DE69600280T2 - Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran - Google Patents

Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran

Info

Publication number
DE69600280T2
DE69600280T2 DE69600280T DE69600280T DE69600280T2 DE 69600280 T2 DE69600280 T2 DE 69600280T2 DE 69600280 T DE69600280 T DE 69600280T DE 69600280 T DE69600280 T DE 69600280T DE 69600280 T2 DE69600280 T2 DE 69600280T2
Authority
DE
Germany
Prior art keywords
difluorofuran
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69600280T
Other languages
English (en)
Other versions
DE69600280D1 (de
Inventor
Douglas Patton Kjell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69600280D1 publication Critical patent/DE69600280D1/de
Application granted granted Critical
Publication of DE69600280T2 publication Critical patent/DE69600280T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69600280T 1995-03-24 1996-03-12 Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran Expired - Lifetime DE69600280T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/410,258 US5633367A (en) 1995-03-24 1995-03-24 Process for the preparation of a 2-substituted 3,3-difluorofuran

Publications (2)

Publication Number Publication Date
DE69600280D1 DE69600280D1 (de) 1998-06-18
DE69600280T2 true DE69600280T2 (de) 1998-10-08

Family

ID=23623945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69600280T Expired - Lifetime DE69600280T2 (de) 1995-03-24 1996-03-12 Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran

Country Status (7)

Country Link
US (1) US5633367A (de)
EP (1) EP0735043B1 (de)
JP (1) JPH08269081A (de)
CA (1) CA2171522A1 (de)
DE (1) DE69600280T2 (de)
DK (1) DK0735043T3 (de)
ES (1) ES2117893T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100954390B1 (ko) * 1998-02-25 2010-04-26 에모리 유니버시티 2'-플루오로뉴클레오사이드
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CA2641719A1 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
SG11202105512PA (en) * 2018-11-25 2021-06-29 Tnt Medical Corp Orally active prodrug of gemcitabine
GB202203421D0 (en) * 2022-03-11 2022-04-27 Laevoroc Chemotherapy Ag Orally active prodrug of gemcitabine
CN115745953A (zh) * 2022-06-29 2023-03-07 上海凌凯医药科技有限公司 一种羟基氟代试剂及羟基氟代方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
WO1988007049A1 (en) * 1987-03-19 1988-09-22 Yamasa Shoyu Kabushiki Kaisha 2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
MX9303708A (es) * 1992-06-22 1994-05-31 Lilly Co Eli Proceso de glucosilacion anionica estereoselectiva para preparar 2'-desoxifluoro-beta nucleosidos.
TW356472B (en) * 1992-09-01 1999-04-21 Lilly Co Eli A process for anomerizing nucleosides

Also Published As

Publication number Publication date
EP0735043B1 (de) 1998-05-13
ES2117893T3 (es) 1998-08-16
DE69600280D1 (de) 1998-06-18
DK0735043T3 (da) 1998-10-07
US5633367A (en) 1997-05-27
EP0735043A1 (de) 1996-10-02
JPH08269081A (ja) 1996-10-15
CA2171522A1 (en) 1996-09-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN