RU93043625A - Композиция, включающая вещество трамадол и ацетаминофен, и способ лечения с ее использованием - Google Patents

Композиция, включающая вещество трамадол и ацетаминофен, и способ лечения с ее использованием

Info

Publication number
RU93043625A
RU93043625A RU93043625/14A RU93043625A RU93043625A RU 93043625 A RU93043625 A RU 93043625A RU 93043625/14 A RU93043625/14 A RU 93043625/14A RU 93043625 A RU93043625 A RU 93043625A RU 93043625 A RU93043625 A RU 93043625A
Authority
RU
Russia
Prior art keywords
tramadol
acetaminophen
treatment
compositions
substance
Prior art date
Application number
RU93043625/14A
Other languages
English (en)
Other versions
RU2121346C1 (ru
Inventor
Б.Раффа Роберт
Л.Вот Джеффри
Original Assignee
МакНейлэб, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by МакНейлэб, Инк. filed Critical МакНейлэб, Инк.
Priority claimed from CN92112594A external-priority patent/CN1071571C/zh
Publication of RU93043625A publication Critical patent/RU93043625A/ru
Application granted granted Critical
Publication of RU2121346C1 publication Critical patent/RU2121346C1/ru

Links

Claims (1)

  1. Изобретение относится к композиции, включающей препарат трамадола и ацетаминофен, и ее использованию. Использованный при этом трамадол относится к различным формам трамадола. Композиции фармакологически применимы при лечении боли и состояний, сопровождающихся кашлем. Композиции являются также средством уменьшить побочные действия опиоидов, такие, как привыкание, запоры, угнетение дыхания. Кроме того, если компоненты в композициях находятся в определенных соотношениях, фармакологические эффекты композиций являются супераддитивными (синергидными).
RU93043625A 1991-09-06 1992-09-03 Композиция, включающая вещество трамадол и ацетаминофен, и способ лечения с ее использованием RU2121346C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75592491A 1991-09-06 1991-09-06
US755924 1991-09-06
US755,924 1991-09-06
CN92112594A CN1071571C (zh) 1991-09-06 1992-10-24 含有反胺苯环醇物质和乙酰氨基苯的组合物及其应用

Publications (2)

Publication Number Publication Date
RU93043625A true RU93043625A (ru) 1996-05-20
RU2121346C1 RU2121346C1 (ru) 1998-11-10

Family

ID=36791806

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93043625A RU2121346C1 (ru) 1991-09-06 1992-09-03 Композиция, включающая вещество трамадол и ацетаминофен, и способ лечения с ее использованием

Country Status (17)

Country Link
US (2) US5336691A (ru)
EP (1) EP0566709B3 (ru)
JP (1) JP3381190B2 (ru)
KR (1) KR100243956B1 (ru)
CN (1) CN1071571C (ru)
AT (1) ATE169498T1 (ru)
AU (1) AU651247B2 (ru)
CA (1) CA2095523C (ru)
DE (2) DE69226624T3 (ru)
DK (1) DK0566709T5 (ru)
ES (1) ES2120451T7 (ru)
HU (1) HU219332B (ru)
LU (1) LU91079I2 (ru)
NL (1) NL300152I2 (ru)
RU (1) RU2121346C1 (ru)
SG (1) SG80535A1 (ru)
WO (1) WO1993004675A1 (ru)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5840731A (en) * 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
ZA975444B (en) * 1996-06-20 1998-12-21 Mcneil Ppc Inc Acetaminophen and meclizine hydrochloride analgesics
WO1998058637A1 (en) * 1996-06-20 1998-12-30 Mcneil-Ppc Acetaminophen and diphenhydramine analgesics
DE19641576C1 (de) * 1996-10-09 1998-05-07 Gruenenthal Gmbh Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten
US5919826A (en) * 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
DE69830728T2 (de) * 1997-04-11 2006-05-18 Nippon Shinyaku Co., Ltd. Arzneimittel zur behandlung von häufigem wasserlassen und harninkontinenz
JP2001510180A (ja) 1997-07-15 2001-07-31 ラシンスキィ・リミテッド トラマドール、その塩酸塩、及びそれらの製造方法
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
PT2266564E (pt) 1997-12-22 2013-06-20 Euro Celtique Sa Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide
US6320214B1 (en) * 1997-12-24 2001-11-20 Matsushita Electric Industrial Co., Ltd. Semiconductor device having a ferroelectric TFT and a dummy element
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
SK286621B6 (sk) * 1999-08-20 2009-02-05 Ortho-Mcneil Pharmaceutical, Inc. Farmaceutický prostriedok obsahujúci kombináciu tramadolového materiálu a antikonvulzívneho činidla, táto kombinácia a jej použitie na výrobu liečiva
PE20010623A1 (es) 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
KR20020059653A (ko) 1999-10-29 2002-07-13 그린 마틴, 브라이언 쥐 테슬리 서방성 하이드로코돈 제형
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US6297286B1 (en) * 1999-11-09 2001-10-02 Darwin Discovery, Ltd. Therapeutic use and formulation
BRPI0108380B8 (pt) 2000-02-08 2021-05-25 Euro Celtique S/A fórmulas de opióides agonistas resistentes à adulteração, método para diminuir o abuso de um opióide agonista numa fórmula de dosagem oral, método de preparação de uma fórmula de dosagem oral e método de tratamento da dor
DE60107393T2 (de) * 2000-03-01 2005-12-01 Euro-Celtique S.A. Verwendung von tramadol zur herstellung eines arzneimittels zur behandlung von funktionelle gastrointestinale krankenheiten
HU230686B1 (en) 2000-10-30 2017-08-28 Euro Celtique Sa Controlled release hydrocodone compositions
DE10059020A1 (de) * 2000-11-28 2002-05-29 Gruenenthal Gmbh Parenteral applizierbare Darreichungsformen
WO2002074241A2 (en) * 2001-03-16 2002-09-26 Dmi Biosciences Inc. Method of delaying ejaculation
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
WO2002092060A1 (en) 2001-05-11 2002-11-21 Endo Pharmaceuticals, Inc. Abuse-resistant controlled-release opioid dosage form
DK1416842T3 (da) 2001-07-18 2009-03-16 Euro Celtique Sa Farmaceutiske kombinationer af oxycodon og naloxon
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
ATE431738T1 (de) 2001-08-06 2009-06-15 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
PT2425821T (pt) 2002-04-05 2017-08-23 Mundipharma Farmacêutica Lda Preparação farmacêutica contendo oxicodona e naloxona
EP1364649A1 (en) * 2002-05-23 2003-11-26 Cilag AG Adduct of topiramate and tramadol hydrochioride and uses thereof
ES2677769T3 (es) 2002-09-20 2018-08-06 Alpharma Pharmaceuticals Llc Subunidad secuestrante y composiciones y procedimientos relacionados
US20090162431A1 (en) * 2002-09-21 2009-06-25 Shuyi Zhang Sustained release formulations containing acetaminophen and tramadol
DE60319252T2 (de) * 2002-09-21 2009-03-05 Zhang, Shuyi Formulierung von acetaminophen und tramadol mit verzögerter freisetzung
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US6864271B2 (en) * 2002-11-12 2005-03-08 The Foundation For The Lsu Health Sciences Center Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
PL377351A1 (pl) * 2002-12-13 2006-01-23 Cilag Ag Preparaty o kontrolowanym uwalnianiu zawierające tramadol i topiramat
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
US20050065172A1 (en) * 2003-09-23 2005-03-24 Shah Indukumar G. Solid dosage form comprising caffeine
US20050067163A1 (en) * 2003-09-25 2005-03-31 George Flint R. Monobore release for tubing conveyed perforating
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
MX2007001597A (es) * 2004-08-12 2007-05-23 Reckitt Benckiser Healthcare Granulos que comprenden paracetamol, un farmaco antiinflamatorio no esteroidal y un alcohol de azucar hecho por extrusion por fusion.
CN100348180C (zh) * 2004-12-24 2007-11-14 河南大学 盐酸曲马多口腔崩解片剂及其制备方法
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
RU2008104638A (ru) 2005-07-07 2009-08-20 Фарнэм Компаниз, Инк. (Us) Фармацевтические композиции хорошо растворимых в воде лекарственных средств, обеспечивающих их замедленное высвобождение
DK1940467T3 (da) 2005-09-09 2017-02-13 Paladin Labs Inc Lægemiddelsammensætning med langvarig frigivelse
ES2385612T3 (es) 2006-06-19 2012-07-27 Alpharma Pharmaceuticals, Llc Composiciones farmacéuticas
US7645767B2 (en) * 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
CA2665841C (en) 2006-10-09 2016-04-05 Charleston Laboratories, Inc. Pharmaceutical compositions
DE102006056458A1 (de) * 2006-11-28 2008-05-29 Grünenthal GmbH Arzneimittelzubereitung von Tramadol und Acetaminophen
EP2120570B1 (en) * 2007-02-12 2012-05-16 DMI Biosciences, Inc. Treatment of comorbid premature ejaculation and erectile dysfunction
NZ579170A (en) 2007-02-12 2012-05-25 Dmi Biosciences Inc Reducing side effects of tramadol
US20080026054A1 (en) * 2007-04-27 2008-01-31 Nectid Inc. Novel anelgesic combination
US20080031950A1 (en) * 2007-04-27 2008-02-07 Nectid Inc. Novel anelgesic combination
US20090028873A1 (en) * 2007-07-27 2009-01-29 Auspex Pharmaceuticals, Inc. Substituted cyclohexanols
JP5453280B2 (ja) * 2007-10-16 2014-03-26 ラボファーム インコーポレイテッド アセトアミノフェンおよびトラマドールを持続的に放出するための二層組成物
US9399012B2 (en) 2007-11-13 2016-07-26 Mallinckrodt Ip Reduced dose intravenous acetaminophen
JP5651818B2 (ja) 2007-12-17 2015-01-14 パラディン ラブス インコーポレーテッド 誤用を防止するための放出制御製剤
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
JP5714910B2 (ja) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ,インコーポレイテッド 薬学的組成物
EP2262484B1 (en) 2008-03-11 2013-01-23 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
MX2011002430A (es) * 2008-09-05 2011-04-05 Gruenenthal Gmbh Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3- metoxi-fenil)-ciclohexano-1, 3-diol y paracetamol.
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
EP2362768B1 (en) * 2008-10-27 2016-04-20 Alza Corporation Extended release oral acetaminophen/tramadol dosage form
EP2367541B1 (en) 2008-12-16 2014-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
ES2706407T3 (es) 2009-03-10 2019-03-28 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona
WO2011006012A1 (en) 2009-07-08 2011-01-13 Charleston Laboratories Inc. Pharmaceutical compositions
ES2353541B1 (es) 2009-07-30 2011-09-20 Farmalider, S.A. Combinacion de ingredientes activos cosmeticos y composicion cosmetica obtenida a partir de la misma, y su utilizacion.
EP2281558A1 (en) * 2009-08-06 2011-02-09 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compounds of O-Desmethyl-Tramadol and COX-inhibitors
US20110104272A1 (en) * 2009-11-05 2011-05-05 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of acetaminophen and phenylephrine
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
DE202010001237U1 (de) 2010-01-21 2010-04-01 Grünenthal GmbH Kombination aus Tramadol und Acetaminophen als Brausetablette
EP2377514A3 (en) * 2010-04-19 2012-04-11 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Liquid parenteral formulation comprising a tramadol material and paracetamol
GR1007315B (el) * 2010-04-19 2011-06-14 Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, Υγρομορφη παρεντερικης χορηγησης συνθεση που περιλαμβανει τραμαδολη hci και παρακεταμολη
US20180264013A1 (en) * 2010-07-08 2018-09-20 Wellesley Pharmaceuticals, Llc Composition and methods for treating sleep disorders
US10010514B2 (en) 2010-07-08 2018-07-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US9532959B2 (en) 2010-07-08 2017-01-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8658631B1 (en) 2011-05-17 2014-02-25 Mallinckrodt Llc Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
US10278925B2 (en) 2012-01-04 2019-05-07 Wellesley Pharmaceuticals, Llc Delayed-release formulations, methods of making and use thereof
US10105330B2 (en) 2012-01-04 2018-10-23 Wellesley Pharmaceuticals, Llc Extended, delayed and immediate release formulation method of manufacturing and use thereof
KR20140108675A (ko) * 2012-01-04 2014-09-12 웰즐리 파마슈티컬스 엘엘씨 배뇨 빈도를 감소시키기 위한 연장-방출형 제제 및 이의 사용 방법
WO2013103389A1 (en) * 2012-01-04 2013-07-11 Wellesley Pharmaceuticals, Llc Delayed-release formulation for reducing the frequency of urination and method of use thereof
ZA201300398B (en) 2012-11-27 2013-09-25 Genfarma Laboratories S L Injectable liquid formulation of the combination of tramadol and paracetamol
NZ716267A (en) 2013-07-23 2017-05-26 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
BR112016014611A8 (pt) 2013-12-24 2023-05-09 Univ Virginia Commonwealth Usos de sulfatos de colesterol oxigenados (ocs)
US10105328B2 (en) 2014-06-06 2018-10-23 Wellesley Pharmaceuticals, Llc Composition for reducing frequency of urination, method of making and use thereof
US9693949B1 (en) * 2015-12-22 2017-07-04 Revogenex Ireland Ltd Intravenous administration of tramadol
EP3423041A4 (en) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. PHARMACEUTICAL COMPOSITIONS
TWI620577B (zh) * 2016-11-23 2018-04-11 乙醯胺酚及曲馬多共溶複方止痛口服液
EP3684753A1 (en) 2017-09-18 2020-07-29 R L Fine Chem Private Limited A process for preparation of o-desmethyltramadol and salts thereof
KR20190038027A (ko) 2017-09-29 2019-04-08 한미약품 주식회사 아세트아미노펜, 및 트라마돌 또는 이의 약학적 허용 가능한 염을 포함하는 연질캡슐 조성물
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2770569A (en) 1952-08-01 1956-11-13 Hoffmann La Roche Analgesic compositions
US3830934A (en) 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3773955A (en) 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
CA1083044A (en) 1976-05-04 1980-08-05 Stewart Wong Antiarthritic potentiation
JPS5492631A (en) * 1977-12-27 1979-07-23 Kowa Co Analgestic
EP0017102A1 (en) 1979-03-22 1980-10-15 Merck & Co. Inc. Composition containing a phenyl benzoic acid compound and acetaminophen combination for the treatment of pain and inflammation and process for preparing the same
US4237140A (en) 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4260629A (en) 1979-10-25 1981-04-07 E. I. Du Pont De Nemours And Company Treating pain with acetaminophen and 1,4-dimethyl-5-p-chlorobenzoyl-pyrrole-2-acetic acid
JPS57128626A (en) 1981-01-30 1982-08-10 Morishita Seiyaku Kk Analgesic composition
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
WO1984002273A1 (en) * 1982-12-09 1984-06-21 Sandoz Ag Analgesic combinations
US4631284A (en) 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US4571400A (en) 1984-12-18 1986-02-18 Belleview Pharmaceutical, Inc. Dihydrocodeine/ibuprofen pharmaceutical compositions and method
US4601894A (en) 1985-03-29 1986-07-22 Schering Corporation Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate
JPS61293911A (ja) 1985-06-24 1986-12-24 Teisan Seiyaku Kk 徐放化製剤
US4730007A (en) 1985-09-04 1988-03-08 Seymour Ehrenpreis Novel analgesic compositions
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
US4769372A (en) 1986-06-18 1988-09-06 The Rockefeller University Method of treating patients suffering from chronic pain or chronic cough
US4943565A (en) 1986-09-15 1990-07-24 Bristol-Myers Squibb Company Analgesic tablet of aspirin and caffeine containing low-substituted hydroxypropyl cellulose
US4806543A (en) 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury
US4829064A (en) 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
DE3830355A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur herstellung von pharmazeutischen tabletten
DE3830353A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
HU208633B (en) 1991-02-04 1993-12-28 Alkaloida Vegyeszeti Gyar Process for production of analgetic compositions as applicable for blocking of opioid-binding spaces /2-receptors/ causing respiration depression
CA2077637C (en) 1991-09-06 2007-01-09 Robert B. Raffa Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone and their use
US5223541A (en) 1991-09-13 1993-06-29 Mcneilab, Inc. Tramadol n-oxide material, enantiomers and compositions thereof, and their use
US5516803A (en) 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5352680A (en) 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
SK286621B6 (sk) 1999-08-20 2009-02-05 Ortho-Mcneil Pharmaceutical, Inc. Farmaceutický prostriedok obsahujúci kombináciu tramadolového materiálu a antikonvulzívneho činidla, táto kombinácia a jej použitie na výrobu liečiva

Similar Documents

Publication Publication Date Title
RU93043625A (ru) Композиция, включающая вещество трамадол и ацетаминофен, и способ лечения с ее использованием
ATE169498T1 (de) Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung
BR1100776A (pt) Forma de dosagem farmacêutica comprimida e obréia farmacêutica comprimida.
CA2258920A1 (en) Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies
MXPA01012882A (es) Composiciones y metodos que comprenden gluconato de morfina.
ITRM910922A1 (it) Composizione farmaceutica anticefalalgica per somministrazione endonasale, procedimento per prepararla e suo impiego terapeutico
DE69531741D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
NO924169L (no) Preparat omfattende et tramadolmateriale og et ikke-stereoid antiinflammatorisk legemiddel
BG103740A (en) Phytostyrene composition for the prevention of the alzheimer's disease
DE19875032I2 (de) Mometason-Furoate-Monohydrat, Verfahren zu seiner Herstellung und das enthaltende pharmazeutische Zusammensetzungen
ATE433959T1 (de) Analoge von kokain
HK1030157A1 (en) Use of consensus interferon and compositions comprising consensus interferon.
ATE128864T1 (de) Zusammensetzung zur behandlung der symptome verursacht durch beseitigung von tabak.
MY118526A (en) Method for improving the pharmacokinetics of tipranavir
DK0460062T3 (da) Huperzin A-analoger
CA2433785A1 (en) Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof
IL126175A0 (en) Method or treating heart failure with endothelin antagonists and pharmaceutical compositions containing the same
SE8402199D0 (sv) Pharmazeutisches preparat enthaltend co-dergocrine und einen calcium-antagonisten
DE3473826D1 (en) N,n-diethyl-5-methyl-2h-1-benzothiopyrano-(4,3,2-cd)-indazole-2-ethanamine, compositions comprising the same and uses therefor
GB9015774D0 (en) Novel treatment
RU93005013A (ru) 1-аминоспиро[изохинолин-4(1н)3-пирролидин-1,2,3,5'(2н)-тетроны] и их аналоги, способ их получения и фармацевтическая композиция
MY114755A (en) Composition comprising a tramadol material and acetaminophen and its use.
EP0384302A3 (en) Use of ubenimex in the manufacture of a medicament for treating myelodysplastic syndrome
RU93044224A (ru) Фармацевтическая композиция, обладающая агонистической активностью для 5 нт1 - подобных рецепторов
KR920702623A (ko) 진해제