A1
(en)
*
|
2007-04-27 |
2008-01-31 |
Nectid Inc. |
Novel anelgesic combination
|
WO2009018169A1
(en)
*
|
2007-07-27 |
2009-02-05 |
Auspex Pharmaceuticals, Inc. |
Substituted cyclohexanols
|
AU2008314454A1
(en)
|
2007-10-16 |
2009-04-23 |
Labopharm (Barbados) Limited |
Bilayer composition for the sustained release of acetaminophen and tramadol
|
US9399012B2
(en)
|
2007-11-13 |
2016-07-26 |
Mallinckrodt Ip |
Reduced dose intravenous acetaminophen
|
JP5651818B2
(ja)
|
2007-12-17 |
2015-01-14 |
パラディン ラブス インコーポレーテッド |
誤用を防止するための放出制御製剤
|
US8623418B2
(en)
|
2007-12-17 |
2014-01-07 |
Alpharma Pharmaceuticals Llc |
Pharmaceutical composition
|
EP2240022B1
(de)
|
2008-01-09 |
2016-12-28 |
Charleston Laboratories, Inc. |
Oxycodone und Promethazine enthaltende zweischichtige Tabletten
|
US8372432B2
(en)
|
2008-03-11 |
2013-02-12 |
Depomed, Inc. |
Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
|
AU2009223061B2
(en)
|
2008-03-11 |
2014-10-09 |
Depomed Inc. |
Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
|
US20100003322A1
(en)
*
|
2008-07-03 |
2010-01-07 |
Lai Felix S |
Enteric coated hydrophobic matrix formulation
|
CN102202660A
(zh)
*
|
2008-09-05 |
2011-09-28 |
格吕伦塔尔有限公司 |
包含6-二甲氨基甲基-1-(3-甲氧基-苯基)-环己烷-1,3-二醇和扑热息痛的药物组合
|
EP2177215A1
(de)
|
2008-10-17 |
2010-04-21 |
Laboratorios Del. Dr. Esteve, S.A. |
Co-Kristalle von Tramadol und NSARs
|
UA102706C2
(ru)
*
|
2008-10-27 |
2013-08-12 |
Алза Корпорейшн |
Лекарственная форма ацетаминофена и комплекса трамадола с замедленным действием для перорального приема
|
CA2746888C
(en)
|
2008-12-16 |
2015-05-12 |
Labopharm (Barbados) Limited |
Misuse preventative, controlled release formulation
|
DK2405915T3
(en)
|
2009-03-10 |
2019-02-11 |
Euro Celtique Sa |
PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE INCLUDING OXYCODON AND NALOXON
|
WO2011006012A1
(en)
|
2009-07-08 |
2011-01-13 |
Charleston Laboratories Inc. |
Pharmaceutical compositions
|
ES2353541B1
(es)
|
2009-07-30 |
2011-09-20 |
Farmalider, S.A. |
Combinacion de ingredientes activos cosmeticos y composicion cosmetica obtenida a partir de la misma, y su utilizacion.
|
EP2281558A1
(de)
*
|
2009-08-06 |
2011-02-09 |
Laboratorios Del. Dr. Esteve, S.A. |
Pharmazeutische Verbindungen von O-Desmethyltramadol und COX-Inhibitoren
|
US20110104272A1
(en)
*
|
2009-11-05 |
2011-05-05 |
Depomed, Inc. |
Gastric retentive extended-release dosage forms comprising combinations of acetaminophen and phenylephrine
|
US9198861B2
(en)
|
2009-12-22 |
2015-12-01 |
Mallinckrodt Llc |
Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
|
US8597681B2
(en)
|
2009-12-22 |
2013-12-03 |
Mallinckrodt Llc |
Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
|
DE202010001237U1
(de)
|
2010-01-21 |
2010-04-01 |
Grünenthal GmbH |
Kombination aus Tramadol und Acetaminophen als Brausetablette
|
EP2377514A3
(de)
*
|
2010-04-19 |
2012-04-11 |
Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. |
Flüssige parenterale Formulierung, die eine Tramadolsubstanz und Paracetamol umfasst
|
GR1007315B
(el)
*
|
2010-04-19 |
2011-06-14 |
Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, |
Υγρομορφη παρεντερικης χορηγησης συνθεση που περιλαμβανει τραμαδολη hci και παρακεταμολη
|
US20180264013A1
(en)
*
|
2010-07-08 |
2018-09-20 |
Wellesley Pharmaceuticals, Llc |
Composition and methods for treating sleep disorders
|
US10010514B2
(en)
|
2010-07-08 |
2018-07-03 |
Wellesley Pharmaceuticals, Llc |
Pharmaceutical formulation for reducing frequency of urination and method of use thereof
|
US9532959B2
(en)
|
2010-07-08 |
2017-01-03 |
Wellesley Pharmaceuticals, Llc |
Pharmaceutical formulation for reducing frequency of urination and method of use thereof
|
US8741885B1
(en)
|
2011-05-17 |
2014-06-03 |
Mallinckrodt Llc |
Gastric retentive extended release pharmaceutical compositions
|
US8858963B1
(en)
|
2011-05-17 |
2014-10-14 |
Mallinckrodt Llc |
Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
|
US8658631B1
(en)
|
2011-05-17 |
2014-02-25 |
Mallinckrodt Llc |
Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
|
US10702485B2
(en)
|
2011-07-09 |
2020-07-07 |
Syntrix Biosystems Inc. |
Compositions and methods for overcoming resistance to tramadol
|
US10105330B2
(en)
|
2012-01-04 |
2018-10-23 |
Wellesley Pharmaceuticals, Llc |
Extended, delayed and immediate release formulation method of manufacturing and use thereof
|
KR20180023057A
(ko)
*
|
2012-01-04 |
2018-03-06 |
웰즐리 파마슈티컬스 엘엘씨 |
배뇨 빈도를 감소시키기 위한 서방형 제제 및 이의 사용 방법
|
US10278925B2
(en)
|
2012-01-04 |
2019-05-07 |
Wellesley Pharmaceuticals, Llc |
Delayed-release formulations, methods of making and use thereof
|
AU2012363789B2
(en)
*
|
2012-01-04 |
2017-04-13 |
Wellesley Pharmaceuticals, Llc |
Extended-release formulation for reducing the frequency of urination and method of use thereof
|
ZA201300398B
(en)
|
2012-11-27 |
2013-09-25 |
Genfarma Laboratories S L |
Injectable liquid formulation of the combination of tramadol and paracetamol
|
KR20180037074A
(ko)
|
2013-07-23 |
2018-04-10 |
유로-셀티큐 에스.에이. |
장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
|
EA201990684A1
(ru)
|
2013-12-24 |
2020-12-30 |
Вирджиния Коммонвелт Юниверсити |
Способы применения оксигенированных холестеролсульфатов (ocs)
|
US10105328B2
(en)
|
2014-06-06 |
2018-10-23 |
Wellesley Pharmaceuticals, Llc |
Composition for reducing frequency of urination, method of making and use thereof
|
US9693949B1
(en)
*
|
2015-12-22 |
2017-07-04 |
Revogenex Ireland Ltd |
Intravenous administration of tramadol
|
EP3423041A4
(de)
|
2016-03-04 |
2019-09-11 |
Charleston Laboratories, Inc. |
Pharmazeutische zusammensetzungen
|
TWI620577B
(zh)
*
|
2016-11-23 |
2018-04-11 |
|
乙醯胺酚及曲馬多共溶複方止痛口服液
|
WO2019053494A1
(en)
|
2017-09-18 |
2019-03-21 |
R L Fine Chem Private Limited |
PROCESS FOR THE PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF
|
KR20190038027A
(ko)
|
2017-09-29 |
2019-04-08 |
한미약품 주식회사 |
아세트아미노펜, 및 트라마돌 또는 이의 약학적 허용 가능한 염을 포함하는 연질캡슐 조성물
|
US11000488B2
(en)
|
2019-03-22 |
2021-05-11 |
Syntrix Biosystems Inc. |
Treating pain using desmetramadol
|