ES2098842T3 - Composicion farmaceutica estabilizada y disolvente estabilizante. - Google Patents
Composicion farmaceutica estabilizada y disolvente estabilizante.Info
- Publication number
- ES2098842T3 ES2098842T3 ES94115180T ES94115180T ES2098842T3 ES 2098842 T3 ES2098842 T3 ES 2098842T3 ES 94115180 T ES94115180 T ES 94115180T ES 94115180 T ES94115180 T ES 94115180T ES 2098842 T3 ES2098842 T3 ES 2098842T3
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- pharmaceutical composition
- anion
- content
- stabilized pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002904 solvent Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title 1
- -1 CARBOXYLATE ANION Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 abstract 1
- 229960001278 teniposide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12802693A | 1993-09-29 | 1993-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2098842T3 true ES2098842T3 (es) | 1997-05-01 |
Family
ID=22433231
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94115180T Expired - Lifetime ES2098842T3 (es) | 1993-09-29 | 1994-09-27 | Composicion farmaceutica estabilizada y disolvente estabilizante. |
ES09402047A Withdrawn ES2095802A1 (es) | 1993-09-29 | 1994-09-29 | Composicion farmaceutica estabilizada y solvente de estabilizacion. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09402047A Withdrawn ES2095802A1 (es) | 1993-09-29 | 1994-09-29 | Composicion farmaceutica estabilizada y solvente de estabilizacion. |
Country Status (28)
Country | Link |
---|---|
US (1) | US5504102A (fr) |
EP (1) | EP0645145B1 (fr) |
JP (1) | JP3447386B2 (fr) |
KR (1) | KR100515631B1 (fr) |
CN (1) | CN1140297C (fr) |
AT (1) | ATE149843T1 (fr) |
AU (1) | AU686651B2 (fr) |
BE (1) | BE1007987A5 (fr) |
BR (1) | BR1100361A (fr) |
CA (1) | CA2132936C (fr) |
CY (1) | CY2035A (fr) |
CZ (2) | CZ287358B6 (fr) |
DE (1) | DE69402022T2 (fr) |
DK (1) | DK0645145T3 (fr) |
ES (2) | ES2098842T3 (fr) |
FI (1) | FI115825B (fr) |
GR (1) | GR3023583T3 (fr) |
HK (1) | HK96797A (fr) |
HU (1) | HU217962B (fr) |
IL (1) | IL111065A (fr) |
IT (1) | IT1279383B1 (fr) |
NO (1) | NO308447B1 (fr) |
NZ (1) | NZ264526A (fr) |
PL (1) | PL176826B1 (fr) |
RU (1) | RU2107500C1 (fr) |
SG (1) | SG50479A1 (fr) |
TW (1) | TW406020B (fr) |
ZA (1) | ZA947482B (fr) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0674510B1 (fr) * | 1992-11-27 | 1998-08-05 | Napro Biotherapeutics, Inc. | Composition injectable comprenant du paclitaxel |
US6753006B1 (en) * | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
US20030068362A1 (en) * | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
US6096331A (en) | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US20030133955A1 (en) * | 1993-02-22 | 2003-07-17 | American Bioscience, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US6749868B1 (en) | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US6335356B1 (en) | 1994-01-07 | 2002-01-01 | Sugen, Inc. | Method of treating a patient by parenteral administration of a lipophilic compound |
US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
NL9500340A (nl) * | 1995-02-22 | 1996-10-01 | Yew Tree Pharmaceuticals B V | Gestabiliseerde paclitaxel-oplossing en farmaceutisch preparaat dat deze oplossing bevat. |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
DE19536165A1 (de) * | 1995-09-28 | 1997-04-03 | Basf Ag | Verfahren zur Reinigung von alkoxylierten Fetten |
US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
CN1209059A (zh) * | 1995-12-21 | 1999-02-24 | 基因实验室技术有限公司 | 紫杉烷类组合物及方法 |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
KR100358934B1 (ko) * | 1996-09-13 | 2003-01-29 | 주식회사한국신약 | 탁솔을함유한주사용약제조성물 |
CA2275889C (fr) | 1996-12-30 | 2008-03-18 | Battelle Memorial Institute | Preparation et methode de traitement de neoplasmes par inhalation |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
BE1011216A3 (fr) * | 1997-06-13 | 1999-06-01 | Thissen En Abrege L T B Lab | Forme pharmaceutique pour l'administration de paclitaxel, procede de preparation d'une composition de paclitaxel prete a l'emploi et utilisation de cette composition. |
US5925776A (en) * | 1997-12-24 | 1999-07-20 | Schein Pharmacetical, Inc. | Polyethoxylated castor oil, process of making the same and formulations thereof |
US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US5922754A (en) * | 1998-10-02 | 1999-07-13 | Abbott Laboratories | Pharmaceutical compositions containing paclitaxel |
CA2347097C (fr) * | 1998-10-20 | 2009-06-16 | Ben Venue Laboratories, Inc. | Procede de purification de solvants s'utilisant pour la preparation de compositions pharmaceutiques |
US6017948A (en) * | 1998-10-30 | 2000-01-25 | Supergen, Inc. | Water-miscible pharmaceutical compositions |
US6071952A (en) * | 1998-12-02 | 2000-06-06 | Mylan Pharmaceuticals, Inc. | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
US6040330A (en) * | 1999-01-08 | 2000-03-21 | Bionumerik Pharmaceuticals, Inc. | Pharmaceutical formulations of taxanes |
US7235583B1 (en) | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
US6136846A (en) | 1999-10-25 | 2000-10-24 | Supergen, Inc. | Formulation for paclitaxel |
US6828346B2 (en) * | 1999-10-25 | 2004-12-07 | Supergen, Inc. | Methods for administration of paclitaxel |
WO2001072300A1 (fr) * | 2000-03-24 | 2001-10-04 | Baker Norton Pharmaceuticals, Inc. | Utilisation de sels metalliques pour stabiliser des compositions a base de taxane |
WO2001076559A1 (fr) | 2000-04-10 | 2001-10-18 | Teva Pharmaceutical Industries Ltd. | Methode relative a une formulation a base de proteine plasmatique de paclitaxel |
AU5887201A (en) | 2000-05-12 | 2001-11-20 | Samyang Corp | Method for the preparation of polymeric micelle via phase separation of block copolymer |
US7217770B2 (en) | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
AU2001279168A1 (en) * | 2000-08-02 | 2002-02-13 | Atossa Healthcare, Inc. | Bimodal emulsions of taxanes and butyrate polyalcohol esters |
US20040033267A1 (en) * | 2002-03-20 | 2004-02-19 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
US6410059B1 (en) * | 2000-10-20 | 2002-06-25 | Council Of Scientific And Industrial Research | Pharmaceutical composition containing cow urine distillate and an antibiotic |
PL203300B1 (pl) * | 2000-10-31 | 2009-09-30 | Akad Medyczna | Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego |
CA2427467C (fr) | 2000-11-09 | 2010-01-12 | Neopharm, Inc. | Complexes lipidiques a base de sn-38 et procedes d'utilisation |
EP1337273A2 (fr) * | 2000-11-28 | 2003-08-27 | Transform Pharmaceuticals, Inc. | Formulations pharmaceutiques contenant du paclitaxel, ses derives et ses sels pharmaceutiquement acceptables |
ES2316489T3 (es) | 2000-12-05 | 2009-04-16 | Childrens Hospital Los Angeles | Composiciones farmaceuticas de fenretinida que tienen biodisponibilidad aumentada y metodos de uso de las mismas. |
US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
MXPA03006412A (es) * | 2001-01-25 | 2003-10-15 | Bristol Myers Squibb Co | Metodos para administrar analogos de epotilona para tratamiento de cancer. |
JP4634694B2 (ja) * | 2001-03-23 | 2011-02-16 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | 脂肪アルコール薬物複合体 |
WO2002076402A2 (fr) | 2001-03-23 | 2002-10-03 | Protarga, Inc. | Conjugues a base d'amines gras et d'agents pharmaceutiques |
DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
US7141251B2 (en) | 2001-04-06 | 2006-11-28 | Cytorex Biosciences, Inc. | Pharmacologically active strong acid solutions |
WO2003030864A1 (fr) * | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Formulation liposomale d'irinotecan |
KR100774366B1 (ko) | 2001-09-10 | 2007-11-08 | 주식회사 중외제약 | 파클리탁셀 주사제 조성물 |
KR20030023369A (ko) * | 2001-09-13 | 2003-03-19 | 한국과학기술연구원 | 화학색전용 파클리탁셀 유성 조성물, 그의 제형 및 제조방법 |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
CA2466851C (fr) * | 2001-11-26 | 2012-09-11 | Supergen, Inc. | Procede de preparation et d'utilisation d'huile de ricin polyoxyethylee dans des compositions pharmaceutiques |
US20040092428A1 (en) * | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
US20080220075A1 (en) * | 2002-03-20 | 2008-09-11 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
CZ294371B6 (cs) * | 2002-06-10 | 2004-12-15 | Pliva - Lachema, A. S. | Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy |
DK1521572T3 (da) * | 2002-07-15 | 2009-05-04 | Alcon Inc | Biologisk nedbrydelig film til indförsel af öjenlægemiddel |
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AU2003291458A1 (en) * | 2002-11-08 | 2004-06-03 | Bristol-Myers Squibb Company | Pharmaceutical compositions and methods of using taxane derivatives |
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EP1624896B1 (fr) * | 2003-05-19 | 2009-07-29 | Ebewe Pharma Ges.m.b.H. Nfg. KG | Procede de preparation d'une composition injectable stable de paclitaxel |
RU2236852C1 (ru) * | 2003-06-23 | 2004-09-27 | Закрытое акционерное общество "ДЕСКО" | Средство для ингибирования репродукции оболоченных вирусов, способ его получения, фармацевтическая композиция и способ ингибирования вирусных инфекций |
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WO2005061474A1 (fr) * | 2003-12-12 | 2005-07-07 | Quiral Química Do Brasil | Procede de preparation d'ingredients pharmaceutiques actifs hydrates et anhydres (api), compositions pharmaceutiques stables preparees a partir de ces derniers et utilisations desdites compositions |
DK1694242T3 (da) * | 2003-12-17 | 2014-06-30 | Bionumerik Pharmaceuticals Inc | Fremgangsmåde til fremstilling af farmaceutiske 7-(2-trimethylsilylethyl)camptothecinpræparater |
JP4433918B2 (ja) * | 2004-07-15 | 2010-03-17 | コニカミノルタエムジー株式会社 | 画像形成方法 |
KR100651728B1 (ko) * | 2004-11-10 | 2006-12-06 | 한국전자통신연구원 | 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법 |
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US7361683B2 (en) * | 2004-11-24 | 2008-04-22 | Yung Shin Pharm. Ind., Co., Ltd | Paclitaxel aqueous injection solution and methods for preparing the same |
SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
US8242165B2 (en) * | 2006-10-26 | 2012-08-14 | Creighton University | Mucoadhesive nanoparticles for cancer treatment |
JP2011509299A (ja) | 2008-01-08 | 2011-03-24 | ブリストル−マイヤーズ スクイブ カンパニー | 増殖性疾患治療のための、抗ctla−4抗体とチューブリン調節剤との組み合わせ |
SI2254570T1 (sl) * | 2008-02-20 | 2014-03-31 | Actelion Pharmaceuticals Ltd. | Kombinacija, obsegajoča paklitaksel, za zdravljenje raka na jajčnikih |
DE102008059201A1 (de) * | 2008-11-27 | 2010-06-02 | GÖPFERICH, Achim, Prof. Dr. | In situ präzipitierende Arzneistofflösungen |
EP2204167A1 (fr) | 2009-01-05 | 2010-07-07 | Azad Pharma AG | Microémulsion pharmaceutique pour la prévention de l'agrégation supramoléculaire de molécules amphiphiles |
DK2769737T3 (en) | 2009-07-20 | 2017-07-24 | Bristol Myers Squibb Co | COMBINATION OF ANTI-CTLA4 ANTIBODY WITH ETOPOSIDE FOR SYNERGISTIC TREATMENT OF PROLIFERATIVE DISEASES |
AR093275A1 (es) | 2010-03-17 | 2015-05-27 | Centro De Excelencia En Productos Y Procesos De Cordoba (Ceprocor) | Una composicion farmaceutica soluble en agua que comprende al menos una sustancia terapeuticamente activa de caracteristicas hidrofobicas y al menos un compuesto seleccionado entre los sialoglicoesfingolipidos, los glicoesfingolipidos o una mezcla de sialoglicoesfingolipidos y glicoesfingolipidos |
EP2637655B1 (fr) * | 2010-11-08 | 2019-01-09 | Cadila Pharmaceuticals Ltd. | Composition pharmaceutique de taxoïdes |
US9198969B2 (en) * | 2012-08-15 | 2015-12-01 | Yung Shin Pharm. Ind. Co., Ltd. | Stable pharmaceutical formulation of cabazitaxel |
ES2873600T3 (es) * | 2013-02-05 | 2021-11-03 | 1Globe Health Inst Llc | Nanopartículas biodegradables y clínicamente compatibles como vehículos de suministro de fármacos. |
EP2777691A1 (fr) * | 2013-03-14 | 2014-09-17 | Pharmachemie B.V. | Taxoïde - purification des excipients liquides |
WO2016005962A2 (fr) | 2014-07-11 | 2016-01-14 | Dr. Reddy’S Laboratories Limited | Formulations liquides stables de cyclophosphamide et procédés associés |
US10849916B2 (en) | 2014-07-11 | 2020-12-01 | Dr. Reddys Laboratories Limited | Stable liquid formulations of cyclophosphamide and its impurities |
AR100034A1 (es) | 2015-01-30 | 2016-09-07 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | Una composición farmacéutica soluble en agua que comprende, al menos, una sustancia terapéuticamente activa y, al menos, una sustancia con capacidad para formar micelas |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR830002614B1 (ko) * | 1980-04-14 | 1983-05-30 | 후로인도 산교오 가부시끼 가이샤 | 활성화된 의약조성물의 제법 |
JPS61152621A (ja) * | 1984-12-27 | 1986-07-11 | Lion Corp | 液状透明口腔用組成物 |
RO92831B1 (ro) * | 1985-07-29 | 1988-01-01 | Viorica Dobrescu | Procedeu de purificare a polietilenglicolilor |
HU201567B (en) * | 1988-07-21 | 1990-11-28 | Gyogyszerkutato Intezet | Process for production of intravenous medical compositions containing cyclosphorin |
JPH02196789A (ja) * | 1989-01-25 | 1990-08-03 | Sankyo Co Ltd | リゾキシン類化合物の安定化法 |
JP2598206B2 (ja) * | 1992-07-17 | 1997-04-09 | ツヤック株式会社 | 蛋白繊維品のハイグラル・エクスパンションの安定化法 |
EP0674510B1 (fr) * | 1992-11-27 | 1998-08-05 | Napro Biotherapeutics, Inc. | Composition injectable comprenant du paclitaxel |
NZ258044A (en) * | 1992-11-27 | 1995-12-21 | Faulding F H & Co Ltd | Pharmaceutical composition comprising taxol, solubilising agent, an acid and an organic solvent |
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1994
- 1994-08-25 TW TW083107808A patent/TW406020B/zh active
- 1994-09-23 NZ NZ264526A patent/NZ264526A/en not_active IP Right Cessation
- 1994-09-26 IL IL11106594A patent/IL111065A/xx not_active IP Right Cessation
- 1994-09-26 CA CA002132936A patent/CA2132936C/fr not_active Expired - Fee Related
- 1994-09-26 ZA ZA947482A patent/ZA947482B/xx unknown
- 1994-09-26 FI FI944448A patent/FI115825B/fi active IP Right Grant
- 1994-09-26 CZ CZ19942349A patent/CZ287358B6/cs not_active IP Right Cessation
- 1994-09-27 EP EP94115180A patent/EP0645145B1/fr not_active Expired - Lifetime
- 1994-09-27 HU HU9402776A patent/HU217962B/hu not_active IP Right Cessation
- 1994-09-27 AT AT94115180T patent/ATE149843T1/de not_active IP Right Cessation
- 1994-09-27 JP JP23011894A patent/JP3447386B2/ja not_active Expired - Lifetime
- 1994-09-27 DK DK94115180.5T patent/DK0645145T3/da active
- 1994-09-27 NO NO943583A patent/NO308447B1/no not_active IP Right Cessation
- 1994-09-27 DE DE69402022T patent/DE69402022T2/de not_active Expired - Fee Related
- 1994-09-27 ES ES94115180T patent/ES2098842T3/es not_active Expired - Lifetime
- 1994-09-27 SG SG1996002365A patent/SG50479A1/en unknown
- 1994-09-28 IT IT94RM000621A patent/IT1279383B1/it active IP Right Grant
- 1994-09-28 CN CNB941165809A patent/CN1140297C/zh not_active Expired - Fee Related
- 1994-09-28 BE BE9400879A patent/BE1007987A5/fr not_active IP Right Cessation
- 1994-09-28 RU RU94037231A patent/RU2107500C1/ru not_active IP Right Cessation
- 1994-09-28 AU AU74273/94A patent/AU686651B2/en not_active Ceased
- 1994-09-29 ES ES09402047A patent/ES2095802A1/es not_active Withdrawn
- 1994-09-29 PL PL94305240A patent/PL176826B1/pl not_active IP Right Cessation
- 1994-09-29 KR KR1019940025248A patent/KR100515631B1/ko not_active IP Right Cessation
-
1995
- 1995-01-18 US US08/374,093 patent/US5504102A/en not_active Expired - Fee Related
-
1997
- 1997-04-28 BR BR1100361-8A patent/BR1100361A/pt active IP Right Grant
- 1997-05-29 GR GR970401231T patent/GR3023583T3/el unknown
- 1997-06-26 HK HK96797A patent/HK96797A/xx not_active IP Right Cessation
-
1998
- 1998-02-20 CY CY203598A patent/CY2035A/xx unknown
- 1998-06-23 CZ CZ19981998A patent/CZ287485B6/cs not_active IP Right Cessation
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