ES2097878T3 - Fijacion de p53 sobre el adn mediante una secuencia especifica. - Google Patents
Fijacion de p53 sobre el adn mediante una secuencia especifica.Info
- Publication number
- ES2097878T3 ES2097878T3 ES92305333T ES92305333T ES2097878T3 ES 2097878 T3 ES2097878 T3 ES 2097878T3 ES 92305333 T ES92305333 T ES 92305333T ES 92305333 T ES92305333 T ES 92305333T ES 2097878 T3 ES2097878 T3 ES 2097878T3
- Authority
- ES
- Spain
- Prior art keywords
- dna
- sequences
- fixation
- wild
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
LAS SECUENCIAS ESPECIFICAS EN EL GENOMA HUMANO SON LOS LUGARES DE FUERTE UNION DE LA PROTEINA DE TIPO SALVAJE P53, PERO NO DE LAS FORMAS MUTANTES DE LA PROTEINA. ESTAS SECUENCIAS SE USAN EN PROCEDIMIENTOS DE DIAGNOSTICO PARA DETECTAR CELULAS EN LAS CUALES LA CANTIDAD DE P53 DE TIPO SALVAJE HA SIDO DISMINUIDA. LAS SECUENCIAS PUEDEN USARSE TAMBIEN PARA FILTRAR AGENTES QUE CORRIGEN LA PERDIDA DEL P53 DE TIPO SALVAJE EN EL DNA DE LAS CELULAS DEL CANCER.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71518291A | 1991-06-14 | 1991-06-14 | |
US07/860,758 US5362623A (en) | 1991-06-14 | 1992-03-31 | Sequence specific DNA binding by p53 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097878T3 true ES2097878T3 (es) | 1997-04-16 |
Family
ID=27109289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92305333T Expired - Lifetime ES2097878T3 (es) | 1991-06-14 | 1992-06-10 | Fijacion de p53 sobre el adn mediante una secuencia especifica. |
Country Status (10)
Country | Link |
---|---|
US (4) | US5362623A (es) |
EP (1) | EP0518650B1 (es) |
JP (1) | JPH0678798A (es) |
AT (1) | ATE147512T1 (es) |
AU (1) | AU666479B2 (es) |
CA (1) | CA2070979C (es) |
DE (1) | DE69216478T2 (es) |
DK (1) | DK0518650T3 (es) |
ES (1) | ES2097878T3 (es) |
GR (1) | GR3022473T3 (es) |
Families Citing this family (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5532220A (en) * | 1987-08-31 | 1996-07-02 | The Regents Of The University Of California | Genetic mechanisms of tumor suppression |
NO312681B1 (no) * | 1990-08-24 | 2002-06-17 | Univ California | Fremgangsmåte for fremstilling av en farmasöytisk blanding med suppresiv virkning/aktivitet |
US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
US6410010B1 (en) | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
CA2108144A1 (en) | 1991-03-06 | 1992-09-07 | Jack A. Roth | Methods and compositions for the selective inhibition of gene expression |
DE69333289T2 (de) * | 1992-04-01 | 2004-08-26 | The Johns Hopkins University School Of Medicine | Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien |
US5670330A (en) * | 1992-09-29 | 1997-09-23 | Mcgill University | Anti-tumor agent assay using PKR |
CA2144768A1 (en) * | 1992-10-01 | 1994-04-14 | Stephen H. Friend | Functional assay for tumor supressor genes |
DE69433915T2 (de) * | 1993-05-14 | 2005-07-21 | Cancer Institute | MDC-Proteine und dafür kodierende DNS |
US5659024A (en) * | 1994-01-14 | 1997-08-19 | The Burnham Institute | Promotors that regulate the expression of genes involved in cell death |
US5753441A (en) * | 1994-08-12 | 1998-05-19 | Myriad Genetics, Inc. | 170-linked breast and ovarian cancer susceptibility gene |
US5693473A (en) * | 1994-08-12 | 1997-12-02 | Myriad Genetics, Inc. | Linked breast and ovarian cancer susceptibility gene |
US5709999A (en) * | 1994-08-12 | 1998-01-20 | Myriad Genetics Inc. | Linked breast and ovarian cancer susceptibility gene |
WO1996005308A1 (en) * | 1994-08-12 | 1996-02-22 | Myriad Genetics, Inc. | Method for diagnosing a predisposition for breast and ovarian cancer |
US5747282A (en) * | 1994-08-12 | 1998-05-05 | Myraid Genetics, Inc. | 17Q-linked breast and ovarian cancer susceptibility gene |
US5573925A (en) * | 1994-11-28 | 1996-11-12 | The Wistar Institute Of Anatomy And Biology | P53 proteins with altered tetramerization domains |
US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
US6169073B1 (en) | 1995-02-16 | 2001-01-02 | Bayer Corporation | Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function |
AU6643596A (en) * | 1995-08-11 | 1997-03-12 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Isolation of amplified genes via cdna subtractive hybridization |
EP0859956B1 (en) | 1995-09-18 | 2003-07-02 | Cancer Research Technology Limited | ASSAY FOR IDENTIFYING INHIBITORS OF THE INTERACTION BETWEEN PROTEINS p53 AND dm2 |
GB9519275D0 (en) | 1995-09-21 | 1995-11-22 | Univ Dundee | Substances and their therapeutic use |
US5847083A (en) * | 1996-08-21 | 1998-12-08 | The Wistar Institute Of Anatomy And Biology | Modified p53 constructs which enhance DNA binding |
AU7242996A (en) * | 1995-09-22 | 1997-04-09 | Wistar Institute Of Anatomy And Biology, The | Modified p53 constructs and uses therefor |
PL186018B1 (pl) * | 1995-11-30 | 2003-09-30 | Regents Board Of | Sposoby i kompozycje do diagnozowania i leczenia nowotworu |
US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
US6242212B1 (en) * | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
JPH09252783A (ja) * | 1996-03-26 | 1997-09-30 | Nippon Suisan Kaisha Ltd | 腸炎ビブリオ検出のためのヌクレオチドおよびそれを用いた検出法 |
US5861249A (en) * | 1996-04-23 | 1999-01-19 | Cold Spring Harbor Laboratory | Assays and reagents for identifying modulators of cdc25-mediated mitotic activation |
US5830751A (en) * | 1996-05-01 | 1998-11-03 | The Johns Hopkins University | Genetic assays and strains using human TP53 |
US5876711A (en) * | 1996-05-31 | 1999-03-02 | Onyx Pharmaceuticals, Inc. | Methods and compositions for determining the tumor suppressor status of cells |
US5858673A (en) * | 1996-06-24 | 1999-01-12 | Charlotte-Mecklenburg Hospital Authority | Method for detecting prostate cells |
US7083983B2 (en) | 1996-07-05 | 2006-08-01 | Cancer Research Campaign Technology Limited | Inhibitors of the interaction between P53 and MDM2 |
US5744310A (en) * | 1996-07-29 | 1998-04-28 | The Burnham Institute | Bax promoter sequence and screening assays for indentifying agents that regulate bax gene expression |
US5827658A (en) * | 1996-08-09 | 1998-10-27 | The United States Of America As Reprsented By The Department Of Health And Human Services | Isolation of amplified genes via cDNA subtractive hybridization |
US6100029A (en) * | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US5952178A (en) * | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
US6146828A (en) * | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
US6020137A (en) * | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
AU8284198A (en) | 1997-07-02 | 1999-01-25 | Board Of Regents, The University Of Texas System | P53 as a regulator of cell differentiation |
CA2214461A1 (en) * | 1997-09-02 | 1999-03-02 | Mcgill University | Screening method for determining individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53 |
US20020064792A1 (en) * | 1997-11-13 | 2002-05-30 | Lincoln Stephen E. | Database for storage and analysis of full-length sequences |
US6388062B1 (en) | 1998-05-08 | 2002-05-14 | The Wistar Institute Of Anatomy And Biology | Modified p53 tetramerization domains having hydrophobic amino acid substitutions |
AU1115300A (en) | 1998-10-13 | 2000-05-01 | Advanced Research And Technology Institute, Inc. | Assays for identifying functional alterations in the p53 tumor suppressor |
DE19847779C1 (de) | 1998-10-16 | 2000-02-03 | Deutsches Krebsforsch | p53-Bindungsregionen |
US6911307B1 (en) * | 1998-12-08 | 2005-06-28 | Proteus S.A. | Method of detection in vitro of a target substance in a sample comprising the labelling of said substance with a reporter gene and with the sequences necessary for the expression of said reporter gene in vitro |
US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
ES2269102T3 (es) | 1999-02-25 | 2007-04-01 | Exact Sciences Corporation | Procedimientos para conservar la integridad del adn. |
AU767983B2 (en) | 1999-04-09 | 2003-11-27 | Esoterix Genetic Laboratories, Llc | Methods for detecting nucleic acids indicative of cancer |
US6297013B1 (en) | 1999-06-24 | 2001-10-02 | Dnab Diagnostics Inc. | Compositions and methods for determining the activity of DNA-binding proteins and of initiation of transcription |
US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
CA2394921A1 (en) * | 1999-12-07 | 2001-06-14 | Anthony P. Shuber | Supracolonic aerodigestive neoplasm detection |
US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
US6831155B2 (en) * | 1999-12-08 | 2004-12-14 | President And Fellows Of Harvard College | Inhibition of p53 degradation |
US6989239B2 (en) * | 2001-06-20 | 2006-01-24 | R.E.D. Laboratories, N.V./S.A. | Methods for diagnosis and treatment of chronic immune diseases |
WO2003058201A2 (en) * | 2001-12-31 | 2003-07-17 | Quark Biotech, Inc. | Methods for identifying marker genes for cancer |
WO2003071252A2 (en) | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
JP4051327B2 (ja) * | 2003-09-19 | 2008-02-20 | 新科實業有限公司 | 垂直磁気記録ヘッドおよびその製造方法、ならびに磁気記録装置 |
US7981607B2 (en) | 2004-08-27 | 2011-07-19 | Esoterix Genetic Laboratories LLC | Method for detecting recombinant event |
MX2007002169A (es) | 2004-08-27 | 2007-08-14 | Cyclacel Ltd | Inhibidores de cdk de purina y pirimidina y su uso para el tratamiento de enfermedades inmunes. |
US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
WO2007044071A2 (en) | 2005-04-21 | 2007-04-19 | Exact Sciences Corporation | Analysis of heterogeneous nucleic acid samples |
WO2011119934A2 (en) * | 2010-03-26 | 2011-09-29 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal neoplasm |
US8470967B2 (en) * | 2010-09-24 | 2013-06-25 | Duke University | Phase transition biopolymers and methods of use |
AU2012212127B2 (en) | 2011-02-02 | 2016-06-02 | Exact Sciences Corporation | Digital sequence analysis of DNA methylation |
ES2712798T3 (es) | 2013-03-14 | 2019-05-14 | Exact Sciences Dev Co Llc | Detección de neoplasias |
US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
US10253358B2 (en) | 2013-11-04 | 2019-04-09 | Exact Sciences Development Company, Llc | Multiple-control calibrators for DNA quantitation |
CN104946737B (zh) | 2013-12-11 | 2019-02-22 | 安可济控股有限公司 | 用于检测罕见序列变体的组合物和方法 |
US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
EP4209600A1 (en) | 2013-12-19 | 2023-07-12 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
WO2015153283A1 (en) | 2014-03-31 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasm |
US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
US10030272B2 (en) | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | PROOF OF DISEASES OF THE DISHES |
EA037478B1 (ru) | 2015-08-04 | 2021-04-01 | Дьюк Юниверсити | Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения |
CN108138235B (zh) | 2015-08-31 | 2022-04-15 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
KR20180055905A (ko) | 2015-10-09 | 2018-05-25 | 아큐라젠 홀딩스 리미티드 | 증폭 산물의 농축을 위한 방법 및 조성물 |
US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
CA3020628A1 (en) | 2016-04-14 | 2017-10-19 | Mayo Foundation For Medical Education And Research | Detecting pancreatic high-grade dysplasia |
US10370726B2 (en) | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
US11427866B2 (en) | 2016-05-16 | 2022-08-30 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
SG11201901296TA (en) | 2016-08-15 | 2019-03-28 | Accuragen Holdings Ltd | Compositions and methods for detecting rare sequence variants |
US11135301B2 (en) | 2016-09-14 | 2021-10-05 | Duke University | Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs |
JP2020500150A (ja) | 2016-09-23 | 2020-01-09 | デューク ユニバーシティ | 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド |
US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
CN110431241B (zh) | 2017-02-28 | 2024-04-19 | 梅约医学教育与研究基金会 | 检测前列腺癌 |
US11554097B2 (en) | 2017-05-15 | 2023-01-17 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
US11680083B2 (en) | 2017-06-30 | 2023-06-20 | Duke University | Order and disorder as a design principle for stimuli-responsive biopolymer networks |
CN107656059B (zh) * | 2017-09-26 | 2019-06-18 | 中南大学 | 一种用于p53蛋白的荧光检测剂及其制备方法和应用 |
AU2018374176A1 (en) | 2017-11-30 | 2020-06-11 | Exact Sciences Corporation | Detecting breast cancer |
US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
US11649275B2 (en) | 2018-08-02 | 2023-05-16 | Duke University | Dual agonist fusion proteins |
US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0204922A3 (en) * | 1985-05-28 | 1987-09-30 | Abbott Laboratories | Immunohistochemical assay for detection of a tumor-associated marker (p53) |
US5447841A (en) * | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
US4917999A (en) * | 1986-09-02 | 1990-04-17 | Miles Inc. | Oligonucleotide probes for detection of α-amylase genes |
US4994371A (en) * | 1987-08-28 | 1991-02-19 | Davie Earl W | DNA preparation of Christmas factor and use of DNA sequences |
DE69032864T3 (de) * | 1989-03-29 | 2013-01-31 | The Johns Hopkins University | Nachweis des Ausfalls des Wildtyps des p53-Gens |
NZ233255A (en) * | 1989-04-11 | 1993-02-25 | Chiron Corp | Plasmodium cs protein analogues lacking one or more of the repeat epitopes, and containing at least one nonrepeat flanking epitope |
US5068175A (en) * | 1989-05-26 | 1991-11-26 | Board Of Regents, The University Of Texas Sysem | Method of detecting ras oncogene related malignancies |
ES2164045T3 (es) * | 1990-06-27 | 2002-02-16 | Univ Princeton | Sondas para la deteccion de p53 mutante. |
AU650677B2 (en) * | 1990-09-24 | 1994-06-30 | General Hospital Corporation, The | Screening assays |
US5434257A (en) * | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
US5571903A (en) * | 1993-07-09 | 1996-11-05 | Lynx Therapeutics, Inc. | Auto-ligating oligonucleotide compounds |
-
1992
- 1992-03-31 US US07/860,758 patent/US5362623A/en not_active Expired - Lifetime
- 1992-06-10 AT AT92305333T patent/ATE147512T1/de active
- 1992-06-10 ES ES92305333T patent/ES2097878T3/es not_active Expired - Lifetime
- 1992-06-10 EP EP92305333A patent/EP0518650B1/en not_active Expired - Lifetime
- 1992-06-10 DE DE69216478T patent/DE69216478T2/de not_active Expired - Lifetime
- 1992-06-10 DK DK92305333.4T patent/DK0518650T3/da active
- 1992-06-10 CA CA002070979A patent/CA2070979C/en not_active Expired - Lifetime
- 1992-06-12 AU AU18200/92A patent/AU666479B2/en not_active Expired
- 1992-06-15 JP JP4155394A patent/JPH0678798A/ja active Pending
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1994
- 1994-09-01 US US08/299,074 patent/US5955263A/en not_active Expired - Lifetime
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1997
- 1997-02-05 GR GR970400120T patent/GR3022473T3/el unknown
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1999
- 1999-09-21 US US09/399,773 patent/US6245515B1/en not_active Expired - Fee Related
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2001
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US20020164595A1 (en) | 2002-11-07 |
US5955263A (en) | 1999-09-21 |
CA2070979C (en) | 2006-01-03 |
AU1820092A (en) | 1992-12-17 |
ATE147512T1 (de) | 1997-01-15 |
JPH0678798A (ja) | 1994-03-22 |
EP0518650A2 (en) | 1992-12-16 |
AU666479B2 (en) | 1996-02-15 |
US5362623A (en) | 1994-11-08 |
US6245515B1 (en) | 2001-06-12 |
GR3022473T3 (en) | 1997-05-31 |
DE69216478T2 (de) | 1998-02-19 |
DK0518650T3 (da) | 1997-01-27 |
DE69216478D1 (de) | 1997-02-20 |
CA2070979A1 (en) | 1992-12-15 |
EP0518650A3 (en) | 1993-01-20 |
EP0518650B1 (en) | 1997-01-08 |
US7087583B2 (en) | 2006-08-08 |
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