ES2117893T3 - Procedimiento para la preparacion de un 3,3-difluorofurano 2-sustituido. - Google Patents

Procedimiento para la preparacion de un 3,3-difluorofurano 2-sustituido.

Info

Publication number
ES2117893T3
ES2117893T3 ES96301685T ES96301685T ES2117893T3 ES 2117893 T3 ES2117893 T3 ES 2117893T3 ES 96301685 T ES96301685 T ES 96301685T ES 96301685 T ES96301685 T ES 96301685T ES 2117893 T3 ES2117893 T3 ES 2117893T3
Authority
ES
Spain
Prior art keywords
substituted
preparation
difluorofuran
procedure
diflurfurano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96301685T
Other languages
English (en)
Inventor
Douglas Patton Kjell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2117893T3 publication Critical patent/ES2117893T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION DE 3,3 DIFLURFURANO 2 - SUSTITUIDO UTILIZANDO DIETIL AMONIO DE TRIFLUORURO DE AZUFRE (DATA) Y FLUORURO DE HIDROGENO DE PIRIDINA. EL PROCESO ES PARTICULARMENTE UTIL PARA PRODUCIR UN 2'',2'' DIFLUORNUCLEOSIDO, PARTICULARMENTE 1 - (2'',2'' - DIFLUORO - {BE} D - ARABINOFURANOSIL)CITOSINA (TAMBIEN CONOCIDA COMO 2'' - DEOXI - 2'',2'' - DIFLUORACETIDINA), UN AGENTE ANTIVIRAL Y ANTITUMORAL CONOCIDO.
ES96301685T 1995-03-24 1996-03-12 Procedimiento para la preparacion de un 3,3-difluorofurano 2-sustituido. Expired - Lifetime ES2117893T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/410,258 US5633367A (en) 1995-03-24 1995-03-24 Process for the preparation of a 2-substituted 3,3-difluorofuran

Publications (1)

Publication Number Publication Date
ES2117893T3 true ES2117893T3 (es) 1998-08-16

Family

ID=23623945

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96301685T Expired - Lifetime ES2117893T3 (es) 1995-03-24 1996-03-12 Procedimiento para la preparacion de un 3,3-difluorofurano 2-sustituido.

Country Status (7)

Country Link
US (1) US5633367A (es)
EP (1) EP0735043B1 (es)
JP (1) JPH08269081A (es)
CA (1) CA2171522A1 (es)
DE (1) DE69600280T2 (es)
DK (1) DK0735043T3 (es)
ES (1) ES2117893T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE344271T1 (de) 1998-02-25 2006-11-15 Univ Emory 2'-fluoronukleoside
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
JP2009526782A (ja) * 2006-02-07 2009-07-23 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CA3120941A1 (en) * 2018-11-25 2020-05-28 Tnt Medical Corporation Orally active prodrug of gemcitabine
GB202203421D0 (en) * 2022-03-11 2022-04-27 Laevoroc Chemotherapy Ag Orally active prodrug of gemcitabine
CN115745953A (zh) * 2022-06-29 2023-03-07 上海凌凯医药科技有限公司 一种羟基氟代试剂及羟基氟代方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
EP0577304B1 (en) * 1992-06-22 1997-03-05 Eli Lilly And Company Stereoselective anion glycosylation process
TW356472B (en) * 1992-09-01 1999-04-21 Lilly Co Eli A process for anomerizing nucleosides

Also Published As

Publication number Publication date
US5633367A (en) 1997-05-27
EP0735043A1 (en) 1996-10-02
CA2171522A1 (en) 1996-09-25
JPH08269081A (ja) 1996-10-15
DK0735043T3 (da) 1998-10-07
EP0735043B1 (en) 1998-05-13
DE69600280D1 (de) 1998-06-18
DE69600280T2 (de) 1998-10-08

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