DE69600280D1 - Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran - Google Patents

Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran

Info

Publication number
DE69600280D1
DE69600280D1 DE69600280T DE69600280T DE69600280D1 DE 69600280 D1 DE69600280 D1 DE 69600280D1 DE 69600280 T DE69600280 T DE 69600280T DE 69600280 T DE69600280 T DE 69600280T DE 69600280 D1 DE69600280 D1 DE 69600280D1
Authority
DE
Germany
Prior art keywords
difluorofuran
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69600280T
Other languages
English (en)
Other versions
DE69600280T2 (de
Inventor
Douglas Patton Kjell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69600280D1 publication Critical patent/DE69600280D1/de
Application granted granted Critical
Publication of DE69600280T2 publication Critical patent/DE69600280T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69600280T 1995-03-24 1996-03-12 Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran Expired - Lifetime DE69600280T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/410,258 US5633367A (en) 1995-03-24 1995-03-24 Process for the preparation of a 2-substituted 3,3-difluorofuran

Publications (2)

Publication Number Publication Date
DE69600280D1 true DE69600280D1 (de) 1998-06-18
DE69600280T2 DE69600280T2 (de) 1998-10-08

Family

ID=23623945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69600280T Expired - Lifetime DE69600280T2 (de) 1995-03-24 1996-03-12 Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran

Country Status (7)

Country Link
US (1) US5633367A (de)
EP (1) EP0735043B1 (de)
JP (1) JPH08269081A (de)
CA (1) CA2171522A1 (de)
DE (1) DE69600280T2 (de)
DK (1) DK0735043T3 (de)
ES (1) ES2117893T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2276515T3 (es) * 1998-02-25 2007-06-16 Emory University 2'-fluoronucleosidos.
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR20080099263A (ko) * 2006-02-07 2008-11-12 케마지스 리미티드 젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
BR112021009988A2 (pt) * 2018-11-25 2021-08-17 Tnt Medical Corporation composto de fórmula (i), ou um n-óxido deste, ou um sal, solvato, polimorfo, tautômero, estereoisômero farmaceuticamente aceitável, uma forma isotópica, ou um pró-fármaco do dito composto de fórmula (i) ou n-óxido deste, composição farmacêutica, e método de tratamento de uma doença neoplásica
GB202203421D0 (en) * 2022-03-11 2022-04-27 Laevoroc Chemotherapy Ag Orally active prodrug of gemcitabine
CN115745953B (zh) * 2022-06-29 2024-06-11 上海凌凯医药科技有限公司 一种羟基氟代试剂及羟基氟代方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
FI932871A (fi) * 1992-06-22 1993-12-23 Lilly Co Eli Stereoselektiv anjonglykosylationsprocess
KR100252451B1 (ko) * 1992-09-01 2000-04-15 피터 지. 스트링거 뉴클레오사이드의아노머화방법

Also Published As

Publication number Publication date
DK0735043T3 (da) 1998-10-07
ES2117893T3 (es) 1998-08-16
EP0735043A1 (de) 1996-10-02
US5633367A (en) 1997-05-27
CA2171522A1 (en) 1996-09-25
JPH08269081A (ja) 1996-10-15
DE69600280T2 (de) 1998-10-08
EP0735043B1 (de) 1998-05-13

Similar Documents

Publication Publication Date Title
DE69628712D1 (de) Verfahren zur Herstellung von Dihalogenazolopyrimidinen
DE69534190D1 (de) Verfahren zur Herstellung von 1,2-Benzisothiazol-3-onen
DE59607656D1 (de) Verfahren zur Herstellung von Alkylhydrogenchlorsilanen
DE59608829D1 (de) Verfahren zur Herstellung von 1,3-Dimethyl-5-fluor-pyrazol-4-carboxaniliden
DE59503847D1 (de) Verfahren zur Herstellung von 3,5-Dimethylpyrazol-blockierten Polyisocyanaten
DE59408701D1 (de) Verfahren zur Herstellung von 2,3,4,5-Tetrafluor-benzotrifluorid
DE69602880D1 (de) Verfahren zur Herstellung von 1,2-Dichlorethan
DE69600280D1 (de) Verfahren zur Herstellung von einem 2-substituierten 3,3-Difluorfuran
DE69408085D1 (de) Verfahren zur Herstellung von 2,2-Diphenylhexafluorpropanen
DE69401368D1 (de) Verfahren zur Herstellung von 1,4-Dicyano-2-buten
DE59303691D1 (de) Verfahren zur Herstellung von alpha-Chlor- 2,4,6-trimethylacetophenon
DE59600661D1 (de) Verfahren zur Herstellung von d,I-Menthol
DE59309922D1 (de) Verfahren zur Herstellung von substituierten 2,3-Difluorpyridinen
DE69508683D1 (de) Verfahren zur Herstellung von 2,6-Di-tert-alkylcyclohexanol
DE69503100D1 (de) Verfahren zur Herstellung von 3,4-Carandiol
DE59401800D1 (de) Verfahren zur Herstellung von 1,1'-Binaphthylen
DE69600385D1 (de) Verfahren zur Herstellung von Aminonitropyridinen
DE59500712D1 (de) Verfahren zur Herstellung von 4,6-Diaminoresorcin
DE69710294D1 (de) Verfahren zur Herstellung von 3,5,5-Trimethyl-Cyclohexa-3-en-1-on
DE69607541D1 (de) Verfahren zur Herstellung von p-Bromfluorobenzol
DE69513008D1 (de) Verfahren zur Herstellung von Hydroxyalkoxybenzophenonen
DE59605105D1 (de) Verfahren zur Herstellung von substituierten Aminocarbonyltriazolinonen
DE59605227D1 (de) Verfahren zur Herstellung von ortho-Nitro-benzonitrilen
DE69502242D1 (de) Verfahren zur Herstellung von 1,3-dialkyl-2-imidazolidinon
DE69600534D1 (de) Verfahren zur Herstellung von 1,5-Hexadien

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN